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Associations Of Hiv Risk Behaviors Among Older Latinas And Their Adult Daughters, Gira J. Ravelo

FIU Electronic Theses and Dissertations

This dissertation examines the associations between adult Latina daughters’ HIV risk behaviors and that of their older Latina mothers’ HIV risk behaviors. The central hypothesis of the study is that adult Latina daughters’ influence their older mothers’ behaviors and that such behaviors interact with the level of their attachment.

Older Latinas are a vulnerable population that face cultural risk factors, health care provider bias, and engage in low rates of HIV testing. The primary mode of HIV infection for Latinas is through heterosexual contact. Yet, traditional gender norms such as marianismo belief place pressure on Latina women to be submissive …

Health Outcomes Of Hispanic Parents Caring For Children With Disabilities, Nelson Sanchez

FIU Electronic Theses and Dissertations

The purpose of this correlational study is to investigate the impact of the child’s functional status, family context, parent acculturation, and social support on parenting stress and, ultimately, on parents physical and mental health. A convenience sample of 50 Hispanic parents was recruited through a Facebook page and from agencies in South Florida providing services to children with disabilities and their families. The parents ages range from 21 to 62 years and the majority were mothers (n= 45). The majority of parents in this study live in low income households, have no college education, showed little participation in the workforce, …

Risk Associated With E-Cigarette Use And Marketing Messages On Other Tobacco Products Use And Dependence Symptoms Among Adolescents, Rehab Auf

FIU Electronic Theses and Dissertations

E-cigarettes became available in the United States during 2007. Studies using national data have found an increase in e- cigarette use among adolescents as early as 2011. In 2014, e-cigarettes became the most commonly used tobacco product among adolescents; however, little is known about its association with other tobacco products use. Therefore, the present study aimed to: 1) Examine the association between initiating tobacco use via e-cigarettes and subsequent use of other tobacco products; 2) Examine the association between the exposure to e-cigarettes marketing messages and tobacco use; 3) Describe symptoms of nicotine dependence associated with e-cigarette use, compared with …

Id3, Estrogenic Chemicals, And The Pathogenesis Of Tumor-Like Proliferative Vascular Lesions, Vincent E. Avecilla

FIU Electronic Theses and Dissertations

Tumor-like proliferative vascular lesions manifest in several diseases such as peripheral arterial disease (PAD) and atherosclerosis (AS) after arterial injury. The cause of the vascular cell dysfunction in PAD patients is not known. Our recent novel discovery shows that inhibitor of differentiation 3 (ID3) is highly expressed in intimal lesions of clinical vascular disease samples. The central hypothesis of our study is: estrogenic chemical induced dysregulation of ID3 target genes is involved in the development of vascular disease. NHANES data analysis demonstrated higher geometric levels of all 6 PCB congeners in both PAD diagnosed participants and participants at risk of …

Epigenetic Instability Induced By Dna Base Lesion Via Dna Base Excision Repair, Zhongliang Jiang

FIU Electronic Theses and Dissertations

DNA damage can cause genome instability, which may lead to human cancer. The most common form of DNA damage is DNA base damage, which is efficiently repaired by DNA base excision repair (BER). Thus BER is the major DNA repair pathway that maintains the stability of the genome. On the other hand, BER mediates DNA demethylation that can occur on the promoter region of important tumor suppressor genes such as Breast Cancer 1 (BRCA1) gene that is also involved in prevention and development of cancer. In this study, employing cell-based and in vitro biochemical approaches along with bisulfite DNA sequencing, …

Molecular Risk Factors Of Pulmonary Arterial Hypertension, Hamza M. Assaggaf

FIU Electronic Theses and Dissertations

The overall objective of the research presented in this dissertation was to investigate molecular risk factors of susceptibility to estrogenic chemicals, polychlorinated biphenyls (PCBs), hormone replacement therapy, and oral contraceptives and how that leads to the development of pulmonary arterial hypertension (PAH). Environmental and molecular risk factors for PAH are not clearly understood. This is a major hurdle for the development of new therapy against PAH as well as understanding individual susceptibility to this disease. Gender has been shown to impact the prevalence of PAH. Although controversial, estrogens have been implicated to be a risk factor for PAH. Thus, we …

Quantitative Yttrium-90 Bremsstrahlung Spect/Ct And Pet/Ct Study For 3d Dosimetry In Radiomicrosphere Therapy, Senait Aknaw Debebe

FIU Electronic Theses and Dissertations

Liver cancer ranks the third most common cause of cancer related mortality worldwide. Radiomicrosphere therapy (RMT), a form of radiation therapy, involves administration of Yttrium-90 (90Y) microspheres to the liver via the hepatic artery. 90Y microspheres bremsstrahlung SPECT/CT or PET/CT imaging could potentially identify an extrahepatic uptake. An early detection of such an uptake, thus, could initiate preventative measures early on. However, the quantitative accuracy of bremsstrahlung SPECT/CT images is limited by the wide and continuous energy spectrum of 90Y bremsstrahlung photons. 90Y PET/CT imaging is also possible but limited by the extremely small internal pair production decay. These limitation …

Examining The Influence Of Contextual Factors On Risky Sexual Behavior Among Young Women In Zomba District, Malawi: A Multilevel Analysis, Melissa K. Ward-Peterson

FIU Electronic Theses and Dissertations

The objective of this study was to examine the association between risky sexual behavior and contextual factors related to economic resources, woman’s empowerment, and health facility characteristics among young women in Zomba district, Malawi. Secondary analyses of the Schooling, Income, and Health Risk (SIHR) study were undertaken. Four outcomes related to risky sexual behavior were examined: if participants had ever had sex, consistent condom use, and two scores measuring risk related to partner history and age during sexual activity. Regression models with cluster-robust standard errors and multilevel regression models were used to estimate associations; analyses were stratified by school enrolment …

Processing Of The English Verb Particle Construction In Persons With Aphasia, David Lopez

FIU Electronic Theses and Dissertations

This study examined comprehension of verb particle constructions in persons with aphasia (PWA) and young and older typical adults according to the semantic classes by Jackendoff (2002). The experimental task focused on the following three classes of verb particle constructions: idiomatic, directional, and aspectual verb particles. Movement of the object NP also was examined. The study involved a picture-matching task counterbalanced for each participant. The results revealed that PWAs showed slower than normal overall processing, slower processing of aspectual verb forms, and slower processing of syntactic form regardless of movement. Error analysis revealed a bias toward the meaning of the …

The Effect Of Target-Specific Biomolecules In Breast Cancer, Mohannad Garoub

FIU Electronic Theses and Dissertations

Cancer is the second leading cause of mortality in the United States and the World, therefore, early effective prevention, diagnosis, and therapy is needed. Estrogens play a major role in the initiation and progression of breast cancer. Elevated lifetime exposure to estrogens is associated with an increased risk of developing breast cancer. Estrogens through influencing mitochondria contribute to estrogen induced breast carcinogenesis; however, the exact mitochondrial mechanisms underlying the estrogen carcinogenic effect in breast tissue are not clearly understood. For this dissertation, the mitotoxic and cytotoxic effects of triphenylphosphonium cation (TPP) and Origanum majorana organic extract (OME) as well as …

The Effect Of Vitamin D3 Supplementation On Kidney Function And Cardiovascular Disease Markers Among Hispanics And African Americans With Type 2 Diabetes, Gustavo G. Zarini

FIU Electronic Theses and Dissertations

Serum vitamin D deficiency/insufficiency, Chronic Kidney Disease (CKD) and elevated blood pressure are important health concerns especially among minorities with type 2 diabetes. The effect of vitamin D₃ supplementation (cholecalciferol) at 6,000 IU/day (d) vs. 4,000 IU/d on kidney function and cardiovascular disease markers among Hispanics and African Americans with type 2 diabetes and hypovitaminosis D (/ml) was evaluated. Subjects (n=63) were recruited from two clinics in Miami-Dade County, FL. Fasting venous blood and fresh, single-voided first morning urine samples were collected from each participant by a certified phlebotomist and analyzed by Solstas Lab Partners, Davie, FL. Linear mixed …

The Effects Of Children's Spiritual Coping After Parent, Grandparent Or Sibling Death On Children's Grief, Personal Growth, And Mental Health, Ivette M. Hidalgo

FIU Electronic Theses and Dissertations

Parental death can have a negative impact on children’s lives with changes in economic resources, and lead to change in residence, loss of contact with friends and neighbors, change in caretakers, and loss of time with the surviving parent. Research on the effects of a grandparent’s death on children is limited. Death of a sibling signifies the loss of a role model, friend, confidante, and playmate. The purpose of this correlational study was to identify: 1) differences in the spiritual coping strategies used by children across age groups, gender, race/ethnicity, participation in religious rituals and practices, and the relationship of …

Identification And Phenotypic Plasticity Of Metastatic Cells In A Mouse Model Of Melanoma, Xiaoshuang Li

FIU Electronic Theses and Dissertations

Melanoma is the deadliest form of skin cancer due to its high propensity to metastasize and resistance to current therapies. We have created a spontaneous mouse model of metastatic melanoma (Dct-Grm1/K5-Edn3) where metastasis to the lungs is 80% penetrant. The primary tumors of these mice present cellular heterogeneity with cells at varying levels of differentiation. The main goal of this study was to determine the metastatic potential of the primary tumor resident Tyrosinase positive cells and evaluate the dynamic phenotypic changes as those cells move from the primary tumors to the sites of metastasis. To accomplish this aim …

Examining The Association Between Racial Residential Segregation, Risky Sexual Behaviors, And Sexually Transmitted Infections., Khaleeq J. Lutfi

FIU Electronic Theses and Dissertations

Sexually transmitted infections (STIs) disproportionately impact non-Hispanic blacks in the United States. Racial differences in sexual networks can contribute to these disparities. Racial residential segregation, the separation of racial groups in a residential context, is a community factor known to influence sexual networks and has been associated with negative health outcomes. Our objective was to examine the association between racial residential segregation (henceforth, referred to as segregation), risky sexual behavior, concurrent partnerships, and STI diagnoses among non-Hispanic blacks. Demographic, sexual behavior, and STI diagnosis data for non-Hispanic blacks 15–44 years of age were obtained from the 2006–2010 National Survey of …

Exploring Breast Health Perceptions, Behaviors, And Social Cohesion Among Ethnically Diverse Black Women, Sheila Y. Mckinney

FIU Electronic Theses and Dissertations

Purpose

Study explored the relationships of ethnic identity, culture, and social cohesion to mammography, cancer screening, and preventive medical visits among African-American and Afro-Caribbean women in Broward County, FL. Purpose was to understand non-compliance to screening recommendations for breast cancer among disadvantaged Black women in an area of high prevalence.

Methods

A bounded convenience sample of 117 women (49% African-American and 51% Afro-Caribbean) completed a cross-sectional survey and a subset (n=87) participated in semi-structured discussion groups. Both measured perceptions related to breast cancer, defined ethnic identity or culture, and suggested social and cultural factors influence of ethnic identity, culture, and …

Hiv Risk Behaviors, Previous Hiv Testing And Positivity Among Hispanic Women Tested For Hiv In Florida, 2012, Janelle Taveras

FIU Electronic Theses and Dissertations

The prevalence of female adults and adolescents living with diagnosed HIV infection continues to rise. Latina women in the United States (US) are not only disproportionately affected by human immunodeficiency virus (HIV) infection, but also underutilize HIV prevention services, such as HIV testing. Data are limited on the differences in HIV risk among Latinas by country of birth, and opportunities still exist to prevent transmission of HIV and reduce HIV-related disparities. This dissertation describes the risk behaviors, testing behaviors, and test results among women tested for HIV at public sites in Florida. Additionally, it compares these characteristics by HIV testing …

Prevalence And Determinants Of Overweight And Obesity In Preschoolers In Miami-Dade County, Catherina Chang

FIU Electronic Theses and Dissertations

Background: The prevalence of childhood overweight in the United States continues to be a national public health problem. The child care and household environments play an important role in the nutrition, physical activity, and screen-time behaviors of preschoolers. Aims: This dissertation aimed to (1) estimate the prevalence of overweight and obesity in 3-5 year old children enrolled in child care centers in Miami-Dade County; (2) identify early life, dietary, and screen-time risk factors of overweight, and (3) assess child care centers' level of adherence to nutrition, physical activity, and screen-time regulations by center socioeconomic location (SEP). Methods: A total of …

Theory Of Gender And Power: Intimate Partner Violence, Hiv Status And Sexual Risk Behaviors In Haitian Women, Anshul Saxena

FIU Electronic Theses and Dissertations

Among women in Haiti, there are a number of factors, including intimate partner violence (IPV), childhood sexual abuse, and alcohol abuse that lead to increased vulnerability to STI/HIV and its sequelae. This study examined the factors associated with IPV and the associations between IPV and HIV in a sample of adult Haitian women.

The current study is a secondary analysis of data collected from HIV+ and HIV- women attending the GHESKIO centers in Haiti. The measures include: Self-reported Questionnaire-20 (SRQ-20); Attitudes Towards Gender Roles; Partner Violence; Alcohol Use Disorders Identification Test (AUDIT); Partner Support; Sexual Relationship Power Scale (SRPS); Centers …

Exploring The Nutrition And Physical Activity Knowledge, Attitudes, And Behaviors Of Low-Income Parents Of Peruvian Preschool Children, Kathleen Mcinvale

FIU Electronic Theses and Dissertations

Obesity and related chronic diseases are emerging public health issues among children in Peru, where more than 13 percent of children five years and younger are overweight or obese. Although parents have been identified as one of the most important determinants of healthy weight in young children, there are no known studies that have explored the perceptions of Peruvian parents regarding obesity prevention. This study assessed the nutrition and physical activity knowledge, attitudes and behaviors of Peruvian parents, and sought to determine if there is a relationship between their knowledge, attitudes and behaviors. The cross-sectional survey study sampled 204 parents …

Parental Attitudes, Beliefs And Behaviors About Caries Prevention Among Black Preschool Children, Rachel Clarke

FIU Electronic Theses and Dissertations

Tooth decay is one of the most common chronic conditions that affect children in the U.S. Non-Hispanic Blacks are among the children facing the greatest racial and ethnic disparities in caries experience and treatment. Parents play a significant role in ensuring the success of preventative measures aimed at reducing prevalence of early childhood caries. It is therefore important for public health professionals to understand the oral health, attitudes, beliefs, and behaviors of Black parents in order to effectively design and tailor interventions for caries prevention among preschool children.

The twofold purpose of this study was to: (a) determine whether attitudes, …

Exploring The Dynamics Of Sexuality Conversations Between Haitian And Jamaican Parents And Their Adolescents, Kemesha Gabbidon

FIU Electronic Theses and Dissertations

Parent-teen sex conversations reduce Black adolescents’ HIV/STI risk. Nationally, most studies about Black teens’ sexual risk behaviors omit Afro-Caribbean groups whom are disproportionately burdened by HIV/STIs. Therefore, this exploratory study guided by the PEN-3 model (a) characterized the nature, perceptions, enablers, and nurturers of sexuality conversations between Haitian and Jamaican parents and adolescents and (b) explained the relationship between sexuality conversations and adolescent sexual activity.

Using narrative inquiry, 6 Haitian and 8 Jamaican mother-teen dyads’ and triads’ (N=31) experiences were used to characterize the nature, perceptions, enablers, and nurturers of parent-teen sex conversations. Thematic content analysis generated common themes. In …

Enzyme Catalyzed And Ultrasound Assisted Transformation Of Selected Pollutants, Yi Tan

FIU Electronic Theses and Dissertations

The widespread use of synthetic drugs and as feed additives has resulted in the release of large amounts of biologically active chemicals into the environment. Exposure to environmentally relevant concentrations of chemicals can have severe effects on human health. Therefore, effective degradation of these synthetic, biologically active compounds is of paramount importance.

Diphenhydramine (DPH) has been selected as a target compound for ultrasound remediation. The results demonstrated that ultrasound-induced degradation has potential applications in managing aqueous media contaminated with DPH.

Atorvastatin and roxarsone have been selected as representative substrates for chloroperoxidase (CPO) catalyzed transformation of pollutants. These studies demonstrate atorvastatin …