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Mechanisms By Which Exercise Training Attenuates Blood Pressure In Animals: Roles Of Cytokines, Oxidative Stress, And Glycogen Synthase Kinase-3Â, Deepmala Agarwal
Mechanisms By Which Exercise Training Attenuates Blood Pressure In Animals: Roles Of Cytokines, Oxidative Stress, And Glycogen Synthase Kinase-3Â, Deepmala Agarwal
LSU Doctoral Dissertations
Hypertension is a chronic multifactorial condition with high morbidity and mortality rates, currently affecting about one billion people worldwide. Currently available anti-hypertensive medications are found to be effective in reducing blood pressure (BP), but still more than 50% of those diagnosed with hypertension fail to respond to these anti-hypertensive regimens. Although hypertension has multiple etiologies, physical inactivity has been found to have strong correlation with the disease, so exercise has recently been recommended as a part of lifestyle modifications for all hypertensive patients. Therefore, the present series of in vivo and in vitro studies were undertaken to gain more insight …
Pharmacological And Non-Pharmacological Approaches To Prevent Hypertension-Induced Renal Disease In The Spontaneously Hypertensive Rate, Carrie Marie Elks
Pharmacological And Non-Pharmacological Approaches To Prevent Hypertension-Induced Renal Disease In The Spontaneously Hypertensive Rate, Carrie Marie Elks
LSU Doctoral Dissertations
Hypertension affects 50 million Americans and remains the second leading cause of renal failure in the United States. Current pharmacological and non-pharmacological approaches to treat hypertension have proven effective, but the complexities of the disease and its renal effects warrant the need for new treatments. The hypothesis of this dissertation was that pharmacological or non-pharmacological approaches to reducing inflammation and oxidative stress would prevent hypertension-induced renal injury in the spontaneously hypertensive rat (SHR). In the first study, we blocked the inflammatory transcription factor, nuclear factor-kappa B (NF-ĸB), with pyrrolidine dithiocarbamate in the SHR kidney. In treated SHR, blood pressure decreased, …
The Role Of Inflammatory Molecules In Hypertension, Jeffrey Paul Cardinale
The Role Of Inflammatory Molecules In Hypertension, Jeffrey Paul Cardinale
LSU Doctoral Dissertations
Hypertension is a serious condition with high morbidity and mortality rates, as well as a major predisposing factor for multiple cardiovascular and renal diseases. Angiotensin II (Ang II) of the renin-angiotensin system (RAS) plays a pivotal role in propagating the hypertensive response. Moreover, hypertension is considered a chronic low-grade inflammatory condition that intimately involves the actions of proinflammatory cytokines (PICs) such as tumor necrosis factor-alpha (TNF). Recent evidence highlights the role that inflammation, specifically TNF, plays in hypertension and in regulating the RAS, but the understanding as to how inflammation is regulated following Ang II or TNF activation, as well …
Interaction Of Tumor Necrosis Factor-Alpha And The Renin Angiotensin System In The Pathogenesis Of Hypertension, Srinivas Sriramula
Interaction Of Tumor Necrosis Factor-Alpha And The Renin Angiotensin System In The Pathogenesis Of Hypertension, Srinivas Sriramula
LSU Doctoral Dissertations
Hypertension is a major predisposing factor for the development of cardiovascular and renal diseases. The renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases such as hypertension, myocardial infarction, heart failure, and stroke. Angiotensin II (Ang II), the effector peptide of the RAS, activates a wide spectrum of signaling responses via the Ang II type-I receptor that mediate its physiological control of blood pressure, thirst and sodium balance. For the past two decades, increasing evidence has demonstrated that the circulatory RAS and local/tissue RAS components (heart and brain) may contribute to the development of hypertensive response. …