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Adoptive Treg Cell-Based Immunotherapy: Frontier Therapeutic Aspects In Rheumatoid Arthritis, Mahdi Zavvar, Sara Assadiasl, Sina Zargaran, Maryam Akhtari, Behzad Poopak, Rassoul Dinarvand, Yousef Fatahi, Lobat Tayebi, Narjes Soleimanifar, Mohammad Hossein Nicknam

School of Dentistry Faculty Research and Publications

The major current focus on treating rheumatoid arthritis is to put an end to long-term treatments and instead, specifically block widespread immunosuppression by developing antigen-specific tolerance, while also permitting an intact immune response toward other antigens to occur. There have been promising preclinical findings regarding adoptive Treg cells immunotherapy with a critically responsible function in the prevention of autoimmunity, tissue repair and regeneration, which make them an attractive candidate to develop effective therapeutic approaches to achieve this interesting concept in many human immune-mediated diseases, such as rheumatoid arthritis. Ex vivo or invivo manipulation protocols are not only utilized to correct …