Digital Commons Network^™

Predicting Malignant Nodules From Screening Ct Scans, Samuel Hawkins, Hua Wang, Ying Liu, Alberto Garcia, Olya Stringfield, Henry Krewer, Qiang Li, Dmitry Cherezov, Matthew Schabath, Lawrence O. Hall, Robert J. Gillies

Computer Science and Engineering Faculty Publications

Objectives

The aim of this study was to determine whether quantitative analyses (“radiomics”) of low-dose computed tomography lung cancer screening images at baseline can predict subsequent emergence of cancer.

Methods

Public data from the National Lung Screening Trial (ACRIN 6684) were assembled into two cohorts of 104 and 92 patients with screen-detected lung cancer and then matched with cohorts of 208 and 196 screening subjects with benign pulmonary nodules. Image features were extracted from each nodule and used to predict the subsequent emergence of cancer.

Results

The best models used 23 stable features in a random forests classifier and could …

Characteristics And Predictors Of Fatigue Among Men Receiving Androgen Deprivation Therapy For Prostate Cancer: A Controlled Comparison, Ashley M. Nelson, Brian D. Gonzalez, Heather S.L. Jim, Julie M. Cessna, Steven K. Sutton, Brent J. Small, Mayer N. Fishman, Babu Zachariah, Paul B. Jacobsen

Aging Studies Faculty Publications

Purpose: Although fatigue is a common problem for men with prostate cancer undergoing androgen deprivation therapy (ADT), there has been little systematic research on this issue. The present study examined changes in fatigue among prostate cancer patients receiving ADT compared to controls and predictors of heightened fatigue in ADT patients.

Methods: Prostate cancer patients treated with ADT (ADT+ group, n = 60) completed assessments of fatigue prior to or just after ADT initiation (baseline) and 6 and 12 months later. Prostate cancer patients treated with prostatectomy only (ADT- group, n = 85) and men without cancer (CA- group, n = …

Population Analysis Of Adverse Events In Different Age Groups Using Big Clinical Trials Data, Jake Luo, Christina Eldredge, Chi C. Cho, Ron A. Cisler

School of Information Faculty Publications

BACKGROUND: Understanding adverse event patterns in clinical studies across populations is important for patient safety and protection in clinical trials as well as for developing appropriate drug therapies, procedures, and treatment plans.

OBJECTIVES: The objective of our study was to conduct a data-driven population-based analysis to estimate the incidence, diversity, and association patterns of adverse events by age of the clinical trials patients and participants.

METHODS: Two aspects of adverse event patterns were measured: (1) the adverse event incidence rate in each of the patient age groups and (2) the diversity of adverse events defined as distinct types of adverse …

Discriminability And Perceptual Saliency Of Temporal And Spectral Cues For Final Fricative Consonant Voicing In Simulated Cochlear-Implant And Bimodal Hearing, Ying-Yee Kong, Matthew B. Winn, Katja Poelmann, Gail S. Donaldson

Communication Sciences and Disorders Faculty Publications

Multiple redundant acoustic cues can contribute to the perception of a single phonemic contrast. This study investigated the effect of spectral degradation on the discriminability and perceptual saliency of acoustic cues for identification of word-final fricative voicing in “loss” versus “laws”, and possible changes that occurred when low-frequency acoustic cues were restored. Three acoustic cues that contribute to the word-final /s/-/z/ contrast (first formant frequency [F1] offset, vowel–consonant duration ratio, and consonant voicing duration) were systematically varied in synthesized words. A discrimination task measured listeners’ ability to discriminate differences among stimuli within a single cue dimension. A categorization task examined …

Intrinsic Disorder In Transmembrane Proteins: Roles In Signaling And Topology Prediction, Jérôme Bürgi, Bin Xue, Vladimir N Uversky, F Gisou Van Der Goot

Molecular Biosciences Faculty Publications

Intrinsically disordered regions (IDRs) are peculiar stretches of amino acids that lack stable conformations in solution. Intrinsic Disorder containing Proteins (IDP) are defined by the presence of at least one large IDR and have been linked to multiple cellular processes including cell signaling, DNA binding and cancer. Here we used computational analyses and publicly available databases to deepen insight into the prevalence and function of IDRs specifically in transmembrane proteins, which are somewhat neglected in most studies. We found that 50% of transmembrane proteins have at least one IDR of 30 amino acids or more. Interestingly, these domains preferentially localize …

Neddylation Promotes Stress Granule Assembly, Aravinth Kumar Jayabalan, Anthony Sanchez, Ra Young Park, Sang Pil Yoon, Gum-Yong Kang, Je-Hyun Baek, Paul Anderson, Younghoon Kee, Takbum Ohn

Molecular Biosciences Faculty Publications

Stress granules (SGs) harbour translationally stalled messenger ibonucleoproteins and play important roles in regulating gene expression and cell fate. Here we show that neddylation promotes SG assembly in response to arsenite-induced oxidative stress. Inhibition or depletion of key components of the neddylation machinery concomitantly inhibits stress-induced polysome disassembly and SG assembly. Affinity purification and subsequent mass-spectrometric analysis of Nedd8-conjugated proteins from translationally stalled ribosomal fractions identified ribosomal proteins, translation factors and RNA-binding proteins (RBPs), including SRSF3, a previously known SG regulator. We show that SRSF3 is selectively neddylated at Lys85 in response to arsenite. A non-neddylatable SRSF3 (K85R) mutant do …

Large Cross-Sectional Study Of Presbycusis Reveals Rapid Progressive Decline In Auditory Temporal Acuity, Erol J. Ozmeral, Ann C. Eddins, Robert Frisina Sr., David A. Eddins

Communication Sciences and Disorders Faculty Publications

The auditory system relies on extraordinarily precise timing cues for the accurate perception of speech, music, and object identification. Epidemiological research has documented the age-related progressive decline in hearing sensitivity that is known to be a major health concern for the elderly. Although smaller investigations indicate that auditory temporal processing also declines with age, such measures have not been included in larger studies. Temporal gap detection thresholds (TGDTs; an index of auditory temporal resolution) measured in 1071 listeners (aged 18–98 years) were shown to decline at a minimum rate of 1.05 ms (15%) per decade. Age was a significant predictor …

Construction And Evaluation Of Rodent-Specific Rtms Coils, Alexander D. Tang, Andrea S. Lowe, Andrew R. Garrett, Robert Woodward, William Bennett, Alison J. Canty, Michael I. Garry, Mark R. Hinder, Jeffery J. Summers, Roman Gersner, Alexander Rotenberg, Gary Thickbroom, Joseph P. Walton, Jennifer Rodger

Communication Sciences and Disorders Faculty Publications

Rodent models of transcranial magnetic stimulation (TMS) play a crucial role in aiding the understanding of the cellular and molecular mechanisms underlying TMS induced plasticity. Rodent-specific TMS have previously been used to deliver focal stimulation at the cost of stimulus intensity (12 mT). Here we describe two novel TMS coils designed to deliver repetitive TMS (rTMS) at greater stimulation intensities whilst maintaining spatial resolution. Two circular coils (8 mm outer diameter) were constructed with either an air or pure iron-core. Peak magnetic field strength for the air and iron-cores were 90 and 120 mT, respectively, with the iron-core coil exhibiting …

Identification Of Ecdysone Hormone Receptor Agonists As A Therapeutic Approach For Treating Filarial Infections, Amruta S Mhashilkar, Sai L Vankayala, Canhui Liu, Fiona Kearns, Priyanka Mehrotra, George Tzertzinis, Subba R Palli, H. Lee Woodcock Iii, Thomas R Unnasch

Chemistry Faculty Publications

BACKGROUND: A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeutic targets.

METHODOLOGY/ PRINCIPAL FINDINGS: Administration of 20-hydroxyecdysone to gerbils infected with B. malayi infective larvae disrupted their development to adult stage parasites. A stable mammalian cell line was created incorporating the B. malayi ecdysone receptor ligand-binding domain, its heterodimer partner and a secreted luciferase reporter in HEK293 cells. This was employed to screen a series of ecdysone agonist, identifying seven agonists active at sub-micromolar concentrations. …

Systematic Replication Of The Effects Of A Supplementary, Technology-Assisted, Storybook Intervention For Preschool Children With Weak Vocabulary And Comprehension Skills, Charles R. Greenwood, Judith J. Carta, Elizabeth S. Kelley, Gabriela Guerrero, Na Young Kong, Jane Atwater, Howard Goldstein

Communication Sciences and Disorders Faculty Publications

In 2013, Spencer, Goldstein, Sherman, et al. reported the promising effects of a supplemental, technology-assisted, storybook intervention (Tier 2) containing embedded instruction targeting the oral language learning of preschool children at risk for delays. We sought to advance knowledge of the intervention by replicating it in a new sample and examining children’s responses to the narrator’s instructional prompts and associations with learning outcomes. Results indicated that children were highly successful in responding with the narrator’s task-management prompts (i.e., turn the page), particularly after the first book. Children were much less proficient in correctly responding to the narrator’s word-teaching prompts …

The Exceptionally High Reactivity Of Cys 621 Is Critical For Electrophilic Activation Of The Sensory Nerve Ion Channel Trpa1, Parmvir K. Bahia, Thomas A. Parks, Katherine R. Stanford, David A. Mitchell, Sameer Varma, Stanley M. Stevens Jr., Thomas E. Taylor-Clark

Molecular Biosciences Faculty Publications

Activation of the sensory nerve ion channel TRPA1 by electrophiles is the key mechanism that initiates nociceptive signaling, and leads to defensive reflexes and avoidance behaviors, during oxidative stress in mammals. TRPA1 is rapidly activated by subtoxic levels of electrophiles, but it is unclear how TRPA1 outcompetes cellular antioxidants that protect cytosolic proteins from electrophiles. Here, using physiologically relevant exposures, we demonstrate that electrophiles react with cysteine residues on mammalian TRPA1 at rates that exceed the reactivity of typical cysteines by 6,000-fold and that also exceed the reactivity of antioxidant enzymes. We show that TRPA1 possesses a complex reactive cysteine …

Reengineering Of Mesh Thesauri For Term Selection To Optimize Literature Retrieval And Knowledge Reconstruction In Support Of Stem Cell Research, Yan Su, James E. Andrews, Hong Huang, Yue Wang, Liangliang Kong, Peter Cannon, Ping Xu

School of Information Faculty Publications

BACKGROUND: PubMed is a widely used database for scientists to find biomedical-related literature. Due to the complexity of the selected research subject and its interdisciplinary nature, as well as the exponential growth in the number of disparate pieces of biomedical literature, it is an overwhelming challenge for scientists to define the right search strategies and quickly locate all related information. Specialized subsets and groupings of controlled vocabularies, such as Medical Subject Headings (MeSH), can enhance information retrieval in specialized domains, such as stem cell research. There is a need to develop effective search strategies and convenient solutions for knowledge organization …

The Effects Of Sensorineural Hearing Impairment On Asynchronous Glimpsing Of Speech, Erol J. Ozmeral, Emily Buss, Joseph W. Hall Iii

Communication Sciences and Disorders Faculty Publications

In a previous study with normal-hearing listeners, we evaluated consonant identification masked by two or more spectrally contiguous bands of noise, with asynchronous square-wave modulation applied to neighboring bands. Speech recognition thresholds were 5.1–8.5 dB better when neighboring bands were presented to different ears (dichotic) than when all bands were presented to one ear (monaural), depending on the spectral width of the frequency bands. This dichotic advantage was interpreted as reflecting masking release from peripheral spread of masking from neighboring frequency bands. The present study evaluated this effect in listeners with sensorineural hearing loss, a population more susceptible to spread …

Changes In Physical Functioning And Muscle Strength In Men Receiving Androgen Deprivation Therapy For Prostate Cancer: A Controlled Comparison, Brian D. Gonzalex, Heather S. L. Jim, Brent J. Small, Mayer N. Fishman, Babu Zachariah, Randy V. Heysek, Paul B. Jacobsen

Aging Studies Faculty Publications

Purpose: The purpose of the study is to examine changes in muscle strength and self-reported physical functioning in men receiving androgen deprivation therapy (ADT) for prostate cancer compared to matched controls.

Methods: Prostate cancer patients scheduled to begin ADT (n = 62) were assessed within 20 days of starting ADT and 6 and 12 months later. Age and geographically matched prostate cancer controls treated with prostatectomy only (n = 86) were assessed at similar time intervals. Grip strength measured upper body strength, the Chair Rise Test measured lower body strength, and the SF-12 Physical Functioning scale measured self-reported physical functioning. …

The Effects Of Acoustic Bandwidth On Simulated Bimodal Benefit In Children And Adults With Normal Hearing, Sterling W. Sheffield, Michelle Simha, Kelly N. Jahn, René H. Gifford

Communication Sciences and Disorders Faculty Publications

Objectives—The primary purpose of this study was to examine the effect of acoustic bandwidth on bimodal benefit for speech recognition in normal-hearing children with a cochlear implant (CI) simulation in one ear and low-pass filtered stimuli in the contralateral ear. The effect of acoustic bandwidth on bimodal benefit in children was compared to the pattern of adults with normal hearing. Our hypothesis was that children would require a wider acoustic bandwidth than adults to 1) derive bimodal benefit, and 2) obtain asymptotic bimodal benefit.

Design—Nineteen children (6–12 years) and ten adults with normal hearing participated in the study. Speech recognition …

Velar–Vowel Coarticulation In A Virtual Target Model Of Stop Production, Stefan A. Frisch, Sylvie M. Wodzinski

Communication Sciences and Disorders Faculty Publications

Velar–vowel coarticulation in English, resulting in so-called velar fronting in front vowel contexts, was studied using ultrasound imaging of the tongue during /k/ onsets of monosyllabic words with no coda or a labial coda. Ten native English speakers were recorded and analyzed. A variety of coarticulation patterns that often appear to contain small differences in typical closure location for similar vowels was found. An account of the coarticulation pattern is provided using a virtual target model of stop consonant production where there are two /k/ allophones in English, one for front vowels and one for non-front vowels. Small differences in …

Apolipoprotein E And Clusterin Can Magnify Effects Of Personality Vulnerability On Declarative Memory Performance In Non‐Demented Older Adults, Sharaddha Sapkota, Sandra A. Wiebe, Brent J. Small, Roger A. Dixon

Aging Studies Faculty Publications

Objectives: Recent research has linked psychological (personality) factors and specific genetic risk polymorphisms to performance on neurocognitive phenotypes. We examined whether episodic or semantic memory performance is associated with (a) three personality traits (i.e. neuroticism, extraversion, and openness to experience), (b) two neurodegenerative‐related polymorphisms (i.e. Apolipoprotein E (APOE; rs7412; rs429358), Clusterin (CLU; rs11136000)), and (c) cross‐domain risk interactions (magnification effects).

Methods: Linear growth models were examined to test independent associations between personality traits and declarative memory performance, and potential interaction effects with APOE and CLU genetic risk. Normal older adults (n = 282) with personality …

Stepped Care Versus Standard Trauma‐Focused Cognitive Behavioral Therapy For Young Children, Alison Salloum, Wei Wang, John Robst, Tanya K. Murphy, Michael S. Scheeringa, Judith A. Cohen, Eric A. Storch

Social Work Faculty Publications

Background

To compare the effectiveness and cost of stepped care trauma‐focused cognitive behavioral therapy (SC‐TF‐CBT), a new service delivery method designed to address treatment barriers, to standard TF‐CBT among young children who were experiencing posttraumatic stress symptoms (PTSS).

Methods

A total of 53 children (ages 3–7 years) who were experiencing PTSS were randomly assigned (2:1) to receive SC‐TF‐CBT or TF‐CBT. Assessments by a blinded evaluator occurred at screening/baseline, after Step One for SC‐TF‐CBT, posttreatment, and 3‐month follow‐up. Trial registration: ClinicalTrials.gov: https://www.clinicaltrials.gov/ct2/show/NCT01603563.

Results

There were comparable improvements over time in PTSS and secondary outcomes in both conditions. Noninferiority of SC‐TF‐CBT …

Molecular Mechanism Of Protein Kinase Recognition And Sorting By The Hsp90 Kinome-Specific Cochaperone Cdc37, Dimitra Keramisanou, Adam Aboalroub, Ziming Zhang, Wenjun Liu, Devon Marshall, Andrea Diviney, Randy W. Larsen, Ralf Landgraf, Ioannis Gelis

Chemistry Faculty Publications

Despite the essential functions of Hsp90, little is known about the mechanism that controls substrate entry into its chaperone cycle. We show that the role of Cdc37 cochaperone reaches beyond that of an adaptor protein and find that it participates in the selective recruitment of only client kinases. Cdc37 recognizes kinase specificity determinants in both clients and nonclients and acts as a general kinase scanning factor. Kinase sorting within the client-to-nonclient continuum relies on the ability of Cdc37 to challenge the conformational stability of clients by locally unfolding them. This metastable conformational state has high affinity for Cdc37 and forms …

Agonist-Mediated Activation Of Sting Induces Apoptosis In Malignant B Cells, Chih-Hang Anthony Tang, Joseph A. Zundell, Sujeewa Ranatunga, Cindy Lin, Yulia Nefedova, Juan R. Del Valle, Chih-Chi Andrew Hu

Chemistry Faculty Publications

Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA sensing, IFN production, and cancer control. Here we show that the IRE-1/XBP-1 pathway functions downstream of STING and that STING agonists selectively trigger mitochondria-mediated apoptosis in normal and malignant B cells. Upon stimulation, STING was degraded less efficiently in B cells, implying that prolonged activation of STING can lead to apoptosis. Transient activation of the IRE-1/XBP-1 pathway partially protected agonist-stimulated malignant B cells from undergoing apoptosis. In Eμ-TCL1 mice with chronic lymphocytic leukemia, injection of …

The Role Of Continuous Low-Frequency Harmonicity Cues For Interrupted Speech Perception In Bimodal Hearing, Soo Hee Oh, Gail S. Donaldson

Communication Sciences and Disorders Faculty Publications

Low-frequency acoustic cues have been shown to enhance speech perception by cochlear-implant users, particularly when target speech occurs in a competing background. The present study examined the extent to which a continuous representation of low-frequency harmonicity cues contributes to bimodal benefit in simulated bimodal listeners. Experiment 1 examined the benefit of restoring a continuous temporal envelope to the low-frequency ear while the vocoder ear received a temporally interrupted stimulus. Experiment 2 examined the effect of providing continuous harmonicity cues in the low-frequency ear as compared to restoring a continuous temporal envelope in the vocoder ear. Findings indicate that bimodal benefit …

The Effect Of Noise Fluctuation And Spectral Bandwidth On Gap Detection, Joseph W. Hall Iii, Emily Buss, Erol J. Ozmeral, John H. Grose

Communication Sciences and Disorders Faculty Publications

Experiment 1 investigated gap detection for random and low-fluctuation noise (LFN) markers as a function of bandwidth (25–1600 Hz), level [40 or 75 dB sound pressure level (SPL)], and center frequency (500–4000 Hz). Gap thresholds for random noise improved as bandwidth increased from 25 to 1600 Hz, but there were only minor effects related to center frequency and level. For narrow bandwidths, thresholds were lower for LFN than random markers; this difference extended to higher bandwidths at the higher center frequencies and was particularly large at high stimulus level. Effects of frequency and level were broadly consistent with the idea …

Attention Demands Of Language Production In Adults Who Stutter, Nathan D. Maxfield, Wendy L. Olsen, Daniel Kleinman, Stefan A. Frisch, Victor S. Ferreira, Jennifer J. Lister

Communication Sciences and Disorders Faculty Publications

Objective: We investigated whether language production is atypically resource-demanding in adults who stutter (AWS) versus typically-fluent adults (TFA).

Methods: Fifteen TFA and 15 AWS named pictures overlaid with printed Semantic, Phonological or Unrelated Distractor words while monitoring frequent low tones versus rare high tones. Tones were presented at a short or long Stimulus Onset Asynchrony (SOA) relative to picture onset. Group, Tone Type, Tone SOA and Distractor Type effects on P3 amplitudes were the main focus. P3 amplitude was also investigated separately in a simple tone oddball task.

Results: P3 morphology was similar between groups in the simple task. In …

Mechanistic Binding Insights For 1-Deoxy-D-Xylulose-5-Phosphatesynthase, The Enzyme Catalyzing The First Reaction Of Isoprenoid Biosynthesis In The Malaria-Causing Protists, Plasmodium Falciparum And Plasmodium Vivax, Matthew R. Battistini, Christopher Shoji, Sumit Handa, Leonid Breydo, David J. Merkler

Chemistry Faculty Publications

We have successfully truncated and recombinantly-expressed 1-deoxy-D-xylulose-5-phosphate synthase (DXS) from both Plasmodium vivax and Plasmodium falciparum. We elucidated the order of substrate binding for both of these ThDP-dependent enzymes using steady-state kinetic analyses, dead-end inhibition, and intrinsic tryptophan fluorescence titrations. Both enzymes adhere to a random sequential mechanism with respect to binding of both substrates: pyruvate and D-glyceraldehyde-3-phosphate. These findings are in contrast to other ThDP-dependent enzymes, which exhibit classical ordered and/or ping-pong kinetic mechanisms. A better understanding of the kinetic mechanism for these two Plasmodial enzymes could aid in the development of novel DXS-specific inhibitors that might prove useful …

Fear Conditioning And Extinction In Youth With Obsessive-Compulsive Disorder, Joseph F. Mcguire, Scott P. Orr, Monica S. Wu, Adam B. Lewin, Brent J. Small, Vicky Phares, Tanya K. Murphy, Sabine Wilhelm, Daniel S. Pine, Daniel Geller, Eric A. Storch

Psychology Faculty Publications

BACKGROUND: Fear acquisition and extinction are central constructs in the cognitive-behavioral model of obsessive-compulsive disorder (OCD), which underlies exposure-based cognitive-behavioral therapy (CBT). Youth with OCD may have impairments in fear acquisition and extinction that carry treatment implications. We examined these processes using a differential conditioning procedure.

METHODS: Forty-one youth (19 OCD, 22 community comparisons) completed a battery of clinical interviews, rating scales, and a differential conditioning task that included habituation, acquisition, and extinction phases. Skin conductance response (SCR) served as the primary dependent measure.

RESULTS: During habituation, no difference between groups was observed. During acquisition, differential fear conditioning was observed …

Anticipatory Coarticulation And Stability Of Speech In Typically Fluent Speakers And People Who Stutter, Stefan A. Frisch, Nathan Maxfield, Alissa Belmont

Communication Sciences and Disorders Faculty Publications

This project replicates and extends previous work on coarticulation in velar-vowel sequences in English. Coarticulatory data for 46 young adult speakers, 23 who stutter and 23 who do not stutter show coarticulatory patterns in young adults who stutter that are no different from typical young adults. Additionally, the stability of velar-vowel production is analysed in token-to-token variability found in multiple repetitions of the same velar-vowel sequence. Across participants, identical patterns of coarticulation were found between people who do and do not stutter, but decreased stability was found in velar closure production in a significant subset of people who stutter. Other …

Activating Clinical Trials: A Process Improvement Approach, Diego Martinez, Athanasios Tsalatsanis, Ali Yalcin, José L. Zayas-Castro, Benjamin Djulbegovic

Industrial and Management Systems Engineering Faculty Publications

Background: The administrative process associated with clinical trial activation has been criticized as costly, complex, and time-consuming. Prior research has concentrated on identifying administrative barriers and proposing various solutions to reduce activation time, and consequently associated costs. Here, we expand on previous research by incorporating social network analysis and discrete-event simulation to support process improvement decision-making.

Methods: We searched for all operational data associated with the administrative process of activating industry-sponsored clinical trials at the Office of Clinical Research of the University of South Florida in Tampa, Florida. We limited the search to those trials initiated and activated between July …

Gut Immunity In A Protochordate Involves A Secreted Immunoglobulin-Type Mediator Binding Host Chitin And Bacteria, Larry J. Dishaw, Brittany Leigh, John P. Cannon, Assunta Liberti, M. Gail Mueller, Diana P. Skapura, Charlotte R. Karrer, Maria R. Pinto, Rosaria De Santis, Gary W. Litman

Marine Science Faculty Publications

Protochordate variable region-containing chitin-binding proteins (VCBPs) consist of immunoglobulin-type V domains and a chitin-binding domain (CBD). VCBP V domains facilitate phagocytosis of bacteria by granulocytic amoebocytes; the function of the CBD is not understood. Here we show that the gut mucosa of Ciona intestinalis contains an extensive matrix of chitin fibrils to which VCBPs bind early in gut development, before feeding. Later in development, VCBPs and bacteria colocalize to chitin-rich mucus along the intestinal wall. VCBP-C influences biofilm formation in vitro and, collectively, the findings of this study suggest that VCBP-C may influence the overall settlement and colonization of bacteria …

Transdiagnostic Psychiatric Symptoms And Event-Related Potentials Following Rewarding And Aversive Outcomes, Jeffrey S. Bedwell, Geoffrey Potts, Diane C. Gooding, Benjamin J. Trachik, Chi C. Chan, Christopher C. Spencer

Psychology Faculty Publications

There is a need for a better understanding of transdiagnostic psychiatric symptoms that relate to neurophysiological abnormalities following rewarding and aversive feedback in order to inform development of novel targeted treatments. To address this need, we examined a transdiagnostic sample of 44 adults (mean age: 35.52; 57% female), which consisted of individuals with broadly-defined schizophrenia-spectrum disorders (n = 16), bipolar disorders (n = 10), other mood and anxiety disorders (n = 5), and no history of a psychiatric disorder (n = 13). Participants completed a Pavlovian monetary reward prediction task during 32-channel electroencephalogram recording. We assessed the event-related potentials (ERPs) …

Differences In Patient Outcomes Of Prevalence, Interval, And Screen-Detected Lung Cancers In The Ct Arm Of The National Lung Screening Trial, Matthew B. Schabath, Pierre P. Massion, Zachary J. Thompson, Steven A. Eschrich, Yoganand Balagurunathan, Dmitry Goldof, Denise R. Aberle, Robert J. Gillies

Computer Science and Engineering Faculty Publications

Lung cancer screening identifies cancers with heterogeneous behaviors. Some lung cancers will be identified among patients who had prior negative CT screens and upon follow-up scans develop a de novo nodule that was determined to be cancerous. Other lung cancers will be identified among patients who had one or more prior stable positive scans that were not determined to be lung cancer (indeterminate pulmonary nodules), but in follow-up scans was diagnosed with an incidence lung cancer. Using data from the CT arm of the National Lung Screening Trial, this analysis investigated differences in patient characteristics and survival endpoints between prevalence-, …