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Two-Component System Response Regulators Involved In Virulence Of Streptococcus Pneumoniae Tigr4 In Infective Endocarditis, My Trihn, Xiuchun Ge, Alleson Dobson, Todd Kitten, Cindy Munro, Ping Xu Jan 2013

Two-Component System Response Regulators Involved In Virulence Of Streptococcus Pneumoniae Tigr4 In Infective Endocarditis, My Trihn, Xiuchun Ge, Alleson Dobson, Todd Kitten, Cindy Munro, Ping Xu

Philips Institute for Oral Health Research Publications

Streptococci resident in the oral cavity have been linked to infective endocarditis (IE). While other viridans streptococci are commonly studied in relation to IE, less research has been focused on Streptococcus pneumoniae. We established for the first time an animal model of S. pneumoniae IE, and examined the virulence of the TIGR4 strain in this model. We hypothesized that two-component systems (TCS) may mediate S. pneumoniae TIGR4 strain virulence in IE and examined TCS response regulator (RR) mutants of TIGR4 in vivo with the IE model. Thirteen of the 14 RR protein genes were mutagenized, excluding only the essential …


Development, Disease, And Regeneration Of Tissues In The Dental-Craniofacial Complex, Brian L. Foster, Yong-Hee P. Chun, Erica L. Scheller, Zhao Lin, Chad M. Novince, Avina Paranjpe Jan 2013

Development, Disease, And Regeneration Of Tissues In The Dental-Craniofacial Complex, Brian L. Foster, Yong-Hee P. Chun, Erica L. Scheller, Zhao Lin, Chad M. Novince, Avina Paranjpe

Periodontics Publications

This article has no abstract.


Biomedical Informatics For Computer-Aided Decision Support Systems: A Survey, Ashwin Belle, Mark A. Kon, Kayvan Najarian Jan 2013

Biomedical Informatics For Computer-Aided Decision Support Systems: A Survey, Ashwin Belle, Mark A. Kon, Kayvan Najarian

Computer Science Publications

The volumes of current patient data as well as their complexity make clinical decision making more challenging than ever for physicians and other care givers. This situation calls for the use of biomedical informatics methods to process data and form recommendations and/or predictions to assist such decision makers. The design, implementation, and use of biomedical informatics systems in the form of computer-aided decision support have become essential and widely used over the last two decades. This paper provides a brief review of such systems, their application protocols and methodologies, and the future challenges and directions they suggest.


Medical Literary Messenger (Vol. 1, No. 1, Fall 2013) Jan 2013

Medical Literary Messenger (Vol. 1, No. 1, Fall 2013)

Medical Literary Messenger

Before the Laying On / Robert Eastwood -- When the Medical Student Teaches / M. Hoya -- Lesion / Stacy R. Nigliazzo -- The Way Back To Childhood / Christopher Woods -- The Uselessness of Our Hands / Sean Prentiss -- Never Forget You Work in Oncology / Lorraine Waltz -- Going Down / Thom Schwarz -- Past Curfew, At a Time Past (1964) / Barbara A. Carrington -- Approaching Shadows / Christopher Woods -- Virginia Nature / Hannah Kim -- Is Six Always Six / Ken Staley -- Cheers (Desvenlafaxine) / Nick D’Annunzio Jones -- Arm Dissection, MCV Gross …


Relationship Between Untreated Dental Caries And Weight And Height Of 6- To 12-Year-Old Primary School Children In Bangladesh, Masuma Pervin Mishu, Martin Hobdell, Mahfujul Haq Khan, Richard M. Hubbard, Wael Sabbah Jan 2013

Relationship Between Untreated Dental Caries And Weight And Height Of 6- To 12-Year-Old Primary School Children In Bangladesh, Masuma Pervin Mishu, Martin Hobdell, Mahfujul Haq Khan, Richard M. Hubbard, Wael Sabbah

Dental Public Health and Policy Publications

Background. Children in low-income developing countries are likely to suffer from undergrowth. Dental caries is another common problem in these countries. Aim. To examine the association between untreated dental caries in primary and permanent teeth with age-adjusted height and weight among 6–12-year-old children in Bangladesh. Design. Social, behavioural, and clinical data were collected from 1699 children in nine different randomly selected primary schools in socially deprived areas of Bangladesh. The associations of age-adjusted weight and height and being underweight with dental caries were examined adjusting for sex, area of residence, socioeconomic position, skipping meals, tooth cleaning, and …