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Characterization Of Sympathetic Ganglion Sensitivity To Substance P In A Genetic And A Non-Genetic Rat Model Of Hypertension., John Daniel Tompkins
Characterization Of Sympathetic Ganglion Sensitivity To Substance P In A Genetic And A Non-Genetic Rat Model Of Hypertension., John Daniel Tompkins
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Intravenous injection of substance P (SP) stimulates sympathetic ganglia to evoke a greater increase in renal sympathetic nerve activity, heart rate (HR) and blood pressure (BP) in hypertensive than normotensive rats due to upregulation of the NK1 receptor. These experiments were designed to determine the cellular basis for the enhanced ganglionic responsiveness to NK1 agonists in spontaneously hypertensive rats (SHR) in comparison to their normotensive counterparts, Wistar-Kyoto rats (WKY). Studies were also conducted to determine whether the increased ganglion responsiveness to SP in SHR is causally related to the increased BP or is a unique characteristic of this …