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Tobacco Smoke Carcinogens Induce Dna Repair Machinery Function Loss: Protection By Carbon Nanotubes, Anukriti Dhasmana, Anupam Dhasmana, Hobani Yahya H, Abdullah Farasani, Mahmoud Habibullah, Freah L. Alshammary, Saif Khan, Shafiul Haque, Mohtashim Lohani
Tobacco Smoke Carcinogens Induce Dna Repair Machinery Function Loss: Protection By Carbon Nanotubes, Anukriti Dhasmana, Anupam Dhasmana, Hobani Yahya H, Abdullah Farasani, Mahmoud Habibullah, Freah L. Alshammary, Saif Khan, Shafiul Haque, Mohtashim Lohani
School of Medicine Publications and Presentations
Purpose: DNA damage is a continuous process occurring within the cells caused by intrinsic and extrinsic factors, but it gets repaired regularly. If the DNA repair process is faulty, the incidences of damages/mutations can accumulate in cells resulting in cell transformation. It is hypothesized that the negative variations in DNA repair pathways in even at one point viz. genetic, translational or posttranslational stage may fairly be crucial for the beginning and development of carcinogenesis. Therefore, we investigated the potential of tobacco specific nitrosamines (TSNs) related carcinogens to interact with the enzymes involved in DNA repair mechanisms in the current study. …
Covid-19: Fighting The Invisible Enemy With Microrna, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Covid-19: Fighting The Invisible Enemy With Microrna, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
School of Medicine Publications and Presentations
Introduction: The novel coronavirus (CoV) disease 2019 (COVID-19) is a viral infection that causes Severe Acute Respiratory Syndrome. It is believed that early reports of COVID-19 cases were noticed in December 2019 and soon after became a global public health emergency. It is advised that COVID-19 transmits through human to human contact and in most cases it remains asymptomatic. Several approaches are being utilized to control the outbreak of this fatal viral disease. microRNAs (miRNAs) are known signature therapeutic tool for the viral diseases; they are small non-coding RNAs that target the mRNAs to inhibit their post-transcriptional expression, therefore, impeding …
Gambogic Acid: A Shining Natural Compound To Nanomedicine For Cancer Therapeutics, Elham Hatami, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Gambogic Acid: A Shining Natural Compound To Nanomedicine For Cancer Therapeutics, Elham Hatami, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
School of Medicine Publications and Presentations
The United State Food and Drug Administration has permitted number of therapeutic agents for cancer treatment. Most of them are expensive and have some degree of systemic toxicity which makes overbearing in clinical settings. Although advanced research continuously applied in cancer therapeutics, but drug resistance, metastasis, and recurrence remain unanswerable These accounts to an urgent clinical need to discover natural compounds with precisely safe and highly efficient for the cancer prevention and cancer therapy. Gambogic acid (GA) is the principle bioactive and caged xanthone component, a brownish gamboge resin secreted from the of Garcinia hanburyi tree. This molecule showed a …
Pectin-Tannic Acid Nano-Complexes Promote The Delivery And Bioactivity Of Drugs In Pancreatic Cancer Cells, Sumeet S. Chauhan, Advait B. Shetty, Elham Hatami, Pallabita Chowdhury, Murali M. Yallapu
Pectin-Tannic Acid Nano-Complexes Promote The Delivery And Bioactivity Of Drugs In Pancreatic Cancer Cells, Sumeet S. Chauhan, Advait B. Shetty, Elham Hatami, Pallabita Chowdhury, Murali M. Yallapu
School of Medicine Publications and Presentations
Pancreatic cancer (PanCa) is a lethal disease. Conventional chemotherapies for PanCa offer severe systemic toxicities. Thus, the development of a successful nanomedicine-based therapeutic regimen with augmented therapeutic efficacy is highly sought. Naturally occurring pectin and modified pectin-based drug delivery systems exhibit remarkable self-targeting ability via galactose residues to various cancer cells. Herein, we developed and used an innovative approach of highly stable nanocomplexes based on modified pectin and tannic acid (MPT-NCs). The nanocomplex formation was enabled by strong intermolecular interactions between pectin and tannic acid under very mild conditions. These nanocomplexes were characterized by particle size and morphology (DLS, TEM, …
Pluronic Polymer-Based Ormeloxifene Nanoformulations Induce Superior Anticancer Effects In Pancreatic Cancer Cells, Neeraj Chauhan, Amber Kruse, Hilary Newby, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan
Pluronic Polymer-Based Ormeloxifene Nanoformulations Induce Superior Anticancer Effects In Pancreatic Cancer Cells, Neeraj Chauhan, Amber Kruse, Hilary Newby, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan
School of Medicine Publications and Presentations
Utilization of safe cytotoxic agents with precise anticancer activity is considered as the prime focus of cancer therapeutics research. A greater incentive for such agents arises from the molecules/drugs that are already being used for other indications. Ormeloxifene (ORM) is a nonsteroidal, nonhormonal selective estrogen receptor modulator (SERM), which has been in human use for contraception purposes. Although in the recent past, many reports have suggested its emerging role as an anticancer agent, no significant attention was paid toward generating simple and safe nanoformulation( s) for improved therapeutic activity and tumor cell-specific delivery. Our aim is to develop nanoformulation(s) of …