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Nicu Experiences Of Adoptive Parents & Desired Preparation, Catherine J. Howe
Nicu Experiences Of Adoptive Parents & Desired Preparation, Catherine J. Howe
MSU Graduate Theses
Parents who have newborns admitted into the Neonatal Intensive Care Unit (NICU) have multiple experiences and emotions. Additional social and emotional layers are experienced by adoptive couples when the infant they wish to adopt needs specialized care. This research study was completed to find out what adoptive parents experience in the NICU and what preparation would have been helpful. The method included semi-structured, open-ended interviews with seven couples who adopted a newborn at a Midwestern adoption agency within the past three years and had a NICU experience. The results described adoptive couples’ experiences on the unit, bonding and attachment, fears …
The Erasure Of Monosexism: An Exploration Of Identity Development In Bisexual Women, Emma M. Leonard
The Erasure Of Monosexism: An Exploration Of Identity Development In Bisexual Women, Emma M. Leonard
MSU Graduate Theses
Research has shown that bisexual individuals experience poorer mental health outcomes, resulting in depression, anxiety, substance use, and suicidal ideation, than their gay or straight counterparts (Calzo, Antonucci, Mays, & Cochran, 2011; Ross, Dobinson, & Eady, 2010; Taylor, Power, & Smith, 2020). These poor mental health outcomes suggest bisexual individuals may be experiencing hardships these other groups are not. This qualitative study sought to gain an understanding of the lived experiences of bisexual women aged 18-25. The researcher sought to gain an understanding of self-identified resiliency factors by the women as it pertains to their sexual/affectional orientation. Detailed interviews were …
Modulation Of Glucose Homeostasis By Nucleotide P2y2 Receptor And Biological Sex, Hailee Anne Marino
Modulation Of Glucose Homeostasis By Nucleotide P2y2 Receptor And Biological Sex, Hailee Anne Marino
MSU Graduate Theses
Recent insights into the pathological role of Nucleotide P2Y2 receptor suggest P2Y2R involvement in high fat diet-induced obesity and potentiates insulin resistance. However, these recent insights do not demonstrate how P2Y2R modulates glucose homeostasis under physiological conditions. Further, it remains unknown how sex biological factors influence P2Y2R receptor signaling in the regulation of glucose homeostasis. The research objective for the present study is to elucidate the novel roles of P2Y2 in fasting blood glucose and glucose tolerance (basal insulin sensitivity) under resting conditions in males and females. We expected that under physiological …
Nucleotide P2y₂ Receptor-Dependent Leukocyte-Endothelial Interaction, Spencer E. Thomas
Nucleotide P2y₂ Receptor-Dependent Leukocyte-Endothelial Interaction, Spencer E. Thomas
MSU Graduate Theses
Extracellular nucleotides (ATP, UTP) released from cells act on nucleotide receptors to promote vascular inflammation. Increased leukocyte-endothelial interaction is a hallmark of vascular inflammation. The nucleotide P2Y₂ receptor (P2Y₂R), activated by extracellular ATP≈UTP, plays a role in cardiovascular homeostasis and immune regulation. Moreover, accumulating evidence from studies in vitro and in vivo models have implicated the P2Y₂R in the inflammatory response significantly contributing to the progression and pathogenesis of asthma, atherosclerosis, sepsis, and ischemia. I hypothesized that P2Y₂R activation by UTP, an agonist of the receptor, increased leukocyte rolling and adhesion in the microvasculature from baseline. To test the hypothesis, …
Predicting Severity Of Traumatic Brain Injury: A Residual Learning Model From Magnetic Resonance Images, Dacosta Yeboah
Predicting Severity Of Traumatic Brain Injury: A Residual Learning Model From Magnetic Resonance Images, Dacosta Yeboah
MSU Graduate Theses
One of the most significant frontiers for computational scientists is the engineering of human healthcare delivery based on intelligent analysis of health data. In a variety of neurological disorders such as Traumatic Brain Injury (TBI), neuro-imaging information plays a crucial role in the decision-making regarding patient care and as a potential prognostic marker for outcome. TBI is a heterogeneous neurological disorder. Due to the economic burdens of the disorder, sorting out this heterogeneity could provide more insights and better understanding of TBI recovery trajectories, thus improving overall diagnosis and treatment options. Magnetic Resonance Imaging (MRI) is a non-invasive technique that …
Working Memory As A Predictor Of Social Distancing And Face Mask Compliance During Covid-19 Pandemic, Cassandra Jean Kemmel
Working Memory As A Predictor Of Social Distancing And Face Mask Compliance During Covid-19 Pandemic, Cassandra Jean Kemmel
MSU Graduate Theses
The COVID-19 pandemic has brought about many changes in daily lives around the world. In the United States, face masks and social distancing rules have been suggested and even enforced in areas throughout the country. Compliance with these regulations will in turn, hopefully, reduce transmission and therefore the threat of the COVID-19 virus. Working memory (WM) has been found to be an integral part of the decision-making process, by assessing costs and benefits, both individually and for others. In May 2019, Xie, Campbell, and Zhang (2020) found that WM capabilities were predictive of social distancing compliance. The purpose of this …
Examining Health Inequity In Ancient Egypt, Samantha Rose Gonzalez
Examining Health Inequity In Ancient Egypt, Samantha Rose Gonzalez
MSU Graduate Theses
This thesis explores the history of medicine in ancient Egypt between the Middle and New Kingdoms, and offers a case study highlighting the use of religion and magic in healing and analyzing health inequity. I am interested in medical practices, treatments, diagnosis methods, and access to healthcare in the ancient world. I seek to bridge the gaps and help unify the knowledge surrounding ancient Egyptian medical practices and contribute to the studies in the history of medicine. I explore types of diseases that commonly affected the ancient Egyptians and how they integrated religion and magic into their understanding and treatment …
Characterization Of Lamellar Liquid Crystal Emulsifiers In Topical Creams Containing A Novel Solvent, Melinda Joanna Sutton
Characterization Of Lamellar Liquid Crystal Emulsifiers In Topical Creams Containing A Novel Solvent, Melinda Joanna Sutton
MSU Graduate Theses
Diethylene glycol monoethyl ether (DEGEE) is a promising solvent component in topical cream formulations due to its superior solubilizing abilities with certain active pharmaceutical ingredients. One of the goals of this study is to characterize the effects of pH on the physical and chemical stabilities of topical cream formulations containing particularly high concentrations of DEGEE by characterizing a full topical pH profile of 3.5 – 9.0. The second goal is to evaluate the presence, amount, and characteristics of lyotropic liquid crystals (LLCs), molecularly structured in a lamellar phase, in a model cream emulsion utilizing polarized light microscopy (PLM). The presence …
Identifying And Comparing Transcriptome Alterations In Saccharomyces Cerevisiae Exposed To A Variety Of Quantum Dots, Cullen Horstmann
Identifying And Comparing Transcriptome Alterations In Saccharomyces Cerevisiae Exposed To A Variety Of Quantum Dots, Cullen Horstmann
MSU Graduate Theses
The primary focus of my research was to obtain global gene expression profiles of baker’s yeast exposed to sub-lethal doses of nanoparticles, such as silver nanoparticles (AgNPs), yellow- emitting CdSe/ZnS quantum dots (QDs), green-emitting CdSe/ZnS QDs, and InP/ZnS QDs, to reveal novel insights on their unique mechanisms of toxicity. Despite their diverse applications, their long-lasting effects on the environment and human health are not well understood. To assess their toxicity, I administered experiments that exposed Saccharomyces cerevisiae to a variety of nanoparticles and measured cell viability, ROS levels, and changes in gene expression. Most notably, I used RNA-sequencing (RNA-seq) to …
Frequency-Modulated Multiple-Tone Distortion Product Otoacoustic Emissions In Young Children With Normal Hearing, Kathryn Arielle Vlietstra Baker
Frequency-Modulated Multiple-Tone Distortion Product Otoacoustic Emissions In Young Children With Normal Hearing, Kathryn Arielle Vlietstra Baker
MSU Graduate Theses
Distortion-product otoacoustic emissions (DPOAEs) are objective tests of the integrity of the outer hair cells of the cochlea in response to a single-tone pair stimulus. Despite advances in DPOAEs test protocols and technology, there is little research about the use of frequency modulated tones to improve response characteristics. This study evaluates the efficacy of a new frequency modulated stimulus with multiple-tone pair DPOAEs (mDPOAEs) compared to the standard stimulus protocol for mDPOAEs to determine whether frequency modulation (FM) will achieve more robust and faster results. Normative data for this novel test protocol were obtained in 11 healthy normal-hearing children aged …
Exploring The Influence Of Self-Efficacy And Autonomy On Outdoor Recreation Behaviors During The Covid-19 Pandemic, Katheryn E. Carpenter
Exploring The Influence Of Self-Efficacy And Autonomy On Outdoor Recreation Behaviors During The Covid-19 Pandemic, Katheryn E. Carpenter
MSU Graduate Theses
Outdoor Recreation (OR) provides the benefits of physical activity and traditional leisure along with the addition of the benefits associated with an outdoor environment. Self Determination Theory (SDT) and Social Cognitive Theory (SCT) state that self-efficacy (SE) and autonomy can increase depending on the physical and social environment. The purpose of this study was to explore the relationship between self-efficacy and autonomy on OR behaviors during the COVID-19 pandemic. It was hypothesized there would be a correlation between individuals who participate in OR activities and self-efficacy as well as autonomy. The research also explored barriers and facilitators to OR via …
Content Validity Of Aba Language Assessments In The Totality Of Skinner's Verbal Operant Theory, Taylor Marie Lauer
Content Validity Of Aba Language Assessments In The Totality Of Skinner's Verbal Operant Theory, Taylor Marie Lauer
MSU Graduate Theses
Content validity describes the degree of which a measure represents all the components of the overall construct being measured. Behavior analytic language assessments are largely based on Skinner’s verbal operant theory (1957). Three behavior analytic language assessments were utilized to measure the coverage of Skinner’s verbal behavior theory: the VB-MAPP, ABLLS-R, and PEAK. The purpose of the current study was to examine the content validity of each of these assessments coverage on the totality of Skinner’s verbal operant theory. Expressive items on each of the three assessments were compared to definitions of Skinner’s verbal operants and were coded as the …
Sodium Pyruvate Ameliorates Influenza A Virus Infection In Vitro And In Vivo, Jessica M. Reel
Sodium Pyruvate Ameliorates Influenza A Virus Infection In Vitro And In Vivo, Jessica M. Reel
MSU Graduate Theses
Pyruvate is produced in duplicate at the end of glycolysis in addition to ATP and NADH. Pyruvate is the metabolite of choice in most cells, whether obtained exogenously or endogenously. Recently we found that the addition of pyruvate’s conjugate base, sodium pyruvate, to cell culture media dampened the immune response to influenza A virus (IAV) infection in cultured innate immune cells. Thus, I decided to investigate the mechanism and potential for treatment of IAV. In vitro using bone marrow derived macrophages that were infected with IAV we found that adding sodium pyruvate to the media decreased immune signaling pathways through …
Healthcare Workers' And Students' Current Knowledge And Perceptions Of Medical Marijuana Laws, Cole Isaac Stomp
Healthcare Workers' And Students' Current Knowledge And Perceptions Of Medical Marijuana Laws, Cole Isaac Stomp
MSU Graduate Theses
As states across the United States enact Medical Marijuana Laws (MMLs), it is important to understand the implications of these policies and what effect they may have on the current healthcare industry. There is a lack of medical marijuana (MM) access due to novel policy and discrepancy of state legislature between those legalizing MM use versus current federal law. As of November, 2018, the state of Missouri has adopted MM policy, yet the perceptions, attitudes, and knowledge of MM and MMLs for current and future healthcare workers remains unknown. Therefore, the purpose of this study was to survey local healthcare …
The Effect Of The Interaction Of Exercise Training And Isolation On The Serotonergic System Of App/Ps1 Mice, Bailey J. Dansby
The Effect Of The Interaction Of Exercise Training And Isolation On The Serotonergic System Of App/Ps1 Mice, Bailey J. Dansby
MSU Graduate Theses
Alzheimer’s disease (AD) is a complex neurodegenerative disease that is characterized by the deposition of amyloid beta (Ab) peptides and, consecutively, by a loss of memory and cognitive functions. The amyloid cascade hypothesis suggests that Ab deposition is the main pathogenic of AD. There is evidence that both changes in production and clearance of Ab may be involved in AD pathology. Past studies have shown that exercise training leads to an upregulation in proteins directly involved with Ab clearance. Chronic stress is thought to exacerbate AD pathology by increasing production of Ab. Studies have also demonstrated a link between serotonin …