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Genetic Deletion Of Interleukin-15 Is Not Associated With Major Structural Changes Following Experimental Post-Traumatic Knee Osteoarthritis In Rats, Ermina Hadzic, Garth Blackler, Holly Dupuis, Stephen James Renaud, Christopher Thomas Appleton, Frank Beier
Genetic Deletion Of Interleukin-15 Is Not Associated With Major Structural Changes Following Experimental Post-Traumatic Knee Osteoarthritis In Rats, Ermina Hadzic, Garth Blackler, Holly Dupuis, Stephen James Renaud, Christopher Thomas Appleton, Frank Beier
Bone and Joint Institute
Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease, leading to articular cartilage breakdown, osteophyte formation, and synovitis, caused by an initial joint trauma. Pro-inflammatory cytokines increase catabolic activity and may perpetuate inflammation following joint trauma. Interleukin-15 (IL-15), a pro-inflammatory cytokine, is increased in OA patients, although its roles in PTOA pathophysiology are not well characterized. Here, we utilized Il15 deficient rats to examine the role of IL-15 in PTOA pathogenesis in an injury-induced model. OA was surgically induced in Il15 deficient Holtzman Sprague-Dawley rats and control wild-type rats to compare PTOA progression. Semi-quantitative scoring of the articular cartilage, subchondral bone, …
Barriers, Facilitators, Preferences And Expectations Of Joint Protection Programmes For Patients With Hand Arthritis: A Cross-Sectional Survey, Pavlos Bobos, Joy Macdermid, Christina Ziebart, Eleni Boutsikari, Emily Lalone, Louis Ferreira, Ruby Grewal
Barriers, Facilitators, Preferences And Expectations Of Joint Protection Programmes For Patients With Hand Arthritis: A Cross-Sectional Survey, Pavlos Bobos, Joy Macdermid, Christina Ziebart, Eleni Boutsikari, Emily Lalone, Louis Ferreira, Ruby Grewal
Bone and Joint Institute
© Author(s) (or their employer(s)) 2021. Objectives The objective of this survey was to investigate the barriers, facilitators, expectations and patient preferences regarding joint protection (JP) programmes in people with hand arthritis. Design Cross-sectional survey. Setting Tertiary clinic. Participants Patients with hand arthritis: Osteoarthritis, rheumatoid arthritis, psoriatic arthritis and other forms of arthritis. Primary and secondary outcome measures This study used a survey among people with hand arthritis. Descriptive statistics and percentages were reported for all the data about the barriers, facilitators and preferences around JP. Results A total of 192 patients consented to participate. Most of the patients (82%) …
Appraisal Of Clinical Practice Guideline: 2018 Update Of The Eular Recommendations For The Management Of Hand Osteoarthritis, Armaghan Dabbagh, Joy C. Macdermid
Appraisal Of Clinical Practice Guideline: 2018 Update Of The Eular Recommendations For The Management Of Hand Osteoarthritis, Armaghan Dabbagh, Joy C. Macdermid
Bone and Joint Institute
No abstract provided.
Medical Comorbidities And Functional Dependent Living Are Independent Risk Factors For Short-Term Complications Following Osteotomy Procedures About The Knee, Eric J. Cotter, Anirudh K. Gowd, Daniel D. Bohl, Alan Getgood, Brian J. Cole, Rachel M. Frank
Medical Comorbidities And Functional Dependent Living Are Independent Risk Factors For Short-Term Complications Following Osteotomy Procedures About The Knee, Eric J. Cotter, Anirudh K. Gowd, Daniel D. Bohl, Alan Getgood, Brian J. Cole, Rachel M. Frank
Bone and Joint Institute
© The Author(s) 2018. Objective: To characterize rates and risk factors for adverse events following distal femoral osteotomy (DFO), high tibial osteotomy (HTO), and tibial tubercle osteotomy (TTO) procedures. Design: Patients undergoing DFO, HTO, or TTO procedures during 2005 to 2016 were identified in the American College of Surgeons National Surgical Quality Improvement Program. Rates of adverse events were characterized for each procedure. Demographic, comorbidity, and procedural factors were tested for association with occurrence of any adverse events. Results: A total of 1,083 patients were identified. Of these, 305 (28%) underwent DFO, 273 (25%) underwent HTO, and 505 (47%) underwent …
Appraisal Of Clinical Practice Guideline: Shoulder Pain And Mobility Deficits: Adhesive Capsulitis, Sanaa A. Alsubheen, Joy C. Macdermid
Appraisal Of Clinical Practice Guideline: Shoulder Pain And Mobility Deficits: Adhesive Capsulitis, Sanaa A. Alsubheen, Joy C. Macdermid
Bone and Joint Institute
No abstract provided.
Correspondence: Reply To Hadidi Et Al, Vanitha Arumugam, Joy C. Macdermid
Correspondence: Reply To Hadidi Et Al, Vanitha Arumugam, Joy C. Macdermid
Bone and Joint Institute
No abstract provided.
Item Reduction Of The Patient-Rated Wrist Evaluation Using Decision Tree Modelling, Mark J.W. Van Der Oest, Jarry T. Porsius, Joy C. Macdermid, Harm P. Slijper, Ruud W. Selles
Item Reduction Of The Patient-Rated Wrist Evaluation Using Decision Tree Modelling, Mark J.W. Van Der Oest, Jarry T. Porsius, Joy C. Macdermid, Harm P. Slijper, Ruud W. Selles
Bone and Joint Institute
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Background: The aim of this study is to assess the viability of a decision tree version of an often used questionnaire to measure wrist pain and disability, the Patient Rated Wrist Evaluation. Methods: Patient Rated Wrist Evaluation scores were collected from a cohort of 10394 patients who are part of a routine outcome measurement system. A decision tree version of the Patient Rated Wrist Evaluation (PRWE) was created. The intraclass correlation was used to evaluate the inter-version reliability between the original PRWE and the decision …
Application Of A Novel Automatic Method For Determining The Bilateral Symmetry Midline Of The Facial Skeleton Based On Invariant Moments, Rodrigo Dalvit Carvalho Da Silva, Thomas Richard Jenkyn, Victor Alexander Carranza
Application Of A Novel Automatic Method For Determining The Bilateral Symmetry Midline Of The Facial Skeleton Based On Invariant Moments, Rodrigo Dalvit Carvalho Da Silva, Thomas Richard Jenkyn, Victor Alexander Carranza
Bone and Joint Institute
© 2020 by the authors. Assuming a symmetric pattern plays a fundamental role in the diagnosis and surgical treatment of facial asymmetry, for reconstructive craniofacial surgery, knowing the precise location of the facial midline is important since for most reconstructive procedures the intact side of the face serves as a template for the malformed side. However, the location of the midline is still a subjective procedure, despite its importance. This study aimed to automatically locate the bilateral symmetry midline of the facial skeleton based on an invariant moment technique using pseudo-Zernike moments. A total of 367 skull images were evaluated …
Neutral, Water-Soluble Poly(Ester Amide) Hydrogels For Cell Encapsulation, Natalie Liang, Lauren E. Flynn, Elizabeth R. Gillies
Neutral, Water-Soluble Poly(Ester Amide) Hydrogels For Cell Encapsulation, Natalie Liang, Lauren E. Flynn, Elizabeth R. Gillies
Bone and Joint Institute
© 2020 Elsevier Ltd Hydrogels are of significant interest for cell encapsulation and delivery in regenerative medicine. Poly(ester amide)s (PEAs) are a class of biodegradable polymers that exhibit promise for biomedical applications due to the degradability of the ester and amide linkages in their backbones, their preparation from biomolecules such as amino acids, and the ability to readily tune their properties through a modular synthesis approach. Water-soluble PEAs containing cationic arginine moieties have previously been developed, but to the best of our knowledge, neutral water-soluble PEAs based on non-charged amino acids have not been reported. Using a poly(ethylene glycol) (PEG)-based …
A Large-Scale Fifteen-Year Minimum Survivorship Of A Cementless Triple Tapered Femoral Stem, Evangelos Tyrpenou, Amir Khoshbin, Shoaib Mohammad, Emil H. Schemitsch, James P. Waddell, Amit Atrey
A Large-Scale Fifteen-Year Minimum Survivorship Of A Cementless Triple Tapered Femoral Stem, Evangelos Tyrpenou, Amir Khoshbin, Shoaib Mohammad, Emil H. Schemitsch, James P. Waddell, Amit Atrey
Bone and Joint Institute
© 2020 Elsevier Inc. Background: This study reports the long-term outcomes of a metaphyseal fit-and-fill cementless femoral component in total hip arthroplasty (THA) with a follow-up of 15-19 years. Methods: We conducted a retrospective review of 376 consecutive THAs (345 patients), using a triple tapered stem performed between 2000 and 2003 with a view to assessing survivorship and radiological and functional outcomes. Images were assessed for initial alignment, terminal osteolysis, or subsidence, while clinical outcomes were assessed using the St Michael's Hip Score. Results: Forty-five (11.9%) hips were lost to follow-up, 20 (5.31%) had died before our 15-year cutoff follow-up, …
Clinical Outcomes After Anterior Cruciate Ligament Injury: Panther Symposium Acl Injury Clinical Outcomes Consensus Group, Eleonor Svantesson, Eric Hamrin Senorski, Kate E. Webster, Jón Karlsson, Theresa Diermeier, Benjamin B. Rothrauff, Sean J. Meredith, Thomas Rauer, James J. Irrgang, Kurt P. Spindler, C. Benjamin Ma, Volker Musahl, Freddie H. Fu, Olufemi R. Ayeni, Francesco Della Villa, Stefano Della Villa, Scott Dye, Mario Ferretti, Alan Getgood, Timo Järvelä, Christopher C. Kaeding, Ryosuke Kuroda, Bryson Lesniak, Robert G. Marx, Gregory B. Maletis, Leo Pinczewski, Anil Ranawat, Bruce Reider, Romain Seil, Carola Van Eck, Brian R. Wolf, Patrick Yung, Stefano Zaffagnini
Clinical Outcomes After Anterior Cruciate Ligament Injury: Panther Symposium Acl Injury Clinical Outcomes Consensus Group, Eleonor Svantesson, Eric Hamrin Senorski, Kate E. Webster, Jón Karlsson, Theresa Diermeier, Benjamin B. Rothrauff, Sean J. Meredith, Thomas Rauer, James J. Irrgang, Kurt P. Spindler, C. Benjamin Ma, Volker Musahl, Freddie H. Fu, Olufemi R. Ayeni, Francesco Della Villa, Stefano Della Villa, Scott Dye, Mario Ferretti, Alan Getgood, Timo Järvelä, Christopher C. Kaeding, Ryosuke Kuroda, Bryson Lesniak, Robert G. Marx, Gregory B. Maletis, Leo Pinczewski, Anil Ranawat, Bruce Reider, Romain Seil, Carola Van Eck, Brian R. Wolf, Patrick Yung, Stefano Zaffagnini
Bone and Joint Institute
© 2020, The Author(s). Purpose: A stringent outcome assessment is a key aspect for establishing evidence-based clinical guidelines for anterior cruciate ligament (ACL) injury treatment. The aim of this consensus statement was to establish what data should be reported when conducting an ACL outcome study, what specific outcome measurements should be used and at what follow-up time those outcomes should be assessed. Methods: To establish a standardized approach to assessment of clinical outcome after ACL treatment, a consensus meeting including a multidisciplinary group of ACL experts was held at the ACL Consensus Meeting Panther Symposium, Pittsburgh, PA; USA, in June …
Follow-Up Study Evaluating The Long Term Outcome Of Chondromimetic In The Treatment Of Osteochondral Defects In The Knee, Agnes Berta, Matthew S. Shive, Andrew K. Lynn, Alan Getgood, Saara Totterman, Grahame Busby, Jerome Hollenstein, Gábor Vásárhelyi, Imre Kéki, László Hangody
Follow-Up Study Evaluating The Long Term Outcome Of Chondromimetic In The Treatment Of Osteochondral Defects In The Knee, Agnes Berta, Matthew S. Shive, Andrew K. Lynn, Alan Getgood, Saara Totterman, Grahame Busby, Jerome Hollenstein, Gábor Vásárhelyi, Imre Kéki, László Hangody
Bone and Joint Institute
© 2020 by the authors. Scaffolds are thought to be a key element needed for successful cartilage repair treatments, and this prospective extension study aimed to evaluate long-term structural and clinical outcomes following osteochondral defect treatment with a cell-free biphasic scaffold. Structural outcomes were assessed using quantitative 3-D magnetic resonance imaging (MRI) and morphological segmentation to determine the percentage of defect filling and repair cartilage T2 relaxation times, and clinical outcomes were determined with the modified Cincinnati Rating System, and the Knee Injury and Osteoarthritis Outcome Score (KOOS). Seventeen subjects with osteochondral defects in the knee were treated with ChondroMimetic …
Contemporary Strategies To Prevent Infection In Hip And Knee Arthroplasty, Lachlan M. Batty, Brent Lanting
Contemporary Strategies To Prevent Infection In Hip And Knee Arthroplasty, Lachlan M. Batty, Brent Lanting
Bone and Joint Institute
© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of Review: Prosthetic joint infection (PJI) remains a serious concern in lower limb arthroplasty. Despite the significant consequences of PJI, the assessment of the safety and efficacy of preventative measures is challenging due to a low event rate. Notwithstanding, enormous efforts have been made in this arena, and prevention strategies continue to evolve. This review provides an update on contemporary literature (published within the last 5 years) pertaining to infection prevention in primary hip and knee arthroplasty. Recent Findings: Patient optimization has been highlighted as a critical preoperative factor …
Agreement Between Original And Rasch-Approved Neck Disability Index, Ze Lu, Joy C. Macdermid, Goris Nazari
Agreement Between Original And Rasch-Approved Neck Disability Index, Ze Lu, Joy C. Macdermid, Goris Nazari
Bone and Joint Institute
© 2020 The Author(s). Background: Given the high prevalence of neck pain, the neck disability index (NDI) has been used to evaluate patient status and treatment outcomes. Modified versions were proposed as solutions to measurement deficits in the NDI. However, the original 10-item NDI was scored out of 50 and is still the most frequently administered version. Examining the extent of agreement between traditional and Rasch-based versions using Bland-Altman (B&A) plots will inform our understanding of score differences that might rise from using different versions. Therefore, the objective of current study was to describe the extent of agreement between different …
Appraisal Of Clinical Practice Guideline: Subacromial Decompression Surgery For Adults With Shoulder Pain, Stephanie Reischl, Joy C. Macdermid
Appraisal Of Clinical Practice Guideline: Subacromial Decompression Surgery For Adults With Shoulder Pain, Stephanie Reischl, Joy C. Macdermid
Bone and Joint Institute
No abstract provided.
Clinical Outcomes After Anterior Cruciate Ligament Injury: Panther Symposium Acl Injury Clinical Outcomes Consensus Group, Eleonor Svantesson, Eric Hamrin Senorski, Kate E. Webster, Jón Karlsson, Theresa Diermeier, Benjamin B. Rothrauff, Sean J. Meredith, Thomas Rauer, James J. Irrgang, Kurt P. Spindler, C. Benjamin Ma, Volker Musahl, The Panther Symposium Acl Injury Clinical Outcomes Consensus Group, Freddie H. Fu, Olufemi R. Ayeni, Francesco Della Villa, Stefano Della Villa, Scott Dye, Mario Ferretti, Alan Getgood, Timo Järvelä, Christopher C. Kaeding, Ryosuke Kuroda, Bryson Lesniak, Robert G. Marx, Gregory B. Maletis, Leo Pinczewski, Anil Ranawat, Bruce Reider, Romain Seil, Carola Van Eck, Brian R. Wolf, Patrick Yung
Clinical Outcomes After Anterior Cruciate Ligament Injury: Panther Symposium Acl Injury Clinical Outcomes Consensus Group, Eleonor Svantesson, Eric Hamrin Senorski, Kate E. Webster, Jón Karlsson, Theresa Diermeier, Benjamin B. Rothrauff, Sean J. Meredith, Thomas Rauer, James J. Irrgang, Kurt P. Spindler, C. Benjamin Ma, Volker Musahl, The Panther Symposium Acl Injury Clinical Outcomes Consensus Group, Freddie H. Fu, Olufemi R. Ayeni, Francesco Della Villa, Stefano Della Villa, Scott Dye, Mario Ferretti, Alan Getgood, Timo Järvelä, Christopher C. Kaeding, Ryosuke Kuroda, Bryson Lesniak, Robert G. Marx, Gregory B. Maletis, Leo Pinczewski, Anil Ranawat, Bruce Reider, Romain Seil, Carola Van Eck, Brian R. Wolf, Patrick Yung
Bone and Joint Institute
© The Author(s) 2020. A stringent outcome assessment is a key aspect of establishing evidence-based clinical guidelines for anterior cruciate ligament (ACL) injury treatment. To establish a standardized assessment of clinical outcome after ACL treatment, a consensus meeting including a multidisciplinary group of ACL experts was held at the ACL Consensus Meeting Panther Symposium, Pittsburgh, Pennsylvania, USA, in June 2019. The aim was to establish a consensus on what data should be reported when conducting an ACL outcome study, what specific outcome measurements should be used, and at what follow-up time those outcomes should be assessed. The group reached consensus …
Appraisal Of Clinical Practice Guideline: Optima Revised Recommendations For Non-Pharmacological Management Of Persistent Headaches Associated With Neck Pain, Stephanie Reischl, Armaghan Dabbagh, Joy C. Macdermid
Appraisal Of Clinical Practice Guideline: Optima Revised Recommendations For Non-Pharmacological Management Of Persistent Headaches Associated With Neck Pain, Stephanie Reischl, Armaghan Dabbagh, Joy C. Macdermid
Bone and Joint Institute
No abstract provided.
Does Endoscopic Sinus Surgery Alter The Biomechanics Of The Orbit?, Leigh J. Sowerby, Matthew S. Harris, Rootu Joshi, Marjorie Johnson, Tom Jenkyn, Corey C. Moore
Does Endoscopic Sinus Surgery Alter The Biomechanics Of The Orbit?, Leigh J. Sowerby, Matthew S. Harris, Rootu Joshi, Marjorie Johnson, Tom Jenkyn, Corey C. Moore
Bone and Joint Institute
© 2020 The Author(s). Objective: The purpose of this study is to determine if removal of ethmoid cell septations as commonly performed in endoscopic sinus surgery leads to a change in orbital wall fracture patterns and the force required to create them. Methods: Six fresh-frozen cadaveric heads were acquired and underwent endoscopic uncinectomy, maxillary antrostomy, and anterior and posterior ethmoidectomy on one, randomized, side. The contralateral sinuses were used as intra-specimen control. Hyaluronic acid gel globe injections were performed to simulate normal intra-ocular pressure. Post-op CT scans confirmed no orbital fractures or violation of the lamina papyracea prior to trauma …
The Role Of Poly(Methyl Methacrylate) In Management Of Bone Loss And Infection In Revision Total Knee Arthroplasty: A Review, Leyla Hasandoost, Omar Rodriguez, Adel Alhalawani, Paul Zalzal, Emil H. Schemitsch, Stephen D. Waldman, Marcello Papini, Mark R. Towler
The Role Of Poly(Methyl Methacrylate) In Management Of Bone Loss And Infection In Revision Total Knee Arthroplasty: A Review, Leyla Hasandoost, Omar Rodriguez, Adel Alhalawani, Paul Zalzal, Emil H. Schemitsch, Stephen D. Waldman, Marcello Papini, Mark R. Towler
Bone and Joint Institute
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Poly(methyl methacrylate) (PMMA) is widely used in joint arthroplasty to secure an implant to the host bone. Complications including fracture, bone loss and infection might cause failure of total knee arthroplasty (TKA), resulting in the need for revision total knee arthroplasty (rTKA). The goals of this paper are: (1) to identify the most common complications, outside of sepsis, arising from the application of PMMA following rTKA, (2) to discuss …
Treatment After Anterior Cruciate Ligament Injury: Panther Symposium Acl Treatment Consensus Group, Theresa Diermeier, Benjamin B. Rothrauff, Lars Engebretsen, Andrew D. Lynch, Olufemi R. Ayeni, Mark V. Paterno, John W. Xerogeanes, Freddie H. Fu, Jon Karlsson, Volker Musahl, Charles H. Brown, Terese L. Chmielewski, Mark Clatworthy, Stefano Della Villa, Lucio Ernlund, Christian Fink, Alan Getgood, Timothy E. Hewett, Yasuyuki Ishibashi, Darren L. Johnson, Jeffrey A. Macalena, Robert G. Marx, Jacques Menetrey, Sean J. Meredith, Kentaro Onishi, Thomas Rauer
Treatment After Anterior Cruciate Ligament Injury: Panther Symposium Acl Treatment Consensus Group, Theresa Diermeier, Benjamin B. Rothrauff, Lars Engebretsen, Andrew D. Lynch, Olufemi R. Ayeni, Mark V. Paterno, John W. Xerogeanes, Freddie H. Fu, Jon Karlsson, Volker Musahl, Charles H. Brown, Terese L. Chmielewski, Mark Clatworthy, Stefano Della Villa, Lucio Ernlund, Christian Fink, Alan Getgood, Timothy E. Hewett, Yasuyuki Ishibashi, Darren L. Johnson, Jeffrey A. Macalena, Robert G. Marx, Jacques Menetrey, Sean J. Meredith, Kentaro Onishi, Thomas Rauer
Bone and Joint Institute
© The Author(s) 2020. Treatment strategies for anterior cruciate ligament (ACL) injuries continue to evolve. Evidence supporting best-practice guidelines for the management of ACL injury is to a large extent based on studies with low-level evidence. An international consensus group of experts was convened to collaboratively advance toward consensus opinions regarding the best available evidence on operative versus nonoperative treatment for ACL injury. The purpose of this study was to report the consensus statements on operative versus nonoperative treatment of ACL injuries developed at the ACL Consensus Meeting Panther Symposium 2019. There were 66 international experts on the management of …
Valgus Stress Radiography Following Superficial Medial Collateral Ligament Reconstruction Using A Modified Laprade Technique With Adjustable Loop Femoral Fixation, Aad Dhollander, Michael Sellan, Andrew Daniel Firth, Alan Getgood
Valgus Stress Radiography Following Superficial Medial Collateral Ligament Reconstruction Using A Modified Laprade Technique With Adjustable Loop Femoral Fixation, Aad Dhollander, Michael Sellan, Andrew Daniel Firth, Alan Getgood
Bone and Joint Institute
Purpose of this study was to assess postoperative laxity of MCL reconstructions utilizing a modified LaPrade superficial MCL reconstruction. We retrospectively reviewed post-operative valgus stress radiographs in 23 multiligament injured patients who underwent concurrent sMCL and cruciate ligament reconstruction by a single surgeon. Post- operatively, 23 patients underwent valgus stress radiographs that were assessed at a mean of 8.7 months (range: 4-13 months), and mean SSD was 0.64mm ± 0.42mm. Eight patients underwent both pre- and post-operative valgus stress radiographs. Post-operative (0.09mm ± 0.63mm) SSD was found to be significantly reduced compared to pre-operative (2.07mm ± 0.44mm) SSD (mean diff. …
Sol-Gel Derived Tertiary Bioactive Glass–Ceramic Nanorods Prepared Via Hydrothermal Process And Their Composites With Poly(Vinylpyrrolidone-Co-Vinylsilane), Dibakar Mondal, Andrei Zaharia, Kibret Mequanint, Amin S. Rizkalla
Sol-Gel Derived Tertiary Bioactive Glass–Ceramic Nanorods Prepared Via Hydrothermal Process And Their Composites With Poly(Vinylpyrrolidone-Co-Vinylsilane), Dibakar Mondal, Andrei Zaharia, Kibret Mequanint, Amin S. Rizkalla
Bone and Joint Institute
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Bioactive glass (BG) nanoparticles have wide applications in bone repair due to their bone-bonding and biodegradable nature. In this work, nanometric rod-shaped ternary SiO2-CaO-P2O5 bioactive glass particles were prepared through sol-gel chemistry followed by a base-induced hydrothermal process at 130 ◦C and 170 ◦C for various times up to 36 h. This facile, low-temperature and surfactant-free hydrothermal process has shown to be capable of producing uniform nanorods and nanowires. …
Heterogeneous Baroreflex Control Of Sympathetic Action Potential Subpopulations In Humans, Stephen A. Klassen, M. Erin Moir, Charlotte W. Usselman, J. Kevin Shoemaker
Heterogeneous Baroreflex Control Of Sympathetic Action Potential Subpopulations In Humans, Stephen A. Klassen, M. Erin Moir, Charlotte W. Usselman, J. Kevin Shoemaker
Bone and Joint Institute
© 2020 The Authors. The Journal of Physiology © 2020 The Physiological Society Key points: Emission patterns in muscle sympathetic nerve activity stem from differently sized action potential (AP) subpopulations that express varying discharge probabilities. The mechanisms governing these firing behaviours are unclear. This study investigated the hypothesis that the arterial baroreflex exerts varying control over the different AP subpopulations. During baseline, medium APs expressed the greatest baroreflex slopes, while small and large APs exhibited weaker slopes. On going from baseline to lower body negative pressure (LBNP; simulated orthostatic stress), baroreflex slopes for some clusters of medium APs expressed the …
Development And Usability Testing Of A Web-Based And Therapist-Assisted Coping Skills Program For Managing Psychosocial Problems In Individuals With Hand And Upper Limb Injuries: Mixed Methods Study, Folarin Omoniyi Babatunde, Joy Macdermid, Ruby Grewal, Luciana Macedo, Mike Szekeres
Development And Usability Testing Of A Web-Based And Therapist-Assisted Coping Skills Program For Managing Psychosocial Problems In Individuals With Hand And Upper Limb Injuries: Mixed Methods Study, Folarin Omoniyi Babatunde, Joy Macdermid, Ruby Grewal, Luciana Macedo, Mike Szekeres
Bone and Joint Institute
© 2020 Folarin Omoniyi Babatunde, Joy MacDermid, Ruby Grewal, Luciana Macedo, Mike Szekeres. Background: Ineffective coping has been linked to prolonged pain, distress, anxiety, and depression after a hand and upper limb injury. Evidence shows that interventions based on cognitive behavioral therapy (CBT) may be effective in improving treatment outcomes, but traditional psychological interventions are resource intensive and unrealistic in busy hand therapy practices. Developing web-based, evidence-based psychological interventions specifically for hand therapy may be feasible in clinical practice and at home with reduced training and travel costs. Hand Therapy Online Coping Skills (HOCOS) is a program developed to supplement …
A Narrative Review And Content Analysis Of Functional And Quality Of Life Measures Used To Evaluate The Outcome After Tsa: An Icf Linking Application, Ze Lu, Joy C. Macdermid, Peter Rosenbaum
A Narrative Review And Content Analysis Of Functional And Quality Of Life Measures Used To Evaluate The Outcome After Tsa: An Icf Linking Application, Ze Lu, Joy C. Macdermid, Peter Rosenbaum
Bone and Joint Institute
© 2020 The Author(s). Background: Total shoulder arthroplasty (TSA) is considered as the standard reconstructive surgery for patients suffering from severe shoulder pain and dysfunction caused by arthrosis. Multiple patient-reported outcome measures (PROMs) have been developed and validated that can be used to evaluate TSA outcomes. When selecting an outcome measure both content and psychometric properties must be considered. Most research to date has focused on psychometric properties. Therefore, the current study aims to summarize what PROMs are being used to assess TSA outcomes, to classify the type of measure (International society for quality of life (ISOQOL) using definitions of …
Gsk3787-Loaded Poly(Ester Amide) Particles For Intra-Articular Drug Delivery, Ian J. Villamagna, Danielle M. Mcrae, Aneta Borecki, Xueli Mei, François Lagugné-Labarthet, Frank Beier, Elizabeth R. Gillies
Gsk3787-Loaded Poly(Ester Amide) Particles For Intra-Articular Drug Delivery, Ian J. Villamagna, Danielle M. Mcrae, Aneta Borecki, Xueli Mei, François Lagugné-Labarthet, Frank Beier, Elizabeth R. Gillies
Bone and Joint Institute
© 2020 by the authors. Osteoarthritis (OA) is a debilitating joint disorder affecting more than 240 million people. There is no disease modifying therapeutic, and drugs that are used to alleviate OA symptoms result in side effects. Recent research indicates that inhibition of peroxisome proliferator-activated receptor ffi (PPARffi) in cartilage may attenuate the development or progression of OA. PPARffi antagonists such as GSK3787 exist, but would benefit from delivery to joints to avoid side effects. Described here is the loading of GSK3787 into poly(ester amide) (PEA) particles. The particles contained 8 wt. % drug and had mean diameters of about …
Appraisal Of Clinical Practice Guideline: Clinical Practice Guidelines For Pain Management In Acute Musculoskeletal Injury, Armaghan Dabbagh, Joy C. Macdermid
Appraisal Of Clinical Practice Guideline: Clinical Practice Guidelines For Pain Management In Acute Musculoskeletal Injury, Armaghan Dabbagh, Joy C. Macdermid
Bone and Joint Institute
No abstract provided.
An Expert Consensus Statement On The Management Of Large Chondral And Osteochondral Defects In The Patellofemoral Joint, Jorge Chahla, Betina B. Hinckel, Adam B. Yanke, Jack Farr, William D. Bugbee, James L. Carey, Brian J. Cole, Dennis C. Crawford, James E. Fleischli, Alan Getgood, Andreas H. Gomoll, Simon Gortz, Allan E. Gross, Deryk G. Jones, Aaron J. Krych, Christian Lattermann, Bert R. Mandelbaum, Peter R. Mandt, Tom Minas, Raffy Mirzayan, Timothy S. Mologne, John D. Polousky, Matthew T. Provencher, Scott A. Rodeo, Oleg Safir, Seth Lawrence Sherman, Eric D. Strauss, Sabrina M. Strickland, Christopher J. Wahl, Riley J. Williams
An Expert Consensus Statement On The Management Of Large Chondral And Osteochondral Defects In The Patellofemoral Joint, Jorge Chahla, Betina B. Hinckel, Adam B. Yanke, Jack Farr, William D. Bugbee, James L. Carey, Brian J. Cole, Dennis C. Crawford, James E. Fleischli, Alan Getgood, Andreas H. Gomoll, Simon Gortz, Allan E. Gross, Deryk G. Jones, Aaron J. Krych, Christian Lattermann, Bert R. Mandelbaum, Peter R. Mandt, Tom Minas, Raffy Mirzayan, Timothy S. Mologne, John D. Polousky, Matthew T. Provencher, Scott A. Rodeo, Oleg Safir, Seth Lawrence Sherman, Eric D. Strauss, Sabrina M. Strickland, Christopher J. Wahl, Riley J. Williams
Bone and Joint Institute
© The Author(s) 2020. Background: Cartilage lesions of the patellofemoral joint constitute a frequent abnormality. Patellofemoral conditions are challenging to treat because of complex biomechanics and morphology. Purpose: To develop a consensus statement on the functional anatomy, indications, donor graft considerations, surgical treatment, and rehabilitation for the management of large chondral and osteochondral defects in the patellofemoral joint using a modified Delphi technique. Study Design: Consensus statement. Methods: A working group of 4 persons generated a list of statements related to the functional anatomy, indications, donor graft considerations, surgical treatment, and rehabilitation for the management of large chondral and osteochondral …
Accelerated Surgery Versus Standard Care In Hip Fracture (Hip Attack): An International, Randomised, Controlled Trial, Flavia K. Borges, Mohit Bhandari, Ernesto Guerra-Farfan, Ameen Patel, Alben Sigamani, Masood Umer, Maria E. Tiboni, Maria Del Mar Villar-Casares, Vikas Tandon, Jordi Tomas-Hernandez, Jordi Teixidor-Serra, Victoria Ra Avram, Mitchell Winemaker, Mmampapatla T. Ramokgopa, Wojciech Szczeklik, Giovanni Landoni, Chew Yin Wang, Dilshad Begum, John D. Neary, Anthony Adili, Parag K. Sancheti, Abdel Rahman Lawendy, Mariano Balaguer-Castro, Paweł Ślęczka, Richard J. Jenkinson, Aamer Nabi Nur, Gavin Ca Wood, Robert J. Feibel, Stephen J. Mcmahon, Alen Sigamani, Ekaterine Popova, Bruce M. Biccard, Iain K. Moppett
Accelerated Surgery Versus Standard Care In Hip Fracture (Hip Attack): An International, Randomised, Controlled Trial, Flavia K. Borges, Mohit Bhandari, Ernesto Guerra-Farfan, Ameen Patel, Alben Sigamani, Masood Umer, Maria E. Tiboni, Maria Del Mar Villar-Casares, Vikas Tandon, Jordi Tomas-Hernandez, Jordi Teixidor-Serra, Victoria Ra Avram, Mitchell Winemaker, Mmampapatla T. Ramokgopa, Wojciech Szczeklik, Giovanni Landoni, Chew Yin Wang, Dilshad Begum, John D. Neary, Anthony Adili, Parag K. Sancheti, Abdel Rahman Lawendy, Mariano Balaguer-Castro, Paweł Ślęczka, Richard J. Jenkinson, Aamer Nabi Nur, Gavin Ca Wood, Robert J. Feibel, Stephen J. Mcmahon, Alen Sigamani, Ekaterine Popova, Bruce M. Biccard, Iain K. Moppett
Bone and Joint Institute
© 2020 Elsevier Ltd Background: Observational studies have suggested that accelerated surgery is associated with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed whether accelerated surgery could reduce mortality and major complications. Methods: HIP ATTACK was an international, randomised, controlled trial done at 69 hospitals in 17 countries. Patients with a hip fracture that required surgery and were aged 45 years or older were eligible. Research personnel randomly assigned patients (1:1) through a central computerised randomisation system using randomly varying block sizes to either accelerated surgery (goal of surgery within 6 h of diagnosis) or …
Sex Differences In The Effects Of Exercise On Cognition Post-Stroke: Secondary Analysis Of A Randomized Controlled Trial, Shereen Khattab, Janice J. Eng, Teresa Liu-Ambrose, Julie Richardson, Joy Macdermid, Ada Tang
Sex Differences In The Effects Of Exercise On Cognition Post-Stroke: Secondary Analysis Of A Randomized Controlled Trial, Shereen Khattab, Janice J. Eng, Teresa Liu-Ambrose, Julie Richardson, Joy Macdermid, Ada Tang
Bone and Joint Institute
OBJECTIVE: To determine whether there are differences in exercise-associated changes in cognitive func-tion between males and females living with stroke. DESIGN: Secondary analysis of data from a prospective assessor-blinded randomized controlled trial. PARTICIPANTS: Fifty participants (50-80 years, > 1 year post-stroke, able to walk ≥ 5 m). METHODS: Participants were allocated into a 6-month aerobic exercise programme (14 males, 11 females) or balance and flexibility programme (15 males, 10 females). Working memory (Verbal Digit Span Backwards Test), selective attention and conflict resolution (Stroop Colour-Word Test), and set shifting/cognitive flexibility (Trail-Making Test B) were assessed before and after the programmes. RESULTS: There …