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Targeted Drug Delivery Systems For Cancer Therapy, Antonio Clementi, Christine O'Connor, Mary Mcnamara, A. Mazzaglia, M. C. Aversa, A. Giuffrida
Targeted Drug Delivery Systems For Cancer Therapy, Antonio Clementi, Christine O'Connor, Mary Mcnamara, A. Mazzaglia, M. C. Aversa, A. Giuffrida
Conference Papers
The role of cyclodextrin’s (CD) in drug delivery has advanced in recent years and this may be attributed to its biocompatibility and well established synthesis. Chemical modification of CDs has shown to extend the physicochemical properties and the host capacity for a variety of drugs. β-CD has been widely used in the early stages of pharmaceutical applications because of its ready availability and its cavity size suitability for a wide range of drugs. Chemical modification of β-CD has proven to enhance aqueous solubilisation, microbiological stability and reduced toxicity in previous studies.1 Folate Receptors are over-expressed in several human cancers including …
Maternal Awareness Of The Association Between Paediatric Diet And Adult Disease Risk: A Follow-Up To The Dit-Coombe Hospital Study., Qianling Zhou, Katherine Younger, John Kearney
Maternal Awareness Of The Association Between Paediatric Diet And Adult Disease Risk: A Follow-Up To The Dit-Coombe Hospital Study., Qianling Zhou, Katherine Younger, John Kearney
Conference Papers
Chronic disease has been traditionally attributed to risk factors in adulthood; however, current orthodoxy suggests that the true origins of such diseases are initiated much earlier in life from inappropriate nutritional circumstances arising during the formative years(1). The present study was undertaken to examine current maternal attitudes towards the importance of paediatric diet in relation to adult diseases and to determine the extent to which attitudinal differences between subgroups in the population exist. A non-randomised postal follow-up survey to the DIT–Coombe Hospital Infant Feeding Study was carried out, involving the recruitment of 209 mothers from a pool sample of 520 …
Photochemical Studies Of Nutraceuticals In The Presence Of Cyclodextrins, Zlata Tofzikovskaya, Christine O'Connor, Mary Mcnamara
Photochemical Studies Of Nutraceuticals In The Presence Of Cyclodextrins, Zlata Tofzikovskaya, Christine O'Connor, Mary Mcnamara
Conference Papers
The photostability studies of Folic acid and Menadione Sodium Bisulfite, also known as vitamin K3, were carried out in their aqueous solutions at room temperature. Solutions of Folic acid ( 4.8 x 10-5 M) and Menadione Sodium Bisulfite (4.0 x 10-4 M) were exposed to ultraviolet radiation at a wavelength of 365 nm. During exposure absorbance of both solutions was measured using a Perkin Elmer Lamda 900 UV/VIS/NIR Spectrometer. During the stability tests it was noted that addition of β Cyclodextrin (1:1 ratio) to aqueous solutions containing the vitamin slowed down the photodegradation process. The unique shape of Cyclodextrins allows …
Patient-Centred Laboratory Validation Using Software Agents, John Mcgrory, Jane Grimson, Frank Clarke, Peter Gaffney
Patient-Centred Laboratory Validation Using Software Agents, John Mcgrory, Jane Grimson, Frank Clarke, Peter Gaffney
Conference Papers
Guidelines are self-contained documents which healthcare professionals reference to obtain knowledge about a specific condition or process. They interface with these documents and apply known facts about specific patients to gain useful supportive information to aid in developing a diagnosis or manage a condition. To automate this process a series of Standard Operating Procedures (SOP) and workflow processes are constructed using the contents of these documents in order to manage the validation flow of a patient sample. These processes decompose the guidelines into workflow plans, which are then called using condition triggers controlled by a centralised management engine. The software …