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Differential Expression Of Cancer Associated Proteins In Breast Milk Based On Age At First Full Term Pregnancy, Wenyi Qin, Ke Zhang, Beth Kliethermes, Rachel L. Ruhlen, Eva P. Browne, Kathleen F. Arcaro, Edward R. Sauter
Differential Expression Of Cancer Associated Proteins In Breast Milk Based On Age At First Full Term Pregnancy, Wenyi Qin, Ke Zhang, Beth Kliethermes, Rachel L. Ruhlen, Eva P. Browne, Kathleen F. Arcaro, Edward R. Sauter
Kathleen Arcaro
Background: First full term pregnancy (FFTP) completed at a young age has been linked to low long term breast cancer risk, whereas late FFTP pregnancy age confers high long term risk, compared to nulliparity. Our hypothesis was that proteins linked to breast cancer would be differentially expressed in human milk collected at three time points during lactation based on age at FFTP. Methods: We analyzed breast milk from 72 lactating women. Samples were collected within 10 days of the onset of lactation (baseline-BL), two months after lactation started and during breast weaning (W). We measured 16 proteins (11 kallikreins (KLKs), …