Digital Commons Network^™

Hepatopulmonary Syndrome In A 22 Year Old Gentleman With Liver Cirrhosis, Blesset Alexander, Joseph Caporusso, Priyasha Suri

Research Symposium

Background: Hepatopulmonary syndrome is a severe complication of end-stage liver disease characterized by triad of liver disease, intrapulmonary vascular dilatation, and arterial hypoxemia. Although the pathogenesis is not completely understood, pulmonary vascular dilatation occurs due to imbalance between vasodilators and vasoconstrictors. Liver injury is thought to increase endothelin production and cause bacterial translocation, causing increased nitric oxide production, causing vasodilation of pulmonary vasculature. History and physical examination are important in leading the physician to the correct diagnosis as the majority of these patients present with non-specific clinical manifestations and imaging. Identification of specific physical exam findings is important in not …

The Effects Of Acute Beetroot Juice Ingestion On Upper And Lower Body Muscular Power During Weightlifting Exercise In Men, Grant Weiderman, Chandler Riley, Joanna Powell, Katie Price, Lauren Wideen, Andrew Fest, Justin Kim, Maya Hammer, Sean Karl, Isabella Lincoln, Noelle Seekamp-Hicks, Joshua Leow, Maddy Espinoza, Adam Pennell, Rachel Tan

Seaver College Research And Scholarly Achievement Symposium

Nitrate-rich beetroot juice (BR) supplementation improves movements with high-velocity and high-power muscle contractions which may be due to enhanced blood flow, oxygenation and contractile function in type II muscle fibers. The literature has focused predominantly on the effects of BR supplementation running and cycling performance, but its efficacy in resistance exercise, a modality that relies on type II muscle fibers, has limited data. Furthermore, it is unknown how supplementation strategies impact the physiological and ergogenic effects of BR during exercise. Therefore, the purpose of this study is to assess whether single or multi-day nitrate ingestion will improve performance and muscle …

The Effect Of Co-Ingesting Beetroot Juice And Vitamin C On Blood Pressure In Hispanic Women: A Literature Review And A Proposal, Mikela De La Flor, Maya Hammer, Noelle Seekamp-Hicks, Rachel Tan

Seaver College Research And Scholarly Achievement Symposium

Dietary nitrate supplementation is known for improving blood pressure through vasodilation and may favorably alter oral microbial populations related to cardiovascular health. Co-ingestion with vitamin C (VITC) may further potentiate these benefits but this remains unexplored. Additionally, this field has yet to examine the influence of sex and ethnicity, which is important given that physiological differences exist between populations. The purpose of this study is to assess the effects of combining dietary nitrate, in the form of beetroot juice, and VITC on blood pressure and the oral microbiome in women of Hispanic, African American, and American descent across multiple institutions. …

Pomegranate Extract Supplementation On Neuromuscular Performance During Resistance Exercise, Katie Price, Joanna Powell, Matthew Joyner, Adam Pennell, Rachel Tan

Seaver College Research And Scholarly Achievement Symposium

Dietary nitrate supplementation has been shown to improve skeletal muscle function during high-velocity and high-power contractions due to its high nitrate levels; however, there is limited data examining its potential in exercise requiring these movements, such as resistance exercise. Nitrate supplementation has been studied extensively as beetroot juice, but its poor taste severely limits its application. Pomegranate extract (POM) may be an alternative nitrate source due to its superior taste, high nitrate content, and additional antioxidants but has yet to be explored. The purpose of the present study is two-fold: 1) to determine the nitrate concentration in POM; and 2) …

The Effects Of Acute Beetroot Juice Ingestion On Upper And Lower Body Muscular Power During Weightlifting Exercise In Men., Sean Karl, Isabella Lincoln, Joanna Powell, Grant Weiderman, Katie Price, Lauren Wideen, Andrew Fest, Justin Kim, Maya Hammer, Noelle Seekamp-Hicks, Joshua Leow, Maddy Espinoza, Adam Pennell, Rachel Tan

Seaver College Research And Scholarly Achievement Symposium

Dietary nitrate supplementation, administered per beetroot juice (BR), has been shown to enhance performance while cycling and running. BR has enhanced skeletal muscle contraction and blood flow within type II fibers which are recruited during high-velocity and high-power contractions. However, it is unknown whether BR influences alternative forms of exercise, such as resistance exercise. The purpose of this study is to assess whether BR supplementation influences neuromuscular performance (muscle power and speed), and repetitions-to-failure in healthy, recreationally active men. In a double-blind, randomized crossover design, 14 males will be recruited to complete two 4-day supplementation periods in which they consume …

Mediation Of The Uncoupled Enos Pathway Following Oxidative Stress Using Tetrahydrobiopterin And Nitric Oxide Donor Drugs To Restore Tetrahydrobiopterin Concentration, Brianna Munnich

Scholar Week 2016 - present

Presentation Location: Warming House, Olivet Nazarene University

Abstract

The eNOS pathway, found in the endothelium of blood vessels, is a key regulator of nitric oxide levels in the circulatory system. The pathway is controlled through several positive and negative feedback loops [2]. The cofactor tetrahydrobiopterin (BH4) is a major control point in this pathway and under conditions of stress can be reduced into the dihydrobiopterin (BH2) [2,6,7,8,9]. When the reduced form is predominant, the pathway produces reactive oxygen species (ROS) rather than nitric oxide, causing stress and damage to the vessels [6,7,8,9]. In this study, different treatments were studied …