Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Gαq-Associated Signaling Promotes Neuroadaptation To Ethanol And Withdrawal-Associated Hippocampal Damage, Anna R. Reynolds
Gαq-Associated Signaling Promotes Neuroadaptation To Ethanol And Withdrawal-Associated Hippocampal Damage, Anna R. Reynolds
Theses and Dissertations--Psychology
Prolonged, heavy consumption of alcohol produces marked neuroadaptations in excitatory neurotransmission. These effects are accelerated following patterns of intermittent heavy drinking wherein periods of heavy consumption are followed by periods of abstinence. Studies have shown that neuroadaptive changes in the glutamatergic N-methyl-D-aspartate (NMDA) receptor produces excitotoxicity during periods of withdrawal; however, upstream targets were not adequately characterized. The present studies sought to identify these targets by assessing the role of group 1 metabotropic glutamate receptors (mGluR) and intracellular calcium in promoting cytotoxicity of hippocampal cell layers in vitro. It was hypothesized that ethanol-induced activity of mGluR1-and-5 contributes to hippocampal …