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Cortisol Receptor Sensitivity As A Risk Factor For Depression, Michela Michielli

Honors Theses

In 2020, the World Health Organization reported over 264 million people across the world were suffering from depression. Studies have demonstrated that one source of depression is a hormonal imbalance involved in the stress response. Cortisol is a stress hormone regulated by the Hypothalamic-Anterior-Pituitary (HPA) Axis. Its effects on the stress response and other metabolic activities in the body are exerted through the glucocorticoid and mineralocorticoid receptors (GR and MR respectively).

Our research has examined mutations known as single-nucleotide-polymorphisms (SNPs) relating to cortisol-receptor sensitivity and the behavior of cortisol in the body to investigate the link between cortisol activity and …

The Impact Of Single Nucleotide Polymorphisms On Cortisol Receptor Activity In Populations With Obesity, Cassidy Michalicka

Honors Theses

Cortisol is a crucial part of the endocrine system; it has the capacity to affect nearly every organ and tissue in the human body. When functioning correctly, cortisol is known to regulate the body’s stress response, control metabolism, suppress inflammation, regulate blood pressure, regulate blood sugar, regulate our body’s circadian rhythm, and much more. When the concentration of cortisol in the blood is elevated for an excessive period, the body responds with symptoms such as hyperglycemia, hypertension, weight gain, and moon face. Commonly this is known as Cushing’s Syndrome (CS), and interestingly, we have seen a phenotypic resemblance when contrasted …

Impact Of Single Nucleotide Polymorphisms On Hpa Axis Functionality In Depression, Claire Kelly

Honors Theses

The hypothalamic-pituitary-adrenal (HPA) axis plays a primary role in stress response through the regulated secretion of the glucocorticoid hormone cortisol. Diseases of cortisol dysregulation such as Cushing’s syndrome (hypercortisolemia) and Addison’s Disease (hypocortisolemia) are both associated with depression. Based on this we, and others, have hypothesized that mutations in the genes for the glucocorticoid receptor (GR), the closely related mineralocorticoid receptor (MR), and regulatory proteins associated with cortisol or GR function may contribute to depression in the absence of hyper- or hypo-cortisolemia. Our study investigated the genotypic frequency in the clinical population of several single nucleotide polymorphisms (SNPs) that affect …

Cognitive And Emotional Correlates Of Improved Gait Distance During The Course Of Physical Therapy Treatment For An Incomplete Spinal Cord Injury, Danielle Miller

Honors Theses

Objective

The focus of spinal cord injury rehabilitation over the past four decades has shifted from medical management to issuses that affect quality of life and community participation (Gómara- Toldrà, Sliwinski, & Dijkers, 2014). However, the care team for spinal cord injury patients still need to collaberate in order to design and implement interventions that result in maximum participation to provide an individual with a spinal cord injury an effective rehabilitation program. In order to create such a rehablitation program, the care team must know how certain psychological and cognitive aspects, such as depression and implict memory, are related to …

Dysfunctional Attitudes And Low Self-Esteem Mediate The Effect Of Attachment Anxiety Priming On Depression, Cassandra C. Devito

Honors Theses

Previous studies regarding the relationship between attachment anxiety and depression and the mediating roles of dysfunctional attitudes and self-esteem have been correlational in nature. The current study used an experimental design to look at these relationships. Attachment style was determined using a shortened version of the Experiences in Close Relationships Scale, and then either secure attachment, anxious attachment, or a control of grocery shopping was primed by instructing participants to write about one of the three scenarios. Dysfunctional attitudes were assessed, followed by state self-esteem and then state depression. Multiple regression analyses revealed that trait attachment anxiety and the anxiety …