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The Effect Of Bacterial Vaginosis Associated Bacteria On Epithelial Factors Mediating Hiv Transmission, April Nguyen
The Effect Of Bacterial Vaginosis Associated Bacteria On Epithelial Factors Mediating Hiv Transmission, April Nguyen
HIM 1990-2015
Bacterial vaginosis (BV), a common female reproductive tract (FRT) condition characterized by an overgrowth of anaerobic species concurrent with the disappearance of commensal Lactobacilli species, is associated with a 60% increased risk of HIV-1 transmission. However, the role of the FRT epithelia in bacterial vaginosis-associated bacteria (BVAB)-augmented HIV- 1 transmission is unclear. To evaluate the increased risk of HIV-1 acquisition, we treated FRT epithelia with Atopobium vaginae, a prevalent BVAB, to determine the nature of the host response to BVAB exposure. Treatment of endocervical cells with A. vaginae resulted in a 1500-fold increase in the expression of the antimicrobial peptide …