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Oral Candida Colonization In Thai Denture Wearing Elderly With Hyposalivation, Nada Buranarom
Oral Candida Colonization In Thai Denture Wearing Elderly With Hyposalivation, Nada Buranarom
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: To examine relationships between hyposalivation, oral Candida colonization and oral health status in generally healthy elders and evaluate factors that affect salivary flow rates and Candida colonization in a cross-sectional study. Materials and methods: Fifty-three elderly participants were enrolled and interviewed for medical history, subjective dry mouth symptoms, oral hygiene practice and denture information. Unstimulated and stimulated salivary flow rates, clinical signs of dry mouth, gingival index, tongue coating index and root caries index were recorded. Stimulated saliva samples were cultured on Sabouraud dextrose agar for colony counts and Candida species were identified with chromogenic Candida agar and polymerase …
Protein Expression And Inflammatory Response After Delivery Of Mrna Encoding Platelet-Derived Growth Factor-Bb In Sucrose Citrate Buffer Into Rat Gingiva, Phan Bhongsatiern
Protein Expression And Inflammatory Response After Delivery Of Mrna Encoding Platelet-Derived Growth Factor-Bb In Sucrose Citrate Buffer Into Rat Gingiva, Phan Bhongsatiern
Chulalongkorn University Theses and Dissertations (Chula ETD)
Messenger RNA (mRNA) has emerged as a novel therapeutic modality in medical fields, including regenerative medicine. The concept of mRNA-based therapy is to use synthesized mRNA encoding therapeutic protein delivered to target tissue. Thus, mRNA encoding growth factor could be a promising alternative to recombinant protein. Platelet-derived growth factor (PDGF) is one of most extensively studied growth factors for periodontal regeneration. To date, mRNA therapy has never been explored in the field of periodontal regeneration. The aim of the study is to examine the effect of nucleoside-modified mRNA encoding PDGF-BB on the level of PDGF-BB protein and inflammatory response at …
Bioengineered Regenerative Therapy For Diabetes Mellitus: Establishment Of Canine Mesenchymal Stem Cell-Derived Insulin Producing Cells, Watchareewan Rodprasert
Bioengineered Regenerative Therapy For Diabetes Mellitus: Establishment Of Canine Mesenchymal Stem Cell-Derived Insulin Producing Cells, Watchareewan Rodprasert
Chulalongkorn University Theses and Dissertations (Chula ETD)
Trend of regenerative therapy for diabetes in human and veterinary practice has conceptually been proven according to Edmonton protocol and animal models. Establishing an alternative insulin-producing cell (IPC) resource is a challenge task for further clinical application. In this study, IPC generation from two practical canine mesenchymal stem cells (cMSCs), canine bone marrow-derived MSCs (cBM-MSCs) and canine adipose-derived MSCs (cAD-MSCs), was of interest. The results illustrated that cBM-MSCs and cAD-MSCs contained distinct pancreatic differentiation potential and required the tailor-made induction protocols. Generation of functional cBM-MSC-derived IPCs needed an integration of genetic and microenvironment manipulation using hanging-drop culture of PDX-1-transfected cBM-MSCs …
The Effect Of Different Surface Treatments On Tensile Bond Strength Of Acrylic Denture Teeth And Light-Cured Composite Resin, Chotinut Wongpornpirot
The Effect Of Different Surface Treatments On Tensile Bond Strength Of Acrylic Denture Teeth And Light-Cured Composite Resin, Chotinut Wongpornpirot
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study evaluated the effect of different surface treatments on the tensile bond strength between acrylic denture teeth and composite resin. Maxillary lateral incisors of conventional acrylic denture teeth (Yamahachi New Ace) and highly cross-linked acrylic denture teeth (Trubyte Bioform IPN teeth) were ground on the labial surfaces. Each type of denture teeth were divided into six groups (n=10) according to surface treatment procedures which are no surface treatment (control), methyl methacrylate treatment (MMA) for 180 seconds, methyl formate-methyl acetate mixture (MF-MA) solution at a ratio of 25:75 (v/v) treatment for 15 seconds, composite bonding agents, MMA (180 seconds) with …
Microhardness Of Light- And Dual-Cured Resin Cements After Light Curing Through Various Translucencies Of Translucent Monolithic Zirconia, Sawanya Pechteewang
Microhardness Of Light- And Dual-Cured Resin Cements After Light Curing Through Various Translucencies Of Translucent Monolithic Zirconia, Sawanya Pechteewang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Purpose: This study aims to investigate the microhardness of light- and dual-cured resin cements under various translucencies of monolithic zirconia specimen; translucent (T), super translucent (ST), high translucent (HT), and extra translucent (XT). Materials and Methods: Four different translucencies of zirconia specimen were prepared in the square shape, size 10×10×1 mm. The light-cured resin cement (Variolink® N LC) and the dual-cured (RelyX™ U200) resin cement were mixed and loaded in a 2-mm height and 5-mm diameter of space in a customized mold and cured through the zirconia specimens and 1-mm thick glass slide in a control group, using the light …
Color Stability, Nanohardness And Elastic Modulus Of Denture Base Acrylic Resins With Various Polymerization Techniques, Sawita Losuphakarn
Color Stability, Nanohardness And Elastic Modulus Of Denture Base Acrylic Resins With Various Polymerization Techniques, Sawita Losuphakarn
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objective of this study was to evaluate color stability, nanohardness and elastic modulus of denture base acrylic resins with various polymerization techniques after storing in coffee, distilled water or dark chamber. Ninety disc-shaped (9X2 mm) specimens of heat-cured (TRX), microwave-cured (BTC) and light-cured (TRD) were fabricated, and randomly divided in three conditions (n=10). The color difference (DE*) was measured using a spectrophotometer at 1, 7, 28 and 56 days; The nanohardness and the elastic modulus were measured from three randomly selected of each group at day 1 and day 56 after color measurement. The repeated mixed analysis of variance …
Service Quality, Patient Satisfaction, And Types Of Medical Insurance Towards The Revisit Intention To Private Hospitals Among Outpatients In South Tangerang City, Indonesia, Fena Amalia Untari
Service Quality, Patient Satisfaction, And Types Of Medical Insurance Towards The Revisit Intention To Private Hospitals Among Outpatients In South Tangerang City, Indonesia, Fena Amalia Untari
Chulalongkorn University Theses and Dissertations (Chula ETD)
Organization for Economic Co-operation and Development (OECD) estimated global health care growth will be higher than 20% of Gross Domestic Product (GDP) by 2050 which impacts the hospital providers to implement the concept of health for all and to ensure it meets the patient’s expectation. In Indonesia, 1,787 private hospitals are operating and being encouraged to involve in developing hospitals. As it reflects the need of excellent quality healthcare, this study aimed to assess the association between socio-demographic characteristics, service quality, patient satisfaction and types of medical insurance towards the revisit intention to private hospitals among outpatients in South Tangerang …
Factors Influencing ‘Stage Of Change’ Among Alcohol Use Disorder Patients In Rehabilitation Centers In Kathmandu, Nepal, Pranab Dahal
Factors Influencing ‘Stage Of Change’ Among Alcohol Use Disorder Patients In Rehabilitation Centers In Kathmandu, Nepal, Pranab Dahal
Chulalongkorn University Theses and Dissertations (Chula ETD)
INTRODUCTION: The ‘stages of change’ model defines behavior change as a process with a series of stages. Alcohol use disorder which includes ‘harmful use’ and ‘alcohol dependence’ is a serious public health concern. With the ever increasing prevalence of ‘alcohol use disorder’ there is an increasing need to better understand the complexities of behavior change among this group. METHODS: A cross- sectional survey was conducted in 8 alcohol and drug rehabilitation centers (residential treatment centers) of Kathmandu, Nepal, in September 2018, involving 225 male patients. AUDIT screening test was used to screen patients with alcohol use disorder. A self-report questionnaire …
Study Of Pharmacist Workforce In Public Sector, Of Republic Of The Union Of Myanmar, Lwin Nyein Aye
Study Of Pharmacist Workforce In Public Sector, Of Republic Of The Union Of Myanmar, Lwin Nyein Aye
Chulalongkorn University Theses and Dissertations (Chula ETD)
Health workforce shortage was common across the world including Myanmar. However, there was not previous study about the pharmacist workforce to ascertain the shortage problem in Myanmar. This study was aimed to analyze the current situation of pharmacist workforce in Myanmar especially in public sector and to construct a simulation model to suggest the appropriate policy options to the policymakers in improving the pharmacist workforce situations in the public hospitals.For the first objective, the study design was a cross-sectional survey using a mixed method which consisted of the secondary data analysis and semi-structured face-to-face interviews. The government registry data related …
Precision Medicine Reimbursement Policy Landscape, Nisita Jirawutkornkul
Precision Medicine Reimbursement Policy Landscape, Nisita Jirawutkornkul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Access to precision medicine is limited due to many factors such as precision medicine technology of each country, high-cost technology that requires high finance, limitations on knowledge and competency of personnel and access to precision medicine. Each country manages access to precision medicine differently. The existing evidences of precision medicine reimbursement policy were limited. Objective: To explore reimbursement decision of precision medicine focusing on diagnostic tests and factors associated with reimbursement decision among high-income and upper-middle-income countries. Methods: A targeted review of literatures was conducted through PubMed, MEDLINE, Embase, Cochrane Library, and hand-searching. The study included 13 selected precision …
Establishment Of Encapsulated Human Dental Pulp Stem Cell-Derived Insulin Producing Cells (Hdpsc-Ipcs) For Translational Stem Cell Based Diabetes Therapy, Suryo Kuncorojakti
Establishment Of Encapsulated Human Dental Pulp Stem Cell-Derived Insulin Producing Cells (Hdpsc-Ipcs) For Translational Stem Cell Based Diabetes Therapy, Suryo Kuncorojakti
Chulalongkorn University Theses and Dissertations (Chula ETD)
Current approach for diabetes treatment remained several adverse events varied from gastrointestinal to life-threatening symptoms. Regenerative therapy regarding Edmonton protocol has been facing serious limitations involving protocol efficiency and safety. This led to the study for alternative insulin-producing cell (IPC) resource and transplantation platform. In this study, evaluation of encapsulated human dental pulp stem cell (hDPSC)-derived IPCs (hDPSC-IPCs) by alginate (ALG) and pluronic F127-coated alginate (ALGPA) was performed. The results showed that ALG and ALGPA preserved hDPSC viability and allowed glucose and insulin diffusion in and out. ALG- and ALGPA-encapsulated hDPSC-IPCs maintained viability for at least 336 hours and sustained …
การเปรียบเทียบกำลังแรงยึดเฉือนของเซอร์โคเนียชนิดใส เมื่อยึดด้วยเรซินซีเมนต์ที่ประกอบด้วยหมู่ฟอสเฟตต่างชนิด, ศิรวิชญ์ จิตสุธีศิริ
การเปรียบเทียบกำลังแรงยึดเฉือนของเซอร์โคเนียชนิดใส เมื่อยึดด้วยเรซินซีเมนต์ที่ประกอบด้วยหมู่ฟอสเฟตต่างชนิด, ศิรวิชญ์ จิตสุธีศิริ
Chulalongkorn University Theses and Dissertations (Chula ETD)
เซอร์โคเนียชนิดใสในงานทันตกรรมมีแนวโน้มถูกใช้โดยทันตแพทย์เพิ่มมากขึ้นในปัจจุบัน เนื่องจากความแข็งแรง และความสวยงามโดยไม่จำเป็นต้องพอกผิวด้วยพอร์ซเลน การยึดวัสดุดังกล่าวต่อฟันมีผลต่อความยั่งยืนของการบูรณะ เรซินซีเมนต์ที่มีฟอสเฟตมอนอเมอร์ชนิดต่างๆถูกอ้างว่าให้แรงยึดที่ดีกว่าต่อวัสดุเซอร์โคเนียชนิดใส หากแต่ยังไม่มีความชัดเจนในศักยภาพของฟอสเฟตมอนอเมอร์ งานวิจัยนี้จึงมีวัตถุประสงค์เพื่อต้องการศึกษาค่ากำลังแรงยึดเฉือนของเรซินซีเมนต์สองชนิดที่ประกอบด้วยหมู่ฟอสเฟตต่างชนิดกันบนเซอร์โคเนียชนิดใสต่อคอมโพสิตเรซิน โดยพื้นที่ยึดติดได้ถูกกำหนดตาม ISO 29022:2013 เซอร์โคเนียชนิดใส (Ceramill® zolid fx White) จึงถูกเตรียมให้มีเส้นผ่านศูนย์กลาง 8.5 มม. หนา 3.2 มม. จำนวน 32 แผ่น และถูกนำมายึดกับคอมโพสิตเรซินชนิดนาโนคอมโพสิต (FiltekTM Z350 XT) ผ่านศูนย์กลาง 3.0 มม. หนา 2.0 มม. ด้วยเรซินซีเมนต์สองชนิดคือ PANAVIA ™ V5 และ Rely X ™ U200 โดยเรซินซีเมนต์แต่ละชนิดจะถูกแบ่งออกอีกเป็นสองกลุ่ม ได้แก่กลุ่มที่ใช้ร่วมกับ Clearfil ceramic primer plus และกลุ่มที่ไม่ใช้ร่วมกับ Clearfil ceramic primer plus ทำให้แบ่งกลุ่มตัวอย่างออกได้เป็น 4 กลุ่ม กลุ่มละ 8 ชิ้น และความหนาของเรซินซีเมนต์ถูกกำหนดตาม ISO 4049:2009 ภายหลังการยึดติดชิ้นงานทุกชิ้นถูกนำไปผ่านกระบวนการเทอร์โมไซคลิงจำนวน 5,000 รอบ และถูกทดสอบกำลังแรงยึดเฉือนจนชิ้นคอมโพสิตเรซินหลุดด้วยเครื่องทดสอบแรงดึงแรงอัด(EZ-S, SHIMADZU) และสังเกตรูปแบบความล้มเหลวด้วยกล้องจุลทรรศน์อิเล็กตรอนแบบส่องกราด(SEM)(FEI Quanta 250) ค่ากำลังแรงยึดเฉือนถูกคำนวณด้วยสถิติการวิเคราะห์ความแปรปรวนทางเดียว และเปรียบเทียบความแตกต่างระหว่างกลุ่มด้วยการทดสอบชนิดทูกีย์ (One-way ANOVA and Tukey’s post hoc test) ที่ระดับความเชื่อมั่นร้อยละ 95 ผลการทดลองกลุ่ม PANAVIA ™ V5 ร่วมกับ Clearfil ceramic primer plus แสดงกำลังแรงยึดเฉือนมากที่สุด (1.38 ± 0.39 เมกะพาสคาล) และมีรูปแบบความล้มเหลวแบบผสมร่วมกับเชื่อมแน่นล้มเหลว โดยความล้มเหลวแบบผสมมีค่าเฉลี่ยร้อยละปริมาณเรซินซีเมนต์คงเหลือบนเซอร์โคเนียชนิดใสมากที่สุด(ร้อยละ 48.56±9.44) กลุ่มPANAVIA …
การวิเคราะห์ค่าเนื้อเยื่ออ่อนจากภาพถ่ายกะโหลกศีรษะด้านข้างในเด็กไทยอายุระหว่าง 7-10 ปี กลุ่มหนึ่ง, ศิพิมพ์ คงเอี่ยม
การวิเคราะห์ค่าเนื้อเยื่ออ่อนจากภาพถ่ายกะโหลกศีรษะด้านข้างในเด็กไทยอายุระหว่าง 7-10 ปี กลุ่มหนึ่ง, ศิพิมพ์ คงเอี่ยม
Chulalongkorn University Theses and Dissertations (Chula ETD)
จุดประสงค์ของการวิจัยนี้เพื่อหาค่าปกติของเนื้อเยื่ออ่อนรูปหน้าด้านข้างในเด็กไทยในช่วงอายุ 7-10 ปี จากภาพถ่ายกะโหลกศีรษะด้านข้างในกลุ่มตัวอย่าง 83 คน อายุเฉลี่ย 9.97±0.78 ปี เป็นเพศชาย 43 คน และเพศหญิง 40 คน โดยกลุ่มตัวอย่างที่เลือกจะต้องมี (1) ฟันกรามแท้ซี่ที่ 1 และฟันตัดซี่กลางแท้ขึ้นครบแล้วทุกซี่ (2) ไม่มีฟันหายตั้งแต่กำเนิดและไม่มีการสูญเสียฟันก่อนกำหนด (3) การสบฟันกรามแท้ซี่ที่ 1 แบบประเภทที่ 1 ตามเกณฑ์ของ Angle (Angle’s classification I) และมีระยะเหลื่อมของฟันในแนวดิ่งและแนวระนาบปกติ (4) การเรียงตัวของฟันปกติ หรือมีฟันบิดซ้อนเกหรือมีช่องว่างได้ไม่เกิน 3 มิลลิเมตร (5) ไม่เคยได้รับการรักษาทางทันตกรรมจัดฟันมาก่อน ผลการศึกษาค่าเฉลี่ยเซฟาโลเมทริกในเด็กไทยที่ได้มีความแตกต่างจากการศึกษาอื่นที่เคยทำในผู้ใหญ่ไทยหรือทำในเด็กต่างประเทศ ค่าเฉลี่ยที่ได้จากการศึกษานี้สามารถใช้เป็นเกณฑ์ในการวิเคราะห์และวินิจฉัย การวางแผนการรักษา และการรักษาผู้ป่วยที่เป็นเด็กไทยในการรักษาทางทันตกรรมจัดฟัน
Influence Of Curved Root Canal On Retreatment Efficacy Of Bioceramic Sealer, Kasemsun Sujaritwanit
Influence Of Curved Root Canal On Retreatment Efficacy Of Bioceramic Sealer, Kasemsun Sujaritwanit
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study evaluated the influence of a curved root canal on the retreatment efficacy of root canals sealed with bioceramic sealer. 60 mandibular molars were divided into 4 subgroups of severely curved canal filled with AH Plus, slightly curved canal filled with AH Plus, severely curved canal filled with BioRoot RCS and slightly curved canal filled with BioRoot. Two weeks after root canal obturation, retreatment was performed with WaveOne Gold Primary and ProTaper Next X3 following with passive ultrasonic irrigation. The retreatment efficacy parameters were regaining canal patency, retreatment time and residual filling material. MicroCT and confocal microscope were used …
Tooth Agenesis In Thai Population: Prevalence, Characteristics And Its Genetic Variant In A Thai Family, Charinya Kanchanasevee
Tooth Agenesis In Thai Population: Prevalence, Characteristics And Its Genetic Variant In A Thai Family, Charinya Kanchanasevee
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: To assess the prevalence and characteristics of tooth agenesis in Thai population and to identify the genetic variants in a family affected with tooth agenesis. Methods: Panoramic radiographs in a random sample of Thai patients from 15 to 20 years of age which were taken in 2017 at the Faculty of Dentistry, Demographic data (age and sex) and dental characteristics of the patients were recorded. A chi-square test was used to determine the differences in the prevalence of tooth agenesis between sexes, maxillary-mandibular teeth, left-right sides, and numbers of missing teeth. Three mL of blood samples were collected for …
Microshear Bond Strength And Microleakage Of Glass Ionomer Cement On Aged Dentin, Chutima Techa-Ungkul
Microshear Bond Strength And Microleakage Of Glass Ionomer Cement On Aged Dentin, Chutima Techa-Ungkul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: To compare the microshear bond strength and microleakage of glass ionomer cements when bonded to aged and young dentin. Background: Root caries commonly occurs in elderly patients. Glass ionomer cement (GIC) is frequently used to restore root caries. Many studies of GIC have been conducted using young dentin, however few studies have assessed adhesion and microleakage of GICs to aged dentin. Materials and methods: Seventy-eight non-carious human molars (patient age 16-30 = 39; patient age ≥ 65 = 39) were tested with three commercial GICs (Fuji II LC, Equia Forte Fil, and Fuji BULK). For microshear bond strength (µSBS), …
Prevalence And Oral Health-Related Factors Associated With Mild Cognitive Impairment In Elderly Dental Patients At Faculty Of Dentistry, Chulalongkorn University, Panatcha Weerapol
Prevalence And Oral Health-Related Factors Associated With Mild Cognitive Impairment In Elderly Dental Patients At Faculty Of Dentistry, Chulalongkorn University, Panatcha Weerapol
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study aims to assess the prevalence of Mild Cognitive Impairment (MCI) and its oral health-related factors in elderly dental patients at Geriatric dentistry clinic and Prosthodontic clinic of Faculty of Dentistry, Total 248 dental patients aged 60 years and above were recruit. Average age of participants was 68.68 years with 73.0 % female. Cognitive functions were assessed by Montreal Cognitive Assessment Thai version (MoCA-T). Individual data were obtained by self-reported interview. Oral examinations were evaluated by a dentist. The prevalence of MCI was found 29.4% in elderly dental patients and was higher than among general elders. Oral health-related factors …
Dental Services Utilization, Oral Status, And Oral Health-Related Quality Of Life Among Thai Elderly: Data From The Eight Thailand National Oral Health Survey, Punkanit Harirugsakul
Dental Services Utilization, Oral Status, And Oral Health-Related Quality Of Life Among Thai Elderly: Data From The Eight Thailand National Oral Health Survey, Punkanit Harirugsakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
The number of older adults in Thailand is currently increasing. To create the appropriate oral health service for them requires understanding the associations between dental service utilization (DSU), oral status and oral health-related quality of life (OHRQoL). The objectives of this study were to examine the associations of DSU and oral status with OHRQoL and to examine the associations between social backgrounds and DSU in Thai older adults. Data on 4,130 Thai older adults from the 8th Thailand National Oral Health Survey were collected through interviews and oral examination. Chi-square test and multiple logistic regression models were applied. Thai older …
A Comparison Of Microrna Profiles Between Rat Incisors And Molars, Sirawit Nipakasem
A Comparison Of Microrna Profiles Between Rat Incisors And Molars, Sirawit Nipakasem
Chulalongkorn University Theses and Dissertations (Chula ETD)
Unlike the molar, rodent incisor is a distinct organ that have continuously growth at distal end of tooth throughout its lifetime to compensate for abrasion. The key of continuous growth is the result of delayed root formation and prolonged crown formation that possibly made by stem cell niche, so-called cervical loop, which involve various genes and signaling pathways. MicroRNAs (miRNAs) are small non-coding single stranded RNAs that involved in biological mechanisms of dental development. To study the role of miRNA, we extracted total RNA from the dental pulp tissue collected from the apical part, coronal part of incisors and molars, …
Comparison Between Hybrid Cbct And Cbct In Detection Of Vertical Root Fracture, Nantida Rueangweerayut
Comparison Between Hybrid Cbct And Cbct In Detection Of Vertical Root Fracture, Nantida Rueangweerayut
Chulalongkorn University Theses and Dissertations (Chula ETD)
Cone beam computerized tomography (CBCT) has been wildly used in many fields of dentistry, especially to investigate the vertical root fracture (VRF). CBCT systems were consisted of various field of view (FOV). As for high cost and large machine size, newly designed of CBCT systems started to develop by combining digital panoramic radiographs with a relatively small-to-medium FOV CBCT system. These new model of CBCT systems was called hybrid CBCT. The aims of this study is to compare the difference in detection of VRF by a hybrid CBCT and a CBCT. For this, forty permanent mandibular premolar teeth were endodontically …
Proximal Caries Detection On Smartphone Display, Napas Lappanakokiat
Proximal Caries Detection On Smartphone Display, Napas Lappanakokiat
Chulalongkorn University Theses and Dissertations (Chula ETD)
The aim of this study was to compare diagnostic accuracy in proximal caries detection between bitewing radiographs exported from PACS software and taken with a smartphone viewed in a smartphone display. A total of 200 proximal surfaces from digital bitewing radiographs were included in this study. Images of all radiographs were captured from a medical-grade and a common display by an iPhone 8 Plus and stored as JPEG files. Exported DICOM files were converted into JPEG format and transferred to the smartphone used for image capturing. Each proximal surface was rated by 7 observers with 5-point-scale. Weighted kappa test was …
The Efficacy Of Vitamin C Oral Supplement On Wound Healing After Tooth Extraction, Nanthanut Pisalsitsakul
The Efficacy Of Vitamin C Oral Supplement On Wound Healing After Tooth Extraction, Nanthanut Pisalsitsakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: The purpose of this study was to evaluate the effect and proper dosage of oral vitamin C supplement on post-extraction wound healing. Methods: This study was a split mouth, double-blind, randomized-controlled clinical trial of 42 patients who underwent symmetric bilateral non-infected premolars extraction. The patients were randomly divided into 3 groups (14 patients for each group); 1.placebo vs vitamin C 600 mg/d, 2.placebo vs vitamin C 1,500 mg/d and 3.vitamin C 600 mg/d vs vitamin C 1,500 mg/d. Each group was prescribed placebo and/or vitamin C three times a day for 10 days after each tooth extraction. The assessment …
Use Of Digital Panoramic Radiographs As A Screening Tool For Diagnosis Of Osteoporosis In Thai Postmenopausal Women, Net-Nada Chongruangsri
Use Of Digital Panoramic Radiographs As A Screening Tool For Diagnosis Of Osteoporosis In Thai Postmenopausal Women, Net-Nada Chongruangsri
Chulalongkorn University Theses and Dissertations (Chula ETD)
Purpose: To investigate the correlation between panoramic radiographic indices and osteoporosis, and to determine whether digital panoramic radiographs could be used as a screening tool for the diagnosis of osteoporosis in Thai postmenopausal women. Materials and Methods: A cross-sectional study of sixty Thai postmenopausal women with and without osteoporosis. The subjects were divided into three groups based on diagnosis by dual-energy X-ray absorptiometry (DXA): normal, osteopenia, and osteoporosis equally in each group. The panoramic radiographic indices measured were mental index (MI) and mandibular cortical index (MCI). Pearson’s correlation test was performed to analyze any correlation between MI, MCI, and BMD …
Association Between Clinical Signs And Quality Of Life In Thai Patients With Oral Lichen Planus, Sasirin Yiemstan
Association Between Clinical Signs And Quality Of Life In Thai Patients With Oral Lichen Planus, Sasirin Yiemstan
Chulalongkorn University Theses and Dissertations (Chula ETD)
Subjective patient’s symptoms and oral health-related quality of life (OHRQoL) were recommended to be involved in oral lichen planus (OLP) studies. Objectives: to evaluate 1) the association between OLP clinical signs and OHRQoL as well as pain perception. 2) the association between OLP pain and OHRQoL. Methods: Sixty-nine OLP or oral lichenoid drug reaction (OLDR) Thai patients were recruited. Data were collected through personal interview with the Numeric Rating Scale (NRS) and Thai version of Oral Impacts on Daily Performance (OIDP) index. OLP signs were examined in aspects of localization, type and clinical severity according to the Thongprasom sign scoring …
The Use Of Modified Mrna Encoding Platelet-Derived Growth Factor-Bb As An Innovation In Periodontal Regeneration, Theeraphat Surisaeng
The Use Of Modified Mrna Encoding Platelet-Derived Growth Factor-Bb As An Innovation In Periodontal Regeneration, Theeraphat Surisaeng
Chulalongkorn University Theses and Dissertations (Chula ETD)
Since the mRNA platform has been recently introduced to several fields in medicine and the achievement of periodontal regeneration is currently unpredictable, therefore, the use of mRNA technology is a promising approach to pursue the complete periodontal regeneration. The aims of this study are to learn if mRNA encoding platelet-derived growth factor-BB (PDGF-BB) induces PDGF production in human periodontal ligament cells (PDLCs) and to investigate the effect of secreted PDGF on PDLC proliferation and promoting endothelial cell tube formation. PDLCs were obtained from extracted teeth of healthy periodontal patients. The N1-methylpseudouridine modified mRNA encoding PDGF-BB were transfected into PDLCs. The …
In Vitro Safety And Permeation Assessments Of Lidocaine Loaded In Dissolving Microneedle Patch For Ocular Administration, Sirikool Thamnium
In Vitro Safety And Permeation Assessments Of Lidocaine Loaded In Dissolving Microneedle Patch For Ocular Administration, Sirikool Thamnium
Chulalongkorn University Theses and Dissertations (Chula ETD)
The challenge in ocular drug delivery have brought much attention in pharmaceutical research. Efforts have been made to improve the low bioavailability causing by physiological limitations of ophthalmic drug administration. Topical lidocaine solution is a popular choice for ocular treatment, but less than 5% of topically applied dose reached to the target site. Lidocaine loaded in dissolving microneedle patch was considered a good alternative approach to treating eyes. The study aimed to investigate the cytotoxicity of the lidocaine loaded in dissolving microneedle administration against human corneal epithelial cells (HCECs) as well as ex vivo drug target localization with tissue penetration. …
ผลของไซมอน เอฟเฟค ทางการได้ยินที่มีต่อเวลาปฏิกิริยาและความถูกต้องของการตอบสนองในนักกีฬาฟุตซอลเพศชาย, จิดาภา ศิริวรรณ์
ผลของไซมอน เอฟเฟค ทางการได้ยินที่มีต่อเวลาปฏิกิริยาและความถูกต้องของการตอบสนองในนักกีฬาฟุตซอลเพศชาย, จิดาภา ศิริวรรณ์
Chulalongkorn University Theses and Dissertations (Chula ETD)
การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อศึกษาผลของไซมอน เอฟเฟค ทางการได้ยินที่มีต่อเวลาปฏิกิริยาและความถูกต้องของการตอบสนองในนักกีฬาฟุตซอลเพศชาย กลุ่มตัวอย่างที่ใช้ในการวิจัยครั้งนี้ คือ นักกีฬาฟุตซอลเพศชาย สังกัดจุฬาลงกรณ์มหาวิทยาลัย อายุระหว่าง 18-21 ปี ทำการทดลองการตอบสนองต่อสิ่งเร้าทางการได้ยินด้วยการเคลื่อนที่เท้าข้างถนัดไปยังเป้าหมายตามทิศทางของคำสั่งอย่างรวดเร็วที่สุดเป็นจำนวน 4 ชุด ชุดละ 10 ครั้ง รวมทั้งสิ้น 40 ครั้ง แบ่งเป็นรูปแบบที่สิ่งเร้าและการตอบสนองสอดคล้องกัน 20 ครั้ง และไม่สอดคล้องกัน 20 ครั้ง นำผลที่ได้มาวิเคราะห์ค่าเฉลี่ย และส่วนเบี่ยงเบนมาตรฐานของค่าเวลาปฏิกิริยา เวลาการเคลื่อนไหวและค่าเปอร์เซ็นความผิดพลาดในการตอบสนองของกลุ่มตัวอย่าง และวิเคราะห์ความแปรปรวนสองทางชนิดที่มีความเกี่ยวข้องกันในกลุ่มตัวอย่าง โดยใช้ 2 way ANOVA 2X2 (two by two) with repeated measures กำหนดค่าความมีนัยสำคัญทางสถิติที่ระดับ .05 ผลการวิจัยพบว่า พบว่าผลของความแตกต่างในเวลาปฏิกิริยาของความสอดคล้องกับไม่สอดคล้องสิ่งเร้ากับการตอบสนองและด้านซ้ายและขวา และของเวลาการเคลื่อนไหวของความสอดคล้องกับไม่สอดคล้องสิ่งเร้ากับการตอบสนองไม่มีความแตกต่างอย่างมีนัยสำคัญทางสถิติ โดยพบว่า นักกีฬาที่มีประสบการณ์ และมีความเคยชินกับสถานการณ์ที่ต้องตอบสนองต่อสิ่งเร้าที่มีความขัดแย้งหรือไม่สอดคล้องกันส่งผลให้เกิดการหักล้าง (elimination) หรือการย้อนกลับ (reverse) ของไซมอน เอฟเฟคได้ และยังพบอิทธิพลของผลไซมอน เอฟเฟค ทางการได้ยินของนักกีฬาฟุตซอล เพศชาย ที่เวลาการเคลื่อนไหว ของการตอบสนองข้างซ้ายและขวา แตกต่างกันอย่างมีนัยสำคัญทางสถิติ ที่ระดับ .05 ผลมาจากการที่ท่าทางกายวิภาคของขาในการก้าว ที่เป็นการหดเข้า (flexor) มีความแข็งแรงมากกว่าการยืดออก (adductor) และมีพลังในการเคลื่อนไหวได้มากกว่า ซึ่งในทางกลับกัน สรุปผลการวิจัย ในนักกีฬาฟุตซอล เพศชาย ไม่ได้รับอิทธิพลของไซมอน เอฟเฟคทางการได้ยิน
Effects Of Non-Albicans Candida Species On Biofilm Formation And Acidogenicity Of Dual-Species Biofilms And On Cariogenic Virulence Gene Expression Of Streptococcus Mutans, Wirunphat Sansanoa
Effects Of Non-Albicans Candida Species On Biofilm Formation And Acidogenicity Of Dual-Species Biofilms And On Cariogenic Virulence Gene Expression Of Streptococcus Mutans, Wirunphat Sansanoa
Chulalongkorn University Theses and Dissertations (Chula ETD)
Early childhood caries is a common oral disease found in children which could affect their general health. Streptococcus mutans is an important cariogenic pathogen since it possesses cariogenic properties, which are acid production, acid tolerance and biofilm formation. Recent studies showed that Candida albicans, which is frequently found together with S. mutans in plaques of children with dental caries, enhances cariogenicity. At the same time, increasing prevalence of non-albicans Candida species (NACs) in children and immune-compromised patients has been reported. Therefore, this study aims to investigate the effects of NACs when co-cultured with S. mutans on cariogenic properties and virulence …
Clinical Evaluation Of Two Glass Ionomer Cement Restorations Placed In Primary Molars With Atraumatic Restorative Treatment Technique: A Randomized Controlled Trial., Manarin Boonyawong
Clinical Evaluation Of Two Glass Ionomer Cement Restorations Placed In Primary Molars With Atraumatic Restorative Treatment Technique: A Randomized Controlled Trial., Manarin Boonyawong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: The purpose of this study was to compare clinical success of a novel material (silver diamine fluoride incorporated with high-viscosity glass ionomer cement (SDF-GIC)) in Class II restoration in primary molars using atraumatic restorative treatment (ART) technique at 6- and 12- month follow-up. Materials and Methods: A randomized controlled clinical trial using a parallel group design was carried out on 150 children aged 3-8 years old, from 5 public school in Samut Sakhon province, Thailand, with at least one class II cavities. They were randomly allocated to two treatment groups: ART restoration using either GIC (Fuji IX GP) or …
Effects Of Non-Albicans Candida Species On Biofilm Formation And Acidogenicity Of Dual-Species Biofilms And On Cariogenic Virulence Gene Expression Of Streptococcus Mutans, Wirunphat Sansanoa
Effects Of Non-Albicans Candida Species On Biofilm Formation And Acidogenicity Of Dual-Species Biofilms And On Cariogenic Virulence Gene Expression Of Streptococcus Mutans, Wirunphat Sansanoa
Chulalongkorn University Theses and Dissertations (Chula ETD)
Early childhood caries is a common oral disease found in children which could affect their general health. Streptococcus mutans is an important cariogenic pathogen since it possesses cariogenic properties, which are acid production, acid tolerance and biofilm formation. Recent studies showed that Candida albicans, which is frequently found together with S. mutans in plaques of children with dental caries, enhances cariogenicity. At the same time, increasing prevalence of non-albicans Candida species (NACs) in children and immune-compromised patients has been reported. Therefore, this study aims to investigate the effects of NACs when co-cultured with S. mutans on cariogenic properties and virulence …