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Rare Occurrence Of Common Filaggrin Mutations In Turkish Children With Food Allergyand Atopic Dermatitis, Neşe Vardar Acar, Özlem Cavkaytar, Ebru Arik Yilmaz, Ayşe Betül Büyükti̇ryaki̇, Özge Uysal Soyer, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel, İbrahi̇m Çağatay Karaaslan, Cansin Saçkesen
Rare Occurrence Of Common Filaggrin Mutations In Turkish Children With Food Allergyand Atopic Dermatitis, Neşe Vardar Acar, Özlem Cavkaytar, Ebru Arik Yilmaz, Ayşe Betül Büyükti̇ryaki̇, Özge Uysal Soyer, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel, İbrahi̇m Çağatay Karaaslan, Cansin Saçkesen
Turkish Journal of Medical Sciences
Background/aim: Filaggrin is a protein complex involved in epidermal differentiation and skin barrier formation. Mutations of the filaggrin gene (FLG) are associated with allergen sensitization and allergic diseases like atopic dermatitis (AD), allergic rhinitis, food allergy (FA), and asthma. The aim of the study is to reveal the frequency of change in the FLG gene and determine the association between FLG loss-of-function (LOF) mutations and FA and/or AD in Turkish children. Materials and methods: Four FLG loss-of-function (LOF) mutations known to be common in European populations were analyzed in 128 healthy children, 405 food-allergic children with or without atopic dermatitis, …
Effects Of Immunization Program On Morbidity And Mortality Rates Ofvaccine-Preventable Diseases In Turkey, Tufan Nayi̇r, Ersi̇n Nazlican, Musa Şahi̇n, Fati̇h Kara, Emi̇ne Alp Meşe
Effects Of Immunization Program On Morbidity And Mortality Rates Ofvaccine-Preventable Diseases In Turkey, Tufan Nayi̇r, Ersi̇n Nazlican, Musa Şahi̇n, Fati̇h Kara, Emi̇ne Alp Meşe
Turkish Journal of Medical Sciences
Background/aim: This study aims to serve as a unique consolidated source in Turkey's vaccination history and as an example for other countries by objectively revealing the change in mortality and morbidity rates in Turkey following the beginning of vaccination without asserting any claim on the benefits or risks of vaccines. This unbiased research will also help health professionals identify the challenges more easily when they face with the people who hesitate to vaccinate their children. Materials and methods: Descriptive research design is adopted in this study. The coverages of vaccinations, mortality, and morbidity rates were identified through a retrospective analysis …
Peripheral Axonal Excitability In Hemiplegia Related To Subacute Stroke, Zeynep Turan, Murat Zi̇nnuroğlu
Peripheral Axonal Excitability In Hemiplegia Related To Subacute Stroke, Zeynep Turan, Murat Zi̇nnuroğlu
Turkish Journal of Medical Sciences
Background/aim: This study aims to investigate peripheral nerve excitability in patients with subacute stroke. Materials and methods: The study was performed in 29 stroke patients within the subacute period and 29 healthy controls using QTRAC software and TRONDNF protocol. The threshold electrotonus, recovery cycle, stimulus-response, strength-duration, and current-threshold relationships were recorded. Results: The membrane was more hyperpolarized, and excitability was decreased in the hemiplegic side. The impairment of inward rectifying channel function, degree of hyperpolarization, and decrease of excitability were directly related to the Brunnstrom stages, which were more pronounced in lower stages. Conclusion: The lower motor neurons were affected …
Emerging And Reemerging Respiratory Viral Infections Up To Covid-19, İlhami̇ Çeli̇k, Esma Saatçi̇, Ayşegül Füsun Eyüboğlu
Emerging And Reemerging Respiratory Viral Infections Up To Covid-19, İlhami̇ Çeli̇k, Esma Saatçi̇, Ayşegül Füsun Eyüboğlu
Turkish Journal of Medical Sciences
Infectious diseases remain as the significant causes of human and animal morbidity and mortality, leading to extensive outbreaks and epidemics. Acute respiratory viral diseases claim over 4 million deaths and cause millions of hospitalizations in developing countries every year. Emerging viruses, especially the RNA viruses, are more pathogenic since most people have no herd immunity. The RNA viruses can adapt to the rapidly changing global and local environment due to the high error rate of their polymerases that replicate their genomes. Currently, coronavirus disease 2019 (COVID-19) is determined as an infectious disease caused by severe acute respiratory syndrome coronavirus 2 …
Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic
Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic
Turkish Journal of Medical Sciences
In the Wuhan Province of China, in December 2019, the novel coronavirus 2019 (COVID-19) has caused a severe involvement of the lower respiratory tract leading to an acute respiratory syndrome. Subsequently, coronavirus 2 (SARS-CoV-2) provoked a pandemic which is considered a life-threatening disease. The SARS-CoV-2, a family member of betacoronaviruses, possesses singlestranded positive-sense RNA with typical structural proteins, involving the envelope, membrane, nucleocapsid and spike proteins that are responsible for the viral infectivity, and nonstructural proteins. The effectual host immune response including innate and adaptive immunity against SARS-Cov-2 seems crucial to control and resolve the viral infection. However, the severity …
Covid-19: Pathogenesis, Genetic Polymorphism, Clinical Features And Laboratory Findings, Recep Öztürk
Covid-19: Pathogenesis, Genetic Polymorphism, Clinical Features And Laboratory Findings, Recep Öztürk
Turkish Journal of Medical Sciences
COVID-19 caused by a novel agent SARS-CoV-2 progressed to a pandemic condition and resulted in a major public health concern worldwide, leading to social and economic issues at the same time. The pathogenesis of COVID-19 starts with the bonding of the virus to ACE2 receptors expressed in many tissues, and the triggered excessive immune response plays a critical role in the course of the disease. The cytokine storm that occurs upon excessive production of pro-inflammatory cytokines is considered responsible for the severe progression of the disease and the organ damage. However, the accurate pathophysiological mechanism of the disease, which progresses …
Tuberous Sclerosis: A Review Of The Past, Present, And Future, Sanem Pinar Uysal, Mustafa Şahi̇n
Tuberous Sclerosis: A Review Of The Past, Present, And Future, Sanem Pinar Uysal, Mustafa Şahi̇n
Turkish Journal of Medical Sciences
Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder that is characterized by cellular and tissue dysplasia in several organs. With the advent of genetic and molecular techniques, mutations in the TSC1 or TSC2 genes were discovered to be responsible for mTOR overactivation, which is the underlying mechanism of pathogenesis. TSC is a highly heterogenous clinical entity with variable presentations and severity of disease. The brain, heart, skin, eyes, kidneys, and lungs are commonly involved in this syndrome, with neurologic symptoms comprising a significant source of morbidity and mortality. In 2012, the diagnostic criteria for TSC were revised by …
Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz
Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz
Turkish Journal of Medical Sciences
A fracture that does not unite in nine months is defined as nonunion. Nonunion is common in fragmented fractures and large bone defects where vascularization is impaired. The distal third of the tibia, the scaphoid bone or the talus fractures are furthermore prone to nonunion. Open fractures and spinal fusion cases also need special monitoring for healing. Bone tissue regeneration can be attained by autografts, allografts, xenografts and synthetic materials, however their limited availability and the increased surgical time as well as the donor site morbidity of autograft use, and lower probability of success, increased costs and disease transmission and …
Mean Platelet Volume And Response To The First Line Therapy In Newly Diagnosed Adultimmune Thrombocytopenia Patients: A Retrospective Study, Erman Akkuş, Çi̇ğdem Fi̇dan, Gülşah Demi̇rci̇, Ali̇ Aytuğ Kuştaş, Meltem Yüksel
Mean Platelet Volume And Response To The First Line Therapy In Newly Diagnosed Adultimmune Thrombocytopenia Patients: A Retrospective Study, Erman Akkuş, Çi̇ğdem Fi̇dan, Gülşah Demi̇rci̇, Ali̇ Aytuğ Kuştaş, Meltem Yüksel
Turkish Journal of Medical Sciences
Background/aim: Immune thrombocytopenia (ITP) is treated by corticosteroids and/or intravenous immune globulin as the first line treatment when necessary. Mean platelet volume (MPV) is a marker of platelet production and function. In this study, we aimed to search the relationship between the MPV and the treatment response in ITP patients and it was hypothesized that MPV can be used as a predictor of the response. Materials and methods: The 70 newly diagnosed adult primary ITP patients and 70 of healthy people were included. MPV between ITP and healthy population, MPV in the diagnosis and after the treatment between the responders …
The Needle Electromyography Findings In The Neurophysiological Classification Of Ulnar Neuropathy At The Elbow, Hali̇t Fi̇danci, İlker Öztürk, Ahmet Candan Köylüoğlu, Mehmet Yildiz, Şencan Buturak, Zülfi̇kar Arlier
The Needle Electromyography Findings In The Neurophysiological Classification Of Ulnar Neuropathy At The Elbow, Hali̇t Fi̇danci, İlker Öztürk, Ahmet Candan Köylüoğlu, Mehmet Yildiz, Şencan Buturak, Zülfi̇kar Arlier
Turkish Journal of Medical Sciences
Background/aim: Although ulnar neuropathy at the elbow (UNE) is the second most common entrapment mononeuropathy, there are few reports on its neurophysiological classification. In this study, we tried to find out the role of needle electromyography (EMG) in the neurophysiological classification of UNE. Materials and methods: UNE patients who met the clinical and neurophysiological diagnostic criteria and healthy individuals were included in this study. Reference values of nerve conduction studies were obtained from healthy individuals. Needle EMG was performed to all UNE patients. According to the neurophysiological classification proposed by Padua, UNE patients were classified as mild, moderate, and severe. …
The Effect Of Iatrogenic Subclinical Hyperthyroidism On Anxiety, Depression And Quality Of Life In Differentiated Thyroid Carcinoma, Nazli Gülsoy Kirnap, Özlem Turhan İyi̇di̇r, Yusuf Bozkuş, Şeri̇fe Mehli̇ka Işildak, Cüneyd Anil, Sevde Nur Firat, Canan Demi̇r, Asli Nar, Nesli̇han Başçil Tütüncü
The Effect Of Iatrogenic Subclinical Hyperthyroidism On Anxiety, Depression And Quality Of Life In Differentiated Thyroid Carcinoma, Nazli Gülsoy Kirnap, Özlem Turhan İyi̇di̇r, Yusuf Bozkuş, Şeri̇fe Mehli̇ka Işildak, Cüneyd Anil, Sevde Nur Firat, Canan Demi̇r, Asli Nar, Nesli̇han Başçil Tütüncü
Turkish Journal of Medical Sciences
Background/aim: Overt thyroidism is known to cause neuropsychiatric disorders but studies on subclinical hyperthyroidism (SCH) are limited. Subclinical hyperthyroidism induction by administering L-Thyroxine (LT4) is the standard treatment method in differentiated thyroid carcinoma (DTC) follow-up. Our aim was to investigate whether anxiety, depression and quality of life are affected in DTC patients followed-up with exogenous SCH. Materials and methods: The patients were divided into exogenous SCH by LT4-DTC (n = 127), euthyroid-DTC (n = 66) and exogenous euthyroid-benign thyroid noduüle (BTN) who underwent thyroidectomy for benign thyroid pathology (n = 85) groups. Results: The rate of moderate/severe anxiety was significantly …
Factors Associated With Severe Lung Disease In An Adult Population With Cystic Fibrosis: A Single-Center Experience, Berri̇n Er, Ebru Çelebi̇oğlu, Ebru Yalçin, Deni̇z Doğru, Özlem Erden Aki̇, Ömrüm Uzun, Murat Akova, Uğur Özçeli̇k, Nural Ki̇per, Sali̇h Emri̇
Factors Associated With Severe Lung Disease In An Adult Population With Cystic Fibrosis: A Single-Center Experience, Berri̇n Er, Ebru Çelebi̇oğlu, Ebru Yalçin, Deni̇z Doğru, Özlem Erden Aki̇, Ömrüm Uzun, Murat Akova, Uğur Özçeli̇k, Nural Ki̇per, Sali̇h Emri̇
Turkish Journal of Medical Sciences
Background/Aim: The patients with cystic fibrosis (CF) are living longer compared to the past, but respiratory failure is still the most common cause of mortality. The aim of this study is to investigate factors associated with severe lung disease in a cohort of adult patients with CF. Materials and methods: Demographic data, clinical and laboratory findings of the patients aged 18 years and more were collected and the patients were grouped according to forced expiratory volume in 1 s (FEV1) as severe group:
Psychometric Evaluation Of The Persian Version Of The Doloplus-2 (P-Doloplus-2) Scale In Elderly With Dementia, Mohammad Zare, Zahra Tagharrobi, Khadijeh Sharifi, Zahra Sooki, Javad Abolhasani
Psychometric Evaluation Of The Persian Version Of The Doloplus-2 (P-Doloplus-2) Scale In Elderly With Dementia, Mohammad Zare, Zahra Tagharrobi, Khadijeh Sharifi, Zahra Sooki, Javad Abolhasani
Turkish Journal of Medical Sciences
Background/aim: A scale for behavioural pain assessment is useful for the detection and determination of pain in the elderly with dementia. This study aimed to translate and evaluate the psychometric properties of Doloplus-2 in the elderly with dementia in Iran. Materials and methods: In this methodological study, after translation and evaluating the face and content validity of Doloplus-2, 100 elderly people were selected by the convenience sampling method in Kashan, 2018-2019. Exploratory factor analysis, convergent validity, and known-groups comparison were applied to determine construct validity. Reliability was also assessed through internal consistency, equivalence, and stability methods were used. The ceiling …
Spectrum Of Germline Cancer Susceptibility Gene Mutations In Turkish Colorectal Cancer Patients: A Single Center Study, Haktan Bağiş Erdem, Taha Bahsi̇
Spectrum Of Germline Cancer Susceptibility Gene Mutations In Turkish Colorectal Cancer Patients: A Single Center Study, Haktan Bağiş Erdem, Taha Bahsi̇
Turkish Journal of Medical Sciences
Background/aim: Quarter of colorectal cancer patients have a family history and 6% of these comprise hereditary cancer syndromes. For developing national health strategies for genetic screening, it is crucial to determine the spectrum of damaging alterations in causative genes and to describe frequent founder mutations. Materials and methods: One hundred and thirty six unrelated colorectal cancer cases were investigated. Qiagen large hereditary cancer panel and Hereditary Cancer Solution v1.1 panel were used for sequencing. The sequencing process was performed on the Illumina MiSeq system. The data analyses were performed on QIAGEN Clinical Insight (QCITM) Analyze software and Sophia DDM software. …
Roles Of Glycoprotein Glycosylation In The Pathogenesis Of An Endemic Osteoarthritis, Kashin-Beck Disease, And Effectiveness Evaluation Of Sodium Hyaluronate Treatment, Sen Wang, Zongqiang Gao, Huan Liu, Peilin Meng, Cuiyan Wu, Mikko Lammi, Xiong Guo
Roles Of Glycoprotein Glycosylation In The Pathogenesis Of An Endemic Osteoarthritis, Kashin-Beck Disease, And Effectiveness Evaluation Of Sodium Hyaluronate Treatment, Sen Wang, Zongqiang Gao, Huan Liu, Peilin Meng, Cuiyan Wu, Mikko Lammi, Xiong Guo
Turkish Journal of Medical Sciences
Background/aim: We aimed to explore the roles of glycoprotein glycosylation in the pathogenesis of Kashin-Beck disease (KBD), and evaluated the effectiveness of sodium hyaluronate treatment. Materials and methods: Blood and saliva were collected from KBD patients before and after the injection of sodium hyaluronate. Normal healthy subjects were included as controls. Saliva and serum lectin microarrays and saliva and serum microarray verifications were used to screen and confirm the differences in lectin levels among the three groups. Results: In saliva lectin microarray, bindings to Sophora japonica agglutinin (SJA), Griffonia (Bandeiraea) simplicifolia lectin I (GSL-I), Euonymus europaeus lectin (EEL), Maackia amurensis …
Alterations In Follicular Fluid Bmp-15 Rna Expression In Women Undergoing Controlled Ovarian Hyperstimulation, Şükri̇ye Derya Deveci̇
Alterations In Follicular Fluid Bmp-15 Rna Expression In Women Undergoing Controlled Ovarian Hyperstimulation, Şükri̇ye Derya Deveci̇
Turkish Journal of Medical Sciences
Background/aim: Bone morphogenetic protein-15 (BMP-15) is one of the maturation indicators of the ovarian follicular pool. The aim of this study was to investigate the possible difference of follicular fluid (FF) BMP-15 RNA expression among low, normal, and high responder women attending controlled ovarian hyperstimulation-intracytoplasmic sperm injection (COH-ICSI) cycles.Materials and methods: This cross-sectional study was conducted with 75 FFs of COH-ICSI cycles performed at the IVF Unit of University Hospital. Twenty FF from low response (group 1), 27 FF from normal response (group 2), and 28 FF from high response (group 3) were recruited for the study between September 2014 …
Development Of Albumin Macroinitiator For Polymers To Use In Dna Origami Coating, Aykut Bi̇li̇r, Ezgi̇ Emül, Necdet Sağlam
Development Of Albumin Macroinitiator For Polymers To Use In Dna Origami Coating, Aykut Bi̇li̇r, Ezgi̇ Emül, Necdet Sağlam
Turkish Journal of Medical Sciences
Background/aim: DNA nanostructures have many advantages over polymers and lipid based drug delivery agents such as biodegradability and biocompatibility. However their transfection rates and stability still limit their widely use in nanomedicine. In this study highly versatile and straightforward albumin coating preparation method is showed for DNA nanostructures.Materials and methods: N-methylolmaleimide was esterified with a-bromoisobutyrl bromide (BiBB) to achive bromine functional structure. Then it was attached to bovine serum albumin (BSA) via cysteine-maleimide bond further to use as macroinitiator for atom transfer radical polymerization (ATRP). Cationic polymers can be synthesized from this end further to use as binding domain for …
Melatonin Attenuates Ovarian Ischemia Reperfusion Injury In Rats By Decreasing Oxidative Stress Index And Peroxynitrite, Şenol Kalyoncu, Bülent Yilmaz, Mustafa Demi̇r, Meltem Tuncer, Zehra Bozdağ, Onur Ince, Mehmet Aki̇f Bozdayi, Hasan Ulusal, Seyi̇than Taysi
Melatonin Attenuates Ovarian Ischemia Reperfusion Injury In Rats By Decreasing Oxidative Stress Index And Peroxynitrite, Şenol Kalyoncu, Bülent Yilmaz, Mustafa Demi̇r, Meltem Tuncer, Zehra Bozdağ, Onur Ince, Mehmet Aki̇f Bozdayi, Hasan Ulusal, Seyi̇than Taysi
Turkish Journal of Medical Sciences
Background/aim: To evaluate the protective effect of melatonin on ovarian ischemia reperfusion injury in a rat model. Materials and methods: Forty-eight rats were separated equally into 6 groups. Group 1: sham; Group 2: surgical control with 3-h bilateral ovarian torsion and detorsion; Group 3: intraperitoneal 5% ethanol (1 mL) just after detorsion (as melatonin was dissolved in ethanol); Group 4: 10 mg/kg intraperitoneal melatonin 30 min before 3-h torsion; Group 5:10 mg/kg intraperitoneal melatonin just after detorsion; Group 6:10 mg/kg intraperitoneal melatonin 30 min before torsion and just after detorsion. Both ovaries and blood samples were obtained 7 days after …
Effects Of Stage I Hypertension On The Recovery Of Early Postoperative Attention Network Function In Elderly Patients Undergoing Elective Hip Or Knee Arthroplasty Surgery, Dan Zhao, Jun Li, Rui Yang, Guanghong Xu
Effects Of Stage I Hypertension On The Recovery Of Early Postoperative Attention Network Function In Elderly Patients Undergoing Elective Hip Or Knee Arthroplasty Surgery, Dan Zhao, Jun Li, Rui Yang, Guanghong Xu
Turkish Journal of Medical Sciences
Background/aim: Hypertension is an important risk factor for cognitive impairment. This study explored whether elderly patients with stage I hypertension (HPs) and normotensive patients (NPs) showed differences in the recovery of postoperative attention network function according to the attentional network test (ANT) performance.Materials and methods: Of 110 patients screened, 25 HPs and 25 NPs completed this study. The Mini-Mental State Examination (MMSE) was applied to all participants before the operation and the ANT (on days 2 and 7) after the operation. All participants completed 1 day preoperatively and the ANT on postoperative days (PODs) 2 and 7.Results: Compared with NPs, …
Severe Neonatal Hyperbilirubinemia In The Southeast Region Of Turkey, Özlem Bozkurt, Ebru Yücesoy, Baran Oğuz, Ömür Akinel, Mehmet Fati̇h Palali, Nurgül Ataş
Severe Neonatal Hyperbilirubinemia In The Southeast Region Of Turkey, Özlem Bozkurt, Ebru Yücesoy, Baran Oğuz, Ömür Akinel, Mehmet Fati̇h Palali, Nurgül Ataş
Turkish Journal of Medical Sciences
Background/aim: Severe neonatal hyperbilirubinemia is an important cause of morbidity and mortality in developing countries. The aim was to assess etiologic reasons for development of severe hyperbilirubinemia and define risk factors for exchange transfusion and acute bilirubin encephalopathy (ABE) in Şanlıurfa located in the southeast region of Turkey.Materials and methods: An observational cohort study included 115 infants with ≥35 weeks of gestation admitted with diagnosis of severe hyperbilirubinemia in a period of 18 months. Potential risk factors associated with exchange transfusion and development of ABE were analyzed.Results: Among 115 infants, 67 (58.3%) received exchange transfusion and 45 (39.1%) developed ABE. …
Early Pregnancy After Bariatric Surgery: A Single-Institute Preliminary Experience, Emre Günakan, Hakan Buluş, Yusuf Aytaç Tohma
Early Pregnancy After Bariatric Surgery: A Single-Institute Preliminary Experience, Emre Günakan, Hakan Buluş, Yusuf Aytaç Tohma
Turkish Journal of Medical Sciences
Background/aim: Pregnancy after bariatric surgery is an issue of growing importance with increasing number of women undergoing bariatric surgery. Therefore, in this study we present patients who conceived after sleeve gastrectomy and evaluate the obstetric outcomes. Materials and methods: This retrospective case-control study includes 23 women who conceived after laparoscopic sleeve gastrectomy. Patients were evaluated in two groups according to the number of months between surgery and conception (group 1: ≤12 months; group 2: >12 months). Results: The mean body mass index of patients before surgery and at the time of conception was 46.6 kg/m2 and 29.7 kg/m2, respectively. Nine …
An Evaluation Of The Effects Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On Secondary Wound Healing Of Oral Mucosal Tissue, Mehmet Gül, Ahmet Günay, Abdulsamet Tanik
An Evaluation Of The Effects Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On Secondary Wound Healing Of Oral Mucosal Tissue, Mehmet Gül, Ahmet Günay, Abdulsamet Tanik
Turkish Journal of Medical Sciences
Background/aim: Caffeic acid phenethyl ester (CAPE) and Ankaferd Blood Stopper (ABS) are considered to contribute to wound healing. The purpose of this study was to investigate the effect of ABS and CAPE on secondary wound healing of oral mucosal tissue. Materials and methods: In total, 63 male Sprague-Dawley rats were used in this study. The animals were randomly divided into three groups and anaesthetized with ketamine (8 mg/100 g, intraperitoneally): a control group, CAPE group, and ABS group. A full-thickness excisional wound was created using a 4 mm punch biopsy tool. Topical ABS and CAPE were then applied in each …
Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi
Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi
Turkish Journal of Medical Sciences
Background/aim: The serum fatty acid binding protein 4 (FABP-4) level increases in chronic inflammatory diseases. The present study aimed to examine serum FABP-4 and interleukin (IL)-6 levels in patients with stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) and the correlation of these markers with airflow limitation. Materials and methods: We measured serum FABP-4 and IL-6 levels in 60 COPD patients [30 stable COPD (SCOPD), and 30 acute exacerbation of COPD (AECOPD)], and 30 healthy subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, …
Shearwave Elastographic Evaluation Of Uterine Leiomyomas After Uterine Arteryembolization: Preliminary Results, Cesur Samanci, Yilmaz Önal
Shearwave Elastographic Evaluation Of Uterine Leiomyomas After Uterine Arteryembolization: Preliminary Results, Cesur Samanci, Yilmaz Önal
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the role of Shearwave Elastography (SWE) in the evaluation of response to uterine artery embolization (UAE) in patients with uterine leiomyomas. Materials and methods: SWE images of the dominant uterin leiomyomas were obtained before and 1.5 months after performing UAE in 33 women suffering from symptoms due to leiomyomas (menometrorrhagia, bulk related symptoms, pelvic pain). Leiomyomas were also evaluated by 2 observers for location and longest diameter in axial plane. Interobserver agreement in the quantitative SWE analysis was calculated using intraclass correlation coefficients. Results: Thirty-three women (mean age, 39.7 years; range, 31-48 years) were examined …
Effect Of Metformin And Detorsion Treatment On Serum Anti-Müllerian Hormonelevels And Ovarian Histopathology In A Rat Ovarian Torsion Model, Sema Karakaş, Ci̇han Kaya, Hakan Güraslan, Damlanur Sakiz, Sema Süzen Çaypinar, Hüseyi̇n Cengi̇z, Murat Eki̇n, Levent Yaşar
Effect Of Metformin And Detorsion Treatment On Serum Anti-Müllerian Hormonelevels And Ovarian Histopathology In A Rat Ovarian Torsion Model, Sema Karakaş, Ci̇han Kaya, Hakan Güraslan, Damlanur Sakiz, Sema Süzen Çaypinar, Hüseyi̇n Cengi̇z, Murat Eki̇n, Levent Yaşar
Turkish Journal of Medical Sciences
Background/aim: Adnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-age women. To evaluate the effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model. Materials and methods: Twenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3 groups: the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy. In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-h period of ischemia. The …
Evaluation Of The Effects Of Ss1-Selective Beta-Blockers On Bone Mineral Density And Fracture Risk In Postmenopausal Women, Betül Yavuz Keleş, Meltem Vural, Burcu Önder, Kadri̇ye Öneş
Evaluation Of The Effects Of Ss1-Selective Beta-Blockers On Bone Mineral Density And Fracture Risk In Postmenopausal Women, Betül Yavuz Keleş, Meltem Vural, Burcu Önder, Kadri̇ye Öneş
Turkish Journal of Medical Sciences
Background/aim: ß1-selective beta-blockers (BBs) are sympatholytic agents, and discerning their effects on bone health would be of great importance. This study aimed to investigate the influence of ß1-selective BBs on bone mineral density (BMD) and fracture risk. Materials and methods: This study included postmenopausal women who used ß1-selective BBs (BB group) and control group. Sociodemographic characteristics, BMD and previous fragility fractures were recorded. Additionally, the 10-year probability of a major osteoporotic and hip fracture was calculated using the fracture risk assessment tool (FRAX). Results: A total of 60 participants were included in the study. L1-4 and L2-4 BMD values were …
Prospective Evaluation Of Vascular Changes In Acute Respiratory Infections In Children With Cystic Fibrosis, Gökçen Kartal Öztürk, Aykut Eşki̇, Fi̇gen Çelebi̇ Çeli̇k, Seçi̇l Conkar, Fi̇gen Gülen, Esen Demi̇r, Ahmet Keski̇noğlu
Prospective Evaluation Of Vascular Changes In Acute Respiratory Infections In Children With Cystic Fibrosis, Gökçen Kartal Öztürk, Aykut Eşki̇, Fi̇gen Çelebi̇ Çeli̇k, Seçi̇l Conkar, Fi̇gen Gülen, Esen Demi̇r, Ahmet Keski̇noğlu
Turkish Journal of Medical Sciences
Background/aim: Acute exacerbations and chronic inflammation are risk factors for cardiovascular disease (CVD) in cystic fibrosis (CF) patients. The aim of this study was to investigate the effects of acute exacerbation therapy on arterial stiffness in children with CF. Materials and methods: Augmentation index (Aix) and pulse wave velocity (PWV) were measured before and after treatment and 1 month after the end of treatment in patients with acute exacerbation. The relationship between hemodynamic measurements and c-reactive protein (CRP) and pulmonary function tests (PFTs) was investigated. Results: Measurements before and after treatment were evaluated in 27 patients and were repeated in …
Alcohol Consumption And Alcohol Policy, Mustafa Necmi̇ İlhan, Di̇lek Yapar
Alcohol Consumption And Alcohol Policy, Mustafa Necmi̇ İlhan, Di̇lek Yapar
Turkish Journal of Medical Sciences
Alcohol is a unique addictive substance used by many people for different reasons. Alcohol use affects not only the users but also the family and the whole society in a negative way. Alcohol is one of the most commonly used substances for entertainment purposes in the world and 1 in 3 people is a current drinker. 2348 billion people (43% of the population) aged 15 and over are current drinkers and males drink about 2 times more frequently than females (53.6%/32.3%). According to the Global Alcohol and Health Report published by the World Health Organization (WHO) (2018), total alcohol per …
Effects Of Acute Hypoxia On Auditory Pathway Of Wistar Albino Rats, Nevreste Di̇dem Sonbay Yilmaz, Cem Saka, Si̇bel Ali̇cura Tokgöz, Murat Çalişkan, Erkan Vuralkan, Ömer Beşalti
Effects Of Acute Hypoxia On Auditory Pathway Of Wistar Albino Rats, Nevreste Di̇dem Sonbay Yilmaz, Cem Saka, Si̇bel Ali̇cura Tokgöz, Murat Çalişkan, Erkan Vuralkan, Ömer Beşalti
Turkish Journal of Medical Sciences
Background/aim: Ischemia is insufficient blood flow to provide adequate oxygenation. In the present study, we aimed to show whether acute hypoxia has a critical oxygen value that may lead to the deterioration of cochlear function. Materials and methods: Under general anesthesia, prehypoxic signal-to-noise ratios were determined by distortion product otoacoustic emissions (DPOAE). The oxygen saturation (SaO2) values of rats were monitored with an oxygen saturation probe. Rats were injected with an extra dose of anesthetic agent, and SaO2 was reduced. DPOAE values in SaO2 100?90, 90?80, 80?70, and 70?60 posthypoxic values were measured and compared statistically with prehypoxic values. Results: …
Validity And Reliability Of The Turkish Version Of The Multidimensional Dyspnea Profile Inoutpatients With Respiratory Disease, Buse Özcan Kahraman, Turhan Kahraman, İsmai̇l Özsoy, Ayli̇n Tanriverdi̇, Asli Papurcu, Nazeni̇n Hande Sezgi̇n, Karya Polat, Serap Acar, Ayli̇n Özgen Alpaydin, Can Sevi̇nç, Sema Savci
Validity And Reliability Of The Turkish Version Of The Multidimensional Dyspnea Profile Inoutpatients With Respiratory Disease, Buse Özcan Kahraman, Turhan Kahraman, İsmai̇l Özsoy, Ayli̇n Tanriverdi̇, Asli Papurcu, Nazeni̇n Hande Sezgi̇n, Karya Polat, Serap Acar, Ayli̇n Özgen Alpaydin, Can Sevi̇nç, Sema Savci
Turkish Journal of Medical Sciences
Background/aim: Dyspnea is the subjective feeling of breathing discomfort, which is a significant problem for patients with heart and respiratory disease and also an important determinant of exercise tolerance, quality of life, and mortality in various diseases. Most of the scales are not enough to investigate the multidimensional effects of dyspnea; therefore, the Multidimensional Dyspnea Profile (MDP) was developed and validated in many languages. This study aimed to translate and culturally adapt the MDP into Turkish and investigate the psychometric properties of this adapted version in outpatients with respiratory disease. Materials and methods: The MDP was translated and culturally adapted …