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Exposure To Endocrine Disrupting Compounds And Reproductive Toxicity In Women, Marisa L. Morgan
Exposure To Endocrine Disrupting Compounds And Reproductive Toxicity In Women, Marisa L. Morgan
FIU Electronic Theses and Dissertations
The overall objective of the research presented in this dissertation was to assess exposure to endocrine disrupting chemicals (EDCs), polychlorinated biphenyls (PCBs), phthalates, and bisphenol A (BPA) in the general population and evaluate their associations with adverse reproductive health effects, including cancers, in women. Given the proven contribution of unopposed estrogens to the risk for endometrial neoplasia or breast cancer, renewed health concerns have aroused about estrogen mimicking EDCs found in food, personal care products or as environmental contaminants. Our meta-analysis showed that exposure to estrogen mimicking PCBs increased summary risk of breast cancer and endometriosis. We further evaluated the …