Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Entire DC Network
Transmembrane Domain Nrg1 Mutant Mice Show Altered Susceptibility To The Neurobehavioural Actions Of Repeated Thc Exposure In Adolescence, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Iain S. Mcgregor, Jonathon C. Arnold, Tim Karl
Transmembrane Domain Nrg1 Mutant Mice Show Altered Susceptibility To The Neurobehavioural Actions Of Repeated Thc Exposure In Adolescence, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Iain S. Mcgregor, Jonathon C. Arnold, Tim Karl
Faculty of Health and Behavioural Sciences - Papers (Archive)
Heavy cannabis abuse increases the risk of developing schizophrenia. Adolescents appear particularly vulnerable to the development of psychosis-like symptoms after cannabis use. To test whether the schizophrenia candidate gene neuregulin 1 (NRG1) modulates the effects of cannabinoids in adolescence, we tested male adolescent heterozygous transmembrane domain Nrg1 mutant (Nrg1 TM HET) mice and wild type-like littermates (WT) for their neurobehavioural response to repeated Δ9-tetrahydrocannabinol (THC, 10 mg/kg i.p. for 21 d starting on post-natal day 31). During treatment and 48 h after treatment withdrawal, we assessed several behavioural parameters relevant to schizophrenia. After behavioural testing we measured autoradiographic …
Comorbid Externalising Behaviour In Ad/Hd: Evidence For A Distinct Pathological Entity In Adolescence, Sharnel Perera, David Crewther, Rodney Croft, Hannah Keage, Daniel Hermens, C Richard Clark
Comorbid Externalising Behaviour In Ad/Hd: Evidence For A Distinct Pathological Entity In Adolescence, Sharnel Perera, David Crewther, Rodney Croft, Hannah Keage, Daniel Hermens, C Richard Clark
Faculty of Health and Behavioural Sciences - Papers (Archive)
While the profiling of subtypes of Attention Deficit Hyperactivity Disorder (AD/HD) have been the subject of considerable scrutiny, both psychometrically and psychophysiologically, little attention has been paid to the effect of diagnoses comorbid with AD/HD on such profiles. This is despite the greater than 80% prevalence of comorbidity under the DSM-IV-TR diagnostic definitions. Here we investigate the event related potential (ERP) and psychometric profiles of Controls, AD/HD, and comorbid AD/HD (particularly AD/HD+ODD/CD) groups on six neurocognitive tasks thought to probe the constructs of selective and sustained attention, response inhibition and executive function. Data from 29 parameters extracted from a child …
Influence Of High Glycemic Index And Glycemic Load Diets On Blood Pressure During Adolescence, Bamini Gopinath, Victoria M. Flood, Elena Rochtchina, Louise A. Baur, Wayne Smith, Paul Mitchell
Influence Of High Glycemic Index And Glycemic Load Diets On Blood Pressure During Adolescence, Bamini Gopinath, Victoria M. Flood, Elena Rochtchina, Louise A. Baur, Wayne Smith, Paul Mitchell
Faculty of Health and Behavioural Sciences - Papers (Archive)
We aimed to prospectively examine the association between the glycemic index and glycemic load of foods consumed and the dietary intakes of carbohydrates, sugars, fiber, and principal carbohydrate-containing food groups (eg, breads, cereals, and sugary drinks) with changes in blood pressure during adolescence. A total of 858 students aged 12 years at baseline (422 girls and 436 boys) were examined from 2004-2005 to 2009-2011. Dietary data were assessed from validated semiquantitative food frequency questionnaires. Blood pressure was measured using a standard protocol. In girls, after adjusting for age, ethnicity, parental education, parental history of hypertension, baseline height, baseline blood pressure, …