Digital Commons Network^™

Characterizing Spoken Discourse In Individuals With Parkinson Disease Without Dementia, Angela C. Roberts

Electronic Thesis and Dissertation Repository

Background: The effects of disease (PD) on cognition, word retrieval, syntax, and speech/voice processes may interact to manifest uniquely in spoken language tasks. A handful of studies have explored spoken discourse production in PD and, while not ubiquitously, have reported a number of impairments including: reduced words per minute, reduced grammatical complexity, reduced informativeness, and increased verbal disruption. Methodological differences have impeded cross-study comparisons. As such, the profile of spoken language impairments in PD remains ambiguous.

Method: A cross-genre, multi-level discourse analysis, prospective, cross-sectional between groups study design was conducted with 19 PD participants (M_age = 70.74, M …

Implications Of Human Umbilical Cord Blood Cells: An Immunotherapeutic Strategy For Alzheimer's Disease, Donna Darlington

USF Tampa Graduate Theses and Dissertations

ABSTRACT

Alzheimer's disease (AD) is the most common progressive age related dementia and the fourth major cause of mortality in the elderly in the United States. AD is pathologically characterized by deposition of amyloid beta (Aβ) plaques in the brain parenchyma and neurofibrillary tangles (NFTs) within the neuronal soma. While pharmacological targets have been discovered, current strategies for the symptomatic or disease-modifying treatment of AD do not significantly slow or halt the underlying pathological progression of the disease. Consequently, more effective treatment is needed. One possibility for amelioration is using human umbilical cord blood cell (HUCBC) therapy. HUCBCs comprise a …

Skill Generalization Following Computer-Based Cognitive Retraining Among Individuals With Acquired Brain Injury, Jonathan William Alonso, Nisha E. Chadha, Jennifer Elizabeth Pulido

Dissertations, Masters Theses, Capstones, and Culminating Projects

Individuals with acquired brain injury (ABI) often experience cognitive deficits. This creates many challenges in learning or relearning skills and generalizing skills among different contexts and task demands. Computer-Based Cognitive Retraining (CBCR) is a common intervention utilized by occupational therapists to help remediate cognitive deficits in individuals with ABI. Although research has shown that CBCR programs are effective at improving cognitive domains, there is limited evidence to support generalization of these skills to functional daily living tasks. Therefore, the primary purpose of this study was to assess the occurrence of generalizing gained skills in overall cognition, attention, and memory from …

Anxiety Disorders And School-Based Treatments: Assessing School Pyschologists' Knowledge And Perceptions, Kelly A. Myhasuk

PCOM Psychology Dissertations

Anxiety disorders are common in children and youth. Despite high prevalence rates, most children with anxiety disorders do not receive treatment. In fact, for the few children who are receiving treatment, schools are the primary source of mental health care. When left untreated, children experience significant disruptions in their academic, social, emotional, and behavioral functioning. Therefore, it is important for those working in schools to recognize and treat children with anxiety disorders. The present study surveyed school psychologists (n = 178) to assess their knowledge about anxiety disorders and about empirically supported school-based treatments. Also, this study sought to investigate …

A Life Span Approach To The Relationship Between Cholesterol, Late Onset Alzheimer’S Disease, And Cognitive Functioning Among Older Adults, Brian Downer

Theses and Dissertations--Gerontology

There is evidence that cholesterol presents an important risk factor for Alzheimer’s disease (AD), but the direction of this relationship is modified by age. High cholesterol during midlife and low cholesterol during late life are both associated with an increased risk for AD. This dissertation research engaged a life span approach to study the relationship between cholesterol, AD and cognitive functioning among older adults. The purpose of this research was to determine if trajectories of cholesterol from midlife through late life differ according to AD status and if these trajectories are associated with cognitive functioning during old age.

This research …

Impact Of Nutrition On Cognition And Its Association With Blood And Brain Alzheimer Disease Related Biomarkers, Samantha Gardener

Theses: Doctorates and Masters

Alzheimer’s disease (AD), the most common form of senile dementia, currently affects over 35 million people worldwide. While there is no cure or effective treatment, early intervention programs hold considerable promise. Following particular dietary patterns represents one potential intervention strategy accessible to all.

Results from previous studies investigating the association of diet, cognition and biomarkers of AD are inconsistent: Positive results have been reported (1-7), whilst others have shown no associations. Prior to this thesis, no study has assessed the relationship of four dietary patterns to cognition, blood-based and neuroimaging biomarkers of AD in a large highly-characterised ageing cohort. Participants …