Digital Commons Network^™

Does Footfall Pattern In Forefoot Runners Change Over A Prolonged Run?, Carl W. Jewell

Masters Theses

There has been much debate on the benefits of a forefoot versus rearfoot strike pattern in distance running in terms of performance and injury prevalence. Shock attenuation occurs more prominently in soft tissues at impact in forefoot runners compared to the passive skeletal loading in rearfoot runners. Recent studies indicate that a forefoot strike pattern may not be maintainable over long distance efforts. Therefore, this study tested the hypothesis that habitual forefoot runners could not maintain their strike pattern throughout a prolonged, intensive run.

Fourteen forefoot runners ran to voluntary exhaustion on an instrumented force treadmill (average run duration: 15.4±2.2 …

Parents' Gender Ideology And Gendered Behavior As Predictors Of Children's Gender-Role Attitudes: A Longitudinal Exploration, Hillary Paul Halpern

Masters Theses

This longitudinal study examined the association between parents’ early and concurrent gender ideology and gendered behaviors and their children’s gender-role attitudes at age six. Specifically, parents' global beliefs about women's and men's "rightful" roles in society, as well as their work preferences for mothers, were considered in relation to the gender-role attitudes held by their first-graders. In addition, parents’ gendered behaviors, including their division of household and childcare tasks, division of paid work hours, and job traditionality were examined as predictors of children’s gender-role attitudes. Based on previous research, it was hypothesized parents’ early and concurrent behavior and ideology would …

Investigating Teenage Drivers' Driving Behavior Before And After Lag (Less Aggressive Goals) Training Program, Jingyi Zhang

Masters Theses

Motor vehicle crashes are a leading cause of death during adolescence, with the fatal crash rate per mile-driven for 16-19 years old drivers being nearly 3 times larger than the rate for drivers age 20 and older. High gravitational events among teenage drivers, such as quick starts, and hard stops, have been shown to be highly correlated with crash rates. The current younger driver training programs developed in the late 1990s, however, do not appear to be especially effective in regard to many skills which are critical to avoiding crashes. With this in mind, a simulator-based training program aimed at …

Effect Of Chemotherapeutic Treatment Schedule On A Tissue Transport Model, Dan E. Ganz

Masters Theses

Current chemotherapeutic treatment schedule prediction methods rely heavily on PK/PD-based models and overlook the important contribution of tissue-level transport and binding. Tissue-level transport and binding phenomena are essential to understanding drug delivery and efficacy in tumors. Drugs with desirable PK/PD properties often fail in vivo due to poor tissue-level transport. We developed an in silico method to predict the effect of treatment schedule on efficacy that couples PK/PD with tissue-level transport. Treatment schedules were implemented on theoretical drugs with different PK/PD and transport properties. For each drug with a given clearance rate, diffusivity, and binding, treatment schedules consisting of one …

Increased Body Weight In Adulthood Following A Peripubertal Stressor And Proposed Mechanism For Effects Of Increased Adiposity On Estrogen-Dependent Behaviors, Christina F. Gagliardi

Masters Theses

Exposure to certain stressors during a sensitive period around puberty can lead to enduring effects on an animal’s response to estradiol. In estradiol-influenced behaviors, such as sexual receptivity, hippocampal-dependent learning and memory, depression-like behavior, and anxiety-like behaviors, exposure to a peripubertal stressor such as shipping stress or an injection of lipopolysaccharide (LPS) can eliminate or even reverse the normal response to estradiol. In addition to regulating these behaviors, estradiol play a role in the regulation of body weight. While some of the previous studies touched on short-term effects on body weight, no systemic long-term study of the effects of a …

The Association Between Urinary Bisphenol-A, Phthalate Metabolites And Body Fat Composition In Us Adults Using Nhanes, Iris E. Corbasson

Masters Theses

Due to the widespread use of the endocrine disruptors Bisphenol-A (BPA) and phthalates in many plastic consumer goods, medical equipment, and personal care products, more than 95% of the US population show detectable levels of urinary BPA and phthalate metabolites. Both have been linked to increased body mass index (BMI in kg/m²), an inexpensive diagnostic tool for obesity, which may however not reflect body fatness. Since excess body fat is associated with cardiovascular diseases, cancer and type II diabetes, it is important to understand the relationship between body fat composition and exposure to BPA and phthalates, a relationship …

The Role Of Sleep Timing On Diet Quality And Physical Activity Among College-Aged Women Participating In The University Of Massachusetts Vitamin D Status Study, Deniz Azarmanesh

Masters Theses

Overweight and obesity are risk factors for various chronic diseases. Sleep has been associated with overweight and obesity. One potential mechanism by which sleep may lead to overweight and obesity is through positive energy balance (i.e. energy intake exceeding expenditure). There are few studies examining the impact of sleep timing (onset and wake time) on diet and exercise. In a cross sectional study, we examined associations between sleep timing and diet quality, and in separate models, between sleep timing and meeting the 2008 Physical Activity Guidelines for Americans among the participants of the UMass Vitamin D Status Study. A total …

The Characterization Of Chitin Microparticle Preparations: Degree Of Acetylation And Its Effect On Immunologic Response, Julianne R. Zimmerman

Masters Theses

Studies examining the immune response upon exposure to chitin microparticles in living models have reached drastically differing conclusions, and the reason remains unclear. One notable issue between the experiments is that they have not characterized their chitin preparations for degree of acetylation. They all use different chitin processing methods prior to administration, which could potentially be the source of the variance between studies. Chitin and chitosan preparations specified in the literature and several novel preparations were analyzed for degree acetylation (DA) using High Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection (HPAEC-PAD). It was found that autoclaving and sonication processing steps …

The Politics Of Psychiatric Experience, Shuko Tamao

Masters Theses

This paper examines the correspondence, manuscripts, and speeches of ex-mental patient activists. I chronicle the activities of the emergent psychiatric survivors movement from its beginnings in the early 1970’s focusing on the work of the Boston based activist, Judi Chamberlin (1944-2010). This paper examines how mental patients in post-war America began to organize in order to have their voices included in the process of their own recovery. I present Chamberlin’s experience as a mental patient as being representative of the “rootlessness” that many post-war women experienced. Chamberlin’s work as an ex-patient activist presented one aspect of the overall struggle on …

Coffee And Tea Consumption And The Risk Of Lung Cancer In A Population Of Postmenopausal Women, Abigail Santos

Masters Theses

Lung cancer has been the leading cause of cancer death in women for
the past three decades. Although smoking is the most important risk
factor for lung cancer, not all lung cancer deaths in American women
are attributed to smoking and the role of dietary exposures remain
unclear.In particular, the effect of coffee consumption and tea
consumption on lung cancer risk remains inconclusive. Therefore we
assessed these associations prospectively in 83,777 women between the
ages of 50-79 who did not have a previous history of cancer. Daily
coffee and tea consumption (cups/d) were assessed via a baseline
questionnaire while the …

Kinetic Asymmetries During Submaximal And Maximal Speed Running, Devon H. Frayne

Masters Theses

An important issue for sports scientists, coaches and athletes is an understanding of the factors within a running stride that can enhance or limit maximal running speed. Previous research has identified many sprint-related parameters as potential kinetic limiters of maximal Center of Mass velocity (Chapman and Caldwell, 1983b; Weyand et al., 2001). Bilateral asymmetry is present for many of these parameters during running; however the degree to which such asymmetries change as running speed increases is unknown. It was hypothesized that asymmetries in key sprinting parameters would be larger at maximal speed than all other tested speeds. Kinematics and kinetics …

Rapid Method Of Processing Sperm For Nucleic Acid Extraction In Clinical Research, Matthew K. De Gannes

Masters Theses

Background: Sperm contain highly compact nuclei, inhibiting DNA extraction using traditional techniques. Current methods extracting sperm DNA involve lengthy lysis and no means of stabilizing DNA, hindering clinical research.

Objective: We sought to optimize an efficient method of extracting high quality human sperm DNA.

Methods: Sperm from three volunteers were isolated using PureCeption. We tested 1) proteinase K with DNA/RNA Shield, 2) DTT and TCEP as reducing agents, 3) QIAshredder homogenization, and 4) stability of sperm DNA fresh (baseline) or after 4 weeks of storage at 4^OC in DNA/RNA Shield using modified Quick-gDNA MiniPrep. DNA was PCR amplified …