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Associations Of Cannabis Use Disorder With Cognition, Brain Structure, And Brain Function In African Americans, Marinka M. G. Koenis, Joke Durnez, Amanda Rodrigue, Samuel R. Mathias, Aaron F. Alexander-Bloch, Jennifer Barrett, Gaelle E. Doucet, Sophia Frangou, Joanne E. Curran, John Blangero
Associations Of Cannabis Use Disorder With Cognition, Brain Structure, And Brain Function In African Americans, Marinka M. G. Koenis, Joke Durnez, Amanda Rodrigue, Samuel R. Mathias, Aaron F. Alexander-Bloch, Jennifer Barrett, Gaelle E. Doucet, Sophia Frangou, Joanne E. Curran, John Blangero
School of Medicine Publications and Presentations
Although previous studies have highlighted associations of cannabis use with cognition and brain morphometry, critical questions remain with regard to the association between cannabis use and brain structural and functional connectivity. In a cross-sectional community sample of 205 African Americans (age 18–70) we tested for associations of cannabis use disorder (CUD, n = 57) with multi-domain cognitive measures and structural, diffusion, and resting state brain-imaging phenotypes. Post hoc model evidence was computed with Bayes factors (BF) and posterior probabilities of association (PPA) to account for multiple testing. General cognitive functioning, verbal intelligence, verbal memory, working memory, and motor speed were …
The Effects Of An Aerobic Training Intervention On Cognition, Grey Matter Volumes And White Matter Microstructure, Claire E. Sexton, Jill F. Betts, Andrea Dennis, Aiden Doherty, Paul Leeson, Cameron Holloway, Erica Dall'armellina, Anderson M. Winkler, Naiara Demnitz, Thomas Wassenaar
The Effects Of An Aerobic Training Intervention On Cognition, Grey Matter Volumes And White Matter Microstructure, Claire E. Sexton, Jill F. Betts, Andrea Dennis, Aiden Doherty, Paul Leeson, Cameron Holloway, Erica Dall'armellina, Anderson M. Winkler, Naiara Demnitz, Thomas Wassenaar
School of Medicine Publications and Presentations
While there is strong evidence from observational studies that physical activity is associated with reduced risk of cognitive decline and dementia, the extent to which aerobic training interventions impact on cognitive health and brain structure remains subject to debate. In a pilot study of 46 healthy older adults (66.6 years ± 5.2 years, 63% female), we compared the effects of a twelve-week aerobic training programme to a waitlist control condition on cardiorespiratory fitness, cognition and magnetic resonance imaging (MRI) outcomes. Cardiorespiratory fitness was assessed by VO max testing. Cognitive assessments spanned executive function, memory and processing speed. Structural MRI analysis …
White Matter Structure And Myelin-Related Gene Expression Alterations With Experience In Adult Rats, Cassandra Sampaio-Baptista, Astrid Vallès, Alexandre A. Khrapitchev, Guus Akkermans, Anderson M. Winkler, Sean Foxley, Nicola R. Sibson, Mark Roberts, Karla Miller, Matthew E. Diamond
White Matter Structure And Myelin-Related Gene Expression Alterations With Experience In Adult Rats, Cassandra Sampaio-Baptista, Astrid Vallès, Alexandre A. Khrapitchev, Guus Akkermans, Anderson M. Winkler, Sean Foxley, Nicola R. Sibson, Mark Roberts, Karla Miller, Matthew E. Diamond
School of Medicine Publications and Presentations
White matter (WM) plasticity during adulthood is a recently described phenomenon by which experience can shape brain structure. It has been observed in humans using diffusion tensor imaging (DTI) and myelination has been suggested as a possible mechanism. Here, we set out to identify molecular and cellular changes associated with WM plasticity measured by DTI. We combined DTI, immunohistochemistry and mRNA expression analysis and examined the effects of somatosensory experience in adult rats. First, we observed experience-induced DTI differences in WM and in grey matter structure. C-Fos mRNA expression, a marker of cortical activity, in the barrel cortex correlated with …