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Medicine and Health Sciences

University of Texas Rio Grande Valley

2021

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Patient Perceptions Of Trauma-Focused Telemental Health Services Using The Telehealth Satisfaction Questionnaire (Tsq), Bianca T. Villalobos, Aubrey R. Dueweke, Rosaura Orengo-Aguayo, Regan W. Stewart Dec 2021

Patient Perceptions Of Trauma-Focused Telemental Health Services Using The Telehealth Satisfaction Questionnaire (Tsq), Bianca T. Villalobos, Aubrey R. Dueweke, Rosaura Orengo-Aguayo, Regan W. Stewart

Psychological Science Faculty Publications and Presentations

Telehealth services can address many barriers to traditional office-based mental health services. Few studies have assessed youth and caregiver perceptions of and satisfaction with trauma-focused interventions delivered via telemental health. The current study presents data collected using the Telehealth Satisfaction Questionnaire (TSQ), which was developed to measure child and caregiver satisfaction with services, comfort with the telehealth equipment, and barriers to traditional office-based services. Thirteen clinicians delivered home- and school-based Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) via videoconferencing on tablets and computers to 60 child patients (71.7% Latinx, 18.3% Black, and 10.0% non-Hispanic White). Patients and caregivers completed the TSQ at …


Levels Of Angiotensin-Converting Enzyme And Apolipoproteins Are Associated With Alzheimer’S Disease And Cardiovascular Diseases, Chun Xu, Debra Garcia, Yongke Lu, Kaysie Ozuna, Donald A. Adjeroh, Kesheng Wang Dec 2021

Levels Of Angiotensin-Converting Enzyme And Apolipoproteins Are Associated With Alzheimer’S Disease And Cardiovascular Diseases, Chun Xu, Debra Garcia, Yongke Lu, Kaysie Ozuna, Donald A. Adjeroh, Kesheng Wang

Health & Biomedical Sciences Faculty Publications and Presentations

Angiotensin-converting enzyme-1 (ACE1) and apolipoproteins (APOs) may play important roles in the development of Alzheimer’s disease (AD) and cardiovascular diseases (CVDs). This study aimed to examine the associations of AD, CVD, and endocrine-metabolic diseases (EMDs) with the levels of ACE1 and 9 APO proteins (ApoAI, ApoAII, ApoAIV, ApoB, ApoCI, ApoCIII, ApoD, ApoE, and ApoH). Non-Hispanic white individuals including 109 patients with AD, 356 mild cognitive impairment (MCI), 373 CVD, 198 EMD and controls were selected from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Multivariable general linear model (GLM) was used to examine the associations. ApoE ε4 allele was associated with …


Genome-Wide Association Study Identified Insc Gene Associated With Trail Making Test Part A And Alzheimer's Disease Related Cognitive Phenotypes, Kesheng Wang, Chun Xu, Amanda Smith, Danqing Xiao, R. Osvaldo Navia, Yongke Lu, Changchun Xie, Ubolrat Piamjariyakul Dec 2021

Genome-Wide Association Study Identified Insc Gene Associated With Trail Making Test Part A And Alzheimer's Disease Related Cognitive Phenotypes, Kesheng Wang, Chun Xu, Amanda Smith, Danqing Xiao, R. Osvaldo Navia, Yongke Lu, Changchun Xie, Ubolrat Piamjariyakul

Health & Biomedical Sciences Faculty Publications and Presentations

Background: The Trail Making Test (TMT) Part A (TMT-A) is a good measure of performance on cognitive processing speed. This study aimed to perform a genome-wide association study of TMT-A in Alzheimer's disease (AD).

Methods: A total of 757 individuals with TMT-A phenotypes and 620,901 single nucleotide polymorphisms (SNPs) were extracted from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI-1) cohort. AD related cognitive phenotypes include TMT-A, TMT-B, Functional Activities Questionnaire (FAQ), Clinical Dementia Rating Sum of Boxes (CDR-SB), and Alzheimer's Disease Assessment Scale-Cognitive Subscale 13 (ADAS13). Multivariable linear regression analysis of TMT-A was conducted using PLINK software. The most TMT-A …


Development Of A Novel Strategy To Improve Checkpoint Immune Response In Pancreatic Cancer, Poornima Devi Shaji Dec 2021

Development Of A Novel Strategy To Improve Checkpoint Immune Response In Pancreatic Cancer, Poornima Devi Shaji

Theses and Dissertations

Pancreatic Cancer is the 3rd lethal causing cancers in United States with a survival rate less than 5-7%. In advanced unresectable pancreatic cancer, treatment options are restrained to surgery because of its extreme aggressiveness. Immunotherapy, one of the current advanced treatments has shown promising response in other cancers. However, this therapy is limited in pancreatic cancer due to desmoplasia and fibrotic tumor microenvironment (TME).

Our superparamagnetic iron oxide nanoparticles (SPIONS) of curcumin (Curcuma longa, principal curcuminoid of turmeric) have potential ability to inhibit desmoplasia and tumor stroma with an increased bioavailability. This would soften up the tumors for …


How Should Medical Schools Foster Equity And Inclusion In Admissions?, Adela Valdez, Lala Forrest, Alessandra Jimenez, Kim-Thu Pham Dec 2021

How Should Medical Schools Foster Equity And Inclusion In Admissions?, Adela Valdez, Lala Forrest, Alessandra Jimenez, Kim-Thu Pham

School of Medicine Publications and Presentations

This commentary in response to a case considers how merit and features of medical school applicants’ dossiers should be drawn upon in admissions processes to promote equity and inclusion in medicine. It is argued that medical schools should incentivize inclusion by redefining merit in their admissions goals and processes, promote meaningful inclusion, and show institutional leadership in addressing social justice.


Exploring Self-Perceived Employability In People With Disabilities And Other Intersecting Identities, Kerra Lajoy Daniel Dec 2021

Exploring Self-Perceived Employability In People With Disabilities And Other Intersecting Identities, Kerra Lajoy Daniel

Theses and Dissertations

People with disabilities are the largest minority group in the world representing 26% of the world’s population. More specifically, in the U.S. 61 million Americans have a diagnosed disability. However, intersectionality studies have not been inclusive of this particular population and disability studies have yet to extensively examine intersectionality in PWDs. Centering individuals with disabilities who also identify with multiple marginalized social identities , such as being a woman, a person of color or a member of the LGBT community is important since these individuals’ experiences are not uniform in nature. PWDs experience higher rates of discrimination, unemployment, and …


Comparison Of Statistical Methods For Modeling Count Data With An Application To Length Of Hospital Stay, Gustavo A. Fernandez Dec 2021

Comparison Of Statistical Methods For Modeling Count Data With An Application To Length Of Hospital Stay, Gustavo A. Fernandez

Theses and Dissertations

Hospital length of stay (LOS) is a key indicator of hospital care management efficiency, cost of care, and hospital planning. Therefore, understanding hospital LOS variability is always an important healthcare focus. Hospital LOS data are count data, with discrete and nonnegative values, typically right-skewed, and often exhibiting excessive zeros. Numerous studies have been conducted to model hospital LOS to identify significant predictors contributing to its variability. Many researchers have used linear regression with or without logarithmic transformation of the outcome variable LOS, or logistic regression on a dichotomized LOS. These regression methods usually violate models’ assumptions and are subject …


A Grounded Theory Study: Barriers And Expectations Of Elementary Educators Who Teach Students With Autism, Abbie M. Munoz Dec 2021

A Grounded Theory Study: Barriers And Expectations Of Elementary Educators Who Teach Students With Autism, Abbie M. Munoz

Theses and Dissertations

This qualitative research study’s purpose is to garner a better understanding of the barriers and expectations of general and special education elementary teachers when teaching students with autism. Pervious research indicates that school aged children being identified with Autism Spectrum Disorder has significantly increased (Evans, 2016). According to federal law (Individuals with Disabilities Education Improvement Act, 2004; No Child Left Behind, 2001) teachers are required to educate all students in their classroom including students with special needs. While several studies have been conducted on how to education and support students with autism in the classroom, few qualitative studies have been …


Factors Influencing Intent To Take A Covid-19 Test In The United States, Sheila Rutto Dec 2021

Factors Influencing Intent To Take A Covid-19 Test In The United States, Sheila Rutto

Theses and Dissertations

In 2020, COVID-19 became the first pandemic in the world’s history that brought the entire world to an abrupt and unexpected halt. Since the first reported case of the disease to date, the novel coronavirus has been able to wreak havoc in literary every corner of the globe and left an ever-growing number of unprecedented fatalities. The normal way of life has been disrupted, and the level of uncertainty about the end of this pandemic continues to manifest to many. Due to the urgency to bring this pandemic under control, medical officers have been able to recommend actions that people …


Positive Well-Being And Satisfaction With Life: Variables Affecting The Quality Of Life Of People With Bipolar Disorder, Maria Del Trevino-Zuniga Dec 2021

Positive Well-Being And Satisfaction With Life: Variables Affecting The Quality Of Life Of People With Bipolar Disorder, Maria Del Trevino-Zuniga

Theses and Dissertations

Bipolar disorder (BD) is a highly prevalent and severe mental illness of significant public health importance. Characteristics of BD include dramatic shifts in mood, energy, and activity levels affecting a person's ability to carry out day-to-day tasks. These shifts in mood and energy levels are more severe than everyone's regular ups and downs (Rihmer & Kiss, 2002). Managing BD is complex; and social and occupational life disruptions are well-documented, including higher divorce rates, unemployment, and suicide (Marrag et al., 2015). Research has consistently shown individuals with BD have a higher mortality rate compared with the general population (Walker et al., …


Investigating The Relations Between Caffeine-Derived Metabolites And Plasma Lipids In 2 Population-Based Studies, Dusan Petrovic, Menno Pruijm, Belén Ponte, Nasser A. Dhayat, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Bruno Vogt, Pierre-Yves Martin, Jesus D. Melgarejo Dec 2021

Investigating The Relations Between Caffeine-Derived Metabolites And Plasma Lipids In 2 Population-Based Studies, Dusan Petrovic, Menno Pruijm, Belén Ponte, Nasser A. Dhayat, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Bruno Vogt, Pierre-Yves Martin, Jesus D. Melgarejo

School of Medicine Publications and Presentations

Objective: To investigate the relations between caffeine-derived metabolites (methylxanthines) and plasma lipids by use of population-based data from 2 European countries.

Methods: Families were randomly selected from the general population of northern Belgium (FLEMENGHO), from August 12, 1985, until November 22, 1990, and 3 Swiss cities (SKIPOGH), from November 25, 2009, through April 4, 2013. We measured plasma concentrations (FLEMENGHO, SKIPOGH) and 24-hour urinary excretions (SKIPOGH) of 4 methylxanthines-caffeine, paraxanthine, theobromine, and theophylline-using ultra-high-performance liquid chromatography-tandem mass spectrometry. We used enzymatic methods to estimate total cholesterol, high-density lipoprotein cholesterol, and triglyceride levels and the Friedewald equation for low-density lipoprotein cholesterol …


College Students’ Well-Being During The Covid-19 Pandemic: A Systematic Review Of The Literature, Michaela Q. Iglesia, Ming-Tsan Lu Nov 2021

College Students’ Well-Being During The Covid-19 Pandemic: A Systematic Review Of The Literature, Michaela Q. Iglesia, Ming-Tsan Lu

School of Medicine Publications and Presentations

Studies have shown increased levels of distress during the coronavirus disease-19 (COVID-19) pandemic, and college students are becoming more recognized as a vulnerable population. This narrative systematic review aims to synthesize the current understanding of mental health, lifestyle, and socioeconomic impacts that the pandemic had on college students in the United States. A search was conducted on PubMed, PsycInfo, and Web of Science. A total of 34 observational studies were included which examined aspects of college students’ health and experiences during the COVID-19 pandemic in the United States. A great deal of students was shown to experience a moderate level …


Scaling A Community-Wide Campaign Intervention To Manage Hypertension And Weight Loss, Belinda M. Reininger, Lisa A. Mitchell-Bennett, Minjae Lee, Paul G. Yeh, Amanda C. Davé, Soo Kyung Park, Tianlin Xu, Alma G. Ochoa-Del Toro Nov 2021

Scaling A Community-Wide Campaign Intervention To Manage Hypertension And Weight Loss, Belinda M. Reininger, Lisa A. Mitchell-Bennett, Minjae Lee, Paul G. Yeh, Amanda C. Davé, Soo Kyung Park, Tianlin Xu, Alma G. Ochoa-Del Toro

Physician Assistant Studies Faculty Publications and Presentations

Public health impacts can be achieved when evidence-based interventions are implemented to those most in need. Too often implementation never or slowly occurs. The community-wide campaign intervention Tu Salud ¡Si Cuenta! has evidence of improving health outcomes related to chronic disease among low-income, Latinos. Using the RE-AIM Framework, this study examined if the scaled-up version of the intervention is associated with improvements in hypertension and obesity in 12 locations. Each element of the RE-AIM framework was examined. For "Effectiveness," we examined outcomes overall and by implementing location. We used linear and logistic regression to assess if exposure in the intervention …


Clinical Predictors Of Response To Depression Treatment In Persons With Epilepsy, Juliana Hager, Frank Gilliam Nov 2021

Clinical Predictors Of Response To Depression Treatment In Persons With Epilepsy, Juliana Hager, Frank Gilliam

MEDI 9331 Scholarly Activities Clinical Years

Abstract:

Background

The literature on predictors of response to treatment of depression for persons with epilepsy is limited. This study examined predictors of response to treatment of major depression disorder (MDD) by cognitive behavioral therapy (CBT) or Sertraline in Epilepsy patients.

Methods:

In the original two-site comparative effectiveness trial, 140 adult outpatients with active epilepsy and current major depressive disorder were randomly assigned to either sertraline (at a dose starting at 50 mg per day, titrating as needed at two-week intervals up to 200 mg per day) or weekly cognitive behavior therapy (CBT) for 16 weeks1. The …


Diabetes Mellitus Correlates With Increased Biological Age As Indicated By Clinical Biomarkers, Nadine Bahour, Briana Cortez, Hui Pan, Hetal Shah, Alessandro Doria, Cristina Aguayo‑Mazzucato Nov 2021

Diabetes Mellitus Correlates With Increased Biological Age As Indicated By Clinical Biomarkers, Nadine Bahour, Briana Cortez, Hui Pan, Hetal Shah, Alessandro Doria, Cristina Aguayo‑Mazzucato

School of Medicine Publications and Presentations

Chronological age (CA) is determined by time of birth, whereas biological age (BA) is based on changes on a cellular level and strongly correlates with morbidity, mortality, and longevity. Type 2 diabetes (T2D) associates with increased morbidity and mortality; thus, we hypothesized that BA would be increased and calculated it from biomarkers collected at routine clinical visits. Deidentified data was obtained from three cohorts of patients (20-80 years old)-T2D, type 1 diabetes (T1D), and prediabetes-and compared to gender- and age-matched non-diabetics. Eight clinical biomarkers that correlated with CA in people without diabetes were used to calculate BA using the Klemera …


Apoe Gene Associated With Cholesterol-Related Traits In The Hispanic Population, Stephanie Lozano, Victoria I. Padilla, Manuel Lee Avila, Mario Gil, Gladys E. Maestre, Kesheng Wang, Chun Xu Nov 2021

Apoe Gene Associated With Cholesterol-Related Traits In The Hispanic Population, Stephanie Lozano, Victoria I. Padilla, Manuel Lee Avila, Mario Gil, Gladys E. Maestre, Kesheng Wang, Chun Xu

Health & Biomedical Sciences Faculty Publications and Presentations

Genetic variants in the apolipoprotein E (APOE) gene are associated with lipid metabolism and lipid-related traits in the non-Hispanic population. There have been limited studies regarding the association between the APOE gene and hypercholesterolemia in the Hispanic population; therefore, our aim for this study is to examine the APOE gene’s associations with cholesterol level and its related phenotypes. The APOE gene consists of three different alleles, ε2, ε3, and ε4, with ε4 being associated with dementia and cardiovascular diseases. A total of 1,382 subjects were collected from the Texas Alzheimer’s Research and Care Consortium (TARCC, N = 1320) and the …


Looking For Crumbs In The Obesity Forest: Anti-Obesity Interventions And Obesity-Associated Cardiometabolic Traits In The Mexican Population. History And Systematic Review With Meta-Analyses, Esperanza M. Garcia-Oropesa, Yoscelina E. Martinez-Lopez, Sonia María Ruiz-Cejudo, José Darío Martínez-Ezquerro, Alvaro Diaz-Badillo, Carlos Ramirez-Pfeiffer, Alejandra Bustamante-Fuentes, Elena B. Lopez-Sosa, Oscar O. Moctezuma-Chavez, Edna J. Nava-Gonzalez, Adriana L. Perales-Torres, Lucia M. Perez-Navarro, Marisol Rosas-Diaz, Kathleen V. Carter, Beatriz Tapia, Juan C. Lopez-Alvarenga Nov 2021

Looking For Crumbs In The Obesity Forest: Anti-Obesity Interventions And Obesity-Associated Cardiometabolic Traits In The Mexican Population. History And Systematic Review With Meta-Analyses, Esperanza M. Garcia-Oropesa, Yoscelina E. Martinez-Lopez, Sonia María Ruiz-Cejudo, José Darío Martínez-Ezquerro, Alvaro Diaz-Badillo, Carlos Ramirez-Pfeiffer, Alejandra Bustamante-Fuentes, Elena B. Lopez-Sosa, Oscar O. Moctezuma-Chavez, Edna J. Nava-Gonzalez, Adriana L. Perales-Torres, Lucia M. Perez-Navarro, Marisol Rosas-Diaz, Kathleen V. Carter, Beatriz Tapia, Juan C. Lopez-Alvarenga

School of Medicine Publications and Presentations

Mexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on weight loss while other treatments on associated conditions like gout, diabetes (T2D), and hypertriglyceridemia. To date, there is no systematic review that synthesizes the origin of obesity clinics in Mexico and the efforts to investigate treatments for obesity tested by randomized clinical trials (RCT). We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve anti-obesity RCT through 2019 and without an inferior temporal limit. The systematic …


Reproductive Health Policy Saga: Restrictive Abortion Laws In Low- And Middle-Income Countries (Lmics), Unnecessary Cause Of Maternal Mortality, Ngo Valery Ngoa, Ngambouk Vitalis Pemuntaa, Basil N. Nduma, Fokunang Estella Tembe, Mbong Sidonnie Eyambe, Keziah Ezra, Henry Che Ngwa, Emmanuel Ombugadu Sabo Nov 2021

Reproductive Health Policy Saga: Restrictive Abortion Laws In Low- And Middle-Income Countries (Lmics), Unnecessary Cause Of Maternal Mortality, Ngo Valery Ngoa, Ngambouk Vitalis Pemuntaa, Basil N. Nduma, Fokunang Estella Tembe, Mbong Sidonnie Eyambe, Keziah Ezra, Henry Che Ngwa, Emmanuel Ombugadu Sabo

Health & Biomedical Sciences Faculty Publications and Presentations

Abortion is a common but controversial phenomenon globally. The discourse on the legality of abortion remains intricate, leaving a substantial number of women restricted from accessing safe abortion. There are evidence of an association between restrictive abortion laws, unsafe abortions, and maternal mortality in low-and middle-income countries (LMICs). We explore how restrictive abortion laws violate women’s right to health and bodily integrity. We used Carol Bacchi’s policy framework to analyze how restrictive abortion laws have been discursively framed (problematization); the assumptions that underpinned the representation; the consequences of the representation; what was left unproblematic; how the representation could be questioned, …


Should Employment Division V Smith Be Overturned?, Jake Greenblum, Ryan Hubbard Nov 2021

Should Employment Division V Smith Be Overturned?, Jake Greenblum, Ryan Hubbard

School of Medicine Publications and Presentations

Health professionals seeking religious exemption from caring for some patients or providing some interventions receive robust legal protection. Similarly, religiously affiliated organizations have great latitude in deciding which services to offer. These protections could soon become stronger, as the US Supreme Court considers 2 cases that revisit constraints on exemption claims established in Employment Division, Department of Human Resources of Oregon v Smith (1990). This article contends that overturning this case’s precedent might result in clinicians claiming more religious exemptions, which, barring acts of US Congress, would erode the rule of law and increase risk of harm to patients.


Exploratory Data Mining Techniques (Decision Tree Models) For Examining The Impact Of Internet-Based Cognitive Behavioral Therapy For Tinnitus: Machine Learning Approach, Hansapani Rodrigo, Eldré W. Beukes, Gerhard Andersson, Vinaya Manchaiah Nov 2021

Exploratory Data Mining Techniques (Decision Tree Models) For Examining The Impact Of Internet-Based Cognitive Behavioral Therapy For Tinnitus: Machine Learning Approach, Hansapani Rodrigo, Eldré W. Beukes, Gerhard Andersson, Vinaya Manchaiah

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

Background: There is huge variability in the way that individuals with tinnitus respond to interventions. These experiential variations, together with a range of associated etiologies, contribute to tinnitus being a highly heterogeneous condition. Despite this heterogeneity, a “one size fits all” approach is taken when making management recommendations. Although there are various management approaches, not all are equally effective. Psychological approaches such as cognitive behavioral therapy have the most evidence base. Managing tinnitus is challenging due to the significant variations in tinnitus experiences and treatment successes. Tailored interventions based on individual tinnitus profiles may improve outcomes. Predictive models of treatment …


The Mechanism And Pattern Of Injuries Of Undocumented Immigrants Crossing The Texas-Mexico Border Along The Rio Grande Valley, Carlos H. Palacio, Bianca Cruz, Cheryl Vanier, Jose Cano, Bradford G. Scott Oct 2021

The Mechanism And Pattern Of Injuries Of Undocumented Immigrants Crossing The Texas-Mexico Border Along The Rio Grande Valley, Carlos H. Palacio, Bianca Cruz, Cheryl Vanier, Jose Cano, Bradford G. Scott

School of Medicine Publications and Presentations

Background

Apprehensions of undocumented immigrants in the Rio Grande Valley sector of the U.S.-Mexico border have grown to account for nearly half of all apprehensions at the border. The purpose of this study is to report the prevalence, mechanism, and pattern of traumatic injuries sustained by undocumented immigrants who crossed the U.S.-Mexico border at the Rio Grande Valley sector over a span of 5 years and were treated at a local American College of Surgeons verified Level II trauma center.

Methods

A retrospective chart review was conducted from January 2014 to December 2019. Demographics, comorbidities, injury severity score (ISS), mechanism …


Testimonios Of Two Latinas In The Academe, Maria G. Bridges Oct 2021

Testimonios Of Two Latinas In The Academe, Maria G. Bridges

School of Rehabilitation Services & Counseling Faculty Publications and Presentations

No abstract provided.


Real-Time Mobile Teleophthalmology For The Detection Of Eye Disease In Minorities And Low Socioeconomics At-Risk Populations, Lama A. Al-Aswad, Cansu Yuksel Elgin, Vipul Patel, Deborah Popplewell, Kalashree Gopal, Dan Gong, Zach Thomas, Devon Joiner, Cha-Kai Chu, Gladys E. Maestre Oct 2021

Real-Time Mobile Teleophthalmology For The Detection Of Eye Disease In Minorities And Low Socioeconomics At-Risk Populations, Lama A. Al-Aswad, Cansu Yuksel Elgin, Vipul Patel, Deborah Popplewell, Kalashree Gopal, Dan Gong, Zach Thomas, Devon Joiner, Cha-Kai Chu, Gladys E. Maestre

School of Medicine Publications and Presentations

Purpose: To examine the benefits and feasibility of a mobile, real-time, community-based, teleophthalmology program for detecting eye diseases in the New York metro area.

Design: Single site, nonrandomized, cross-sectional, teleophthalmologic study.

Methods: Participants underwent a comprehensive evaluation in a Wi-Fi-equipped teleophthalmology mobile unit. The evaluation consisted of a basic anamnesis with a questionnaire form, brief systemic evaluations and an ophthalmologic evaluation that included visual field, intraocular pressure, pachymetry, anterior segment optical coherence tomography, posterior segment optical coherence tomography, and nonmydriatic fundus photography. The results were evaluated in real-time and follow-up calls were scheduled to complete a secondary questionnaire form. Risk …


Apoc3 Genetic Variation, Serum Triglycerides, And Risk Of Coronary Artery Disease In Asian Indians, Europeans, And Other Ethnic Groups, Shiwali Goyal, Yosuke Tanigawa, Weihua Zhang, Jin-Fang Chai, Marcio Almeida, Juan M. Peralta, Donna M. Lehman, Joanne E. Curran, Ravi Duggirala, John Blangero Sep 2021

Apoc3 Genetic Variation, Serum Triglycerides, And Risk Of Coronary Artery Disease In Asian Indians, Europeans, And Other Ethnic Groups, Shiwali Goyal, Yosuke Tanigawa, Weihua Zhang, Jin-Fang Chai, Marcio Almeida, Juan M. Peralta, Donna M. Lehman, Joanne E. Curran, Ravi Duggirala, John Blangero

School of Medicine Publications and Presentations

Background

Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are cardioprotective in American Indians and Europeans. However, there is a lack of data in other Europeans and non-Europeans. Also, whether genetically increased plasma TG due to ApoC-III is causally associated with increased CAD risk is still unclear and inconsistent. The objectives of this study were to verify the cardioprotective role of earlier reported six LoF variants of APOC3 in South Asians and other multi-ethnic cohorts and to evaluate the causal association …


Circulating Fatty Acids Associated With Advanced Liver Fibrosis And Hepatocellular Carcinoma In South Texas Hispanics, Jingjing Jiao, Suet-Ying Kwan, Caroline M. Sabotta, Honami Tanaka, Lucas Veillon, Marc O. Warmoes, Philip L. Lorenzi, Ying Wang, Peng Wei, Jose Luis Almeda, Joseph B. Mccormick, Susan P. Fisher-Hoch Sep 2021

Circulating Fatty Acids Associated With Advanced Liver Fibrosis And Hepatocellular Carcinoma In South Texas Hispanics, Jingjing Jiao, Suet-Ying Kwan, Caroline M. Sabotta, Honami Tanaka, Lucas Veillon, Marc O. Warmoes, Philip L. Lorenzi, Ying Wang, Peng Wei, Jose Luis Almeda, Joseph B. Mccormick, Susan P. Fisher-Hoch

School of Medicine Publications and Presentations

Background: Hispanics in South Texas have high rates of hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Liver fibrosis severity is the strongest predictive factor of NAFLD progression to HCC. We examined the association between free fatty acids (FA) and advanced liver fibrosis or HCC in this population.

Methods: We quantified 45 FAs in plasma of 116 subjects of the Cameron County Hispanic Cohort, 15 Hispanics with HCC, and 56 first/second-degree relatives of Hispanics with HCC. Liver fibrosis was assessed by FibroScan.

Results: Advanced liver fibrosis was significantly associated with low expression of very long chain (VLC) saturated FAs …


Bilingual Problem-Solving Training For Caregivers Of Adults With Dementia: A Randomized, Factorial-Design Protocol For The Cades Trial, Shannon B. Juengst, Charlene Supnet, Chung Lin (Novelle) Kew, Valeria Silva, Marlene Vega, Gang Han, Brendan Kelley, Matthew Lee Smith, Gladys E. Maestre Sep 2021

Bilingual Problem-Solving Training For Caregivers Of Adults With Dementia: A Randomized, Factorial-Design Protocol For The Cades Trial, Shannon B. Juengst, Charlene Supnet, Chung Lin (Novelle) Kew, Valeria Silva, Marlene Vega, Gang Han, Brendan Kelley, Matthew Lee Smith, Gladys E. Maestre

School of Medicine Publications and Presentations

Objective: Caregivers of individuals with Alzheimer's disease and related dementias (ADRD) often experience debilitating caregiver burden and emotional distress. To address these negative emotional consequences of caregiving, we will test and refine a strategy training intervention - Problem-Solving Training (PST) - that promotes self-efficacy and reduces caregiver burden and depressive symptoms. Previous research supports efficacy of PST; however, we do not know exactly how many PST sessions are needed or if post-training "boosters" are required to maintain PST benefits. Additionally, we translated and culturally-adapted PST into "Descubriendo Soluciones Juntos" (DSJ), our novel intervention for Spanish-speaking caregivers.

Method: In this 2 …


Frailty Index In The Colonias On The Us-Mexico Border: A Special Report, Eron G. Manusov, Carolina Gomez De Ziegler, Vincent P. Diego, Gerardo Munoz-Monaco, Sarah Williams-Blangero Aug 2021

Frailty Index In The Colonias On The Us-Mexico Border: A Special Report, Eron G. Manusov, Carolina Gomez De Ziegler, Vincent P. Diego, Gerardo Munoz-Monaco, Sarah Williams-Blangero

School of Medicine Publications and Presentations

Frailty is the age-related decline in well-being. The Frailty index (FI) measures the accumulation of health deficits and reflects biopsychosocial and cultural determinants of well-being. Frailty is measured as a static phenotype or as a Frailty Index comprising a ratio of suffered health deficits and total deficits. We report a Frailty Index calculated from routinely measured clinical variables gathered from residents of two Colonias (neighborhoods) in South Texas. A Colonia is a predominantly Hispanic, economically distressed, unincorporated neighborhood. We analyzed retrospective data from 894 patients that live in two Colonias located on the Texas-Mexico border. We calculated the FI with …


Relationships Between Perceived Quality Of Life And Spiritual Beliefs, Education Level, Socioeconomic Status, Gender, And Ethnicity In Cancer Patients And Cancer Survivors, Eva Arjona Aug 2021

Relationships Between Perceived Quality Of Life And Spiritual Beliefs, Education Level, Socioeconomic Status, Gender, And Ethnicity In Cancer Patients And Cancer Survivors, Eva Arjona

Theses and Dissertations

The purpose of this study was to identify a relationship between perceived Quality of Life and religious/spiritual beliefs. Additionally, it aimed to explore relationships between perceived QOL and age, gender, ethnicity, education level, and Socioeconomic Status (SES). The research question examined in this study was: What is the relationship between perceived quality of life and spiritual beliefs, education level, socioeconomic status, age gender, and ethnicity in cancer patients and cancer survivors? A total of 100 cancer patients or cancer survivors were surveyed for this study. A regression analysis was conducted to explore relationships among the variables; the alpha level was …


Prevalence Of Dementia In Latin America: A Collaborative Study Of Population-Based Cohorts, Ricardo Nitrini, Cássio M. C. Bottino, Cecilia Albala, Nilton Santos Custodio Capuñay, Carlos Ketzoian, Juan J. Llibre Rodriguez, Gladys E. Maestre, Ana Teresa A. Ramos-Cerqueira Jul 2021

Prevalence Of Dementia In Latin America: A Collaborative Study Of Population-Based Cohorts, Ricardo Nitrini, Cássio M. C. Bottino, Cecilia Albala, Nilton Santos Custodio Capuñay, Carlos Ketzoian, Juan J. Llibre Rodriguez, Gladys E. Maestre, Ana Teresa A. Ramos-Cerqueira

School of Medicine Publications and Presentations

Background:

Dementia is becoming a major public health problem in Latin America (LA), yet epidemiological information on dementia remains scarce in this region. This study analyzes data from epidemiological studies on the prevalence of dementia in LA and compares the prevalence of dementia and its causes across countries in LA and attempts to clarify differences from those of developed regions of the world.

Methods:

A database search for population studies on rates of dementia in LA was performed. Abstracts were also included in the search. Authors of the publications were invited to participate in this collaborative study by sharing missing …


The Power Of Interdependence: Linking Health Systems, Communities, And Health Professions Educational Programs To Better Meet The Needs Of Patients And Populations, Richard N. Van Eck, Heidi L. Gullett, Sara M. Lamb, Helene J. Krouse, Lauren Mazzurco, Onelia G. Lage, Joy H. Lewis, Kimberly D. Lomis Jul 2021

The Power Of Interdependence: Linking Health Systems, Communities, And Health Professions Educational Programs To Better Meet The Needs Of Patients And Populations, Richard N. Van Eck, Heidi L. Gullett, Sara M. Lamb, Helene J. Krouse, Lauren Mazzurco, Onelia G. Lage, Joy H. Lewis, Kimberly D. Lomis

School of Medicine Publications and Presentations

Promoting optimal health outcomes for diverse patients and populations requires the acknowledgement and strengthening of interdependent relationships between health professions education programs, health systems, and the communities they serve. Educational programs must recognize their role as integral components of a larger system. Educators must strive to break down silos and synergize efforts to foster a health care workforce positioned for collaborative, equitable, community-oriented practice. Sharing interprofessional and interinstitutional strategies can foster wide propagation of educational innovation while accommodating local contexts. This paper outlines how member schools of the American Medical Association Accelerating Change in Medical Education Consortium leveraged interdependence to …