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Anticipatory Threat Responding: Associations With Anxiety, Development, And Brain Structure, Rany Abend, Andrea L. Gold, Jennifer C. Britton, Kalina J. Michalska, Tomer Shechner, Jessica F. Sachs, Anderson M. Winkler, Ellen Leibenluft
Anticipatory Threat Responding: Associations With Anxiety, Development, And Brain Structure, Rany Abend, Andrea L. Gold, Jennifer C. Britton, Kalina J. Michalska, Tomer Shechner, Jessica F. Sachs, Anderson M. Winkler, Ellen Leibenluft
School of Medicine Publications and Presentations
BACKGROUND: While translational theories link neurodevelopmental changes in threat learning to pathological anxiety, findings from studies in patients inconsistently support these theories. This inconsistency may reflect difficulties in studying large patient samples with wide age ranges using consistent methods. A dearth of imaging data in patients further limits translational advances. We address these gaps through a psychophysiology and structural brain imaging study in a large sample of patients across the lifespan.
METHODS: A total of 351 participants (8-50 years of age; 209 female subjects; 195 healthy participants and 156 medication-free, treatment-seeking patients with anxiety) completed a differential threat conditioning and …
Infant Behavioral Reactivity Predicts Change In Amygdala Volume 12 Years Later, Courtney A. Filippi, Jessica F. Sachs, Dominique Phillips, Anderson M. Winkler, Andrea L. Gold, Ellen Leibenluft, Daniel S. Pine, Nathan A. Fox
Infant Behavioral Reactivity Predicts Change In Amygdala Volume 12 Years Later, Courtney A. Filippi, Jessica F. Sachs, Dominique Phillips, Anderson M. Winkler, Andrea L. Gold, Ellen Leibenluft, Daniel S. Pine, Nathan A. Fox
School of Medicine Publications and Presentations
The current study examined the link between temperamental reactivity in infancy and amygdala development in middle childhood. A sample (n = 291) of four-month-old infants was assessed for infant temperament, and two groups were identified: those exhibiting negative reactivity (n = 116) and those exhibiting positive reactivity (n = 106). At 10 and 12 years of age structural imaging was completed on a subset of these participants (n = 75). Results indicate that, between 10 and 12 years of age, left amygdala volume increased more slowly in those with negative compared to positive reactive temperament. These results provide novel evidence …
Intrauterine Exposure To Chronic Hypoxia In The Rat Leads To Progressive Diastolic Function And Increased Aortic Stiffness From Early Postnatal Developmental Stages, Praveen Kumar, Jude S. Morton, Amin Shah, Victor Do, Consolato Sergi, Jesus Serrano-Lomelin, Sandra T. Davidge, Donna Beker, Jody Levasseur, Lisa K. Hornberger
Intrauterine Exposure To Chronic Hypoxia In The Rat Leads To Progressive Diastolic Function And Increased Aortic Stiffness From Early Postnatal Developmental Stages, Praveen Kumar, Jude S. Morton, Amin Shah, Victor Do, Consolato Sergi, Jesus Serrano-Lomelin, Sandra T. Davidge, Donna Beker, Jody Levasseur, Lisa K. Hornberger
School of Medicine Publications and Presentations
Aim
We sought to explore whether fetal hypoxia exposure, an insult of placental insufficiency, is associated with left ventricular dysfunction and increased aortic stiffness at early postnatal ages.
Methods
Pregnant Sprague Dawley rats were exposed to hypoxic conditions (11.5% FiO2) from embryonic day E15‐21 or normoxic conditions (controls). After delivery, left ventricular function and aortic pulse wave velocity (measure of aortic stiffness) were assessed longitudinally by echocardiography from day 1 through week 8. A mixed ANOVA with repeated measures was performed to compare findings between groups across time. Myocardial hematoxylin and eosin and picro‐sirius staining were performed to evaluate myocyte …