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Two-Year Responses Of Office And Ambulatory Blood Pressure To First Occupational Lead Exposure, Yu-Ling Yu, Wen-Yi Yang, Lutgarde Thijs, Jesus D. Melgarejo, Cai-Guo Yu, Dong-Mei Wei, Fang-Fei Wei, Tim S. Nawrot, Zhen-Yu Zhang, Jan A. Staessen
Two-Year Responses Of Office And Ambulatory Blood Pressure To First Occupational Lead Exposure, Yu-Ling Yu, Wen-Yi Yang, Lutgarde Thijs, Jesus D. Melgarejo, Cai-Guo Yu, Dong-Mei Wei, Fang-Fei Wei, Tim S. Nawrot, Zhen-Yu Zhang, Jan A. Staessen
School of Medicine Publications and Presentations
Lead exposure causing hypertension is the mechanism commonly assumed to set off premature death and cardiovascular complications. However, at current exposure levels in the developed world, the link between hypertension and lead remains unproven. In the Study for Promotion of Health in Recycling Lead (URL: https://www.clinicaltrials.gov; Unique identifier: NCT02243904), we recorded the 2-year responses of office blood pressure (average of 5 consecutive readings) and 24-hour ambulatory blood pressure to first occupational lead exposure in workers newly employed at lead recycling plants. Blood lead (BL) was measured by inductively coupled plasma mass spectrometry (detection limit 0.5 µg/dL). Hypertension was defined …
Nighttime Blood Pressure Interacts With Apoe Genotype To Increase The Risk Of Incident Dementia Of The Alzheimer’S Type In Hispanics, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Ciro Gaona, Carlos A. Chavez, Gustavo E. Calmon, Egle R. Silva, Gabriel A. De Erausquin, Mario Gil, Luis J. Mena, Joseph D. Terwilliger, Humberto Arboleda, Nikolaos Scarmeas, Joseph H. Lee, Gladys E. Maestre
Nighttime Blood Pressure Interacts With Apoe Genotype To Increase The Risk Of Incident Dementia Of The Alzheimer’S Type In Hispanics, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Ciro Gaona, Carlos A. Chavez, Gustavo E. Calmon, Egle R. Silva, Gabriel A. De Erausquin, Mario Gil, Luis J. Mena, Joseph D. Terwilliger, Humberto Arboleda, Nikolaos Scarmeas, Joseph H. Lee, Gladys E. Maestre
School of Medicine Publications and Presentations
Background: Dementia of the Alzheimer’s type (DAT) impacts Hispanics disproportionately, with almost a twofold elevated risk of developing DAT, as well as earlier onset of the disease, than in non-Hispanic Whites. However, the role of main risk factors for DAT, such as APOE ɛ4 and blood pressure (BP) levels, remains uncertain among Hispanics.
Objective: To investigate the association of APOE ɛ4 and BP levels, measures with 24 h ambulatory BP monitoring, with incidence of DAT in an elderly cohort of Hispanics.
Methods:1,320 participants from the Maracaibo Aging Study, free of dementia at the baseline, and with ambulatory BP …