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Articles 1 - 18 of 18
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A Comparison Of The Magnitude Of The Mental Health Benefits Of Exercising Outdoors Vs Exercising Indoors: A Review, Greta M. Rueschmann
A Comparison Of The Magnitude Of The Mental Health Benefits Of Exercising Outdoors Vs Exercising Indoors: A Review, Greta M. Rueschmann
MSU Graduate Theses
Many people in the United States suffer from poor mental health which can lead to suicide, self-harm, or negative effects on job performance and relationships. Not everyone can afford traditional therapy nor feels comfortable with it. With a greater emphasis placed on taking care of one’s mental health during the COVID-19 pandemic, there should also be a greater emphasis placed on finding alternative types of therapy that can be matched to individuals based on their personalities and preferences. One such alternative is outdoor exercise. This review was conducted to examine whether exercising or performing physical activity outdoors results in greater …
Effect Of Electrocochleography Stimulus Rate And Intensity On Identification Of Noise Induced Hidden Hearing Loss In Humans, Amanda E. Mccarthy
Effect Of Electrocochleography Stimulus Rate And Intensity On Identification Of Noise Induced Hidden Hearing Loss In Humans, Amanda E. Mccarthy
MSU Graduate Theses
Noise exposure has been known to cause both temporary and permanent shifts in hearing thresholds in humans. Animal and human studies have shown noise exposure to lead to damage to the ribbon synapses of the cochlea. This damage, referred to as noise induced hidden hearing loss (NIHHL), is not detectable with standard hearing assessments, though can be the cause of difficulties understanding speech in the presence of background noise. Recent studies have begun to explore the use of electrocochleography (ECochG) to detect this neural damage in humans. Such studies strive to aid in the development of a clinical tool for …
Cesarean Skin-To-Skin Contact: Who Gets The Experience In The Operating Room?, Jessica S. Junk-Wilson
Cesarean Skin-To-Skin Contact: Who Gets The Experience In The Operating Room?, Jessica S. Junk-Wilson
MSU Graduate Theses
For the past decade, skin-to-skin contact immediately after birth has been the general recommendation for all births, as there is evidence that it provides many benefits for mothers and infants. Yet, research has shown that immediate skin-to-skin contact is not the standard practice after most Cesarean births. This study assessed access, incidence, and circumstances surrounding Cesarean skin-to-skin contact (CSSC) in the operating room and examined influencing maternal characteristics of age, education, race, and number of births via a survey of 2327 people. Women who experienced a Cesarean section birth in the past 10 years were recruited through Facebook groups for …
Intracellular Trafficking And Distribution Of Cd And Inp Quantum Dots In Hela And Ml-1 Thyroid Cancer Cells, Min Zhang
MSU Graduate Theses
The study of the interaction of engineered nanoparticles, including quantum dots (QDs), with cellular constituents and the kinetics of their localization and transport, has provided new insights into their biological consequences in cancers and for the development of effective cancer therapies. The present study aims to elucidate the toxicity and intracellular transport kinetics of CdSe/ZnS and InP/ZnS QDs in late-stage ML-1 thyroid cancer using well-tested HeLa cells as a control. The XTT viability assay showed that ML-1 cells, and non-cancerous mouse fibroblast cells, exhibit no viability defect in response to these QDs, whereas HeLa cell viability decreases. These results suggest …
Effectiveness Of Stabilized Hypochlorous Acid In Acute Peritonitis Treatment: A Murine Surgical Study, Benjamin Michael Pomeroy
Effectiveness Of Stabilized Hypochlorous Acid In Acute Peritonitis Treatment: A Murine Surgical Study, Benjamin Michael Pomeroy
MSU Graduate Theses
Peritonitis is an inflammatory condition affecting the mesothelial cells that line the peritoneal cavity and is commonly induced by bowel perforations. This medical emergency is treated through antibiotic therapy and surgical intervention followed by tissue irrigation (lavage). Acute treatments aim to remove the bacterial burden, however recurring peritoneal infections occur at high rates and contribute to patient morbidity. These recurring infections are likely due to the inability of lavage solutions to remove the entire massive intra-abdominal bacterial load due to intestinal perforation. Numerous antiseptic solutions and antibiotic additives have been evaluated in their ability to improve source control by abdominal …
The Role Of Actin Associated Sptbn1 Host Factor In Hiv-1 Infection In Microglial Cells, Hannah Matheney
The Role Of Actin Associated Sptbn1 Host Factor In Hiv-1 Infection In Microglial Cells, Hannah Matheney
MSU Graduate Theses
Human immunodeficiency virus (HIV) is a chronic illness affecting more than 32.7 million individuals worldwide. The virus infects immune cells, weakening the immune system overtime eventually leading to acquired immunodeficiency syndrome (AIDS) if left untreated. Infection starts with a fusion step, followed by uncoating of the HIV capsid once in the cytoplasm of the cell. HIV uses host cell proteins to complete the infection process, like the actin associated factor, SPTBN1. The Hulme lab has previously shown that SPTBN1 knockdown by siRNA in microglial cells decreased HIV infection and delayed uncoating of HIV. Because fusion is prior to uncoating, it …
Parent Style Of Coping Based On Attachment In The Nicu, Claire Elizabeth Payne
Parent Style Of Coping Based On Attachment In The Nicu, Claire Elizabeth Payne
MSU Graduate Theses
This quantitative study sought to identify any relationship between attachment type and coping style in the Neonatal Intensive Care Unit, to better understand and provide resources and support to families in this environment. This study included ten participants who had an infant in the Neonatal Intensive Care Unit for at least five days. Each participant met the additional criteria of being older than the age of 18 and speaking English. Responses were recorded through a self-report survey, consisting of 115 Likert scale statements. Results indicated that most parents self-report secure attachment and that styles of coping varied within those securely …
Equine-Assisted Therapy And Learning Interventions With Youth: A Meta-Analysis And Quasi-Experimental Study., Sarah Lovins
Equine-Assisted Therapy And Learning Interventions With Youth: A Meta-Analysis And Quasi-Experimental Study., Sarah Lovins
MSU Graduate Theses
Equine-assisted psychotherapy interventions have become increasingly used and tested as an alternative or complementary approach with youth. This project presents two studies. The first study consists of an overview of existing reviews and a meta-analysis of controlled and comparison studies on the effectiveness of equine interventions with youth. A comprehensive search and selection procedure produced 3,525 records, from which 56 quantitative studies were identified, and ultimately 16 controlled or comparison studies were selected for inclusion in the meta-analysis. Results showed a statistically significant, medium, and homogenous effect size for the overall effectiveness of equine interventions for youth psycho-social outcomes ( …
The Role Of The Host Factor Sptbn1 In Hiv-1 Infection Of Microglial Cells, Marc Gordon Havlicek
The Role Of The Host Factor Sptbn1 In Hiv-1 Infection Of Microglial Cells, Marc Gordon Havlicek
MSU Graduate Theses
HIV-1 is the etiological agent that cause AIDS. Since the 1980’s when HIV-1 was discovered, much has been discovered, however a cure for HIV-1 has eluded researchers. Effective therapeutics do exist but can have adverse side effects including HAND/HAD which leads to neurodegeneration in patients regardless of viral suppression. One area of research that holds the possibility of discovering new viral targets and therapeutics is host factor interaction within the replication process. One host factor that can cause a decrease in HIV-1 infectivity is SPTBN1. SPTBN1 is a cytoskeletal protein that was shown to bind to the capsid and nucleocapsid …
Child Life Student Approaches To And Purposes Of Play, Taylor L. Brower
Child Life Student Approaches To And Purposes Of Play, Taylor L. Brower
MSU Graduate Theses
The aim of this study was to research and gain a greater understanding of what child life students are learning about play. Qualitative data was collected via Qualtrics. Participants reported learning child-led play, structured play, and expressive play as learned approaches to play. Students reported the most learned purpose of play being self–expression, and normalization. Participants provided self-given definitions of the theories and concepts of play as the survey prompted in keeping with the researcher’s goals. The Daisy model in the communication theory Coordinated Management of Meaning provided the theoretical framework, supporting preparation or familiarization, express emotions, process, or cope, …
Modulation Of Electrocochleography Responses By Contralateral Broadband Noise In Young Adults, Riley J. Rickman
Modulation Of Electrocochleography Responses By Contralateral Broadband Noise In Young Adults, Riley J. Rickman
MSU Graduate Theses
While it is known the auditory efferent system contains two distinct subgroups – the medial olivocochlear nucleus (MOC) and the lateral olivocochlear nucleus (LOC) – not much is known regarding the function of the LOC in humans. This study aims to evaluate the effect of activating the lateral olivocochlear (LOC) neurons via contralateral broad band noise (CBBN) on electrocochleography responses. A ten-minute time-blocked paradigm was utilized to evaluate both the slow and fast effect of the LOC neurons. Recordings were obtained at four points within this ten-minute block both with and without the presence of 50 dB SPL CBBN to …
Characterization Of Nanoparticles Using Inductively-Coupled Plasma Mass Spectrometry, Jabez D. Campbell
Characterization Of Nanoparticles Using Inductively-Coupled Plasma Mass Spectrometry, Jabez D. Campbell
MSU Graduate Theses
Nanomaterials are a relatively new class of materials that have many applications which span a wide host of fields from medical products to consumer products. The possible compositions and forms of nanomaterials are just as varied as the applications. Therefore, a versatile characterization method is needed for researchers and regulators alike to ensure nanomaterials are properly used. Single Particle Inductively Coupled Plasma Mass Spectrometry (SP-ICP-MS) is a functional method that could fill the characterization need in the nanomaterial research field. Using data from both SP-ICP-MS tests and data from literature established characterization methods, the viability of making SP-ICP-MS the standard …
Utilizing Virtual Reality Goggles During Pediatric Laceration Repairs To Reduce Perceived Pain In Pediatric Patients, Emily C. Bozzer
Utilizing Virtual Reality Goggles During Pediatric Laceration Repairs To Reduce Perceived Pain In Pediatric Patients, Emily C. Bozzer
MSU Graduate Theses
In pediatric emergency departments, several providers assess pediatric patients in need a laceration repair, require procedural sedation in order to ensure compliance and complete the laceration repair. This study explored one safe alternative to procedural sedation during pediatric laceration repairs by assessing what pain scores pediatric patients report when undergoing a laceration repair utilizing virtual reality goggles. Pediatric patients ages 6-17 years old perceived pain scores utilizing FACES pain scale was documented. This study found a majority of patients reported lower pain scores during the laceration repair in comparison to their baseline pain score.
Physical Activity As A Predictor Of Obesity In Autistic Children, Cody A. Mullins
Physical Activity As A Predictor Of Obesity In Autistic Children, Cody A. Mullins
MSU Graduate Theses
Research has found autistic children to be 40% more likely to be obese compared to their non-autistic peers. Reduced physical activity (PA) is thought to be a contributing factor to the increased prevalence of obesity in autistic children. This was one of the first studies to investigate the PA behaviors of autistic children during an adapted physical education (APE) class using accelerometry. The purpose of this study was to examine the PA of autistic children and determine the relationship between PA and obesity. Participants were recruited from a school for students with disabilities who participate in a once-weekly APE class …
A Study Of Cobalt (Iii) Oxide Nanoparticle Delivery Of Sirna Molecules Directed Against Signaling Intermediates Of The P2y2 Receptor, Rachel Blair Stroud
A Study Of Cobalt (Iii) Oxide Nanoparticle Delivery Of Sirna Molecules Directed Against Signaling Intermediates Of The P2y2 Receptor, Rachel Blair Stroud
MSU Graduate Theses
G protein-coupled receptors are evolutionarily ubiquitous sensors of extracellular signals, propagating intracellular signal cascades through heterotrimeric G proteins. P2Y2 receptors are GPCRs which are activated by extracellular nucleotides to mediate signaling cascades via Gαq coupling. Many GPCRs are subject to a common mechanism for signal termination involving phosphorylation of the C-terminal tail followed by β-arrestin binding and subsequent endocytic internalization of the complex. This effect has been described for the P2Y2 R in the 1321N1 astrocytoma cell line, and UTP-induced activation and desensitization profiles have been previously defined. There is need to develop molecular vehicles for safe and …
Role Of Cyclophilin A And Trim5Α In Hiv-1 Infection And Capsid Uncoating, Emma Lk Wise
Role Of Cyclophilin A And Trim5Α In Hiv-1 Infection And Capsid Uncoating, Emma Lk Wise
MSU Graduate Theses
Microglial cells are immune cells that protect the central nervous system and are subject to HIV- 1 infection. HIV-1 infection of these cells can lead to HIV Associated Neurocognitive Disorders (HAND). Since HIV-1 only codes for 15 different proteins, the virus also uses cellular factors, like Cyclophilin A (CypA), to assist in viral replication. The cell also has antiretroviral restriction factors, like tripartite motif-containing protein 5 (TRIM5α), to protect against infection. The goal of this project is to investigate the role of CypA in the early steps of HIV-1 replication and TRIM5α restriction in microglial cells. I hypothesize that CypA …
Speaker Encoding For Zero-Shot Speech Synthesis, Tristin W. Cory
Speaker Encoding For Zero-Shot Speech Synthesis, Tristin W. Cory
MSU Graduate Theses
Spoken communication, for many, is an essential part of everyday life. Some individuals can lose or not be born with the ability to speak. To function on a day-to-day basis, these individuals find other ways of communication. Adaptive speech synthesis is one of those ways. It recreates a user’s previous voice or creates a voice that blends with their regional dialect. Current adaptive speech synthesis techniques that achieve human-like speech require thirty minutes, to a few hours of high-quality audio recordings of a target speaker. This amount of recorded audio is not commonly possessed by people in need of a …
Qualitative Comparison Of The United States And United Kingdom Healthcare Systems, Rachel Cazzaniga
Qualitative Comparison Of The United States And United Kingdom Healthcare Systems, Rachel Cazzaniga
MSU Graduate Theses
The United States and United Kingdom healthcare systems vary based on their public access, financial dependence, health outcomes, gross domestic product, and much more. The systems have continued to grow with different focuses of importance in the quality of care that is being distributed to their populations. The U.K. universal healthcare system represents their value of accessibility and affordability, while the U.S. privatized system(s) represents their value of economic growth. The study provided a qualitative analysis of the systems' differences by integrating real world experiences and perceptions of the systems from individuals that have encountered and interacted as a patient …