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Treatment Of Later Humoral Rejection With Anti-Cd20 Monoclonal Antibody Rituximab: A Single Centre Experience, Helen Hayes, Clare Wood, Lawrence Dembo, Gerry O'Driscoll

Medical Conference Papers

Humoral or vascular rejection is a B cell-mediated production of immunoglobulin (Ig) G antibody against a transplanted organ that results in immune complex deposition on the vascular endothelium, activation of the complement cascade, production of endothelial dysfunction and regional ischaemic injury.

Pedometer-Determined Physical Activity, Bmi And Waist Girth In 7- To 16- Year-Old Children And Adolescents, Beth P. Hands, Helen Parker

Health Sciences Papers and Journal Articles

Background: Different approaches to measuring physical activity and fatness in youth have resulted in studies reporting relationships ranging from very strong to non-existent.

Methods: The sample comprised 787 males and 752 females aged between 7 and 16 years. Pedometer-determined physical activity, height, weight and waist girth measures were taken.

Results: Significant differences were found in activity level between BMI-determined weight categories for the females (F(1, 742) = 9.07, p = .003) but not for the males (F(1, 777) = 3.59, p = .06) and between truncal adiposity groupings for both the males (F(1, 777) = 4.69, p = .03) and …

The Relationship Between Physical Activity, Motor Competence And Health-Related Fitness In 14-Year-Old Adolescents, Beth P. Hands, Dawne Larkin, Helen Parker, Leon Straker, Mark Perry

Health Sciences Papers and Journal Articles

Physical activity, physical fitness, and motor competence are important health-related constructs. However, the relationship between them, particularly among children and adolescents, is still unclear. In this study, motor competence (measured by the McCarron Assessment of Neuromuscular Development), pedometer-determined physical activity and physical fitness (aerobic fitness, muscle strength, muscle endurance, flexibility and body composition) were examined in a cohort of 1585 adolescents (771 girls, 814 boys) of mean age 14.1 yrs. Significant gender differences were observed for all measures except motor competence. Apart from hip and shoulder flexibility, males outperformed females. For both males and females, motor competence was associated with …

Fitness, Motor Competence And Body Composition As Correlates Of Adolescent Neck/Shoulder Pain: An Exploratory Cross-Sectional Study, Mark Perry, Leon Straker, Peter O'Sullivan, Anne Smith, Beth P. Hands

Health Sciences Papers and Journal Articles

Background: Adolescent neck/shoulder pain (NSP) is a common and sometimes debilitating problem. Several risk factors for this condition have been investigated, but no studies have previously evaluated associations between fitness, motor competence, body composition and adolescent NSP.

Methods: 1608 males and females of mean age 14 years answered questions on their history of NSP (4 measures), and were tested for aerobic fitness, upper and lower limb power, trunk endurance, grip strength, shoulder flexibility, motor competence and anthropometric factors. Univariate and multivariate logistic regressions were used to test for associations between NSP and physical variables.

Results: There were significant gender differences …

Referring Patients To Specialists: A Structured Vignette Survey Of Australian And British Gps, Moyez Jiwa, Michael Gordon, Hayley Arnet, Hooi Ee, Max Bulsara, Brigitte Colwell

Medical Papers and Journal Articles

Background: In Australia and in the United Kingdom (UK) access to specialists is sanctioned by General Practitioners (GPs). It is important to understand how practitioners determine which patients warrant referral.

Methods: A self-administered structured vignette postal survey of General Practitioners in Western Australia and the United Kingdom. Sixty-four vignettes describing patients with colorectal symptoms were constructed encompassing six clinical details. Nine vignettes, chosen at random, were presented to each individual. Respondents were asked if they would refer the patient to a specialist and how urgently. Logistic regression and parametric tests were used to analyse the data.

Results: We received 260 …

Irritable Bowel Syndrome Patients Exhibit Depressive And Anxiety Scores In The Subsyndromal Range, Sean D. Hood, Jonathon Q. Shufflebotham, Julie Hendry, Dana A. Hince, Ann S. Rich, Chris S J Probert, John Potokar

Medical Papers and Journal Articles

Irritable bowel syndrome (IBS) patients frequently experience affective disorders and psychiatric outpatients frequently meet criteria for IBS. The exact nature of this co-morbidity is not clear. 34 patients with Rome-II diagnosed IBS were recruited from a Gastroenterology clinic. Patients with social anxiety disorder (10 SSRI-remitted and 7 untreated subjects) were used as a psychiatric comparison, 28 normal subjects from our register were included as a fourth group (Volunteers). Depressive and anxiety symptoms were measured by the Beck Depression Inventory (BDI) and Spielberger Trait Anxiety Inventory (STAI), respectively. Personality traits were measured with the Swedish universities Scales of Personality (SSP). IBS …

The Influence Of Health Inquiries On Clinical Governance Systems: A Case Study Of The Douglas Inquiry, Heather Gluyas

Theses

Major failures in patient safety often lead to high profile inquiries set up to establish the facts, and to identify areas of improvement to prevent further failures. In order to learn from inquiries, we need to be able to identify if, and how, the inquiry process influences improvements. Using a case study strategy, this research study examined the perceptions of external stakeholders in regards to the impact or influence of the Douglas Inquiry on KEMH’s clinical governance systems. The research focused on two areas that were highlighted in the final Inquiry report as requiring reform. These systems deal with the …

Changes In Motor Skill And Fitness Measures Among Children With High And Low Motor Competence: A Five-Year Longitudinal Study, Beth Hands

Health Sciences Papers and Journal Articles

Children with low motor competence (LMC) are less able to participate fully in many sports and recreational activities typically enjoyed by their well-coordinated peers. Poor fitness outcomes have been reported for these children, although previous studies have not tracked these outcomes over time. In this study, 19 children (8 girls and 11 boys) with LMC aged between 5 and 7 years were matched by age and gender with 19 children with high motor competence (HMC). Six fitness (body compostion and cardiovascular endurance) and motor skill (sprint run, standing broad jump and balance) measures were repeated for each group once a …