Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- Selected Works (4)
- Liberty University (2)
- Bellarmine University (1)
- East Tennessee State University (1)
- Faculty of Medicine, Menoufia University (1)
-
- Minnesota State University, Mankato (1)
- The Texas Medical Center Library (1)
- Thomas Jefferson University (1)
- University at Albany, State University of New York (1)
- University of Central Florida (1)
- University of Kentucky (1)
- University of Massachusetts Amherst (1)
- University of Tennessee Health Science Center (1)
- Western University (1)
- Publication
-
- Senior Honors Theses (2)
- All Graduate Theses, Dissertations, and Other Capstone Projects (1)
- Department of Pathology Honors Program Student Research Symposium (1)
- Dissertations & Theses (Open Access) (1)
- Doctoral Dissertations (1)
-
- ETSU Faculty Works (1)
- Electronic Theses and Dissertations (1)
- Electronic Thesis and Dissertation Repository (1)
- Erich Yahner (1)
- Erich Yahner, MSLIS (1)
- Graduate Theses, Dissertations, and Capstones (1)
- Legacy Theses & Dissertations (2009 - 2024) (1)
- Liz Isenring (1)
- Menoufia Medical Journal (1)
- Robert H. I. Dale (1)
- Theses and Dissertations (ETD) (1)
- Theses and Dissertations--Psychology (1)
- Publication Type
Articles 1 - 18 of 18
Full-Text Articles in Entire DC Network
Genetic And Chemical Dissection Of Bloodbrain Barrier Development In Zebrafish, Robyn Anne Umans
Genetic And Chemical Dissection Of Bloodbrain Barrier Development In Zebrafish, Robyn Anne Umans
Theses and Dissertations (ETD)
The blood-brain barrier (BBB) maintains a homeostatic environment as well as prohibits the entrance of xenobiotics into the brain. Because of these qualities, drug delivery is a fundamental challenge for the treatment of many diseases of the central nervous system (CNS). Along with limiting the access of therapeutics into the brain, the BBB is also impaired in CNS pathologies. Understanding the molecular cues that are essential for healthy BBB development and integrity may reveal targets for drug delivery leading to decreased progression or possible treatment of many detrimental CNS diseases. While the central features of the BBB have been accepted, …
Pancreatic Beta Cell Plasticity And Involvement Of Insulin-Expressing Progenitor Cells, Christine A. Beamish
Pancreatic Beta Cell Plasticity And Involvement Of Insulin-Expressing Progenitor Cells, Christine A. Beamish
Electronic Thesis and Dissertation Repository
Islet transplants have been successfully used as treatment for diabetes, but are limited by shortages of cadaveric insulin-producing β-cells. An alternate source may be the dedifferentiation, expansion, and subsequent redifferentiation of pancreatic islets or β-cells using in vitro techniques prior to transplant. Based on protocols which described the dedifferentiation of human islets to ductal-like cells, we hypothesized that neonatal mouse islets could be similarly dedifferentiated in vitro. Dedifferentiation techniques produced significant duct-like cells, but redifferentiation to insulin-expressing cells was limited. RIPCre;Z/AP+/+ mice were consequently utilized to lineage trace β-cell fate during culture by a human placental alkaline phosphatase (HPAP) reporter. …
Transformational Leadership In Nursing: A Pilot Nurse Leader Development Program, Audria G. Denker
Transformational Leadership In Nursing: A Pilot Nurse Leader Development Program, Audria G. Denker
Graduate Theses, Dissertations, and Capstones
Current research reveals that staff nurses are routinely placed into front-line leadership roles with little formal preparation. The purpose of this project was the development, implementation, and evaluation of a pilot nurse leader development program for nurse leaders at a small community hospital located in Clarksville, Indiana. This study consisted of a quasi-experimental design, with the intervention consisting of a leadership course delivered to a convenience sample of nurses in managerial positions. Leadership attributes was quantified, both pre/post interventions, through the administration of the Leadership Practices Inventory (LPI), a Likert-scaled survey. The LPI was administered to the nurse leaders, their …
Annotated Bibliography: Interaction With Animals (1998-2013), Erich Yahner
Annotated Bibliography: Interaction With Animals (1998-2013), Erich Yahner
Erich Yahner, MSLIS
No abstract provided.
Hsisp Annotated Bibliography: Interaction With Animals (1998-2013), Erich Yahner
Hsisp Annotated Bibliography: Interaction With Animals (1998-2013), Erich Yahner
Erich Yahner
No abstract provided.
The Effect Of Zinc Supplementation On Growth And Development In Preterm Neonates, Hosam Hemdan Hegran, Sameh Ali Kassem, Seham Mohammed Ragab
The Effect Of Zinc Supplementation On Growth And Development In Preterm Neonates, Hosam Hemdan Hegran, Sameh Ali Kassem, Seham Mohammed Ragab
Menoufia Medical Journal
Objective This study aimed to show the effect of zinc supplementation on growth and development in preterm neonates in the first 6 months of life. Background Preterm infants have impaired zinc status because of low body stores as 60% of fetal zinc is acquired during the third trimester of pregnancy in addition to their limited capacity to absorb and retain micronutrients, coupled with increased endogenous losses associated with organ immaturity. Patients and methods The present study was carried out in the Department of Obstetrics in Nasr City Health Insurance Hospital on 80 healthy preterm infants between 32 and 36 weeks …
Interpreting, Stephanie Jo Kent
Interpreting, Stephanie Jo Kent
Doctoral Dissertations
What do community interpreting for the Deaf in western societies, conference interpreting for the European Parliament, and language brokering in international management have in common? Academic research and professional training have historically emphasized the linguistic and cognitive challenges of interpreting, neglecting or ignoring the social aspects that structure communication. All forms of interpreting are inherently social; they involve relationships among at least three people and two languages. The contexts explored here, American Sign Language/English interpreting and spoken language interpreting within the European Parliament, show that simultaneous interpreting involves attitudes, norms and values about intercultural communication that overemphasize information and discount …
The Apical Polarity Complex Protein, Pals1, Regulates Cell Fate In The Development Of Cerebellum And Neocortex, Jun Young Park
The Apical Polarity Complex Protein, Pals1, Regulates Cell Fate In The Development Of Cerebellum And Neocortex, Jun Young Park
Dissertations & Theses (Open Access)
Through their biased localization and function within the cell, polarity complex proteins are necessary to establish the cellular asymmetry required for tissue organization. Well-characterized germinal zones, mitogenic signals, and cell types make the cerebellum and neocortex excellent models to address the critical function of polarity complex proteins in the generation and organization of neural tissues. Here we report a focal distribution of Pals1, a central component of the apical complex, in progenitors. Our genetic analyses revealed that Pals1 deletion in the brain developed a remarkably undersized and disrupted layer structure of cerebral cortex and cerebellum. Furthermore we demonstrated that Pals1 …
Consensus-Based Nutritional Recommendations For Patients With Head-And-Neck Cancer, Elizabeth Isenring
Consensus-Based Nutritional Recommendations For Patients With Head-And-Neck Cancer, Elizabeth Isenring
Liz Isenring
Extract: Patients with head-and-neck cancer constitute one of the diagnostic groups that most commonly experience deterioration of nutrition status. Malnutrition in patients with head-and-neck cancer is well known to potentially result in impaired wound healing, reduced immunocompetence, and decreased tolerance to treatment—and thus undesired treatment breaks and unplanned hospital admissions.
A Survey Of The Management And Development Of Captive African Elephant (Loxodonta Africana) Calves: Birth To Three Months Of Age, Nicole L. Kowalski, Robert H.I. Dale, Christa L. H. Mazur
A Survey Of The Management And Development Of Captive African Elephant (Loxodonta Africana) Calves: Birth To Three Months Of Age, Nicole L. Kowalski, Robert H.I. Dale, Christa L. H. Mazur
Robert H. I. Dale
We used four surveys to collect information about the birth, physical growth, and behavioral development of 12 African elephant calves born in captivity. The management of the birth process and neonatal care involved a variety of standard procedures. All of the calves were born at night, between 7PM and 7AM. The calves showed a systematic progression in behavioral and physical development, attaining developmental milestones at least a quickly as calves in situ. This study emphasized birth-related events, changes in the ways that calves used their trunks, first instances of behaviors, and interactions of the calves with other, usually adult, elephants. …
Haploidentical Hematopoietic Stem Cell Transplantation: Rationale, Development, And Jefferson’S Method, Susan Mcilvaine, Dolores Grosso, Rn, Crnp, Dnp, Beth Colombe
Haploidentical Hematopoietic Stem Cell Transplantation: Rationale, Development, And Jefferson’S Method, Susan Mcilvaine, Dolores Grosso, Rn, Crnp, Dnp, Beth Colombe
Department of Pathology Honors Program Student Research Symposium
INTRODUCTION
There are many indications for hematopoietic stem cell transplantation. In addition to hematologic malignancies, transplants are performed in certain non-hematologic malignancies, for marrow disorders such as Sickle Cell Anemia, and for various inherited disorders such as SCID. Traditionally, transplants have been performed between donors and recipients that are a complete HLA match (typically matched siblings). That is, patients have identical HLA alleles on both copies of chromosome 6. HLA alleles code for major histocompatibility complex molecules, which are the proteins that cause transplant rejection when a mismatch between donor and recipient is present. Thus, matched transplants have been historically …
Possible Psychosocial Benefits Of Having A Sibling With A Disability, Jenna M. Talbott
Possible Psychosocial Benefits Of Having A Sibling With A Disability, Jenna M. Talbott
Senior Honors Theses
Possible psychosocial benefits resulting from exposure to siblings with disabilities are investigated in the current study. Previous literature has generally overlooked the possibility of psychosocial benefits by exclusively focusing on the negative effects of having a sibling with disabilities. Contact theory suggests that the increased exposure to individuals with disabilities should increase positive attitude toward those who are struggling with disadvantages. This investigation hypothesized that this tendency would be manifested as elevated empathy and compassion in individuals who have siblings with disabilities, and that these traits would be influenced by certain demographic variables. A survey was distributed, and the responses …
Role Of Cardiac Catecholamines In Embryos And Adults Under Stress, Candice Baker
Role Of Cardiac Catecholamines In Embryos And Adults Under Stress, Candice Baker
Electronic Theses and Dissertations
Cardiovascular disease is responsible for the loss of one life every 38 seconds and accounts for 26.6 percent of all infants that die of congenital birth defects. Adrenergic hormones are critically important regulators of cardiovascular physiology in embryos and adults. They are key mediators of stress responses and have profound stimulatory effects on cardiovascular function, and dysregulation of adrenergic function has been associated with many adverse cardiac conditions, including congenital malformations, arrhythmias, ischemic heart disease, heart failure, and sudden cardiac death. Despite intensive study, the specific roles these hormones play in the developing heart is not well-understood. Further, there is …
Neuronal Reorganization In Adult Rats Neonatally Exposed To (±)-3,4-Methylenedioxymethamphetamine, Michael T. Williams, Matthew R. Skelton, Ian D. Longacre, Kimberly N. Huggins, Amanda M. Maple, Charles V. Vorhees, Russell W. Brown
Neuronal Reorganization In Adult Rats Neonatally Exposed To (±)-3,4-Methylenedioxymethamphetamine, Michael T. Williams, Matthew R. Skelton, Ian D. Longacre, Kimberly N. Huggins, Amanda M. Maple, Charles V. Vorhees, Russell W. Brown
ETSU Faculty Works
The abuse of methylenedioxymethamphetamine (MDMA) during pregnancy is of concern. MDMA treatment of rats during a period of brain growth analogous to late human gestation leads to neurochemical and behavioral changes. MDMA from postnatal day (P)11–20 in rats produces reductions in serotonin and deficits in spatial and route-based navigation. In this experiment we examined the impact of MDMA from P11 to P20 (20 mg/kg twice daily, 8 h apart) on neuronal architecture. Golgi impregnated sections showed significant changes. In the nucleus accumbens, the dendrites were shorter with fewer spines, whereas in the dentate gyrus the dendritic length was decreased but …
Relationships Between Breastfeeding, Maternal Cigarette Smoking During Pregnancy, And The Cognitive Functioning Of Akwesasne Mohawk Adolescents Exposed To Environmental Pollution, Georgia Brooke
Legacy Theses & Dissertations (2009 - 2024)
Previous research has suggested that breastfeeding is beneficial for children's health and that maternal cigarette smoking during pregnancy is harmful for children's health. However, there is not a consensus in the existing literature about whether or not these two maternal behaviors impact the cognitive development of children. Furthermore, understanding the role of breastfeeding in children's development is complicated by the fact that breastfeeding transmits toxicants that are stored in the mother's body, including polychlorinated biphenyls (PCBs), to the infant. Existing research suggests that PCBs negatively impact children's cognitive functioning. The current study examined relationships between breastfeeding, maternal cigarette smoking during …
The Benefits Of Breastfeeding, Avery Kordus
The Benefits Of Breastfeeding, Avery Kordus
Senior Honors Theses
Breastfeeding research is plentiful, and the majority of the literature shows that breast milk is the superior form of infant nutrition except in the rare circumstances of infant metabolic disorders, maternal drug use, or positive HIV status. In comparison to formula, breast milk provides improved cognition, development, behavior, bonding, nutrition, digestion, immunity, and long-term health with fewer diseases and conditions in infants. Mothers are benefited by breastfeeding through bonding, faster weight loss, and reduction in certain cancers and conditions. Breast milk contains the proper amount of carbohydrates, fats, proteins, vitamins, and minerals, and is also specialized for each infant and …
Cochlear Development And Auditory Function In The Absence Of Thyroid Hormone Transporters Mct8 And Oatp1c1, Richard Sinn
Cochlear Development And Auditory Function In The Absence Of Thyroid Hormone Transporters Mct8 And Oatp1c1, Richard Sinn
All Graduate Theses, Dissertations, and Other Capstone Projects
Thyroid hormone (TH) is essential for the development and maturation of the nervous system. The thyroid gland secretes an active form of TH, triiodothyronine, and a prohormone, thyroxine, into the blood. TH is charged, which prevents it from passively diffusing across cell membranes and thus requires cell membrane transporters to facilitate its movement into and out of cells. However, whether TH transporters are required for TH-mediated developmental events, including the auditory system, is largely unknown.
The purpose of the present study was to investigate two specific TH transporters, monocarboxylate transporter 8 (Mct8) and organic anion transporting polypeptide 1c1 (Oatp1c1), and …
Eating Disorder Onset In Young Girls: A Longitudinal Trajectory Analysis, Carolyn M. Pearson
Eating Disorder Onset In Young Girls: A Longitudinal Trajectory Analysis, Carolyn M. Pearson
Theses and Dissertations--Psychology
To investigate whether there are different patterns of development for binge eating and purging behavior among pre-adolescent and early adolescent girls, I conducted trajectory analyses of those behaviors in 938 girls across eight waves of data from the spring of 5th grade (the last year of elementary school) through the spring of 9th grade (the first year of high school). Analyses revealed four separate developmental trajectories for binge eating behavior (labeled none, increasing, decreasing, and high steady) and three separate developmental trajectories for purging behavior (labeled none, dabble, and increasing). Fifth grade scores on risk factors that were …