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It's A Hard Nacht Life: Understanding How Nlrp12 Ticks, Abbigale Julia Brown Dec 2019

It's A Hard Nacht Life: Understanding How Nlrp12 Ticks, Abbigale Julia Brown

MSU Graduate Theses

The protein NOD- like receptor pyrin domain containing 12 (NLRP12) comes from a family of protein receptors with a wide range of functions including fertility as well as anti-inflammatory properties. The biological role of NLRP12 is poorly understood: research on the mechanisms behind its function and/or activation remains contradictory between different cell models. Current research suggests its involvement in a multi-protein complex named the inflammasome. The alternative hypothesis that has also been proposed is that NLRP12 is not a part of the inflammasome, rather it negatively regulates a transcription factor known as NF-��B down stream of Toll-like receptors. NLRP12 is …


Elucidating Immune Signaling Of Influenza A Virus And Aspergillus Fumigatus Co-Infections Through Pioneered Model Development, Meagan Danyelle Rippee-Brooks Aug 2019

Elucidating Immune Signaling Of Influenza A Virus And Aspergillus Fumigatus Co-Infections Through Pioneered Model Development, Meagan Danyelle Rippee-Brooks

MSU Graduate Theses

Bacterial co-infections with influenza A virus (IAV) are extremely serious and life-threatening. However, there exists limited understanding about the importance of fungal infections with IAV. Clinical case reports indicate that fungal co-infections do occur and suggest the IAV pandemic of 2009 had a propensity to predispose patients to secondary fungal infections more than previous IAV strains. IAV-fungal co-infections are marked by high mortality rates of 47 to 61% in previously healthy individuals between the ages of 20 and 60. Yet, the variables involved in this co-infection remain undetermined. I achieved effective recapitulation of this co-infection using a C57Bl/6 murine (mouse) …


Yoga To Decrease The Stress Response: Gentle Yoga Encourages Faster Decline In Salivary Cortisol Concentrations Following Participation In Tsst, Tabetha Gaile Hopke Aug 2019

Yoga To Decrease The Stress Response: Gentle Yoga Encourages Faster Decline In Salivary Cortisol Concentrations Following Participation In Tsst, Tabetha Gaile Hopke

MSU Graduate Theses

Short-term, activation of the human stress response system is beneficial as it prepares the body to deal with stressors at hand (McEwen & Stellar, 1993). If this system is overactive or chronically active however, it can negatively impact health and longevity (Cohen, Janicki-Deverts, & Miller, 2007). According to a review conducted by Ross & Thomas (2010) implementation of a yoga practice has been shown to down-regulate the stress response system. The present study aimed to expand on current research involving yoga for stress reduction by exploring whether participation in gentle yoga could decrease the stress response more quickly than naturally …


Orthorexia Nervosa Among Collegiate Female Student-Athletes, Maryse Bard-Martel May 2019

Orthorexia Nervosa Among Collegiate Female Student-Athletes, Maryse Bard-Martel

MSU Graduate Theses

Orthorexia nervosa (ON) is a specific style of disordered eating defined as an unhealthy obsession with eating healthy food, or going to extremes in the pursuit of a diet that is supposed to be good for you. The purpose of this study was to explore the prevalence of orthorexia nervosa tendencies in college female soccer players in the NCAA Division 1. Purposive sampling was used, and participants were current student-athletes from the Missouri State women’s soccer team (n=18). Survey research was utilized to assess athletes’ attitudes and behaviors related to various aspects of diet and training, and the control it …


Examining The Effects Of Service-Learning On Students' Perceptions Of The Ches Responsibilities– A Pilot Study, Victoria M. Surratt May 2019

Examining The Effects Of Service-Learning On Students' Perceptions Of The Ches Responsibilities– A Pilot Study, Victoria M. Surratt

MSU Graduate Theses

Purpose: To evaluate the effectiveness of a service-learning project on students' willingness, confidence, and perceived importance to incorporate the Certified Health Education Specialist, Areas of Responsibility (CHES-AOR), into their profession. It was hypothesized that students participation in a service-learning project in an undergraduate health and wellness course would be more willing, confident, and perceive it as more important to apply the CHES-AOR within their chosen health profession. Methods: Missouri State University students registered in the fall 2018, undergraduate Health and Wellness service-learning course (KIN-350-001), completed an online survey at the beginning and the end of the semester. Seven questions were …


Assessment Of Motor Function, Motor Learning, & Olivary Climbing Fiber Distribution Within Developmental Hyperserotonemia Rat Model For Autism Spectrum Disorder, Elizabeth Diane Holland May 2019

Assessment Of Motor Function, Motor Learning, & Olivary Climbing Fiber Distribution Within Developmental Hyperserotonemia Rat Model For Autism Spectrum Disorder, Elizabeth Diane Holland

MSU Graduate Theses

While Autism Spectrum Disorder (ASD) is defined by deficits in social communication, compromised motor function and motor learning have been increasingly reported. Motor deficits could compound social impairment through delayed language acquisition, reduced opportunity for social interaction, and affected nonverbal communication. One area of interest in the investigation of motor dysfunction is the cerebellum, where altered cerebellar structure and connectivity have been reported in those diagnosed with ASD. Morphological and functional changes in cerebellar circuitry could disrupt motor skill development and may be associated with developmental alterations of the serotonergic system. Elevated blood serotonin in perinatal development, developmental hyperserotonemia (DHS), …


College Students’ Mental Health: Exploring The Relationship With Resilience And Academic Performance, Bailey Hart May 2019

College Students’ Mental Health: Exploring The Relationship With Resilience And Academic Performance, Bailey Hart

MSU Graduate Theses

Negative mental health outcomes are becoming increasingly prevalent in college students. Depression, anxiety, and stress have been previously shown to negatively impact academic motivation and performance. Resilience and social support can serve as preventative factors to protect students from this adversity. Resilience is a dynamic process that changes based on environmental factors. An individual’s perceptions of social support can be influenced by friends, family, and significant others. Another possible influence in the perception of social support and resilience is race/ethnicity. Social support especially has been viewed differently based on culture. The purpose of this study was to examine the links …


Further Characterization Of The Skeletal Phenotype In A Hurler Syndrome Mouse Model And The Ethical Treatment Of Children In Medicine, Anna Marie Mcwoods May 2019

Further Characterization Of The Skeletal Phenotype In A Hurler Syndrome Mouse Model And The Ethical Treatment Of Children In Medicine, Anna Marie Mcwoods

MSU Graduate Theses

Mucopolysaccharidosis type I (MPS I) is a rare, autosomal recessive disorder caused by the deficiency of the lysosomal enzyme α-L-iduronidase (IDUA). Absence of IDUA results in the accumulation of dermatan and heparin sulfate and ultimately causes multi-system dysfunction. The most severe form of MPS I is Hurlers syndrome, a rapidly progressive disorder that, if left untreated, is fatal. Current treatment options for diagnosed individuals includes hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy (ERT). These treatments are able to ameliorate the majority of symptoms with the exception of the bone phenotype. This investigation aimed to further characterize the bone …


Training Load Management And Injury Prevention In Collegiate Men's Soccer, Lorenzo Salvatore Tomasiello Jr. May 2019

Training Load Management And Injury Prevention In Collegiate Men's Soccer, Lorenzo Salvatore Tomasiello Jr.

MSU Graduate Theses

Soccer is a popular sport within the National Collegiate Athletic Association (NCAA) evidenced by 23,602 athletes participating in Men’s soccer as of 2014. The sports complexity, coupled with the structure of a collegiate season, demands athletes train to improve performance and prevent injuries. Coaches are able to monitor training through the use of global positioning system (GPS) technology to properly prescribe training loads to meet the individual demands for an athlete. By utilizing an acute to chronic ratio derived from GPS data, coaches are able to determine whether an athlete is prepared for the workloads they are going to be …