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A Research Agenda For Assessment And Management Of Psychosis In Emergency Department Patients, J. Peltzer-Jones, K. Nordstrom, G. Currier, J. S. Berlin, C. Singh, S. Schneider

Journal Articles

© 2019 Peltzer-Jones et al. Introduction: Emergency departments (ED) manage a wide variety of critical medical presentations. Traumatic, neurologic, and cardiac crises are among the most prevalent types of emergencies treated in an ED setting. The high volume of presentations has led to collaborative partnerships in research and process development between experts in emergency medicine (EM) and other disciplines. While psychosis is a medical emergency frequently treated in the ED, there remains a paucity of evidence-based literature highlighting best practices for management of psychotic presentations in the ED. In the absence of collaborative research, development of best practice guidelines cannot …

Structural Variation Of Centromeric Endogenous Retroviruses In Human Populations And Their Impact On Cutaneous T-Cell Lymphoma, Sézary Syndrome, And Hiv Infection, M. H. Kaplan, M. Kaminski, J. M. Estes, S. D. Gitlin, J. Zahn, J. T. Elder, T. Tejasvi, E. Gensterblum, J. P. Mcgowan, R. Contreras-Galindo, +7 Additional Authors

Journal Articles

© 2019 The Author(s). Background: Human Endogenous Retroviruses type K HML-2 (HK2) are integrated into 117 or more areas of human chromosomal arms while two newly discovered HK2 proviruses, K111 and K222, spread extensively in pericentromeric regions, are the first retroviruses discovered in these areas of our genome. Methods: We use PCR and sequencing analysis to characterize pericentromeric K111 proviruses in DNA from individuals of diverse ethnicities and patients with different diseases. Results: We found that the 5′ LTR-gag region of K111 proviruses is missing in certain individuals, creating pericentromeric instability. K111 deletion (-/- K111) is seen in about 15% …

Comparative Effectiveness, Safety, And Costs Of Rivaroxaban And Warfarin Among Morbidly Obese Patients With Atrial Fibrillation., E. D. Peterson, V. Ashton, Y. Chen, B. Wu, A. C. Spyropoulos

Journal Articles

BACKGROUND: There are limited data regarding clinical outcomes and healthcare resource utilization of direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) who are morbidly obese (body mass index >40 kg/m

METHODS: Using data from 2 US healthcare claims databases, we identified patients initiating rivaroxaban or warfarin who had ≥1 medical claim with an AF diagnosis, a diagnostic code for morbid obesity (ICD-9: 278.01, V85.4%; ICD-10: E66.01%, E66.2%, Z68.4%), and a minimum continuous enrollment of 12 months before and 3 months after treatment initiation. Patients were excluded if they had mitral stenosis, a mechanical heart valve procedure, an organ/tissue …

Focused Hla Analysis In Caucasians With Myositis Identifies Significant Associations With Autoantibody Subgroups., S. Rothwell, H. Chinoy, J. A. Lamb, F. W. Miller, L. G. Rider, L. R. Wedderburn, N. J. Mchugh, A. T. Lee, P. K. Gregersen, I. E. Lundberg, +23 Additional Authors

Journal Articles

OBJECTIVES: Idiopathic inflammatory myopathies (IIM) are a spectrum of rare autoimmune diseases characterised clinically by muscle weakness and heterogeneous systemic organ involvement. The strongest genetic risk is within the major histocompatibility complex (MHC). Since autoantibody presence defines specific clinical subgroups of IIM, we aimed to correlate serotype and genotype, to identify novel risk variants in the MHC region that co-occur with IIM autoantibodies.

METHODS: We collected available autoantibody data in our cohort of 2582 Caucasian patients with IIM. High resolution human leucocyte antigen (HLA) alleles and corresponding amino acid sequences were imputed using SNP2HLA from existing genotyping data and tested …

Tele-Monitored Tdcs Rehabilitation: Feasibility, Challenges And Future Perspectives In Parkinson's Disease, A. Cucca, K. Sharma, S. Agarwal, A. S. Feigin, M. C. Biagioni

Journal Articles

© 2019 The Author(s). Transcranial direct current stimulation (tDCS) is a modality of non-invasive brain stimulation involving the application of low amplitude direct current via surface electrodes on the scalp. tDCS has been studied in healthy populations and in multiple brain disorders and has the potential to be a treatment for several neuropsychiatric conditions by virtue of its capability of influencing cognitive, motor and behavioral processes. tDCS is a generally safe technique when performed within standardized protocols in research or clinical settings. Furthermore, tDCS portability, high acceptability and user-friendly interface makes it highly appealing for telemedicine practices. The term "telemedicine" …

Sex-Related Differences In Homebound Advanced Parkinson's Disease Patients, L. Nwabuobi, W. Barbosa, M. Sweeney, S. Oyler, T. Meisel, A. Di Rocco, J. Chodosh, J. E. Fleisher

Journal Articles

No abstract provided.

Changes In Quality Of Life After Surgery Or Radiotherapy In Early-Stage Lung Cancer, R. M. Schwartz, N. Alpert, K. Rosenzweig, R. Flores, E. Taioli

Journal Articles

No abstract provided.

Molecular Study Of Thyroid Cancer In World Trade Center Responders, M. A. Van Gerwen, S. Tuminello, G. J. Riggins, T. B. Mendes, M. Donovan, E. K. Benn, E. Genden, J. M. Cerutti, E. Taioli

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Thyroid cancer incidence is higher in World Trade Center (WTC) responders compared with the general population. It is unclear whether this excess in thyroid cancer is associated with WTC-related exposures or if instead there is an over-diagnosis of malignant thyroid cancer among WTC first responders due to enhanced surveillance and physician bias. To maximize diagnostic yield and determine the false positive rate for malignancy, the histological diagnoses of thyroid cancer tumors from WTC responders and age, gender, and histology matched non-WTC thyroid cancer cases were evaluated using biomarkers of malignancy. Using …

Quantifying The Impact Of Patient-Specific Factors And Disease Severity On Clinical Decision Making In Cuff Tear Arthropathy: A Case-Based Survey, A. P. Schumaier, Y. H. Bedeir, J. S. Dines, K. Kenter, L. V. Gulotta, D. M. Dines, B. M. Grawe

Journal Articles

© 2019, The Author(s). Background: Rotator cuff tears are a common cause of disability. Some patients with massive and irreparable tears can develop cuff tear arthropathy (CTA), which makes management more challenging. Questions/Purposes: We sought to examine how orthopedists determine treatment for patients with CTA. Specifically, we investigated (1) the effect of patient age, symptoms, activity level, range of motion, and radiographic findings on the decision making of shoulder specialists and (2) the observer reliability of the Seebauer and Hamada grading systems. Methods: Five shoulder surgeons were each sent 108 simulated patient cases. Each simulated patient had a different combination …

Full-Body Radiographic Analysis Of Postoperative Deviations From Age-Adjusted Alignment Goals In Adult Spinal Deformity Correction And Related Compensatory Recruitment., P. G. Passias, C. M. Jalai, B. G. Diebo, D. L. Cruz, G. W. Poorman, A. J. Buckland, L. M. Day, J. H. Oren, T. J. Errico, V. Lafage, +8 Additional Authors

Journal Articles

Background: Full-body stereographs for adult spinal deformity (ASD) have enhanced global deformity and lower-limb compensation associations. The advent of age-adjusted goals for classic ASD parameters (sagittal vertical axis, pelvic tilt, spino-pelvic mismatch [PI-LL]) has enabled individualized evaluation of successful versus failed realignment, though these remain to be radiographically assessed postoperatively. This study analyzes pre- and postoperative sagittal alignment to quantify patient-specific correction against age-adjusted goals, and presents differences in compensation in patients whose postoperative profile deviates from targets.

Methods: Single-center retrospective review of ASD patients ≥ 18 years with biplanar full-body stereographic x-rays. Inclusion: ≥ 4 levels fused, complete baseline …

Differentiating Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features From Classic Papillary Thyroid Carcinoma: Analysis Of Cytomorphologic Descriptions Using A Novel Machine-Learning Approach., S. Maleki, A. Zandvakili, S. Gera, S. D. Khutti, A. Gersten, S. N. Khader

Journal Articles

Background:Recent studies show various cytomorphologic features that can assist in the differentiation of classic papillary thyroid carcinoma (cPTC) from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Differentiating these two entities changes the clinical management significantly. We evaluated the performance of support vector machine (SVM), a machine learning algorithm, in differentiating cases of NIFTP and encapsulated follicular variant of papillary thyroid carcinoma with no capsular or lymphovascular invasion (EFVPTC) from cases of cPTC with the use of microscopic descriptions. SVM is a supervised learning algorithm used in classification problems. It assigns the input data to one of two categories …

Prevalence Of Cardiovascular Disease Risk Factors In Childhood Glomerular Diseases, I. F. Ashoor, S. A. Mansfield, M. M. O'Shaughnessy, R. S. Parekh, J. Zee, T. L. Vasylyeva, A. J. Kogon, C. B. Sethna, L. M. Guay-Woodford, +170 Additional Authors

Journal Articles

No abstract provided.

Psychosocial Screening In Disorders/Differences Of Sex Development: Psychometric Evaluation Of The Psychosocial Assessment Tool, M. M. Ernst, M. Gardner, C. A. Mara, E. C. Délot, P. Y. Fechner, M. Fox, M. M. Rutter, P. W. Speiser, C. Foley, B. Yashar, +24 Additional Authors

Journal Articles

© 2019 S. Karger AG, Basel. Background/Aims: Utilization of a psychosocial screener to identify families affected by a disorder/difference of sex development (DSD) and at risk for adjustment challenges may facilitate efficient use of team resources to optimize care. The Psychosocial Assessment Tool (PAT) has been used in other pediatric conditions. The current study explored the reliability and validity of the PAT (modified for use within the DSD population; PAT-DSD). Methods: Participants were 197 families enrolled in the DSD-Translational Research Network (DSD-TRN) who completed a PAT-DSD during a DSD clinic visit. Psychosocial data were extracted from the DSD-TRN clinical registry. …

A Prospective Investigation Of Interleukin-8 Levels In Pediatric Acute Respiratory Failure And Acute Respiratory Distress Syndrome, H. Flori, A. Sapru, M. W. Quasney, G. Gildengorin, M. A. Curley, M. A. Matthay, M. K. Dahmer, S. T. Bateman, J. B. Schneider, D. Wypij, +20 Additional Authors

Journal Articles

© 2019 The Author(s). Background: The association of plasma interleukin-8 (IL-8), or IL-8 genetic variants, with pediatric acute respiratory distress syndrome (PARDS) in children with acute respiratory failure at risk for PARDS has not been examined. The purpose of this study was to examine the association of early and sequential measurement of plasma IL-8 and/or its genetic variants with development of PARDS and other clinical outcomes in mechanically ventilated children with acute respiratory failure. Methods: This was a prospective cohort study of children 2 weeks to 17 years of age with acute airways and/or parenchymal lung disease done in 22 …

Immunosuppressive Therapy For Pediatric Aplastic Anemia: A North American Pediatric Aplastic Anemia Consortium Study., Z. R. Rogers, T. A. Nakano, T. S. Olson, A. A. Bertuch, W. Wang, A. Gillio, T. D. Coates, A. Chawla, A. Vlachos, A. Shimamura, +19 Additional Authors

Journal Articles

Quality of response to immunosuppressive therapy and long-term outcomes for pediatric severe aplastic anemia remain incompletely characterized. Contemporary evidence to inform treatment of relapsed or refractory severe aplastic anemia for pediatric patients is also limited. The clinical features and outcomes for 314 children treated from 2002 to 2014 with immunosuppressive therapy for acquired severe aplastic anemia were analyzed retrospectively from 25 institutions in the North American Pediatric Aplastic Anemia Consortium. The majority of subjects (n=264) received horse anti-thymocyte globulin (hATG) plus cyclosporine (CyA) with a median 61 months follow up. Following hATG/CyA, 71.2% (95%CI: 65.3,76.6) achieved an objective response. In …

Plasma Zonulin Levels In Childhood Nephrotic Syndrome, H. Trachtman, D. S. Gipson, K. V. Lemley, J. P. Troost, C. Faul, D. J. Morrison, S. M. Vento, D. H. Ahn, C. Sethna, C. Avila-Casado, +90 Additional Authors

Journal Articles

© 2019 Trachtman, Gipson, Lemley, Troost, Faul, Morrison, Vento, Ahn and Goldberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Objective: We conducted this study to test the hypothesis that plasma zonulin levels are elevated in pediatric patients with nephrotic syndrome …

Demographics And Anthropometrics Impact Benefits Of Health Intervention: Data From The Reduce Obesity And Diabetes Project., L. Ostrowski, P. W. Speiser, S. Accacha, L. Altshuler, I. Fennoy, B. Lowell, R. Rapaport, W. Rosenfeld, S. P. Shelov, Road Group, +2 Additional Authors

Journal Articles

Objective:To determine the efficacy of a 4-month school-based health, nutrition and exercise intervention on body fatness and examine possible effects of demographic and anthropometric covariates. Methods:Height, weight, waist circumference and body composition were measured in a diverse population of 644 NYC middle school students (mean ± SD age 12.7 ± 0.9 years; 46% male; 38% Hispanic, 17% East Asian, 15% South Asian, 13.5% African American, 8.5% Caucasian, 8% other) during the fall and spring semesters. Year 1 participants (n = 322) were controls. Experimental participants (year 2, n = 469) received a 12-session classroom-based health and nutrition educational programme with …

Proceeding Report Of The Second Symposium On Hidradenitis Suppurativa Advances (Shsa) 2017, E. Shavit, A. Alavi, F. G. Bechara, R. G. Bennett, M. Bourcier, R. Cibotti, S. Daveluy, J. W. Frew, A. Garg, M. A. Lowes, +20 Additional Authors

Journal Articles

No abstract provided.

Structural Brain Characteristics In Treatment-Resistant Depression: Review Of Magnetic Resonance Imaging Studies, M. P. Klok, P. F. Van Eijndhoven, M. Argyelan, A. H. Schene, I. Tendolkar

Journal Articles

No abstract provided.

Association Between Decreased Serum Tbil Concentration And Immediate Memory Impairment In Schizophrenia Patients, X. L. Yin, Q. F. Jia, G. Y. Zhang, J. P. Zhang, T. Shirao, C. X. Jiang, X. Y. Yin, Y. S. Liu, P. Chen, L. Hui, +4 Additional Authors

Journal Articles

© 2019, The Author(s). Cognitive impairment is a core feature of schizophrenia (SCH). In addition to the toxic effect of Bilirubin (BIL), it has antioxidant properties that were associated with the psychopathology and cognitive impairment of psychiatric disorders. The aim of this study was to examine the correlation of serum total BIL (TBIL) concentration with cognitive impairment in SCH patients. We recruited 34 SCH patients and 119 healthy controls (HCs) in this case-control design. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum TBIL concentration was measured using the immunoturbidimetric method. Serum TBIL concentration …

The Impact Of Pharmacological And Non-Pharmacological Interventions To Improve Physical Health Outcomes In People With Schizophrenia: A Meta-Review Of Meta-Analyses Of Randomized Controlled Trials, D. Vancampfort, J. Firth, C. U. Correll, M. Solmi, D. Siskind, M. De Hert, R. Carney, A. Koyanagi, A. F. Carvalho, F. Gaughran, B. Stubbs

Journal Articles

No abstract provided.

Cardiovascular Risk Factor Control And Lifestyle Factors In Young To Middle-Aged Adults With Newly Diagnosed Obstructive Coronary Artery Disease, M. S. Garshick, G. D. Vaidean, A. Vani, J. A. Underberg, J. D. Newman, J. S. Berger, E. A. Fisher, E. Gianos

Journal Articles

No abstract provided.

Predictors And Impact Of Right Heart Failure Severity Following Left Ventricular Assist Device Implantation, R. D. Baxter, K. M. Tecson, S. Still, J. D. G. Collier, J. Felius, S. M. Joseph, S. A. Hall, B. Lima

Journal Articles

No abstract provided.

Incidence Of Acute Kidney Injury In Patients With Chronic Renal Insufficiency: Transcatheter Versus Surgical Aortic Valve Replacement, M. Catalano, D. Lin, H. Cassiere, N. Kohn, B. Rutkin, G. Maurer, J. A. Berg, R. Esposito, A. Hartman, P. Yu, +1 Additional Author

Journal Articles

No abstract provided.

Standardized Video Interviews Do Not Correlate To United States Medical Licensing Examination Step 1 And Step 2 Scores, D. J. Egan, A. Husain, M. C. Bond, W. Caputo, L. Cygan, J. Van Dermark, J. M. Shoenberger, I. Li, B. Ardolic, M. Weizberg, +7 Additional Authors

Journal Articles

© 2019 Egan et al. Introduction: In 2017, the Standardized Video Interview (SVI) was required for applicants to emergency medicine (EM). The SVI contains six questions highlighting professionalism and interpersonal communication skills. The responses were scored (6-30). As it is a new metric, no information is available on correlation between SVI scores and other application data. This study was to determine if a correlation exists between applicants' United States Medical Licensing Examination (USMLE) and SVI scores. We hypothesized that numeric USMLE Step 1 and Step 2 Clinical Knowledge (CK) scores would not correlate with the SVI score, but that performance …

Implementation And Validation Of The 2013 Caprini Score For Risk Stratification Of Arthroplasty Patients In The Prevention Of Venous Thrombosis, E. S. Krauss, A. Segal, M. A. Cronin, N. Dengler, M. L. Lesser, S. Ahn, J. A. Caprini

Journal Articles

© The Author(s) 2019. Appropriate chemoprophylaxis choice following arthroplasty requires accurate patient risk assessment. We compared the results of our prospective department protocol to the Caprini risk assessment model (RAM) retrospectively in this study group. Our goal was to determine whether the department protocol or the Caprini score would identify venous thromboembolism (VTE) events after total joint replacement. A secondary purpose was to validate the 2013 Caprini RAM in joint arthroplasty and determine whether patients with VTE would be accurately identified using the Caprini score. A total of 1078 patients met inclusion criteria. A Caprini score of 10 or greater …

Assessment Of Pain Symptoms And Quality Of Life Using The International Spinal Cord Injury Data Sets In Persons With Chronic Spinal Cord Injury, K. Gibbs, A. Beaufort, A. Stein, T. M. Leung, N. Sison, Z. Bloom

Journal Articles

Introduction: Traumatic spinal cord injury (SCI) triggers complex changes that can negatively impact health and quality of life. The International SCI Data Sets were developed to enable more comparable data collection on the complex sequelae of SCI across studies. This should facilitate progress in mechanistic understanding and improving treatments of SCI. Study design: Prospective observational pilot study. Objectives: To collect data on pain symptoms and quality of life (QoL) in adults living with chronic SCI. Setting: Academic medical center, New York, USA. Methods: The International SCI Basic Pain and Qol Data Sets were used to collect data from participants with …

A Quality Improvement Assessment Of The Delivery Of Mental Health Services Among Wtc Responders Treated In The Community, M. Bellehsen, J. Moline, R. Rasul, K. Bevilacqua, S. Schneider, J. Kornrich, R. M. Schwartz

Journal Articles

No abstract provided.

Increased Incidence Of Thyroid Cancer Among World Trade Center First Responders: A Descriptive Epidemiological Assessment, S. Tuminello, M. A. Van Gerwen, E. Genden, M. Crane, W. Lieberman-Cribbin, E. Taioli

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (WTC) responders by looking at the demographic data and questionnaire responses of thyroid cancer cases from the Mount Sinai WTC Health Program (WTCHP). WTCHP thyroid cancer tumors were of a similar size (p = 0.4), and were diagnosed at a similar age (p = …

Change In Quality Of Life After A Cancer Diagnosis Among A Nationally Representative Cohort Of Older Adults In The Us, R. M. Schwartz, K. A. Ornstein, B. Liu, N. Alpert, K. G. Bevilacqua, E. Taioli

Journal Articles

No abstract provided.