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Depression

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Utilization Of Depression Screening In Patients With Type 2 Diabetes Mellitus, John T. Norris Bsn, Rn, Dnp-Pmhnp Student, Robin Gordon Bsn, Rn, Dnp-Pmhnp Student, Margaret Harvey Phd, Aprn-Bc, Acnp, Chfn, Laura Reed Dnp, Fnp-Bc May 2024

Utilization Of Depression Screening In Patients With Type 2 Diabetes Mellitus, John T. Norris Bsn, Rn, Dnp-Pmhnp Student, Robin Gordon Bsn, Rn, Dnp-Pmhnp Student, Margaret Harvey Phd, Aprn-Bc, Acnp, Chfn, Laura Reed Dnp, Fnp-Bc

Doctor of Nursing Practice Projects

Purpose/Background

Type 2 diabetes is a chronic metabolic disorder affecting millions of individuals worldwide. Research has shown that individuals with diabetes are at a higher risk of developing depression in comparison to those of the general population. Depression affects the individual's emotional well-being and has a significant impact on the management and outcomes of diabetes (Mather, 2022). This research study aims to investigate the feasibility and effectiveness of implementing the Patient Health Questionnaire-9 (PHQ-9). The PHQ-9 is one the most effective assessment tools available to identify symptoms of depression (Celik, 2020).

Methods

In this retrospective chart review, at least 50 …


Relations Among Self-Disclosure, Digital Communications Behavior, And Mental Health In College Students During And After Covid-19, Estephanie Baez-Vazquez May 2024

Relations Among Self-Disclosure, Digital Communications Behavior, And Mental Health In College Students During And After Covid-19, Estephanie Baez-Vazquez

Honors College

This study aimed to investigate adolescents’ comfort in self-disclosing (i.e., sharing personal information with another) in both face-to-face and electronic communication contexts during the COVID-19 pandemic and currently. In addition, the role of several possible moderating factors, including gender, sexuality, depression, and social anxiety, was examined. Participants were 137 college students between 18 and 20 years of age who responded to an online survey assessing their depressive symptomatology, social anxiety symptomatology, and comfort in several aspects of self- disclosure within electronic and face-to-face settings during the COVID-19 pandemic and currently.

Results indicated that there were no significant differences in comfort …


Relations Of Emotional Functioning And Hormonal Contraceptive Use In Umaine Female Students, Shannen Fitzjurls May 2024

Relations Of Emotional Functioning And Hormonal Contraceptive Use In Umaine Female Students, Shannen Fitzjurls

Honors College

The purpose of this study was to examine the relations of hormonal contraceptive use to emotional functioning in biological women. Hormonal contraceptives contain one of two hormones, progestin and estrogen, which are key regulatory hormones in women. Estrogen and progestin help to regulate brain networks and processes related to changes in stress response, cognition, and emotion regulation. Participants included 86 female college students, ages 18-25, who responded to measures that assessed hormonal contraceptive use, depressive symptoms, relationship quality, and mood. Results revealed no significant differences in depressive symptoms or mood states between women using hormonal contraceptives (51% of the sample) …


Statistical Genetic Approaches To Investigate Genotype-By-Environment Interaction: Review And Novel Extension Of Models, Vincent P. Diego, Eron G. Manusov, Marcio Almeida, Sandra Laston, David Ortiz, John Blangero, Sarah Williams-Blangero Apr 2024

Statistical Genetic Approaches To Investigate Genotype-By-Environment Interaction: Review And Novel Extension Of Models, Vincent P. Diego, Eron G. Manusov, Marcio Almeida, Sandra Laston, David Ortiz, John Blangero, Sarah Williams-Blangero

School of Medicine Publications and Presentations

Statistical genetic models of genotype-by-environment (G×E) interaction can be divided into two general classes, one on G×E interaction in response to dichotomous environments (e.g., sex, disease-affection status, or presence/absence of an exposure) and the other in response to continuous environments (e.g., physical activity, nutritional measurements, or continuous socioeconomic measures). Here we develop a novel model to jointly account for dichotomous and continuous environments. We develop the model in terms of a joint genotype-by-sex (for the dichotomous environment) and genotype-by-social determinants of health (SDoH; for the continuous environment). Using this model, we show how a depression variable, as measured by the …


Brain Matters: Cognitive-Behavioral Therapy And Antidepressants For Post-Stroke Depression, Lindsey Anne Smith Apr 2024

Brain Matters: Cognitive-Behavioral Therapy And Antidepressants For Post-Stroke Depression, Lindsey Anne Smith

MSN Capstone Projects

Stroke is the leading cause of death and disability in the United States, and approximately one-third of these patients will develop post-stroke depression, which is associated with higher rates of morbidity and mortality (American Stroke Association, 2022). Even though post-stroke depression is prevalent, it often goes undertreated. The combination of antidepressants and cognitive-behavioral therapy has shown to be an effective method of treating post-stroke depression. There are cognitive-behavioral exercises that nurses can implement, such as group therapy, acceptance therapy, and cognitive retraining, a method of coaching the patient to replace negative thoughts with positive ones (Byun et al., 2021). With …


Implementing Universal Adult Depression Screening In A Rural Maine Free Medical Clinic, Karen Hussion Apr 2024

Implementing Universal Adult Depression Screening In A Rural Maine Free Medical Clinic, Karen Hussion

Doctor of Nursing Practice Scholarly Projects

Abstract

BACKGROUND: Depression in adults is a leading cause of disability, morbidity and mortality worldwide with an estimated prevalence of 20% in the US population. Despite estimates that one out of every five Americans suffers from depression, less than 50% of adult primary care patients with depression are identified, and less than 5% of all adult primary care patients are screened. To increase early detection and management of depression, the United States Protective Service Task Force (USPSTF) recommends routine depression screening for adults older than 18 years in primary care settings.

LOCAL PROBLEM: This project site was a rural, free, …


Depression And Other Risk Factors Of Suicide, Mckenna Newnam, Jaeyong Choi Apr 2024

Depression And Other Risk Factors Of Suicide, Mckenna Newnam, Jaeyong Choi

Criminal Justice Student Work

Substance abuse, other mental disorders, and individual characteristics all play a role in the risk of suicide when concurrent with depression. Far more research exists on depression as it effects suicide alone. Future research needs to focus on depression as it effects suicide and explore the other possible factors that can impact the outcome. Understanding the different aspects of depression as it effects suicide will provide a template for scholars and individuals involved in the mental health system to enhance treatment.


Reliability And Validity Of The Patient Health Questionnaire-4 Scale And Its Subscales Of Depression And Anxiety Among Us Adults Based On Nativity, David Adzrago, Timothy J Walker, Faustine Williams Mar 2024

Reliability And Validity Of The Patient Health Questionnaire-4 Scale And Its Subscales Of Depression And Anxiety Among Us Adults Based On Nativity, David Adzrago, Timothy J Walker, Faustine Williams

Journal Articles

BACKGROUND: The burdens of anxiety and depression symptoms have significantly increased in the general US population, especially during this COVID-19 epidemiological crisis. The first step in an effective treatment for anxiety and depression disorders is screening. The Patient Health Questionnaire-4 (PHQ-4, a 4-item measure of anxiety/depression) and its subscales (PHQ-2 [a 2-item measure of depression] and Generalized Anxiety Disorder [GAD-2, a 2-item measure of anxiety]) are brief but effective mass screening instruments for anxiety and depression symptoms in general populations. However, little to no study examined the psychometric properties (i.e., reliability and validity) of the PHQ-4 and its subscales (PHQ-2 …


Effectiveness Of Probiotic Therapy On The Symptoms Of Major Depressive Disorder (Mdd), Lydia L.M. Sprague Feb 2024

Effectiveness Of Probiotic Therapy On The Symptoms Of Major Depressive Disorder (Mdd), Lydia L.M. Sprague

Non-Thesis Student Work

Major Depressive Disorder (MDD) represents a pervasive mental health challenge globally, necessitating effective treatment approaches. This paper examines the efficacy of probiotic therapy compared to placebo in individuals diagnosed with MDD, addressing the PICOT question: In people diagnosed with MDD, what effect does probiotic therapy versus placebo have on their symptoms of depression? Through a review of six randomized controlled trials (RCTs), the study elucidates the potential of probiotics as adjunctive treatments for MDD. Findings indicate that probiotic interventions may yield improvements in depression symptoms, reflecting promising avenues for complementary therapeutic strategies. However, variations in study designs and probiotic strains …


Profiles Of Activity Engagement And Depression Trajectories As Covid-19 Restrictions Were Relaxed, Jonathan L. Chia, Andree Hartanto, William Tov Feb 2024

Profiles Of Activity Engagement And Depression Trajectories As Covid-19 Restrictions Were Relaxed, Jonathan L. Chia, Andree Hartanto, William Tov

Research Collection School of Social Sciences

Given elevated depression rates since the onset of the pandemic and potential downstream implications, this research examined the association between activity engagement and depression among middle-aged and older adults postlockdown. This study aimed to (a) identify activity engagement profiles among middle-aged and older adults, (b) understand factors associated with profile memberships, and (c) compare depression trajectories across profiles as COVID-19 restrictions eased over 16 months in Singapore. This longitudinal study involved 6,568 middle-aged and older adults. Latent growth analysis was first conducted to obtain estimates of depression trajectories for each individual. Latent profile analysis was then conducted to identify different …


"It's Not That We Care Less": Insights Into Health Care Utilization For Comorbid Diabetes And Depression Among Latinos, Sharon Borja, Miriam G Valdovinos, Kenia M Rivera, Natalia Giraldo-Santiago, Robin E Gearing, Luis R Torres Jan 2024

"It's Not That We Care Less": Insights Into Health Care Utilization For Comorbid Diabetes And Depression Among Latinos, Sharon Borja, Miriam G Valdovinos, Kenia M Rivera, Natalia Giraldo-Santiago, Robin E Gearing, Luis R Torres

Journal Articles

Despite robust knowledge regarding the socio-economic and cultural factors affecting Latino* access to healthcare, limited research has explored service utilization in the context of comorbid conditions like diabetes and depression. This qualitative study, embedded in a larger mixed-methods project, aimed to investigate perceptions held by Latinos and their social support systems (i.e., family members) regarding comorbid diabetes and depression and to identify barriers and facilitators to their help-seeking behaviors and treatment engagement. Bilingual and bicultural researchers conducted eight focus groups with 94 participants in a large U.S. metropolitan area and were primarily conducted in Spanish. The participants either had a …


“It’S Not That We Care Less”: Insights Into Health Care Utilization For Comorbid Diabetes And Depression Among Latinos, Sharon Borja, Miriam G. Valdovinos, Kenia M. Rivera, Natalia Giraldo-Santiago, Robin Gearing, Luis R. Torres-Hostos Jan 2024

“It’S Not That We Care Less”: Insights Into Health Care Utilization For Comorbid Diabetes And Depression Among Latinos, Sharon Borja, Miriam G. Valdovinos, Kenia M. Rivera, Natalia Giraldo-Santiago, Robin Gearing, Luis R. Torres-Hostos

School of Social Work Faculty Publications and Presentations

Despite robust knowledge regarding the socio-economic and cultural factors affecting Latino* access to healthcare, limited research has explored service utilization in the context of comorbid conditions like diabetes and depression. This qualitative study, embedded in a larger mixed-methods project, aimed to investigate perceptions held by Latinos and their social support systems (i.e., family members) regarding comorbid diabetes and depression and to identify barriers and facilitators to their help-seeking behaviors and treatment engagement. Bilingual and bicultural researchers conducted eight focus groups with 94 participants in a large U.S. metropolitan area and were primarily conducted in Spanish. The participants either had a …


Patient Satisfaction With The Quality Of Care Received Is Associated With Adherence To Antidepressant Medications, Macarius M. Donneyong, Mary Bynum, Ameena Kemavor, Norah L. Crossnohere, Anne Schuster, John Bridges Jan 2024

Patient Satisfaction With The Quality Of Care Received Is Associated With Adherence To Antidepressant Medications, Macarius M. Donneyong, Mary Bynum, Ameena Kemavor, Norah L. Crossnohere, Anne Schuster, John Bridges

All Faculty and Staff Scholarship

Background

There is a paucity of evidence on the association between satisfaction with quality of care and adherence to antidepressants.

Objectives

To examine the association between patient satisfaction with healthcare and adherence to antidepressants.

Methods

A cohort study design was used to identify antidepressant users from the 2010-2016Medical Expenditure Panel Survey data, a national longitudinal complex survey study design on the cost and healthcare utilization of the noninstitutionalized population in the United States. The Consumer Assessment of Healthcare Providers and Systems were used to measure participants’ satisfaction with access and quality of care, patient-provider communication and shared decision-making (SDM). Patients …


Implications Of Preoperative Depression For Lumbar Spine Surgery Outcomes: A Systematic Review And Meta-Analysis, Saad Javeed, Braeden Benedict, Salim Yakdan, Samia Saleem, Justin K Zhang, Kathleen Botterbush, Madelyn R Frumkin, Angela Hardi, Brian Neuman, Jay F Piccirillo, Burel R Goodin, Thomas L Rodebaugh, Wilson Z Ray, Jacob K Greenberg, Et Al. Jan 2024

Implications Of Preoperative Depression For Lumbar Spine Surgery Outcomes: A Systematic Review And Meta-Analysis, Saad Javeed, Braeden Benedict, Salim Yakdan, Samia Saleem, Justin K Zhang, Kathleen Botterbush, Madelyn R Frumkin, Angela Hardi, Brian Neuman, Jay F Piccirillo, Burel R Goodin, Thomas L Rodebaugh, Wilson Z Ray, Jacob K Greenberg, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Comorbid depression is common among patients with degenerative lumbar spine disease. Although a well-researched topic, the evidence of the role of depression in spine surgery outcomes remains inconclusive.

OBJECTIVE: To investigate the association between preoperative depression and patient-reported outcome measures (PROMs) after lumbar spine surgery.

DATA SOURCES: A systematic search of PubMed, Cochrane Database of Systematic Reviews, Embase, Scopus, PsychInfo, Web of Science, and ClinicalTrials.gov was performed from database inception to September 14, 2023.

STUDY SELECTION: Included studies involved adults undergoing lumbar spine surgery and compared PROMs in patients with vs those without depression. Studies evaluating the correlation between …


The Influence Of Vitamin D On The Severity Of Depressive Symptoms In Children And Adolescents: A Systematic Review, Haley Flanagan Jan 2024

The Influence Of Vitamin D On The Severity Of Depressive Symptoms In Children And Adolescents: A Systematic Review, Haley Flanagan

2024 Awards for Excellence in Student Research and Creative Activity - Documents

This review aims to investigate the influence vitamin D has on the severity of depressive symptoms in children and adolescents. Current studies have shown the potential role of vitamin D on mental health in adults, but results have been inconclusive among children. Using PubMed, Scopus, and CINAHL Complete, studies were selected by searching the terms “Vitamin D, depression, children and adolescents.” The inclusion criteria consisted of data over the last five years, presenting vitamin D intake or status in subjects between the ages of 2-17, and a diagnosis of depression. Eleven studies met the eligibility criteria. Nine of the studies …


Risk Of Depression In Persons With Alzheimer's Disease: A National Cohort Study, Casey Crump, Weiva Sieh, Barbara G Vickrey, Alexis C Edwards, Jan Sundquist, Kristina Sundquist Jan 2024

Risk Of Depression In Persons With Alzheimer's Disease: A National Cohort Study, Casey Crump, Weiva Sieh, Barbara G Vickrey, Alexis C Edwards, Jan Sundquist, Kristina Sundquist

Journal Articles

INTRODUCTION: Depression is a risk factor and possible prodromal symptom of Alzheimer's disease (AD), but little is known about subsequent risk of developing depression in persons with AD.

METHODS: National matched cohort study was conducted of all 129,410 persons diagnosed with AD and 390,088 with all-cause dementia during 1998-2017 in Sweden, and 3,900,880 age- and sex-matched controls without dementia, who had no prior depression. Cox regression was used to compute hazard ratios (HRs) for major depression through 2018.

RESULTS: Cumulative incidence of major depression was 13% in persons with AD and 3% in controls. Adjusting for sociodemographic factors and comorbidities, …


Masculine Ideals And Health In Older Men: Findings From The Wisconsin Longitudinal Study, Shane D. Burns, Patricia Drentea Dec 2023

Masculine Ideals And Health In Older Men: Findings From The Wisconsin Longitudinal Study, Shane D. Burns, Patricia Drentea

APC Fund

How do older men’s masculine ideals affect their health? Are masculine activities involved in this relationship? Masculine identity upholds beliefs about masculine enactment. These beliefs can be detrimental to men and can lead to behaviors that can put undue stress on them. We examine how masculine ideals are associated with health and depressive symptomatology in older men. We used 2011 data from the Wisconsin Longitudinal Study (n = 2,594) to investigate how masculine ideals inform older men’s health and how participation in masculine activities might shape these outcomes. Findings from this study illustrate that traditional masculine ideals are associated …


Animal-Assisted Therapy In Mental Illness, Chanae Cypress Dec 2023

Animal-Assisted Therapy In Mental Illness, Chanae Cypress

MSN Capstone Projects

Mental health disorders are a significant global health concern, with a growing need for alternative therapeutic approaches. Animal-assisted therapy has gained recognition for its potential to improve the emotional and psychological well-being of individuals struggling with these disorders.

This Capstone Benchmark proposed project explores the potential positive impact of animal-assisted therapy (AAT) on patients with mental health disorders during inpatient hospitalization. The project outlines a 4-week intervention program involving 45-60 minutes sessions with dogs, which patients receive 2-3 times per week. For this Capstone Benchmark project, the selected PICOT question is: In patients with mental health disorder (P) how does …


Social Media & Mental Health: An Examination Of Tiktok & Mental Health Outcomes, Jessica Maddox Dec 2023

Social Media & Mental Health: An Examination Of Tiktok & Mental Health Outcomes, Jessica Maddox

Masters Theses & Specialist Projects

The goal of this research study was to examine the relationship between amount of Tiktok use and the results of various mental health scales. The hypothesis was that increased Tiktok use would be correlated with a decrease in self-esteem, and an increase in depressive symptoms, anxiety symptoms, and overall loneliness. Participants were recruited on Amazon Mechanical Turk (MTurk) and paid a small monetary benefit in exchange for completion of the study. There were a total of 285 participants. Correlations and linear regression analysis were used to determine statistical significance; results showed no statistical significance and none of the hypotheses were …


Sexual Minorities Are More Depressed And Anxious Than Heterosexuals In The U.S., Especially Among Women, Joshua Grove Nov 2023

Sexual Minorities Are More Depressed And Anxious Than Heterosexuals In The U.S., Especially Among Women, Joshua Grove

Population Health Research Brief Series

Depression and anxiety are harmful to health. People who suffer from depression or anxiety are more likely to engage in risky health behaviors and have higher risk of various chronic diseases and premature death. This data slice uses data from the 2022 National Wellbeing Survey to explore the prevalence of depression and anxiety among U.S. adults ages 18-64. The results show that sexual minority adults are significantly more likely than those who identify as heterosexual to suffer from depression and anxiety, and differences in prevalence rates between sexual minority and heterosexual women are larger than the differences between men.


Social Activity Restriction And Psychological Health Among Caregivers Of Older Adults With And Without Dementia, Elliane Irani, Kylie Meyer, Scott Emory Moore, Kedong Ding Nov 2023

Social Activity Restriction And Psychological Health Among Caregivers Of Older Adults With And Without Dementia, Elliane Irani, Kylie Meyer, Scott Emory Moore, Kedong Ding

Faculty Scholarship

Objectives: We examined associations between social activity restriction and psychological distress and well-being for caregivers of older adults with and without dementia, and if the identified associations are different for the two groups. Methods: Using data from the 2017 National Study of Caregiving, we identified caregivers of older adults with (N = 541) and without (N = 1701) dementia. Linear regression models were estimated, adjusting for caregivers’ age, gender, race, education, relationship to care recipient, and self-rated health. Results: Restriction in visiting friends and family and attending religious services were associated with higher distress in dementia caregivers. Restriction in visiting …


Covid‑19‑Related Risk, Resilience, And Mental Health Among Mexican American Mothers Across The First Year Of The Pandemic, Amy L. Non, Elizabeth S. Clausing, Sandraluz Lara‑Cinisomo, Kimberly L. D’Anna Hernandez Nov 2023

Covid‑19‑Related Risk, Resilience, And Mental Health Among Mexican American Mothers Across The First Year Of The Pandemic, Amy L. Non, Elizabeth S. Clausing, Sandraluz Lara‑Cinisomo, Kimberly L. D’Anna Hernandez

Center for Brain, Biology, and Behavior: Faculty and Staff Publications

Background Latina mothers have been especially affected by the pandemic and historically exhibit high rates of depression and anxiety. However, few longitudinal studies have assessed the effect of the pandemic on this vulnerable population. We hypothesized that COVID-19-related stressors would associate with psychological distress among Latina mothers across the first year of the pandemic.

Methods We investigated COVID-19-related impact, stigma, and fears across two critical time points and changes in these measures in relation to changes in maternal anxiety and depression among mothers of Mexican descent living in Southern California (n=152). Surveys were administered within 5–16 weeks of …


Food Insecurity Increases Risk Of Depression And Anxiety Among Women In Senegal Living With Diabetes And/Or Hypertension, Rachel P Allred, Ndèye Aminata Mbaye, Fatoumata Diagne, Sheryl A Mccurdy, Melissa B Harrell, Emma Nelson Bunkley Oct 2023

Food Insecurity Increases Risk Of Depression And Anxiety Among Women In Senegal Living With Diabetes And/Or Hypertension, Rachel P Allred, Ndèye Aminata Mbaye, Fatoumata Diagne, Sheryl A Mccurdy, Melissa B Harrell, Emma Nelson Bunkley

Journal Articles

Food insecurity affects close to half the population of Senegal, West Africa, a country simultaneously affected by the ongoing global diabetes pandemic. Diabetes and food insecurity are associated with adverse mental health, yet research exploring the relationship between chronic physical illness, food insecurity, and mental illness in Senegal is currently lacking. The objective of this study was to investigate the association between food insecurity and depression and anxiety, separately, in Senegalese women living with diabetes and hypertension. Food insecurity was measured using the Household Food Insecurity Access Scale. Occurrence of depression and anxiety symptoms was assessed using the Modified Hopkins …


Depression By Gender And Associated Factors Among Older Adults In India: Implications For Age-Friendly Policies, Ronak Paul, T. Muhammad, Rashmi Rashmi, Palak Sharma, Shobhit Srivastava, Preeti Zanwar Oct 2023

Depression By Gender And Associated Factors Among Older Adults In India: Implications For Age-Friendly Policies, Ronak Paul, T. Muhammad, Rashmi Rashmi, Palak Sharma, Shobhit Srivastava, Preeti Zanwar

College of Population Health Faculty Papers

Inspite of implementing policies to control mental health problems, depression remains a severe health concern among older adults in India. We examined self-reported differences in the depression among older men and women in India and examined associated factors for gender differences in depression at the population level. We utilized nationally representative data from the Longitudinal Aging Study in India (LASI) wave I, for years 2017-2019. Our analytical sample comprised of 30,637 older adults ages 60 years and above (14,682 men and 15,655 women). We conducted descriptive statistics and Chi-Square tests followed by binary logistic regression and multivariate decomposition analyses to …


Longitudinal Associations Between Cognitive Functioning And Depressive Symptoms Among Couples In The Mexican Health And Aging Study, Joan K Monin, Gail Mcavay, Katie Newkirk, Rafael Samper-Ternent Oct 2023

Longitudinal Associations Between Cognitive Functioning And Depressive Symptoms Among Couples In The Mexican Health And Aging Study, Joan K Monin, Gail Mcavay, Katie Newkirk, Rafael Samper-Ternent

Journal Articles

OBJECTIVE: To examine the bidirectional associations between older adult spouses' cognitive functioning and depressive symptoms over time and replicate previous findings from the United States (US) in Mexico.

DESIGN: Longitudinal, dyadic path analysis with the actor-partner interdependence model.

SETTING: Data were from the three most recent interview waves (2012, 2015, and 2018) of the Mexican Health and Aging Study (MHAS), a longitudinal national study of adults aged 50+ years in Mexico.

PARTICIPANTS: Husbands and wives from 905 community-dwelling married couples (N = 1,810).

MEASUREMENTS: The MHAS cognitive battery measured cognitive function. Depressive symptoms were assessed using a modified nine-item Center …


Gene-By-Environment Interaction In Non-Alcoholic Fatty Liver Disease And Depression: The Role Of Hepatic Transaminases, Eron G. Manusov, Vincent P. Diego, Edward Abrego, Kathryn Herklotz, Marcio A. Almeida, Xi Mao, Sandra L. Laston, John Blangero, Sarah Williams-Blangero Sep 2023

Gene-By-Environment Interaction In Non-Alcoholic Fatty Liver Disease And Depression: The Role Of Hepatic Transaminases, Eron G. Manusov, Vincent P. Diego, Edward Abrego, Kathryn Herklotz, Marcio A. Almeida, Xi Mao, Sandra L. Laston, John Blangero, Sarah Williams-Blangero

School of Medicine Publications and Presentations

Non-alcoholic fatty liver disease (NAFLD) encompasses a range of liver conditions, from benign fatty accumulation to severe fibrosis. The global prevalence of NAFLD has risen to 25-30%, with variations across ethnic groups. NAFLD may advance to hepatocellular carcinoma, increases cardiovascular risk, is associated with chronic kidney disease, and is an independent metabolic disease risk factor. Assessment methods for liver health include liver biopsy, magnetic resonance imaging, ultrasound, and vibration-controlled transient elastography (VCTE by FibroScan). Hepatic transaminases are cost-effective and minimally invasive liver health assessment methods options.

This study focuses on the interaction between genetic factors underlying the traits (hepatic transaminases …


Mixed Method Approach Towards The Life Of University Students During The Covid-19 Pandemic, Raihan Khan, Andrew White, Tony Jehi Sep 2023

Mixed Method Approach Towards The Life Of University Students During The Covid-19 Pandemic, Raihan Khan, Andrew White, Tony Jehi

Department of Health Sciences - Faculty Scholarship

Background

The COVID-19 pandemic negatively impacted the higher education system. This mixed-methods study aimed to assess COVID-19 fear, anxiety, and stress among Shenandoah Valley college students.

Methods

An online survey was fielded and completed by n=680 students. Qualitative semi-structured interviews were conducted with 20 students.

Results

The mean participant age was 22.14±5.48 years, and primarily White (81.9%), women (80.4%), and undergraduate (78.0%) students. Approximately 41% were enrolled in health-related majors (41.4%). Women students had significantly higher anxiety, depression, and fear of contracting COVID-19 than men. Undergraduate students had significantly higher depression than graduate students. Qualitative analysis revealed several major themes: …


Can I Count On You? Social Support, Depression And Suicide Risk, Christiana Silva, Christopher Mcgovern, Stephanie Gomez, Eleanor Beale, James Overholser Jul 2023

Can I Count On You? Social Support, Depression And Suicide Risk, Christiana Silva, Christopher Mcgovern, Stephanie Gomez, Eleanor Beale, James Overholser

Student Scholarship

Objectives: Interpersonal factors play an important role in the etiology and treatment of depression. Social support derives from compassionate words and helpful actions provided by family, friends or a significant other. The present study was designed to examine various sources of social support as they relate to the severity of depressive symptoms, hopelessness and suicide risk in adult psychiatric outpatients. Method: Participants were recruited through mental health clinics at a veteran's affairs medical centre. A total of 96 depressed patients were assessed using a diagnostic interview and self-report measures of depression severity, hopelessness and social support. Among these depressed adults, …


Exploratory Genome-Wide Analyses Of Cortical Inhibition, Facilitation, And Plasticity In Late-Life Depression, Rafae A Wathra, Xiaoyu Men, Samar S M Elsheikh, Victoria S Marshe, Tarek K Rajji, Jennifer I Lissemore, Benoit H Mulsant, Jordan F Karp, Charles F Reynolds 3rd, Eric J Lenze, Zafiris J Daskalakis, Daniel J Müller, Daniel M Blumberger Jun 2023

Exploratory Genome-Wide Analyses Of Cortical Inhibition, Facilitation, And Plasticity In Late-Life Depression, Rafae A Wathra, Xiaoyu Men, Samar S M Elsheikh, Victoria S Marshe, Tarek K Rajji, Jennifer I Lissemore, Benoit H Mulsant, Jordan F Karp, Charles F Reynolds 3rd, Eric J Lenze, Zafiris J Daskalakis, Daniel J Müller, Daniel M Blumberger

2020-Current year OA Pubs

Late-life depression (LLD) is a heterogenous mood disorder influenced by genetic factors. Cortical physiological processes such as cortical inhibition, facilitation, and plasticity may be markers of illness that are more strongly associated with genetic factors than the clinical phenotype. Thus, exploring the relationship between genetic factors and these physiological processes may help to characterize the biological mechanisms underlying LLD and improve diagnosis and treatment selection. Transcranial magnetic stimulation (TMS) combined with electromyography was used to measure short interval intracortical inhibition (SICI), cortical silent period (CSP), intracortical facilitation (ICF), and paired associative stimulation (PAS) in 79 participants with LLD. We used …


Improvements In Physical Function And Pain Interference And Changes In Mental Health Among Patients Seeking Musculoskeletal Care, Wei Zhang, Som P Singh, Amdiel Clement, Ryan P Calfee, Janine D Bijsterbosch, Abby L Cheng Jun 2023

Improvements In Physical Function And Pain Interference And Changes In Mental Health Among Patients Seeking Musculoskeletal Care, Wei Zhang, Som P Singh, Amdiel Clement, Ryan P Calfee, Janine D Bijsterbosch, Abby L Cheng

2020-Current year OA Pubs

IMPORTANCE: Among patients seeking care for musculoskeletal conditions, there is mixed evidence regarding whether traditional, structure-based care is associated with improvement in patients' mental health.

OBJECTIVE: To determine whether improvements in physical function and pain interference are associated with meaningful improvements in anxiety and depression symptoms among patients seeking musculoskeletal care.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study included adult patients treated by an orthopedic department of a tertiary care US academic medical center from June 22, 2015, to February 9, 2022. Eligible participants presented between 4 and 6 times during the study period for 1 or more musculoskeletal conditions …