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Characterizing The Roles Of Nuclear Proteins Dbc1, G9a, And Glp In Adipocyte Function And Metabolic Health, Ashley Ann Able
Characterizing The Roles Of Nuclear Proteins Dbc1, G9a, And Glp In Adipocyte Function And Metabolic Health, Ashley Ann Able
LSU Doctoral Dissertations
Obesity is a metabolic disorder characterized by excess energy storage in adipose tissue and it increases the risk for Type 2 diabetes. Impaired or altered adipocyte function during obesity can contribute to metabolic dysfunction. DBC1 (deleted in breast cancer 1) and EHMTs 1 and 2 (euchromatic histone lysine methyltransferases 1 and 2) have been shown to have a role in fat cell development and function. DBC1 is typically localized in the nucleus and can regulate a variety of epigenetic modifiers, transcription factors, and nuclear receptors. EHMTs 1 and 2, also known respectively as GLP and G9a, were initially classified as …