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A Role For Retinoids In The Treatment Of Covid-19?, Steven E. Trasino
A Role For Retinoids In The Treatment Of Covid-19?, Steven E. Trasino
Publications and Research
The 2020 global outbreak of the novel coronavirus (SARS-CoV-2 or COVID-19) is a serious threat to international health, and thus, there is an urgent need for discoverynof novel therapies or use of repurposed drugs that can make a significant impact on slowing the spread of the virus. Type 1 interferons (IFN-I) are a family cytokines of the early innate immune response to viruses that are being tested against SARSCoV- 2. However, coronaviruses similar to SARS-CoV-2 can suppress host IFN-I antiviral responses. Retinoids are a family molecules related to vitamin A that possess robust immune-modulating properties, including the ability to increase …
Post-Infectious Sequela Of Sars-Cov-2 Infection In Adults And Children: An Overview Of Available Agents And Clinical Responsiveness, David S. Younger
Post-Infectious Sequela Of Sars-Cov-2 Infection In Adults And Children: An Overview Of Available Agents And Clinical Responsiveness, David S. Younger
Publications and Research
The SARS-CoV-2 2019 pandemic has created challenges to managing the post-infectious autoimmune consequences of a disease that leads to the high case fatality in adults and children. The spectrum of agents available to modulate and suppress the immune system in combination with other appropriate antiviral antibiotics and life support measures is reviewed. All of the agents envisioned to treat Covid-19 disorders, including a newly recognized pediatric multi-system inflammatory syndrome, impact post-infectious mechanisms in keeping with the multiplier effect of infection, immunity and inflammation known as I-Cubed (I3).