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Gambogic Acid Potentiates Gemcitabine Induced Anticancer Activity In Non-Small Cell Lung Cancer, Elham Hatami, Prashanth K. B. Nagesh, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Gambogic Acid Potentiates Gemcitabine Induced Anticancer Activity In Non-Small Cell Lung Cancer, Elham Hatami, Prashanth K. B. Nagesh, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
School of Medicine Publications and Presentations
Non-small cell lung cancer (NSCLC) is the most frequent type of lung cancer accounting up to 80-85% of all lung cancer (LC) cases. Gemcitabine (Gem), a pyrimidine nucleoside antimetabolite, is widely used chemotherapy offering several months survival benefit in patients with NSCLC. The emergence of Gem resistance is a main clinical concern in cancer treatment and thus a continuous demand for development of new therapeutic strategies to improve its antitumor activity. Hence, we report an adjuvant therapeutic regimen based on natural compound, gambogic acid (GA) which has been shown to enhanced Gem induced inhibition of cancer cell growth, arrest cell …
Gambogic Acid: A Shining Natural Compound To Nanomedicine For Cancer Therapeutics, Elham Hatami, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Gambogic Acid: A Shining Natural Compound To Nanomedicine For Cancer Therapeutics, Elham Hatami, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
School of Medicine Publications and Presentations
The United State Food and Drug Administration has permitted number of therapeutic agents for cancer treatment. Most of them are expensive and have some degree of systemic toxicity which makes overbearing in clinical settings. Although advanced research continuously applied in cancer therapeutics, but drug resistance, metastasis, and recurrence remain unanswerable These accounts to an urgent clinical need to discover natural compounds with precisely safe and highly efficient for the cancer prevention and cancer therapy. Gambogic acid (GA) is the principle bioactive and caged xanthone component, a brownish gamboge resin secreted from the of Garcinia hanburyi tree. This molecule showed a …
Pectin-Tannic Acid Nano-Complexes Promote The Delivery And Bioactivity Of Drugs In Pancreatic Cancer Cells, Sumeet S. Chauhan, Advait B. Shetty, Elham Hatami, Pallabita Chowdhury, Murali M. Yallapu
Pectin-Tannic Acid Nano-Complexes Promote The Delivery And Bioactivity Of Drugs In Pancreatic Cancer Cells, Sumeet S. Chauhan, Advait B. Shetty, Elham Hatami, Pallabita Chowdhury, Murali M. Yallapu
School of Medicine Publications and Presentations
Pancreatic cancer (PanCa) is a lethal disease. Conventional chemotherapies for PanCa offer severe systemic toxicities. Thus, the development of a successful nanomedicine-based therapeutic regimen with augmented therapeutic efficacy is highly sought. Naturally occurring pectin and modified pectin-based drug delivery systems exhibit remarkable self-targeting ability via galactose residues to various cancer cells. Herein, we developed and used an innovative approach of highly stable nanocomplexes based on modified pectin and tannic acid (MPT-NCs). The nanocomplex formation was enabled by strong intermolecular interactions between pectin and tannic acid under very mild conditions. These nanocomplexes were characterized by particle size and morphology (DLS, TEM, …