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Structural And Dynamic Analysis Of Wild And Splice Variants Human Μ-Opiod Receptors In Complex With Morphine And Ibntxa And Human Topoisomerase Ii Alpha Mutational Basis Of Amsacrine Resistance, Safaa Sader

Theses and Dissertations

Morphine prescribing is limited by its high addiction tendency and other serious effects. Recent animal’s biological studies on Mu 6TM splice variants, which mainly include G1, G2 and Mu3, supported a high safety and potency profiles of IBNtxA as potential alternative of Morphine. Nevertheless, there is no high-resolution structures of these 6TM variants, and the detailed structural features and dynamic characteristics of these splice variants remain elusive. We applied homology modeling and MD simulation to probe the structural, dynamic and ligand binding differences between the wild type (7TM) and two major truncated 6TM variants (G1 and G2). MD results underscored …

The United States Medical Licensing Exam (Usmle) And Medical Student Wellness: An Ethnographic Qualitative Study At Cooper Medical School Of Rowan University, Patricia Davis Vanston

Theses and Dissertations

Research indicates that medical students experience unusually high levels of stress, anxiety, depression, and loss of empathy while in medical school. As the number of medical students rises and residency positions remain stagnant, the USMLE receives greater emphasis as a barometer to determine residency placement and future career paths thereby increasing levels of stress among students. Stress is associated with diminished self-care, potentially leading to a negative impact on well-being. This ethnographic, qualitative study sought to examine the extent to which the anticipation of, preparation for, and implications of the USMLE contribute to medical student stress, wellness, and self-care. Through …

A Mechanical Study Of Cancer Drug-Receptor Interactions, Specifically In G-Quadruplex Dna And Topoisomerase I Enzymes, Kelly Ann Mulholland

Theses and Dissertations

Computational methods are becoming essential in drug discovery as they provide information that traditional drug development methods lack. Using these methods to understand drug-receptor interactions in detail, researchers are able to efficiently design promising drug candidates. In this study, extra precision Glide docking, molecular dynamics simulations and MMGBSA binding energy calculations provided information about the binding behavior of small molecules to two specific targets for current cancer therapeutics: G-quadruplex DNA and Topoisomerase I enzyme. The first study focuses on the compound Telomestatin, which induces apoptosis of various cancer cells with a relatively low effect on somatic cells due to its …

Fostering Humanism In Medicine: A Mixed Methods Study On The Influence Of Humanism In Medicine Workshops On Medical Student Empathy, Marion J. Lombardi

Theses and Dissertations

Medicine has evolved to encompass an alliance between the doctor and patient, in which the doctor must understand the patient holistically (Kaba & Sooriakumaran, 2007). Research suggests that doctor-patient relationship focused training has a meaningful effect on measured health outcomes in patients with conditions such as obesity, diabetes, asthma or osteoarthritis (Reiss & Reinero, 2014). Therefore, the humanistic qualities of medicine, encompassing honesty, integrity, caring, compassion, altruism, empathy, and respect for self, patients, and others are more important than ever in cultivating a strong doctor-patient relationship (Weissmann et al., 2006).

Existing research suggests an underlying capacity for emotional intelligence (EI) …

Stories Of Becoming And Being An Associate Degree Nurse Educator: A Narrative Inquiry Study Examining How Participants' Ways Of Knowing Evolved Through Their Experiences, Bonnie Jill Ross

Theses and Dissertations

This study explored the stories of the experiences of three associate degree nurse educators and how they evolved in the way they viewed their world as they transitioned in their role from nurse expert to experienced nurse educator. As associate degree nursing education is the most commonly reported initial nursing education of registered nurses in the United States, and, because of the highly affordable and accessible means for educating the next generation of nurses, the purpose of this study was to address the projected nurse and nursing faculty shortage. Through narrative inquiry, this study has provided a means to inform …

Recruitment And Retention Of Hispanic Nursing Students: Through The Lens Of Associate Degree Nursing Program Administrators And Hispanic Nursing Students, Debra Jean Handlos Devoe

Theses and Dissertations

The Hispanic population in the United States is changing and will constitute 30% of the population in 2050; however, the Hispanic registered nurse population is less than 3%. Cultural differences between patients and nurses may cause harm and a mistrust that can affect patient outcomes. A mixed methods convergent research study was done by an electronic survey, non-electronic surveys, telephone interviews, and focus groups to compare the perceptions of nursing program administrators at seven community colleges in a Mid-Atlantic state, in the United States, and the perceptions of 15 Hispanic nursing students regarding the challenges, barriers, and obstacles of Hispanic …