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T Cell Homeostasis Is Regulated By A Program Of Mrna Alternative Splicing Mediated By Heterogeneous Nuclear Ribonuclear Protein L-Like (Hnrnpll), Gerard F. Hoyne
T Cell Homeostasis Is Regulated By A Program Of Mrna Alternative Splicing Mediated By Heterogeneous Nuclear Ribonuclear Protein L-Like (Hnrnpll), Gerard F. Hoyne
Health Sciences Conference Papers
It is essential that the immune system maintains stable numbers of a diverse range of lymphocytes since they play important roles in both innate and adaptive immune responses. T lymphocytes are critical for generating cellular immunity and memory following infections (e.g. CD4+ and CD8+ TCR ab + cells), they are also involved in immune regulation (e.g. CD4+ foxp3+ regulatory T cells), as well as immune surveillance at mucosal surfaces and controlling responses to tumors (e.g. TCR gd + cells, NKT cells). Each cell lineage must be contained within a defined cellular compartment and the size of each compartment is physically …