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White Matter Hyperintensities Predict Functional Decline In Voiding, Mobility And Cognition In Older Persons, Dorothy B. Wakefield, George A. Kuchel, Richard F. Kaplan, Leslie I. Wolfson
White Matter Hyperintensities Predict Functional Decline In Voiding, Mobility And Cognition In Older Persons, Dorothy B. Wakefield, George A. Kuchel, Richard F. Kaplan, Leslie I. Wolfson
UCHC Articles - Research
Objective
To compare MRI data to functional assessments of mobility, urinary control, and cognition to determine common or distinctive features in the distribution of brain white matter hyperintensities (WMHs) associated with functional decline/impairment.
Design
Baseline data from subjects 75-89 years enrolled in a longitudinal study. Assessors and subjects were blinded to group assignment.
Participants
99 subjects were enrolled using a balanced 3×3 matrix stratified by age and mobility performance. Exclusion criteria included: medication, systemic conditions, and neurologic diseases which can compromise mobility.
Setting
Healthy community-dwelling volunteers.
Measurements
WMHs were identified using semi-automated segmentation method and regional burdens were assessed utilizing …