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Aberrant Neurogenic And Epigenetic Processes Are Associated With Depression Induced By Developmental Arsenic Exposure, Christina Rene Tyler
Aberrant Neurogenic And Epigenetic Processes Are Associated With Depression Induced By Developmental Arsenic Exposure, Christina Rene Tyler
Biomedical Sciences ETDs
Arsenic is a pervasive environmental contaminant derived from both natural and anthropogenic sources. Epidemiological evidence supports a correlation between arsenic exposure in drinking water and increased rates of psychiatric disorders, including depression, in exposed populations. Previous studies have established that perinatal exposure to arsenic (through all three trimesters of fetal/neonatal development, DAE) has long-lasting consequences into adulthood including deficits in learning and memory, molecular aberrations in the hypothalamic-adrenal-pituitary (HPA) axis, and depressive-like symptoms in mice. The studies described in this dissertation were designed to assess the impact of DAE on adult hippocampal neurogenesis (AHN) as a possible mechanism of action …
Metadata Determination For A Cadaveric Collection, Shamsi Berry
Metadata Determination For A Cadaveric Collection, Shamsi Berry
Biomedical Sciences ETDs
The number, size and complexity of research databases continue to grow unabated. Yet, despite significant advances in information technology, scientists continue to struggle with 'data wrangling' or issues of finding, sharing, and reusing data, often for unanticipated future purposes. Most research databases are designed ad hoc, by native investigators for specific research functions and immediate needs with little to no input from database designers, informaticians, or other subject matter experts. Little thought is usually given to the implications of future data retrieval, sharing and reuse. When the needs of future investigators or research requirements change, the original design of the …
Engineering Catalytic Molecular Logic Devices For Biodetection, Carl Brown Iii
Engineering Catalytic Molecular Logic Devices For Biodetection, Carl Brown Iii
Biomedical Sciences ETDs
This dissertation describes the development of DNA computing techniques and molecular logic devices specifically engineered for direct translation to biological sample detection. As disease states originate at the molecular level, it is critical to design diagnostic and therapeutic devices that are capable of molecular-scale sensing and decision-making in the cellular environment. The predictable nature of DNA hybridization and secondary structure formation enables programmable interactions, providing a stable, cost-effective, and biocompatible mechanism for making decisions on the molecular scale. The incorporation of DNAzymes, DNA strands that can perform a variety of chemical reactions, adds innate catalysis and a rich biochemical diversity …
Mechanisms Responsible For Decreased Rat Pulmonary Arterial H2o2 Levels In A Model Of Chronic Hypoxia-Induced Pulmonary Hypertension, Danielle Plomaritas
Mechanisms Responsible For Decreased Rat Pulmonary Arterial H2o2 Levels In A Model Of Chronic Hypoxia-Induced Pulmonary Hypertension, Danielle Plomaritas
Biomedical Sciences ETDs
Our laboratory has demonstrated an important role for acid-sensing ion channel 1 (ASIC1) in pulmonary hypertension through augmented Ca2+ influx in pulmonary arterial smooth muscle cells (PASMC) following chronic hypoxia (CH). However, this enhanced calcium (Ca2+) influx is not dependent on an increase in ASIC1 protein expression. This suggests other regulatory mechanisms influencing ASIC1 activity are altered following CH. ASIC1 is a redox sensitive ion channel and recent studies from our laboratory have shown that the oxidant hydrogen peroxide (H2O2) inhibits ASIC1-dependent Ca2+ influx in PASMC. Reactive oxygen species are known to be altered in pulmonary hypertension, however the direction …