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Author Correction: Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis And Is Traceable In The Circulating Extracellular Vesicles (Scientific Reports, (2019), 9, 1, (11632), 10.1038/S41598-019-48064-W), Anbarasu Kannan, Julie V. Philley, Kate L. Hertweck, Harrison Ndetan, Karan P. Singh, Subramaniam Sivakumar, Robert B. Wells, Ratna K. Vadlamudi, Santanu Dasgupta
Author Correction: Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis And Is Traceable In The Circulating Extracellular Vesicles (Scientific Reports, (2019), 9, 1, (11632), 10.1038/S41598-019-48064-W), Anbarasu Kannan, Julie V. Philley, Kate L. Hertweck, Harrison Ndetan, Karan P. Singh, Subramaniam Sivakumar, Robert B. Wells, Ratna K. Vadlamudi, Santanu Dasgupta
School of Medicine Faculty Publications and Presentations
Triple negative breast cancer (TNBC) has poor survival, exhibits rapid metastases, lacks targeted therapies and reliable prognostic markers. Here, we examined metastasis promoting role of cancer testis antigen SPANXB1 in TNBC and its utility as a therapeutic target and prognostic biomarker. Expression pattern of SPANXB1 was determined using matched primary cancer, lymph node metastatic tissues and circulating small extracellular vesicles (sEVs). cDNA microarray analysis of TNBC cells stably integrated with a metastasis suppressor SH3GL2 identified SPANXB1 as a potential target gene. TNBC cells overexpressing SH3GL2 exhibited decreased levels of both SPANXB1 mRNA and protein. Silencing of SPANXB1 reduced migration, invasion …