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The Role Of Vitamin D Deficiency In Parathyroid Hormone Levels, Alpaslan Kiliçarslan, Alma Cenoli̇ Aslan, Gamze Gezgen
The Role Of Vitamin D Deficiency In Parathyroid Hormone Levels, Alpaslan Kiliçarslan, Alma Cenoli̇ Aslan, Gamze Gezgen
Turkish Journal of Medical Sciences
Vitamin D deficiency is an important cause of secondary hyperparathyroidism. We aimed to investigate the effect of vitamin D levels on parathyroid hormone (PTH) levels. Materials and methods: We retrospectively chose 2226 patients who were admitted to our hospital’s general internal medicine department for various reasons and had both PTH and vitamin D tests on the same day. Results: It was found that 22.3% of the patients had high levels of PTH and 92% of them had secondary hyperparathyroidism. The average vitamin D level was 16.4 ng/mL. The vitamin D levels of 64% of the patients were below 20 ng/mL …
A Multicenter Study Of The Application Of Six Sigma Management In Clinical Rational Drug Use Via Pharmacist Intervention, Lidao Bao, Nan Chen, Tao Shang, Puyan Fang, Zhanping Xu, Wenchang Guo, Yi Wang
A Multicenter Study Of The Application Of Six Sigma Management In Clinical Rational Drug Use Via Pharmacist Intervention, Lidao Bao, Nan Chen, Tao Shang, Puyan Fang, Zhanping Xu, Wenchang Guo, Yi Wang
Turkish Journal of Medical Sciences
The status of outpatient irrational prescription drug use before and after pharmacist interventions in 6 large scale hospitals was investigated to determine the underlying reasons and to promote rational clinical drug use. Materials and methods: The 5-step DMAIC method (define, measure, analyze, improve, control) in Six Sigma management was utilized to investigate irrational drug use in prescriptions. The statistical software package SAS9.1.3 was adopted to analyze the results, determine possible reasons that could lead to irrational drug use, and then intervene accordingly. Statistics before and after the intervention were compared to analyze the function and effect of Six Sigma management …
The Value Of Apparent Diffusion Coefficient Measurements In The Differential Diagnosis Of Vertebral Bone Marrow Lesions, Gülten Taşkin, Lütfi̇ İncesu, Keri̇m Aslan
The Value Of Apparent Diffusion Coefficient Measurements In The Differential Diagnosis Of Vertebral Bone Marrow Lesions, Gülten Taşkin, Lütfi̇ İncesu, Keri̇m Aslan
Turkish Journal of Medical Sciences
To be able to differentiate benign vertebral bone marrow lesions from malign lesions according to apparent diffusion coefficient (ADC) values, enabling quantitative assessment, and to determine the sensitivity and the specificity in differentiating benign and malign lesions according to the optimal cutoff ADC value. Materials and methods: In 99 patients, 133 lesions in total were included in the study, 59 of which were benign (acute vertebral compression fracture depending on osteoporosis or trauma, spondylitis, atypical hemangioma), and 74 malign (malign compression fracture, metastasis). Each of the benign lesions was compared to the malign lesions. In the statistical analysis, normality tests, …
The In Vitro Determination Of Genotoxicity In Peripheral Lymphocytes Of Welders Exposed To Fumes From Metal Arc Welding, Ceylan Şener, Hali̇l Erhan Eroğlu
The In Vitro Determination Of Genotoxicity In Peripheral Lymphocytes Of Welders Exposed To Fumes From Metal Arc Welding, Ceylan Şener, Hali̇l Erhan Eroğlu
Turkish Journal of Medical Sciences
Gas metal arc welding is a widely used method in many industrial areas. In this study, the peripheral blood lymphocytes of 23 welders and 25 nonexposed subjects were monitored for genotoxicity. Materials and methods: The blood samples obtained from the subjects were incubated with a culture medium at 37 °C for 72 h. Cytochalasin-B and BrdU were added for micronucleus and replication index. After incubation, the cultures were harvested, stained, and examined. Results: The micronucleus rate (2.165 ± 1.645) of the welders was quite higher than that of those not exposed (1.352 ± 0.978) (P < 0.01). There was a significant difference between micronucleus rates of smoking and nonsmoking subjects. It was found that as the time of exposure to welding fumes increased, so did the micronucleus rates (2.938 ± 1.723) (P < 0.05). A positive correlation was observed between micronucleus frequency and age. The replication index rate (1.026 ± 0.020) of the welders was higher than that of those not exposed (1.019 ± 0.016) (P = 0.01). Conclusion: It is advised that welders who work with gas metal arc welding be instructed and that necessary protective measures be taken because of the risk caused by metal arc welding fumes.
The Assessment Of Accessory Mental Foramina Using Cone-Beam Computed Tomography, Mustafa Göregen, Özkan Mi̇loğlu, İbrahi̇m Ersoy, İbrahi̇m Şevki̇ Bayrakdar, Hayati̇ Murat Akgül
The Assessment Of Accessory Mental Foramina Using Cone-Beam Computed Tomography, Mustafa Göregen, Özkan Mi̇loğlu, İbrahi̇m Ersoy, İbrahi̇m Şevki̇ Bayrakdar, Hayati̇ Murat Akgül
Turkish Journal of Medical Sciences
The aim of the present study is to assess accessory mental foramina (AMFs) in a Turkish population using cone-beam computed tomography (CBCT). Materials and methods: The CBCT records of 315 patients (196 males and 119 females) were retrospectively analyzed. The differences in AMF incidence by sex, age, side, and location were evaluated using chi-square tests. The distances between the AMF and the mental foramen (MF) and between the AMF and the mandibular canal were measured. Additionally, the relationship between MF size and the presence and absence of the AMF was investigated. Results: AMFs were observed in 6.3% of the patients. …
Comparing Extracorporeal Shock Wave And Hyaluronic Acid In A Rabbit Cartilage Defect Model: The Effects Of Esw On Cartilage Defect, Zekeri̇ya Öztemür, Hati̇ce Özer, Umut Hatay Gölge, Emi̇ne Eli̇f Altuntaş, Okay Bulut
Comparing Extracorporeal Shock Wave And Hyaluronic Acid In A Rabbit Cartilage Defect Model: The Effects Of Esw On Cartilage Defect, Zekeri̇ya Öztemür, Hati̇ce Özer, Umut Hatay Gölge, Emi̇ne Eli̇f Altuntaş, Okay Bulut
Turkish Journal of Medical Sciences
To compare the efficiency of extracorporeal shock wave (ESW) treatment with hyaluronic acid (HA) viscosupplementation in an experimental rabbit cartilage defect model. Materials and methods: A total of 24 New Zealand rabbits were randomly divided into 4 groups: HA, ESW, ESW + HA, and control. Chondral defects were created in the left knees of the rabbits. HA viscosupplementation was performed on the HA and ESW + HA groups, and after 24 h, 0.16 mJ/mm2 ESW was performed on the ESW and ESW + HA groups. After an 8-week follow-up, the rabbits were sacrificed and histopathological examination of the defects was …
Insulin Resistance Impairs Response To Doxazosin Therapy In Men With Benign Prostatic Hyperplasia, Cevdet Serkan Gökkaya, Çeti̇n Volkan Özteki̇n, Cüneyt Özden, Emi̇n Öztürk, Bi̇nhan Kağan Aktaş, Ali̇ Memi̇ş
Insulin Resistance Impairs Response To Doxazosin Therapy In Men With Benign Prostatic Hyperplasia, Cevdet Serkan Gökkaya, Çeti̇n Volkan Özteki̇n, Cüneyt Özden, Emi̇n Öztürk, Bi̇nhan Kağan Aktaş, Ali̇ Memi̇ş
Turkish Journal of Medical Sciences
To evaluate the effects of insulin resistance (IR) on outcomes of doxazosin treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). Materials and methods: This prospective study included 64 patients with LUTS due to BPH. LUTS were evaluated using the international prostate symptom score (IPSS) and maximum flow rate (Qmax) in uroflowmetry. Diagnosis of IR was achieved using homeostasis model assessment (HOMA) score and patients were grouped with respect to absence (group 1, n = 44) or presence (group 2, n = 20) of IR. Patients were evaluated before and after 3 months of daily doxazosin …
Molecular Characterization Of Acanthamoeba Isolated From Kayseri Well Water, Sali̇h Kuk, Süleyman Yazar, Süheyla Doğan, Ülfet Çeti̇nkaya, Çağri Şakalar
Molecular Characterization Of Acanthamoeba Isolated From Kayseri Well Water, Sali̇h Kuk, Süleyman Yazar, Süheyla Doğan, Ülfet Çeti̇nkaya, Çağri Şakalar
Turkish Journal of Medical Sciences
Potentially pathogenic free-living amoebae have a cosmopolitan distribution in soil, dust, air, and water. Generally, environmental free-living amoebae do not threaten human health. This study aimed to investigate the presence of Acanthamoeba in well waters drawn from different locations in Kayseri, Turkey, which are mainly used for drinking or irrigation by the residents in the region. Materials and methods: Twenty-nine samples, including 26 well water sediment samples and 3 tap water samples as the control, were collected from 3 different locations. Melting snow feeds 5, rain water 18, and tap water 3 of these wells. Results: Five of 26 well …
Assessment Of Hearing Ability With Pure-Tone Audiometry And Otoacoustic Emission Methods In Patients Undergoing Spinal Anesthesia, Zi̇ya Kaya, Levent Gürbüzler, Mustafa Süren, Semi̇h Arici, Serkan Karaman
Assessment Of Hearing Ability With Pure-Tone Audiometry And Otoacoustic Emission Methods In Patients Undergoing Spinal Anesthesia, Zi̇ya Kaya, Levent Gürbüzler, Mustafa Süren, Semi̇h Arici, Serkan Karaman
Turkish Journal of Medical Sciences
To investigate the frequency of hearing loss after spinal anesthesia in patients undergoing spinal anesthesia using pure-tone audiometry and otoacoustic emission methods. Materials and methods: A total of 80 patients (40 females, 40 males, aged 18-65 years) were included in the study. For spinal anesthesia, a 27-gauge Quincke spinal needle was entered at the first attempt into the subarachnoidal space through the L4-L5 interval with the patient in the lateral decubitus position. The first day before spinal anesthesia, pure-tone audiometry, transient evoked otoacoustic emission, distortion product otoacoustic emission, and tympanometry were performed on all patients, and the same procedures were …
Invasive Device-Associated Hospital Infection Rates, Etiological Agents, And Their Antibiotic Susceptibilities In The Medical Intensive Care Unit Of A University Hospital In Turkey, Sali̇ha Çevi̇k, Vuslat Boşnak, Mustafa Namiduru, İlkay Karaoğlan, Ayşe Özlem Mete
Invasive Device-Associated Hospital Infection Rates, Etiological Agents, And Their Antibiotic Susceptibilities In The Medical Intensive Care Unit Of A University Hospital In Turkey, Sali̇ha Çevi̇k, Vuslat Boşnak, Mustafa Namiduru, İlkay Karaoğlan, Ayşe Özlem Mete
Turkish Journal of Medical Sciences
To determine the rate, etiological agents, antibiotic susceptibilities, and empirical treatment options of etiological agents of invasive device-associated hospital infections (IDAHIs) in the medical intensive care unit of a university hospital. Materials and methods: Between February 2007 and December 2009, 780 IDAHI cases were evaluated in 1650 patients. Results: Ventilator associated pneumonia, catheter-associated urinary tract infection, and central venous catheter-associated blood stream infection were observed in 415, 242, and 143 IDAHI cases, respectively. The most frequently isolated etiological agents were Acinetobacter spp. in ventilator-associated pneumonia, coagulase-negative staphylococci (CoNS) in central venous catheter-associated blood stream infection, and Candida spp. and E. …
Effect Of Hepatic Steatosis On Virological Response To Nucleos(T)Ide Analogs Therapy In Patients With Chronic Hepatitis B, Ahmet Karaman, Şebnem Gürsoy, Işin Soyuer, Hati̇ce Karaman, Muhammet Edi̇p Torun, Mustafa Alper Yurci̇, Mevlüt Başkol, Kadri̇ Güven, Ömer Özbakir, Mehmet Yücesoy
Effect Of Hepatic Steatosis On Virological Response To Nucleos(T)Ide Analogs Therapy In Patients With Chronic Hepatitis B, Ahmet Karaman, Şebnem Gürsoy, Işin Soyuer, Hati̇ce Karaman, Muhammet Edi̇p Torun, Mustafa Alper Yurci̇, Mevlüt Başkol, Kadri̇ Güven, Ömer Özbakir, Mehmet Yücesoy
Turkish Journal of Medical Sciences
To evaluate the impact of hepatic steatosis on the outcome of treatment in patients with chronic hepatitis B infection treated with oral antiviral therapy. Materials and methods: The study was designed in Erciyes University Medical Faculty Department of Gastroenterology. Patients who received oral antiviral therapy because of chronic hepatitis B were included in the study. Liver biopsy specimens were re-evaluated and classified according to Brunt’s steatosis classification. Virological response to oral antiviral therapy was compared between patients with and without steatosis. Results: One hundred and nineteen patients were included in the study, of which 36.1% had hepatic steatosis. Virological response …
A Small Outbreak Of Tularemia In A Rural Area, İbak Gönen
A Small Outbreak Of Tularemia In A Rural Area, İbak Gönen
Turkish Journal of Medical Sciences
To assess clinically and epidemiologically an outbreak of tularemia detected in a small village in Tokat Province in Turkey. Materials and methods: Recorded clinical and laboratory data of 15 serologically confirmed patients, who either presented to hospital or were diagnosed during family medicine visits to the village during the outbreak, were assessed. Forms including a questionnaire about the symptomatology and previously given treatments were filled out by the patients. In addition, the entire village was investigated to establish the origin of the outbreak. Results: Ages of the 15 individuals (9 females) ranged between 10 and 75, and the mean was …
The Mr Imaging Features And The Analyses Of Quantitative Parameters In Cases With Surgically Repaired Tetralogy Of Fallot, Sali̇h Hamcan, Bülent Karaman, Bi̇lal Battal, Veysel Akgün, Kemal Kara, Tuncay Hazirolan, Uğur Bozlar
The Mr Imaging Features And The Analyses Of Quantitative Parameters In Cases With Surgically Repaired Tetralogy Of Fallot, Sali̇h Hamcan, Bülent Karaman, Bi̇lal Battal, Veysel Akgün, Kemal Kara, Tuncay Hazirolan, Uğur Bozlar
Turkish Journal of Medical Sciences
To present postoperative cardiac magnetic resonance (CMR) imaging features of cases of surgically repaired tetralogy of Fallot (TOF) and to evaluate the relationship among data used in follow-up procedures, such as right ventricular ejection fraction (RV-EF), pulmonary regurgitation fraction (PRF), and the degree of right ventricular (RV) dysfunction. Materials and methods: Fourteen patients (9 males and 5 females; mean age 11.9 ± 3.6 years) with surgically repaired TOF who were admitted to our clinic for follow-up CMR imaging between July 2008 and September 2011 were included in the study. A protocol that consisted of cine steady-state free precession (SSFP) and …
Mmp-2, Timp-2, And Mmp-2/Timp-2 Complex Levels In Epidermoid Lung Cancer, Müfi̇de Öncel, Mehmet Aköz, Murat Öncel, Aysel Kiyici, Burhan Api̇li̇oğullari
Mmp-2, Timp-2, And Mmp-2/Timp-2 Complex Levels In Epidermoid Lung Cancer, Müfi̇de Öncel, Mehmet Aköz, Murat Öncel, Aysel Kiyici, Burhan Api̇li̇oğullari
Turkish Journal of Medical Sciences
To investigate serum levels of MMP-2, TIMP-2, and MMP-2/TIMP-2 complex in epidermoid lung cancer and determine whether one of these markers or any combination of them can be used as a prognostic factor and in the management of this disease. Materials and methods: Twenty-eight patients with non-small cell lung cancer and 21 healthy, age-matched individuals participated in this study. MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were measured in the sera of the patients and controls with the ELISA technique. Results: MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were significantly elevated in patients with non-small cell lung cancer compared to the controls …
Assessment Of Left-Ventricular Diastolic Function In Diabetic Patients: The Role Of Cardiac Mr Imaging, İhsan Yüce, İbrahi̇m Hali̇l Tanboğa, Ümmügülsüm Bayraktutan, Enbi̇ya Aksakal, Hayri̇ Oğul, Ahmet Yalçin, Yeşi̇m Kizrak, Abdulmeci̇t Kantarci
Assessment Of Left-Ventricular Diastolic Function In Diabetic Patients: The Role Of Cardiac Mr Imaging, İhsan Yüce, İbrahi̇m Hali̇l Tanboğa, Ümmügülsüm Bayraktutan, Enbi̇ya Aksakal, Hayri̇ Oğul, Ahmet Yalçin, Yeşi̇m Kizrak, Abdulmeci̇t Kantarci
Turkish Journal of Medical Sciences
To evaluate the reliability of cardiac magnetic resonance (CMR) imaging in diabetic patients with clinically suspected cardiomyopathy and to compare the consistency of CMR imaging with 2-dimensional echocardiography (2DE). Materials and methods: Twenty-one diabetic patients with clinically suspected cardiomyopathy were evaluated with CMR imaging and 2DE. Two observers for each modality performed the evaluation. Quantitative data (the ejection fraction, end-systolic volume, end-diastolic volume, left-ventricular mass index, and left-atrial volume index) were acquired from both observers. The data were compared for statistical agreement using the Bland-Altman test between the modalities. Results: The CMR examination and 2DE results were consistent with each …
Pyrazinamide Monoresistance In Clinical Isolates, Nezaket Kalir, Ayşe Aydan Özkütük, Nuran Esen, Nuri̇ Özkütük
Pyrazinamide Monoresistance In Clinical Isolates, Nezaket Kalir, Ayşe Aydan Özkütük, Nuran Esen, Nuri̇ Özkütük
Turkish Journal of Medical Sciences
To determine pyrazinamide (PZA) monoresistance in clinical isolates of Mycobacterium tuberculosis complex (MTBC) isolated in hospitals in and around İzmir. Materials and methods: The study was performed between 2004 and 2009 with 150 streptomycin, isoniazid, rifampicin, and ethambutol susceptible MTBC clinical strains isolated in the university hospitals of İzmir and Manisa. The PZA susceptibility of the isolates was determined by the BACTEC 460 TB test. Results: The results indicated that resistance to PZA was present in 5 (3.3%) of the 150 MTBC isolates susceptible to all primary drugs except PZA. Conclusion: It is not essential to perform PZA susceptibility tests …
Investigation Of The Protective Effects Of L-Carnitine And L-Arginine On Cardiovascular Changes Induced By Acth And Dexamethasone In Rabbits, Bi̇rkan Topçu, Metehan Uzun
Investigation Of The Protective Effects Of L-Carnitine And L-Arginine On Cardiovascular Changes Induced By Acth And Dexamethasone In Rabbits, Bi̇rkan Topçu, Metehan Uzun
Turkish Journal of Medical Sciences
To determine the protective effects of L-carnitine on cardiovascular changes that may occur in rabbits treated with adrenocorticotropic hormone (ACTH) and dexamethasone (DEX). Materials and methods: Rabbits of equal weight were divided into 7 groups with 6 animals in each. Blood samples were collected from all groups on days 1, 7, and 14, and blood pressure values and ECG monitoring were recorded. Nitric oxide (NO), creatine kinase MB (CK-MB), and troponin I (TnI) levels were determined in blood samples. Heart rate, QT, and corrected QT (QTc) values were calculated from ECG records. Results: The QT and QTc times were prolonged …
Rehabilitation Idea Begins At Sumers, Yusuf Kemal Kemaloğlu, Pinar Yaprak Kemaloğlu, Güven Mengü
Rehabilitation Idea Begins At Sumers, Yusuf Kemal Kemaloğlu, Pinar Yaprak Kemaloğlu, Güven Mengü
Turkish Journal of Medical Sciences
No abstract provided.
Plasma Soluble Thrombomodulin And Soluble Endothelial Protein C Receptor Levels In Colorectal Cancer Patients, Serap Ünal Ti̇lki̇, Hüseyi̇n Engi̇n, Ayla Gökmen, Cemi̇l Bi̇li̇r, Yücel Üstündağ
Plasma Soluble Thrombomodulin And Soluble Endothelial Protein C Receptor Levels In Colorectal Cancer Patients, Serap Ünal Ti̇lki̇, Hüseyi̇n Engi̇n, Ayla Gökmen, Cemi̇l Bi̇li̇r, Yücel Üstündağ
Turkish Journal of Medical Sciences
Thrombomodulin (TM) and endothelial protein C receptor (EPCR) are 2 transmembrane proteins that are thought to play an important role in cancer. We aimed to discover whether these 2 proteins are prognostic indicators in colorectal cancer. Materials and methods: Plasma TM and EPCR levels were measured using the ELISA method in 50 patients in different tumor stages that had been recently diagnosed with colorectal cancer and in a healthy control group of 50 people. Results: In colorectal cancer patients, higher plasma TM (21.3 ± 22.8 ng/mL, 13.2 ± 16.2 ng/mL, P = 0.010) and plasma EPCR levels (149.9 ± 79.6, …
Demonstration Of Mutations Conferring Resistance To Lamivudine In Liver Tissue Of Chronic Hepatitis B Patients Under Lamivudine Therapy, İsmai̇l Yaşar Avci, Can Polat Eyi̇gün, Emi̇ne Günal, Ayhan Kubar, Hanefi̇ Cem Gül, Ömer Coşkun, Hakan Erdem, Levent Görenek, Bülent Ahmet Beşi̇rbelli̇oğlu
Demonstration Of Mutations Conferring Resistance To Lamivudine In Liver Tissue Of Chronic Hepatitis B Patients Under Lamivudine Therapy, İsmai̇l Yaşar Avci, Can Polat Eyi̇gün, Emi̇ne Günal, Ayhan Kubar, Hanefi̇ Cem Gül, Ömer Coşkun, Hakan Erdem, Levent Görenek, Bülent Ahmet Beşi̇rbelli̇oğlu
Turkish Journal of Medical Sciences
To demonstrate the genotypic lamivudine resistance in liver tissue of patients with negative serum hepatitis B virus (HBV) DNA under long-term lamivudine therapy. Materials and methods: Fourteen patients (10 patients with elevated alanine aminotransferase and 4 patients under long-term lamivudine therapy for severe liver disease) with undetected serum HBV DNA were included in the study. A liver biopsy was performed for each patient, and HBV DNA extracted from liver tissue was analyzed with TaqMan real-time polymerase chain reaction. Results: Mutations conferring lamivudine resistance were shown for all 14 patients in their liver tissue-extracted HBV DNA. One patient had rtM204V, 4 …
Compliance To Treatment And Reaching Of Metabolic Goals Are Better In Oad-Treated Diabetics Than Insulin-Treated Diabetics In The Turkish Population, Sema Uçak, Emi̇ne Şatir, Okcan Basat, Yüksel Altuntaş
Compliance To Treatment And Reaching Of Metabolic Goals Are Better In Oad-Treated Diabetics Than Insulin-Treated Diabetics In The Turkish Population, Sema Uçak, Emi̇ne Şatir, Okcan Basat, Yüksel Altuntaş
Turkish Journal of Medical Sciences
We assessed the success rates of reaching glycated haemoglobin (HbA1c) goals in different treatment groups. Materials and methods: This was a single-centre, retrospective study including 2995 patients. The proportion of patients reaching their HbA1c goals, according to the International Diabetes Federation (IDF), American Association of Clinical Endocrinologists (AACE), and American Diabetes Association (ADA), were determined. Results: There were 4 different treatment groups: 1) diet group (n = 140), 2) oral antidiabetic drug (OAD) group (n = 1238), 3) insulin group (n = 765), and 4) insulin + OAD group (n = 812). According to the IDF and AACE criteria, the …
Comparison Of The Efficacies Of I-Gel^{Tm} And Lma-Proseal^{Tm} For Airway Management In Pediatric Patients, Orhan Tokgöz, Adnan Tüfek, Serbülent Gökhan Beyaz, Mustafa Uğur Yüksel, Feyzi̇ Çeli̇k, İlker Öngüç Aycan, Abdulmenap Güzel
Comparison Of The Efficacies Of I-Gel^{Tm} And Lma-Proseal^{Tm} For Airway Management In Pediatric Patients, Orhan Tokgöz, Adnan Tüfek, Serbülent Gökhan Beyaz, Mustafa Uğur Yüksel, Feyzi̇ Çeli̇k, İlker Öngüç Aycan, Abdulmenap Güzel
Turkish Journal of Medical Sciences
The present study was performed to compare the performance of I-gel^{TM} with LMA-ProSeal^{TM} in children undergoing anesthesia. Materials and methods: A total of 185 patients who were scheduled for elective surgery in Dicle University's hospital were randomly divided into 2 groups: the I-gel^{TM} group (Group-I, n = 95) and the p-LMA^{TM} group (Group-P, n = 90). Airway leakage pressure, insertion time, fiberoptic laryngeal image scores, ease of insertion, and possible complications were compared between these groups. Results: The airway leakage pressure of Group-I was significantly higher than that of Group-P (means ± SD: 28 ± 5 vs. 20 ± 4 …
Polymorphisms In Abc Transporters (Abca1 And Abcc8) In Metabolic Syndrome, Orhan Değer, Yunus Emre Yandi, Mi̇hri̇ban Ayvaz, Ci̇hangi̇r Erem, Ari̇f Bayram Hacihasanoğlu
Polymorphisms In Abc Transporters (Abca1 And Abcc8) In Metabolic Syndrome, Orhan Değer, Yunus Emre Yandi, Mi̇hri̇ban Ayvaz, Ci̇hangi̇r Erem, Ari̇f Bayram Hacihasanoğlu
Turkish Journal of Medical Sciences
To identify important single nucleotide polymorphisms (SNPs) in the ABCA1 and ABCC8 (SUR1) genes and determine if they are associated with metabolic syndorome (MetS). Materials and methods: Fifty-eight subjects fulfilling all 5 MetS criteria were chosen from 4809 subjects who participated in our screening study (Trabzon MetS study). Forty-three subjects who did not fulfill any MetS criteria were chosen as the control group. Genotyping of the samples after DNA isolation was performed by direct sequencing. For SNP analysis, exons 7, 15, 19, 36, 41, and 49 for ABCA1 and exons 16 and 18 for ABCC8 were selected. Results: The most …
Comparison Of The Effects Of Intraarticular Hyaluronic Acid And Antiinflammatory Drug Treatments On The Surgical Intervention Rates In Patients With Gonarthrosis, Murat Korkmaz, Yalçin Erdoğan, Ayli̇n Okur, Ayşe Yeşi̇m Göçmen, İlhan Günaydin
Comparison Of The Effects Of Intraarticular Hyaluronic Acid And Antiinflammatory Drug Treatments On The Surgical Intervention Rates In Patients With Gonarthrosis, Murat Korkmaz, Yalçin Erdoğan, Ayli̇n Okur, Ayşe Yeşi̇m Göçmen, İlhan Günaydin
Turkish Journal of Medical Sciences
The aim of this study was to compare the frequencies of surgical interventions between patients receiving intraarticular hyaluronic acid (IAHA) injection and those receiving only oral antiinflammatory drug treatment at the end of a 1-year follow-up period. Materials and methods: A total of 705 patients diagnosed with knee osteoarthritis (OA) between 2007 and 2009 were included in this study. Their records were investigated retrospectively. We divided 218 of the patients into 3 groups according to the Kellgren–Lawrence criteria, and they received sodium hyaluronate once a week for 3 weeks. Another 487 patients with gonarthrosis served as group 2 and were …
Clinical Manifestations Of 16 Oropharyngeal Tularemia Patients: Experience Of A Referral Hospital In The City Of Konya, Turkey, Mesut Sabri̇ Tezer, Gülteki̇n Övet, Necat Alataş, Mehmet Hakan Görgülü, Ersen Koç, Mehmet Aki̇f Öztürk
Clinical Manifestations Of 16 Oropharyngeal Tularemia Patients: Experience Of A Referral Hospital In The City Of Konya, Turkey, Mesut Sabri̇ Tezer, Gülteki̇n Övet, Necat Alataş, Mehmet Hakan Görgülü, Ersen Koç, Mehmet Aki̇f Öztürk
Turkish Journal of Medical Sciences
In recent years, tularemia's importance has been reemerging in Turkey. However, the majority of tularemia cases were reported in the northern cities of Turkey. In this study, we report 16 oropharyngeal tularemia patients living in rural areas of the city of Konya, which is located in the southern zone of the Central Anatolia Region of Turkey. Materials and methods: Sixteen patients (12 males, 4 females; mean age: 33.7 years, range: 10–73 years) were included in this study. All patients were admitted to our clinic for the evaluation of intractable cervical mass lesions. The diagnosis of tularemia was made after exclusion …
Dexmedetomidine Infusion Prevents Postoperative Shivering In Patients Undergoing Gynecologic Laparoscopic Surgery, Semra Karaman, İlkben Günüşen, Mustafa Arda Ceylan, Yücel Karaman, Esra Nur Çeti̇n, Abdurrahi̇m Derbent, Ahmet Mete Ergenoğlu
Dexmedetomidine Infusion Prevents Postoperative Shivering In Patients Undergoing Gynecologic Laparoscopic Surgery, Semra Karaman, İlkben Günüşen, Mustafa Arda Ceylan, Yücel Karaman, Esra Nur Çeti̇n, Abdurrahi̇m Derbent, Ahmet Mete Ergenoğlu
Turkish Journal of Medical Sciences
This placebo-controlled, randomized study was performed to evaluate the efficacy of dexmedetomidine in preventing postoperative shivering. Materials and methods: Sixty patients undergoing gynecologic laparoscopic surgery were assigned randomly to 2 groups to be administered either dexmedetomidine as a loading of 1 µg kg^{-1} for 10 min followed by a maintenance infusion of 0.5 µg kg^{-1} h^{-1} (Group D, n = 30), or a normal saline infusion (Group S, n = 30). Results: Postoperative shivering was observed in 14 patients in Group S and in 3 patients in Group D (P = 0.001). The sedation scores were higher in the dexmedetomidine …
Alfacalcidol Suppresses Α-Receptor–Mediated Vasoconstriction Via An Endothelium Dependent Mechanism, İsmai̇l Ün, Aki̇f Hakan Kurt, Ali̇ Batuş, Kansu Büyükafşar
Alfacalcidol Suppresses Α-Receptor–Mediated Vasoconstriction Via An Endothelium Dependent Mechanism, İsmai̇l Ün, Aki̇f Hakan Kurt, Ali̇ Batuş, Kansu Büyükafşar
Turkish Journal of Medical Sciences
Vitamin D level could be related to blood pressure and cardiovascular health. However, the direct suppressor effect of vitamin D on vascular contraction has not yet been explored. Therefore, the effects of alfacalcidol (1\alpha-hydroxyvitamin D_3) and calcitriol (1\alpha,25-dihydroxyvitamin D_3) on contractions induced by phenylephrine (10^{-8} to 10^{-5} M) in mice aorta were investigated. Materials and methods: Arterial rings were suspended in isolated organ chambers filled with Krebs bicarbonate solution gassed with 95% O_2 and 5% CO_2 maintained at 37 °C. Tissue responses were recorded isometrically with a force transducer and displayed on an acquisition system. Alfacalcidol and calcitriol were applied …
The Effect Of Combined Treatment Of Alpha-Tocopherol, Ascorbic Acid, And Pyridoxine With Nmda Blocker Memantine On Penicillin-Induced Epileptiform Activity In Rats, Duygu Aydin, Mehmet Yildirim, Mustafa Ayyildiz, Erdal Ağar
The Effect Of Combined Treatment Of Alpha-Tocopherol, Ascorbic Acid, And Pyridoxine With Nmda Blocker Memantine On Penicillin-Induced Epileptiform Activity In Rats, Duygu Aydin, Mehmet Yildirim, Mustafa Ayyildiz, Erdal Ağar
Turkish Journal of Medical Sciences
To evaluate the effects of coadministration of vitamins alpha-tocopherol, ascorbic acid, and pyridoxine with memantine on a penicillin-induced experimental epilepsy model in rats so as to clarify the eventual interaction between these vitamins and the N-methyl-D-aspartate (NMDA) system. Materials and methods: The epileptic focus was produced by intracortical penicillin G potassium injection. The effects of intraperitoneal injections of memantine, memantine + alpha-tocopherol, memantine + ascorbic acid, and memantine + pyridoxine combinations on epileptiform activity were evaluated in electrocorticogram recordings. Results: The antiepileptiform effects appeared earlier in all memantine and vitamin coadministrated groups compared to the memantine-alone group, but the difference …
The Outcomes Of The Pregnancies Of Lactating Women, Özlem Şengül, Ahmet Akin Si̇vaslioğlu, Mahmut Kuntay Kokanali, Işik Üstüner, Ayşe Fi̇li̇z Avşar
The Outcomes Of The Pregnancies Of Lactating Women, Özlem Şengül, Ahmet Akin Si̇vaslioğlu, Mahmut Kuntay Kokanali, Işik Üstüner, Ayşe Fi̇li̇z Avşar
Turkish Journal of Medical Sciences
To evaluate the outcomes of pregnancies occurring during lactation. Materials and methods: Sixty-one women who had interpregnancy intervals of 2 years were evaluated. Group 1 included 39 pregnancies of lactating women. Group 2 included 22 pregnancies of women who ceased lactation before conception. The groups were compared for gestational weight gain, birth weight, and obstetric complications. Results: The birth weights of the subsequent pregnancies of the first group were statistically lower than the second group (3086.6 ± 379.2 versus 3386.8 ± 388.1 g, P = 0.006). There was no statistically significant difference in obstetric complications observed between the 2 groups …
Lung Abscess: Analysis Of The Results As Community-Acquired Or Nosocomial, Nuri̇ Tutar, Fatma Sema Oymak, Asi̇ye Kanbay, Hakan Büyükoğlan, Afra Yildirim, İnsu Yilmaz, Suat Ali̇ Doğan, İnci̇ Gülmez, Ramazan Demi̇r
Lung Abscess: Analysis Of The Results As Community-Acquired Or Nosocomial, Nuri̇ Tutar, Fatma Sema Oymak, Asi̇ye Kanbay, Hakan Büyükoğlan, Afra Yildirim, İnsu Yilmaz, Suat Ali̇ Doğan, İnci̇ Gülmez, Ramazan Demi̇r
Turkish Journal of Medical Sciences
To assess the etiology, underlying disease, treatment procedures, and mortality rate of lung abscesses by dividing the patients into community-acquired lung abscess (CALA) and nosocomial lung abscess (NLA) subgroups. Materials and methods: We reviewed and analyzed data on 62 adult cases of CALA and NLA treated during 2000-2011 at a tertiary university hospital in Turkey. Results: Of these 62 patients, 44 had CALA and 18 had NLA. Etiologic microorganisms were isolated in 20 of the 44 patients (45.4%) in the CALA group and in 15 of the 18 patients (83.3%) in the NLA group. Among these patients, Staphylococcus aureus (20.0%) …