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Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity, Kelly Haagenson
Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity, Kelly Haagenson
Wayne State University Dissertations
ABSTRACT
EXPRESSION AND REGULATION OF MAP KINASE PHOSPHATASES 1 and 2 IN BREAST CANCER TAMOXIFEN SENSITIVITY
by
KELLY K. HAAGENSON
May 2013
Advisor: Dr. Malathy Shekhar
Co-Advisor: Dr. Gen Sheng Wu
Major: Cancer Biology
Degree: Doctor of Philosophy
The deregulation of cell signaling is a very important component in the development and progression of cancer. One group of signaling molecules that has been implicated in these processes is the Mitogen-Activated Protein Kinase (MAPK) family which consists of three major branches in mammalian cells: ERK, JNK and p38. The activity of these kinases has wide-ranging effects within the cell and must …
The Bca2 And Ampk Paradigm: Unraveling The Cancer Connection, Daniela (Buac) Ventro
The Bca2 And Ampk Paradigm: Unraveling The Cancer Connection, Daniela (Buac) Ventro
Wayne State University Dissertations
THE BCA2 & AMPK PARADIGM: UNRAVELING THE CANCER CONNECTION
By
DANIELA (BUAC) VENTRO
December 2013
Advisor: Dr. Q Ping Dou and Angelika M. Burger (deceased)
Major: Cancer Biology
Degree: Doctor of Philosophy
Adenosine monophosphate-activated kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular target in the prevention of breast cancer, and phase II and III clinical trials using the FDA-approved, AMPK activating, anti-diabetic drug metformin are promising in this regard, but the question of why metformin is protective for some women but not others still remains. Breast Cancer Associated Gene 2 (BCA2/Rabring7/RNF115), a novel …