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Medicine and Health Sciences

Virginia Commonwealth University

Theses and Dissertations

Theses/Dissertations

1976

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Sexual Adjustment After Myocardial Infarction, Brenda Hove Long Jan 1976

Sexual Adjustment After Myocardial Infarction, Brenda Hove Long

Theses and Dissertations

"Cardiovascular diseases claim more American lives than all other causes of death combined,”1 as stated in the American Heart Association's Heart Facts 1975. In 1972, it was estimated that 1,036,560 individuals died of cardiovascular disease; 683,100 of these were attributable to acute myocardial infarction.2 In addition, an estimated 28,420,000 Americans have some type of cardiovascular disease at a cost of $20 billion annually.3 The figures ”bring home" a stalking reality; cardiovascular disease is epidemic in this country, the incidence and ramifications of which make it an ever-present threat to all Americans. The greatest threat is heart attack, …


The Effects Of Chronic Anaerobic Infection On Atherosclerosis In Rabbits, Janet Smitheran Bissell Jan 1976

The Effects Of Chronic Anaerobic Infection On Atherosclerosis In Rabbits, Janet Smitheran Bissell

Theses and Dissertations

Arterial disease is virtually a universal entity in man. Some cultures, such as the African Bantus have very little in the way of vascular lesions, while in the United States and other industrialized nations atherosclerosis affects a large segment of the population. With this in mind it is not hard to understand why ischemia, or arteriosclerotic heart disease, is second only to cardiovascular diseases in general as the major cause of death in the United States (4, 42).

Ruffer (112) noted the presence of arterial lesions in Egyptian mummies dating back 3,400 years. The presence of atherosclerotic lesions has also …


Prostaglandin Synthesis In The Feline Adrenal Cortex, Suzanne Gale Laychock Jan 1976

Prostaglandin Synthesis In The Feline Adrenal Cortex, Suzanne Gale Laychock

Theses and Dissertations

Studies were carried out on the feline adrenal gland to ascertain the role of prostaglandins in the mechanism of action of ACTH. Using tritiated arachidonic acid as a prostaglandin (PG) precursor , it was demonstrated by column and thin layer chromatography techniques that isolated trypsinized adrenocortical cells possess an active PG synthetase capable of synthesizing radiolabeled PGE, PGF, and PGA/B-like substances. Concentrations of ACTH (125 - 250 μU) which stimulate steroidogenesis enhanced the conversion of radiolabeled arachidonic acid to PGE, PGF and the PGA/B products extracted from cortical cells and incubation media.

PG biosynthesis by isolated cortical cells was …