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MSU Graduate Theses

Theses/Dissertations

Compound action potential

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Modulation Of Electrocochleography Responses By Contralateral Broadband Noise In Young Adults, Riley J. Rickman Jan 2022

Modulation Of Electrocochleography Responses By Contralateral Broadband Noise In Young Adults, Riley J. Rickman

MSU Graduate Theses

While it is known the auditory efferent system contains two distinct subgroups – the medial olivocochlear nucleus (MOC) and the lateral olivocochlear nucleus (LOC) – not much is known regarding the function of the LOC in humans. This study aims to evaluate the effect of activating the lateral olivocochlear (LOC) neurons via contralateral broad band noise (CBBN) on electrocochleography responses. A ten-minute time-blocked paradigm was utilized to evaluate both the slow and fast effect of the LOC neurons. Recordings were obtained at four points within this ten-minute block both with and without the presence of 50 dB SPL CBBN to …


Spatial Irregularities Of Compound Action Potential Origination In Individual Cochleae, Kaitlyn M. Kennedy May 2016

Spatial Irregularities Of Compound Action Potential Origination In Individual Cochleae, Kaitlyn M. Kennedy

MSU Graduate Theses

The present study aims to evaluate the origin of compound action potential (CAP) responses in the guinea pig ear using the following method. Pipettes were sealed into the cochlear apex of 26 guinea pigs to inject ototoxic pharmaceuticals that inhibit nerve responses without affecting cochlear function. The rate of the injection was adjusted once each minute to account for variations in the diameter of the cochlea and to maintain a steady flow of pharmaceuticals. CAP measurements collected at around 90-second intervals using tone burst stimuli during the injections allowed evaluation of the neural responses over time. Responses to higher stimulation …