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Ifn-Γ Stimulated Dental Follicle Mesenchymal Stem Cells Regulate Activated Lymphocyte Response In Rheumatoid Arthritis Patients In Vitro, Noushin Zibandeh, Deni̇z Genç, Güzi̇de Nevsun İnanç, Rafi̇ Haner Di̇reskeneli̇, Tunç Akkoç
Ifn-Γ Stimulated Dental Follicle Mesenchymal Stem Cells Regulate Activated Lymphocyte Response In Rheumatoid Arthritis Patients In Vitro, Noushin Zibandeh, Deni̇z Genç, Güzi̇de Nevsun İnanç, Rafi̇ Haner Di̇reskeneli̇, Tunç Akkoç
Turkish Journal of Medical Sciences
Background/aim: Multipotent mesenchymal stem cells (MSCs) have been investigated in autoimmune diseases such as rheumatoid arthritis (RA) due to their immunomodulatory and regenerative properties. In this study, their immunosuppressive effects on peripheral blood mononuclear cells (PBMC) of RA patients were studied.Materials and methods: Dental follicle stem cells (DFSCs) were isolated from follicle tissue in the orofacial region. Characterization and multipotency analyses were performed. Lymphocytes were isolated from peripheral venous blood of RA patients (n = 5) and healthy individuals (n = 5). DFSCs were preincubated with IFN-γ for 48 h. PBMCs of RA patients and healthy individuals were separately cultured …