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Lateralizing Ability Of Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging In Temporal Lobe Epilepsy, Rasha Ali El-Kapany, Ibrahim Al-Sayed Al-Ahmar, Mona Sabry Elkholy, Rasha Abdelhafiz Aly, Ahmed Ali Saad Ali Hassan

Menoufia Medical Journal

Background: Temporal lobe epilepsy (TLE) is the most common type of intractable and partial epilepsies. The only standard treatment for seizure-free status with manifest TLE is surgical which includes amygdala-hippocampectomy. The majority of temporal lobe seizures originate in the mesial temporal structures, primarily in the hippocampus, para hippocampal gyrus and amygdala.

Objectives: To compare lateralizing ability of Magnetic resonance spectroscopy and Diffusion tensor imaging in patients with temporal lobe epilepsy.

Methods: The study recruited 50 participant assigned into two groups: the first group included 25 epileptic cases and the second group included 25normal controls. Age showed a mean ± SD …

Estimation Of Free Water-Corrected Microscopic Fractional Anisotropy., Nico J J Arezza, Tales Santini, Mohammad Omer, Corey A Baron

Medical Biophysics Publications

Water diffusion anisotropy MRI is sensitive to microstructural changes in the brain that are hallmarks of various neurological conditions. However, conventional metrics like fractional anisotropy are confounded by neuron fiber orientation dispersion, and the relatively low resolution of diffusion-weighted MRI gives rise to significant free water partial volume effects in many brain regions that are adjacent to cerebrospinal fluid. Microscopic fractional anisotropy is a recent metric that can report water diffusion anisotropy independent of neuron fiber orientation dispersion but is still susceptible to free water contamination. In this paper, we present a free water elimination (FWE) technique to estimate microscopic …