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The Effects Of Synthetic And Dietary Therapeutics On Learning, Memory, Motor Coordination, And Seizure In An Angelman Syndrome Mouse Model, Stephanie Lynn Ciarlone

USF Tampa Graduate Theses and Dissertations

Angelman syndrome (AS) is a rare genetic and neurological disorder presenting with severe developmental delay, ataxia, epilepsy, and lack of speech. AS is associated with a neuron-specific loss of function of the maternal UBE3A allele, a gene encoding an E3 ubiquitin ligase. Currently, no cure exists for this disorder; however, recent research using an AS mouse model suggests that pharmacological intervention is plausible, and can alleviate some of the detrimental phenotypes reported in AS patients.

Although there is no curative treatment for AS, seizure medication and behavioral therapies are most commonly prescribed in order to minimize symptoms. However, these options …

Levels Of Distress Among Women Veterans Attending A Women’S Health Specialty Clinic In The Va Healthcare System, Debbie T. Devine

USF Tampa Graduate Theses and Dissertations

Currently, between 21.9 and 23 million veterans have served in the United States armed forces. Of those, 2 million are women, and of those, only 6.5% use the Veterans Health Administration system. These females often suffer from physical and mental health disorders, and overall impaired quality of life (QOL), rendering their healthcare needs complex. Seeking, and providing care in this specialty area may become overwhelming not only for the women seeking the care, but also for healthcare systems that are unfamiliar with the specific needs of this population.

A retrospective medical records review was completed of 51 female veterans between …

Family Communication Concerning End-Of-Life Care Preferences, Lindsay Jo Peterson

USF Tampa Graduate Theses and Dissertations

Communication concerning the care one wishes to receive at the end of life (EOL) is central to ensuring that wishes are honored. Many studies have examined doctor-patient or doctor-family EOL communication. However, relatively few studies have focused on the occurrence of EOL care discussions among family members. This is an important topic, as research suggests that advance directives (ADs) are ineffective if patients have not involved surrogate decision-makers, most of whom are family members. This study examined EOL care discussions among family members. It used quantitative and qualitative data from a diverse sample of older adults from West Central Florida …

Hormone Replacement Therapy (Hrt) Modulates Peripheral And Central Auditory System Processing With Aging, Tanika Williamson

USF Tampa Graduate Theses and Dissertations

After the findings were reported for the Women’s Health Initiative (WHI) study in the past decade, there has been a significant decline in the overall use of hormone replacement therapy (HRT) among women. However, there are still millions of middle-aged, menopausal women in the U.S. who are currently undergoing hormone therapy. Their reasons for continuing treatment include relief of severe menopausal symptoms, aid in the management of osteoporosis and reduction in the risk of colon cancer (Ness et al., 2005). The purpose of the following investigation was to evaluate the impact of HRT on the central and peripheral auditory systems …

Access To Health Services And Health Seeking Behavior Among Former Child Soldiers In Manizales, Colombia, Adriana Marcella Dail

USF Tampa Graduate Theses and Dissertations

Through the Colombian Institute for Family Welfare (ICBF), the Colombian government aims to provide comprehensive reintegration for children demobilized from the country’s various armed groups. The reestablishment of rights, including the right to health (guaranteed by the Colombian constitution), is a key factor in successful reintegration. This thesis explores the topic of access to health care and health seeking behavior among former child soldiers in Manizales, Colombia who are over the age of 18 and were previously in the Hogar Tutor program (foster care-based youth reintegration) in Manizales. This thesis utilizes semi-structured interviews (n=9) and body mapping (n=9) with former …

Rhabdomyosarcoma Incidence And Survival In Whites, Blacks, And Hispanics From 1973-2013: Analysis From The Surveillance, Epidemiology, And End Results Program, Heather Tinsley

USF Tampa Graduate Theses and Dissertations

Purpose

Our objectives were to 1) determine the difference in Rhabdomyosarcoma (RMS) incidence and survival between different race/ethnicity groups, and 2) evaluate the difference in survival of RMS between children and adults of these race/ethnicity groups, using the Surveillance, Epidemiology, and End Results Program (SEER) database between 1973-2013.

Patients and Methods

We analyzed racial characteristic and incidence data from 4,280 patients diagnosed with RMS, between 1973-2013, that were reported to the SEER database. Survival and hazard analyses were conducted on 4,268 patients with known follow-up data, with end point being death from any cause.

Results

Over the 40-year study period …

Predictive Mapping Of Mycobacterium Tuberculosis At The County Level In The State Of Florida, Ali Moradi

USF Tampa Graduate Theses and Dissertations

Introduction: One of the major barriers to developing an accurate tuberculosis (TB) surveillance program for Florida is the design and implementation of a sampling system that will adequately monitor and predict varying sizes and characteristics of county-level vulnerable endemic sub-populations and their explanatory covariates (e.g., living or working in a residential care facility). The aim of this research study is to envision an endemic, tuberculosis-related web-based interface for use by public health officials in the State of Florida which includes generating essential information such as a real-time syndrome-based reporting to regulate automated and immediate 'Alerts' to public health officials, doctors, …

Hiv/Stis And Intimate Partner Violence: Results From The Togo 2013-2014 Demographic And Health Surveys, Anthony H. Nguyen

USF Tampa Graduate Theses and Dissertations

Background: Among clinic based studies, intimate partner violence (IPV) has been shown to contribute to HIV/AIDS among young girls and women. Results from studies among the general population have been less consistent. This study evaluated the associations between HIV infection, any sexually transmitted infections, and IPV in a population based sample of Togolese women.

Methods: Data from the Togo 2013-2014 Demographic and Health Surveys were utilized for these analyses. Women aged 15-49 who were currently married, had HIV test results and answered the Domestic Violence Module were analyzed (n = 2386). Generalized linear mixed-models adjusting for sociodemographic variables, risk behaviors, …

Adaptive Styles And Coping Strategies Of Youth Diagnosed With Cancer: Relationship To Well-Being, Psychosocial And Educational Adjustment, And Parents’ Adaptive Styles, Renee Corbett

USF Tampa Graduate Theses and Dissertations

Although almost 16,000 children and adolescents are diagnosed with cancer each year, the incident rates have remained stable over recent years, and mortality has decreased consistently since 1975 (American Cancer Society, 2016). With increased survivorship, research and practice in pediatric oncology has focused more on the psychosocial well-being of patients during and after treatment. With research repeatedly indicating that patients and families appear to exhibit great resilience and adjustment, and low incidences of psychosocial difficulties (e.g., Kazak, 1994, Eiser et al. 2000), some researchers have examined adaptive style as a possible construct that may help explain the predominantly positive outcomes …

Designing The Haptic Interface For Morse Code, Michael Walker

USF Tampa Graduate Theses and Dissertations

Two siblings have a muscular degenerative condition that has rendered them mostly blind, deaf and paraplegic. Currently, the siblings receive communication by close range sign language several feet in front of their vision. Due to the degenerative nature of their condition, it is believed that the siblings will eventually become completely blind and unable to communicate in this fashion. There are no augmented communication devices on the market that allow communication reception for individuals who cannot see, hear or possess hand dexterity (such as braille reading). To help the siblings communicate, the proposed communication device will transmit Morse code information …

Contextual Factors And The Syndemic Of Alcohol Use And Risky Sexual Behaviors Among Men Who Have Sex With Men, Humberto López Castillo

USF Tampa Graduate Theses and Dissertations

Since the early 1990s with the AIDS pandemic, there has been an increasing interest on the importance of risky sexual behaviors, especially among men who have sex with men (MSM). An important antecedent for these behaviors is alcohol use. Studies consistently show an increased frequency of both alcohol use and risky sexual behaviors in MSM populations. However, to date, there has not been a precise estimate of the effect size in these diverse populations and a consistent way to measure it. More so, the importance of context is often cited as a source of variability, but is rarely measured in …

Racial And Ethnic Differences In Low-Risk Cesarean Deliveries In Florida, Yuri Combo Vanda Sebastiao

USF Tampa Graduate Theses and Dissertations

Background and Significance: Cesarean delivery rates increased by more than 50% between 1996 and 2011 in the United States. The large increase in rates for the procedure was generally not associated with significant improvements in obstetric outcomes, raising concern about quality and prompting recommendations for prevention. Primary cesareans provide the best opportunity to reduce overall cesarean rates, and the group of first-time mothers considered low-risk for cesarean (known as nulliparous, term, singleton, vertex, NTSV) constitutes the focus of prevention efforts. Studies increasingly report racial and ethnic differences in NTSV cesareans, which remain after controlling for health factors. However, the reasons …

Regulation Of Nachrs And Stemness By Nicotine And E-Cigarettes In Nsclc, Courtney Schaal

USF Tampa Graduate Theses and Dissertations

Lung cancer is the leading cause of cancer-related death in both men and women, nationally and internationally and kills more people each year than breast, prostate, and colon cancers combined. Non-small cell lung carcinoma (NSCLC) is the most common histological subtype of lung cancer, and accounts for 85% of all cases. Cigarette smoking is the single greatest risk factor for lung cancer, and is correlated with 80-90% of all lung cancer deaths. Nicotine, the addictive component of tobacco smoke, is not a carcinogen and cannot initiate tumors itself; however, it is known to act as a tumor promoter, by enhancing …

Moderation Analysis Of Bowel Function Among Nutrients And Physical Function Or Depression, As Well As Whether Bowel Function Is Related To Cognition In Older Adults, Jessie Alwerdt

USF Tampa Graduate Theses and Dissertations

As we age, the risk for gut issues, such as smooth muscle tone, may be an underlying indirect or direct cause or risk factor for many age-related issues, such as frailty. Consequences of decreased motility and depleted epithelial barrier may result in nutrient deficiencies that may increase the risk for malnutrition (Brownie, 2006). Further, there is increasing evidence that there is a gut-brain-axis relationship that may influence cognition and mental health issues, such as depression and anxiety. While there are relationships established, the interconnections of these factors have yet to be fully understood.

This dissertation examined several relationships specific to …

Access And Barriers To Services For Dependent And Non-Dependent Commercially Sexually Exploited Children In Florida, Brianna O'Steen

USF Tampa Graduate Theses and Dissertations

“Human trafficking” has become part of the everyday lexicon in the United States and globally over the last fifteen years. The issue has made its way into political platforms, scholarly work, church congregations, and international aid agendas. Florida is currently recognized as third in the nation for number of cases of human trafficking. This thesis employs ethnographic interviews and observations to understand one portion of Florida’s human trafficking problem referred to as domestic minor sex trafficking. This type of trafficking affects mostly teenage girls from marginalized populations, such as those that have experienced the child welfare system, homelessness, and impoverished …

Antimalarial Exoerythrocytic Stage Drug Discovery And Resistance Studies, Lynn Dong Blake

USF Tampa Graduate Theses and Dissertations

Malaria is a devastating global health issue that affects approximately 200 million people yearly and over half a million deaths are caused by this parasitic protozoan disease. Most commercially available drugs only target the blood stage form of the parasite, but the only way to ensure proper elimination is to treat the exoerythrocytic stages of the parasite development cycle. There is a demand for the discovery of new liver stage antimalarial compounds as there are only two current FDA approved drugs for the treatment of liver stage parasites, one of which fails to eliminate dormant forms and the other inducing …

Teacher Child Interaction Therapy: An Ecological Approach To Intervening With Young Children Who Display Disruptive Behaviors, Sara Marie Hinojosa

USF Tampa Graduate Theses and Dissertations

A model of Teacher Child Interaction Therapy (TCIT) was implemented in two kindergarten classrooms of students (n = 2) who successfully completed Parent Child Interaction Therapy, but continued to demonstrate disruptive behaviors in the classroom. The current study first indicated that TCIT was implemented with integrity by both the therapists and teacher participants. Next, the effects of this intervention on the teacher’s skills, students’ disruptive behaviors, teacher’s stress, and teacher-child relationships were investigated. The treatment acceptability was also examined. Both visual and statistical analyses found a treatment effect in both cases was seen for both teachers’ increased use of positive …

Care Setting Of The Last Resort: Care Transitions For Nursing Home Residents Directly Admitted From The Community, Amanda A. Holup

USF Tampa Graduate Theses and Dissertations

Since the late 1980s, policymakers have attempted to reduce the institutional bias of their long-term services and supports by investing in more accessible home and community-based services for older adults with long-term care needs and adults with disabilities. To further advance rebalancing discussions, this study examined the resident, facility, and state characteristics associated with the admission of community-dwelling older adults to the nursing home and the subsequent discharge of this population back to community settings. Data from the Minimum Data Set (MDS) 2.0 were used to construct episodes of care for all newly-admitted residents aged 65 and older to any …

Large Cross-Sectional Study Of Presbycusis Reveals Rapid Progressive Decline In Auditory Temporal Acuity, Erol J. Ozmeral, Ann C. Eddins, Robert Frisina Sr., David A. Eddins

Communication Sciences and Disorders Faculty Publications

The auditory system relies on extraordinarily precise timing cues for the accurate perception of speech, music, and object identification. Epidemiological research has documented the age-related progressive decline in hearing sensitivity that is known to be a major health concern for the elderly. Although smaller investigations indicate that auditory temporal processing also declines with age, such measures have not been included in larger studies. Temporal gap detection thresholds (TGDTs; an index of auditory temporal resolution) measured in 1071 listeners (aged 18–98 years) were shown to decline at a minimum rate of 1.05 ms (15%) per decade. Age was a significant predictor …

Interspeech Posture In Spanish-English Bilingual Adults, Merrily Rose Shary

USF Tampa Graduate Theses and Dissertations

Interspeech posture (ISP) is a term used to define the position of a person’s articulators when they are preparing to speak. Research suggests that ISP may be representative of a speaker’s phonological knowledge in a particular language, as determined empirically with ultrasound measures of the tongue in English-French bilinguals (Wilson & Gick, 2014). It is possible, therefore, that measuring ISP could be a diagnostic tool for determining phonological knowledge in bilingual speakers. However, more information on ISP in typical adult bilingual speakers is needed before diagnostic claims can be made. For example, ISP is believed to be language specific, and …

Relationship Between Teacher Characteristics And Accuracy In Identifying Middle School Students With Symptoms Of Anxiety And Depression, Elizabeth Storey

USF Tampa Graduate Theses and Dissertations

As a universal screening method, teacher nominations have been found to both miss and misidentify a substantial proportion of students with internalizing disorders such as anxiety and depression (Cunningham & Suldo, 2014; Gelley, 2014; Moor et al., 2007). Although some research has explored the accuracy of teacher nominations when used to identify students with anxiety and depression, no research examined the teacher characteristics that are potentially related to accuracy. The current study conducted a secondary analysis of an archival dataset (Gelley, 2014) to determine which characteristics of teachers (N= 19) are more closely related to accuracy in identifying …

Environmental And Community Health In South San Diego County: A Behavior Analysis Of Recreational Ocean Users Along Imperial Beach, California, Trista Brophy

USF Tampa Graduate Theses and Dissertations

Garbage & sewage runoff into the Pacific Ocean at the shoreline along the U.S./Mexico Border region poses serious health and environmental threats. The purpose of this study was to analyze the current beach users’ behavioral factors that may be linked to illness prevalence from Coronado Island to the U.S./Mexico border at Imperial Beach in San Diego County. It is a continuation of a study completed by Wildcoast and Imperial Beach Clinic in 2011. The study tried to answer the following two major questions: How have the number of illnesses reported by users along South San Diego County beaches changed in …

Smoking Among Youth Living With Hiv: The Intersection Of Behavioral Health And Chronic Disease, Todd Wells

USF Tampa Graduate Theses and Dissertations

Smoking amongst youth living with HIV (YLWH) has major public health implications. When combined with the complications associated with smoking such as chronic obstructive pulmonary disorder (COPD) or heart disease, the impact of a HIV positive diagnosis increases morbidity exponentially (Nahvi & Cooperman, 2009). The purpose of this study was two-fold, to investigate the perceptions of smoking amongst YLWH aged 18-25 who received care at the CMS Clinic located at the University of South Florida and to determine factors related to cessation. A study design utilizing two components, a systematic literature review and primary qualitative data was used in this …

The Effectiveness Of An Intervention Designed To Improve Chlorhexidine (Chg) Bathing Technique In Adults Hospitalized In Medical Surgical Units, Janette Echemendia Denny

USF Tampa Graduate Theses and Dissertations

Central line associated bloodstream infections (CLABSIs) are one of the most fatal types of healthcare associated infections (HAIs) and their economic impact is significant. Although some studies have found no signification reduction in CLABSI rates with chlorhexidine gluconate (CHG) bathing; good evidence exists to support the use of CHG bathing as an intervention to reduce CLABSIs (Bleasdale et al., 2007; Climo et al., 2009; Climo et al., 2013; Montecalvo et al., 2012). CHG bathing performance may influence the effectiveness of the CHG bathing protocol.

The purpose of this study was to determine the effect of a targeted educational approach involving …

Longitudinal Study Of Adjustable Workstations, Megan Elizabeth Sandy

USF Tampa Graduate Theses and Dissertations

Workplace interventions to reduce discomfort and sedentary time have been studied in a variety of settings. Adjustable workstations are one type of ergonomic intervention that is used to potentially reduce occupational sitting time, negative health impacts, and to increase productivity. This investigation compared two types of ergonomic interventions, as well as contrasting behavioral interventions among workers with and without adjustable workstations. Seventy-two sedentary office workers were selected to participate in a longitudinal study to evaluate interventions for a reduction in occupational sitting time, to understand the effect on productivity and to evaluate musculoskeletal pain and behaviors. Workers were randomly placed …

Sleep Duration Patterns From Adolescence To Young Adulthood And Their Impact On Asthma And Inflammation, Chighaf Bakour

USF Tampa Graduate Theses and Dissertations

This dissertation includes three studies that examined the impact of inadequate sleep duration in adolescents and young adults on asthma and systemic inflammation. We used data from the Florida Youth Risk Behavior Survey (YRBS), years 2009-2013, and from the National Longitudinal Study of Adolescent to Adult Health (Add health), which was conducted between 1994 and 2008.

The first study used data from 16,738 high school students participating in the Florida YRBS. We examined the cross-sectional association between sleep duration and asthma, and the interactive effects of sleep duration and BMI. We found that short and long sleep durations were associated …

Cardiovascular Disease Risk Scores And Novel Risk Factors In Relation To Race And Gender, Johanna Wilson

USF Tampa Graduate Theses and Dissertations

The use of cardiovascular risk scores remains the foundation for risk stratification to guide clinical management. Clinicians have access to several cardiovascular risk scores in practice settings. While having several risk scores with different risk factors may provide more information, it does not imply accuracy of the cardiovascular risk score used to calculate individual patient cardiovascular risk. The objective of this study was to compare the Framingham Risk score, Reynolds Risk scores, and the Pooled Cohort Risk Equation (3 commonly used equations) scores with respect to ability to predict cardiovascular events in a diverse ethnic population. Additionally, the potential predictive …

Statistical Analysis And Modeling Health Data: A Longitudinal Study, Bhikhari Prasad Tharu

USF Tampa Graduate Theses and Dissertations

Lung cancer has been considered one of the leading causes of deaths while cancer re- mains the second most common cause of deaths in the USA. Understanding the behavior of a disease over time could yield important information to make decisions about the disease. Statistical models could provide crucial clues and help to make a decision about the dis- ease, budget allocation, evaluation, and implement prevention. Longitudinal trend analysis of the diseases helps to understand long term effects and nature. Cholesterol level is one of the most contributing risk factors for Coronary Heart Disease. Studying cholesterol statistically helps to know …

Systematic Replication Of The Effects Of A Supplementary, Technology-Assisted, Storybook Intervention For Preschool Children With Weak Vocabulary And Comprehension Skills, Charles R. Greenwood, Judith J. Carta, Elizabeth S. Kelley, Gabriela Guerrero, Na Young Kong, Jane Atwater, Howard Goldstein

Communication Sciences and Disorders Faculty Publications

In 2013, Spencer, Goldstein, Sherman, et al. reported the promising effects of a supplemental, technology-assisted, storybook intervention (Tier 2) containing embedded instruction targeting the oral language learning of preschool children at risk for delays. We sought to advance knowledge of the intervention by replicating it in a new sample and examining children’s responses to the narrator’s instructional prompts and associations with learning outcomes. Results indicated that children were highly successful in responding with the narrator’s task-management prompts (i.e., turn the page), particularly after the first book. Children were much less proficient in correctly responding to the narrator’s word-teaching prompts …

Neighborhood Perceptions Of Proximal Industries In Progress Village, Fl, Laura E. Baum

USF Tampa Graduate Theses and Dissertations

Progress Village, a historically Black neighborhood outside of Tampa, FL, encountered structural violence that included construction of an adjacent phosphogypsum stack. Why the neighborhood signed a legal agreement with the stack’s operating industry and the impacts of this decision provides a lesson in critical environmental justice. Theories of urban political ecology frame exploration of resident priorities, relationships with industry, risk perceptions, and health concerns. Utilizing activist anthropology, this thesis aims to be mutually beneficial to scholarly and neighborhood development. Ultimately, this research demonstrates how southern gradualism, racism, and a trend towards isolationism created today’s striving, yet marginalized and divided community. …