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Study Of Interferon-Γ-Inducible Protein-10 Levels During Antiviral Therapy Of Hepatitis C Patients With Sofosbuvir Plus Ribavirin And Interferon In Menoufia Hospitals, Ahmed A. Salama, Elsayed I. Elshayb, Ghada R. El-Hendawy, Nancy R. Ahmed Elhosseny
Study Of Interferon-Γ-Inducible Protein-10 Levels During Antiviral Therapy Of Hepatitis C Patients With Sofosbuvir Plus Ribavirin And Interferon In Menoufia Hospitals, Ahmed A. Salama, Elsayed I. Elshayb, Ghada R. El-Hendawy, Nancy R. Ahmed Elhosseny
Menoufia Medical Journal
Objective The aim of this work was to study the effect of treatment with sofosbuvir, ribavirin, and interferon on the level of interferon-γ-inducible protein-10 (IP-10) and to determine its role in hepatitis C virus (HCV) patients with liver cirrhosis. Background IP-10 is a small cytokine belonging to the CXC chemokine secreted by several cell types in response to interferons (interferon-γ). IP-10 has been attributed to several roles, such as chemoattraction for monocytes, macrophages, T cells, natural killer cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. …