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Non-Mass Transfer Limited Crystal Growth, Ryan J. Smyth, Caitlin Schram, Stephen P. Beaudoin Oct 2013

Non-Mass Transfer Limited Crystal Growth, Ryan J. Smyth, Caitlin Schram, Stephen P. Beaudoin

The Summer Undergraduate Research Fellowship (SURF) Symposium

There are many different active pharmaceutical ingredients (APIs) that have been discovered in research labs all around the world that can be used to treat and cure patients with a variety of different ailments. The challenge with these APIs in treatments is that they are not soluble in water, thus they low absorption into the blood stream (bio-availability). The key to making these APIs more bio-available is to understand how they grow as crystals and drop out of the aqueous solutions. One of the ways these APIs were made more bio-available is to render them amorphous and suspend them in …


An Evaluation Of Ferrihydrite- And Metsorb™-Dgt Techniques For Measuring Oxyanion Species (As, Se, V, P): Effective Capacity, Competition And Diffusion Coefficients, Helen L. Price, Peter R. Teasdale, Dianne F. Jolley Jan 2013

An Evaluation Of Ferrihydrite- And Metsorb™-Dgt Techniques For Measuring Oxyanion Species (As, Se, V, P): Effective Capacity, Competition And Diffusion Coefficients, Helen L. Price, Peter R. Teasdale, Dianne F. Jolley

Faculty of Science, Medicine and Health - Papers: part A

tThis study investigated several knowledge gaps with respect to the diffusive gradients in thin films(DGT) technique for measurement of oxyanions (As(III), As(V), Se(IV), Se(VI), PO43−, and V(V)) usingthe ferrihydrite and MetsorbTMbinding layers. Elution efficiencies for each binding layer were higherwith 1:20 dilutions, as analytical interferences for ICP-MS were minimised. Diffusion coefficients mea-sured by diffusion cell and by DGT time-series experiments were found to agree well and generallyagreed with previously reported values, although a range of diffusion coefficients have been reportedfor inorganic As and Se species. The relative binding affinity for both ferrihydrite and MetsorbTMwasPO43−≈ As(V) > V(V) ≈ As(III) > Se(IV) ≫ …