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Non-Invasive Mitochondrial Modulation With Near-Infrared Light Reduces Brain Injury After Stroke, Christos Dionisos Strubakos
Non-Invasive Mitochondrial Modulation With Near-Infrared Light Reduces Brain Injury After Stroke, Christos Dionisos Strubakos
Wayne State University Dissertations
Acute ischemic stroke is a debilitating disease that causes significant brain injury.
While rapid restoration of blood flow is critical to salvage the ischemic brain, reperfusion
of tissue can further drive brain damage by inducing generation of mitochondrial reactive
oxygen species (Chouchani et al., 2014a). Recent studies by our group found that noninvasive
mitochondrial modulation (NIMM) with near-infrared (NIR) light can limit the
production of reactive oxygen species following global brain ischemia (T. H. Sanderson
et al., 2018). NIR interacts with the rate limiting step of the mitochondrial electron
transport chain (ETC), cytochrome c oxidase (COX), and modulates mitochondrial
respiration. …