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Medicine and Health Sciences

Selected Works

1982

Articles 1 - 5 of 5

Full-Text Articles in Entire DC Network

Experimental Eye Research Volume 35, Issue 6, December 1982, Pages 625–642 Cover Image Retinal Degenerations In The Dog Iii Abnormal Cyclic Nucleotide Metabolism In Rod-Cone Dysplasia, Gustavo Aguirre, Debora Farber, Richard Lolley, Paul O'Brien, James Alligood, R Fletcher Nov 1982

Experimental Eye Research Volume 35, Issue 6, December 1982, Pages 625–642 Cover Image Retinal Degenerations In The Dog Iii Abnormal Cyclic Nucleotide Metabolism In Rod-Cone Dysplasia, Gustavo Aguirre, Debora Farber, Richard Lolley, Paul O'Brien, James Alligood, R Fletcher

Gustavo D. Aguirre, VMD, PhD

In dogs bred to develop rod-cone dysplasia, retinal development is normal until 13 days of age.Afterwards, there is an arrest of visual cell differentiation. Rod inner segments remain diminutive and outer segments fail to elongate as in controls; the outer segments show lamellar disorientation and disorganization. Affected visual cells degenerate, but the degeneration process is more rapid and extensive for rods than cones.
Cyclic GMP levels become elevated in affected retinas early during the postnatal differentiation of visual cells; this elevation precedes any morphological evidence of photoreceptor disease. Retinal protein synthesis is normal during the time that retinal cGMP levels …

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Pathogenesis Of Progressive Rod-Cone Degeneration In Miniature Poodles, Gustavo D. Aguirre, James P. Alligood, P O'Brien, N Buyukmihci Oct 1982

Pathogenesis Of Progressive Rod-Cone Degeneration In Miniature Poodles, Gustavo D. Aguirre, James P. Alligood, P O'Brien, N Buyukmihci

Gustavo D. Aguirre, VMD, PhD

Visual cell pathologic changes and outer segment renewal were investigated in miniature poodles with progressive rod-cone degeneration. Early in this disease, visual cells in the posterior pole and equatorial regions show outer segment lamellar disorientation and vesicular profiles. Visual cells are normal in the periphery. Outer segment renewal determined after intravitreal injection of 3H-leucine was abnormally slower in affected animals than in controls. This renewal abnormality was similar in structurally normal and diseased photoreceptors, suggesting that the renewal defect is the earliest recognizable abnormality in the disease. The pigment epithelium was normal; the presence and density of pigment did not …

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Caring For Retarded Persons, Barry Hoffmaster Dec 1981

Caring For Retarded Persons, Barry Hoffmaster

C. Barry Hoffmaster

No abstract provided.

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Utilization Of The Facilitative Conditions Within The Nurse-Client Relationship, Sharon Strang Dec 1981

Utilization Of The Facilitative Conditions Within The Nurse-Client Relationship, Sharon Strang

Sharon L. Strang

No abstract provided.

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Cluster Analysis To Determine Headache Types, Paula Diehr Dec 1981

Cluster Analysis To Determine Headache Types, Paula Diehr

Paula Diehr

Cluster analysis was used to separate 726 headache patients into clusters of patients with similar symptoms. This was done to answer two questions: what "naturally occurring' groups of patients can be found? And how do these groups correspond to traditional headache types? When only two clusters were required, the best two clusters were tension and migraine-like. However, eight clusters could also be distinguished, and the migraine group then became very small. The clusters were tested for clinical interpretability by having 12 physicians name and prescribe treatment for the clusters. The suggested treatment was similar to what patients had actually received …

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